Bioanalytical Method List

Transcription

1 Bioanalytical Method List APRIL 2019 Anapharm Bioanalytics Encuny 22, 2nd floor Barcelona, Spain T Page 1 / 18

2 Newly developed or recently updated methods Anidulafungin LC/MS/MS Human EDTA Cholecalciferol (Vitamin D3) LC/MS/MS Human EDTA Cinitapride LC/MS/MS pg/ml Human EDTA Eslicarbazepine LC/MS/MS Human EDTA Exenatide LC/MS/MS pg/ml Human EDTA Fluoxetine LC/MS/MS 1-80 Human EDTA Ibandronic acid LC/MS/MS Human EDTA Ibuprofen LC/MS/MS Human EDTA Memantine LC/MS/MS pg/ml; pg/ml Human EDTA Mesalamine LC/MS/MS Human EDTA Nilotinib LC/MS/MS Human EDTA Olanzapine LC/MS/MS pg/ml Human EDTA Oxycodone LC/MS/MS pg/ml Human EDTA Paliperidone (9-OH Risperidone) LC/MS/MS pg/ml Human EDTA Pitavastatin LC/MS/MS Human EDTA Quetiapine LC/MS/MS Human EDTA Risperidone; 9-OH-Risperidone LC/MS/MS pg/ml ; pg/ml Human EDTA Sildenafil LC/MS/MS Human EDTA Temozolomide LC/MS/MS Human EDTA Ticagrelor LC/MS/MS Human EDTA Page 2 / 18

3 List of bioanalytical methods Abiraterone LC/MS/MS Human EDTA Abiraterone LC/MS/MS Human EDTA Aceclofenac LC/MS/MS Human EDTA Acetylsalicylic Acid; Salicylic Acid LC/MS/MS ; Human EDTA Acetylsalicylic Acid; Salicylic Acid LC/MS/MS ; Human EDTA Acetylsalicylic Acid; Salicylic Acid LC/MS/MS ; Human EDTA Acyclovir LC/MS/MS pg/ml Human EDTA Acyclovir LC/MS/MS Human EDTA Acyclovir LC/MS/MS Human EDTA Adefovir LC/MS/MS Human EDTA Agomelatine LC/MS/MS pg/ml Human EDTA Agomelatine LC/MS/MS pg/ml Human EDTA Alendronic Acid (Alendronate) LC/MS/MS Human EDTA Almotriptan LC/MS/MS Human EDTA Alprazolam LC/MS/MS Human EDTA Amlodipine LC/MS/MS pg/ml Human EDTA Amlodipine LC/MS/MS pg/ ml Human EDTA Amlodipine LC/MS/MS pg/ml Human EDTA Amoxicillin LC/MS/MS Human EDTA Amoxicillin LC/MS/MS Human EDTA Anagrelide LC/MS/MS pg/ml Human EDTA Anagrelide LC/MS/MS pg/ml Human EDTA Anastrozole LC/MS/MS Human EDTA Anidulafungin LC/MS/MS Human EDTA Anti-FIIa Chromogenic IU/mL Human CTAD Assay Anti-FXa Chromogenic IU/mL Human CTAD Assay Apixaban LC/MS/MS Human EDTA Apomorphine LC/MS/MS Rat Aprepitant LC/MS/MS Human EDTA Aripiprazole LC/MS/MS Human EDTA Aripiprazole LC/MS/MS Human EDTA Asenapine LC/MS/MS pg/ml Human EDTA Atazavanir LC/MS/MS Human EDTA Atenolol LC/MS Human Sodium Heparinized Atomoxetine LC/MS/MS Human EDTA Page 3 / 18

4 Atomoxetine LC/MS/MS Human EDTA plasma Atorvastatin LC/MS/MS Human EDTA Atorvastatin; o- OH- Atorvastatin; p- LC/MS/MS pg/ml; pg/ml; Human EDTA OH- Atorvastatin pg/ml Atorvastatin; o- OH- Atorvastatin; p- LC/MS/MS pg/ml; pg/ml; Human EDTA OH- Atorvastatin pg/ml Atorvastatin; o- OH- Atorvastatin; p- LC/MS/MS pg/ml; pg/ml; Human EDTA OH- Atorvastatin pg/ml Atorvastatin; o- OH- Atorvastatin; p- LC/MS/MS ; ; Human EDTA OH- Atorvastatin pg/ml Azithromycin LC/MS/MS Human EDTA Barnidipine LC/MS/MS pg/ml Human EDTA Benznidazole LC/MS/MS Human EDTA Betahistine metabolite (2-pyridylacetic LC/MS/MS Human EDTA acid ) Betaxolol LC/MS/MS Human EDTA Bicalutamide LC/MS/MS Human EDTA Bicalutamide (R-(-) Bicalutamide; S-(+) LC/MS/MS ; Human EDTA Bicalutamide) Bicalutamide (R-(-) Bicalutamide; S-(+) LC/MS/MS ; Human EDTA Bicalutamide) Bicalutamide (R-(-)Bicalutamide ; S-(+) LC/MS/MS ; Human EDTA Bicalutamide) Bilastine LC/MS/MS Human Sodium Heparinized Bisoprolol LC/MS/MS Human EDTA Bisoprolol LC/MS/MS Human EDTA Bosentan LC/MS/MS Human EDTA Brinzolamide LC/MS/MS Human Whole Blood Budesonide LC/MS/MS pg/ml Human EDTA Buprenorphine LC/MS/MS pg/ml Human EDTA Buprenorphine; Norbuprenorphine LC/MS/MS pg/ml; pg/ml Human EDTA Bupropion; Hydroxybupropion LC/MS/MS ; Human EDTA Bupropion; hydroxybupropion; LC/MS/MS ; ; Human EDTA erythrohydroxybupropion; threohydroxybupropion ; Caffeine LC/MS/MS Human EDTA Candesartan LC/MS/MS Human EDTA Candesartan LC/MS/MS Human EDTA Candesartan LC/MS/MS Human EDTA Page 4 / 18

