Table I Output of major NSAID bulk pharmaceuticals in China, ,545 12,412 10, ,408 58,766

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1 I-1 General Situation of NSAIDs in China NSAID, non-steroidal anti-inflammatory drugs, is a series of medicines with the curative effects such as defervesce, acesodyne, anti-inflammation, anti-rheumatism, etc.. Table I Output of major NSAID bulk pharmaceuticals in China, Item Year Analgin Aspirin Ibuprofen Naproxen/Na proxen sodium Others Total of NSAID ,545 12,412 10, ,408 58, ,620 13,175 10, ,544 60, , ,733 Output, tonne ,026 10,540 9, ,500 72, ,211 9,500 12,715 N/A 370 N/A N/A ,400 N/A N/A N/A N/A N/A N/A ,746 13,580 11,370 4,089 1,100 11, , % 21.12% 17.88% 1.27% 0.25% 9.20% % % 21.76% 16.72% 1.40% 0.38% 12.46% % Output share, % % 18.73% 14.17% 1.75% 0.28% 10.70% % % 14.50% 13.17% 1.14% 0.27% 11.70% % % 11.24% 9.41% 3.39% 0.91% 9.85% % ,834 7,200 6, , ,552 7, , ,848 8, ,546 Export, tonne ,163 8,100 5, ,500 47, ,810 7,394 7,572 1, ,158 58, ,821 N/A N/A N/A N/A N/A N/A ,412 4,7581 N/A2 4,019 N/A N/A N/A Import, tonne N/A N/A N/A N/A N/A N/A ,713 5,212 4, ,908 21, ,070 5,580 3, ,044 19,771 Apparent consumption tonne ,777 5,885 4,307 1, ,500 32, ,864 2,441 4, ,500 25, ,406 2,106 5,143 N/A N/A N/A N/A ,581 N/A N/A N/A N/A N/A N/A ,340 N/A N/A N/A N/A N/A N/A Apparent consumption share, % % 23.82% 19.22% 3.41% 0.45% 8.72% % % 28.22% 16.89% 2.65% 1.09% 15.40% % % 18.00% 13.18% 3.59% 0.13% 26.00% % % 9.51% 17.51% 1.46% 0.02% 13.63% %

2 I-3 Brief Review of Industry in China Table I-3.1 Overview of paracetamol industry development in China Time Event Influence end 1970s to 1980s in the 1990s Started to produce paracetamol in 1959 The output was only 24 tonnes in Commercial production of paracetamol started The output in 1980 was 1,362 tonnes. By 1985 it was 5,549 tonnes, and by 1990, it was 8,893. Began to export paracetamol to the overseas market, from trail quantity to large quantity. Chinese paracetamol enjoyed two golden times: in and in late 1990s. It had been accepted gradually by the overseas customers The golden time for expansion By 2000, China s paracetamol output was nearly 30,000 tonnes, three times that of China s supply capability and the export kept growing. Chinese manufacturers began to diversify. has become the dominant variety among traditional bulk medicines in China in Export tax rebate on paracetamol has reduced since July 1, 2007 The price of crude oil increased sharply to USD147.25/barrel on July 11th. Financial crisis of US was further worse in 2008, which affected the price of raw material and export volume China began to have its own paracetamol started industrialization, and products began to enter international market. developed fast promoted by demand from domestic and overseas markets. went into a quick expansion and slim profit age. faced domestic and international press.

3 I-5 Production Situation of in 2008 List and Geographical Distribution of Active Manufacturers in 2008 Table I Production summary of paracetamol in the past years No. Abbreviation Location GMP 08 Cap. '08 Cap. '07 Cap. '06 Cap. '05 (t/a) Prod. Oct '08 Prod. Apr '05 Output 07 (t) Output 05 (t) Est. exp. 07 Est. exp. 05 (Y/N) (t/a) (t/a) (t/a) (t/m)* (t/m)* (t) (t) II-1.01 Lu an Pharm Shandong Yes 24,000 24,000 24,000 24,000 1,500 2,000 18,736 14,000 16,167 9,871 II-1.02 Zhejiang Conler Zhejiang Yes 12,000 12,000 12,000 14, ,606 7,000 6,684 5,964 II-1.03 Hebei Jiheng Hebei Yes 15,000 15,000 13,000 12,000 1,100 1,000 10,000 6,000 6,334 4,101 II-1.04 Wuxi Rhodia Jiangsu Yes 7,000 7,000 6,000 5, ,600 5,700 5,560 5,579 II-1.05 Bengbu Bayi Anhui Yes 15,000 15,000 15,000 5, ,000 5,000 1,563 3,284 II-1.06 Zhejiang Conch Zhejiang Yes 5,000 5,000 5,000 5, ,000 3, ,738 II-1.07 Jilin Baikang Jilin Yes 5,000 5,000 5,000 4, ,338 3,000 1,312 1,537 II-1.08 Jiangsu Huagang Jiangsu Yes 8,000 8,000 5,000 5, ,000 3, ,769 II-1.09 Tianjin Bofa Tianjin Yes 10,000 5, ,339-3,870 - II-1.10 Jiangsu World Kindly Jiangsu Applying 5,000 5, ,000-2,299 - II-1.11 Anhui Jiameng Anhui Yes 5,000 4,500 4,500 4, ,500 2, II-1.12 Liaoning Tiancheng Liaoning Yes 5,000 5,000 4,500 3, , II-1.13 Anhui Yong an Anhui Yes 8,000 8,000 8,000 5, ,000 1,000-0 II-2.01 Guangdong Jinshi (idled) Guangdong Yes II-2.02 Shaanxi Nuoke (idled) Shaanxi ,000 5, , II-3.01 Henan Xin an (stopped) Henan Yes - - 4,000 4, , II-3.02 Tianjin Xinxin (stopped) Tianjin ,500 3, , ,303 II-3.03 Liaoning Jiutai (stopped) Liaoning , II-3.04 Anhui Topsun (stopped) Anhui , II-3.05 Jiangsu Guoheng (stopped) Jiangsu No - - 4,000 4, Others/unidentifiable ,466 Total 124, , , ,300 7,620 7,475 78,746 59,400 44,574 39,823 Source: CCM International Ltd.

4 I-8.1 Apparent Consumption of in China Table I Production and consumption situation of paracetamol in China, , tonne Year Output Export Import Apparent consumption Annual increment ,905 7,411 N/A 3, ,012 7,651 N/A 4, % ,758 8,271 N/A 5, % ,924 8,562 N/A 6, % ,600 11, , % ,437 14, , % ,688 19, , % ,545 19, , % ,620 21, , % , , , % , , , % ,211 32, , % ,400 39, , % ,092 46, , % ,746 46, , %

5 Table I Major end users of bulk or DC grade paracetamol in China in 2008 Manufacturer Shanghai Johnson Johnson & Pharmaceutica ls Ltd. Tianjin SmithKline Preparation Active component Active content of Company Contact brand name paracetamol entity Tylenol Tablets tablet 500mg/tablet JV Tel: Tylenol Extended Relief tablet 650mg/tablet Tylenol Cold 325mg/tablet Tylenol Infant s Fever Drop 80mg/0.8ml Tylenol Children s Fever Liq uid Tylenol Junior Strength Cap let tablet 160mg/tablet Infant s Tylenol 80mg/0.8ml Acetaminophen Suspension Drops Children s Tylenol Acetaminophen Suspension Drops Tylenol Children s Cold Liquid Panadol tablet 500mg/tablet JV Tel: Bristol-Myers Bufferin 500mg/tablet JV Tel: Squibb Company Fax: Jilin Wutai Gankang 250mg/tablet Tel: Group