5 Candesartan LC/MS/MS Human EDTA Capecitabine LC/MS/MS Human EDTA Capecitabine; 5 Fluorouracil (5-FU) LC/MS/MS ; Human EDTA Capecitabine; 5 -DFCR LC/MS/MS Human EDTA Carbidopa ; Levodopa LC/MS/MS ; Human EDTA Carbidopa ; Levodopa LC/MS/MS 2-75 ; Human EDTA Carbidopa ; Levodopa LC/MS/MS ; Human EDTA Carbidopa ; Levodopa LC/MS/MS ; Human EDTA Carbocisteine LC/MS/MS Human EDTA Carisoprodol; Meprobamate LC/MS/MS ; Human EDTA Cefaclor LC/MS/MS Human EDTA Cefaclor LC/MS/MS Human EDTA Cefadroxil LC/MS/MS μg/ml Human EDTA Cefadroxil LC/MS/MS μg/ml Human EDTA Cefditoren LC/MS/MS Human EDTA Cefixime LC/MS/MS Human EDTA Cefpodoxime LC/MS/MS Human EDTA Celecoxib LC/MS Human Lithium Heparinized Cetirizine LC/MS Human EDTA Chlorphenamine (refer to Chlorpheniramine) Chlorpheniramine LC/MS/MS Human EDTA Chlorpheniramine (S-(+)- LC/MS/MS ; Human EDTA clorpheniramine; R-(-)- Chlorpheniramine) Chlorthalidone LC/MS/MS Human EDTA Chlorthalidone LC/MS/MS Human Whole Blood Cholecalciferol (Vitamin D3) LC/MS/MS Human EDTA Cholecalciferol (Vitamin D3) LC/MS/MS Human EDTA Cholecalciferol (Vitamin D3); 25- LC/MS/MS ; Human EDTA Hydroxy Cholecalciferol (25-Hydroxy Vitamin D3) Cholecalciferol (Vitamin D3); 25- LC/MS/MS ; Human EDTA Hydroxy Cholecalciferol (25-Hydroxy Vitamin D3) Cilostazol LC/MS/MS Human EDTA Cilostazol; OPC LC/MS/MS ; Human EDTA Cilostazol; OPC-13015; OPC LC/MS/MS ; ; Human EDTA Page 5 / 18

6 Cinacalcet LC/MS/MS Human EDTA Cinitapride LC/MS/MS pg/ml Human EDTA Cinnarizine LC/MS/MS Human EDTA Ciprofloxacin HPLC/FLR Human EDTA Citalopram LC/MS/MS Human EDTA Citrulline LC/MS/MS μg/ml Human EDTA Cizolirtine; N-Desmethylcizolirtine LC/MS/MS Human Lithium Heparinized Clarithromycin LC/MS/MS Human EDTA Clarithromycin LC/MS/MS Human EDTA Clavulanic acid LC/MS Human EDTA Clavulanic acid LC/MS/MS Human EDTA Clobazam LC/MS/MS Human EDTA Clobazam; N-Desmethylclobazam LC/MS/MS ; Human EDTA Clopidogrel LC/MS/MS pg/ml Human EDTA Clopidogrel LC/MS/MS pg/ml Human EDTA Clopidrogel LC/MS/MS pg/ml Human EDTA Clopidrogel Carboxylic Acid LC/MS/MS Human EDTA Clopidrogel Carboxylic Acid LC/MS/MS Human EDTA Clozapine; N-Desmethyl Clozapine LC/MS/MS ; Human EDTA Codeine LC/MS/MS ng/ ml Human EDTA Cortisol LC/MS/MS Human EDTA Cyclosporin A LC/MS Human Whole Blood Dabigatran Unconjugated LC/MS/MS Human EDTA Dasatinib LC/MS/MS Human EDTA Dasatinib LC/MS/MS Human EDTA Deflazacort metabolite (21-OH- LCMS/MS Human EDTA Deflazacort) Descarboethoxy Loratadine; 3-hydroxy LC/MS/MS pg/ml; pg/ml Human EDTA Desloratadine Desloratadine LCMS/MS pg/ml Human EDTA Dexamethasone LC/MS/MS Human EDTA Dexketoprofen LC/MS/MS Human EDTA Diclofenac LC/MS/MS Human EDTA Diclofenac LC/MS/MS Human EDTA Dienogest LC/MS/MS Human EDTA Dienogest LC/MS/MS Human EDTA Digoxin LC/MS/MS pg/ml Human Sodium Heparanized Page 6 / 18

7 Diltiazem LC/MS/MS Human Lithium Heparinized Diltiazem; N-desmethyl Diltiazem; LC/MS/MS ; ; Human EDTA Desacetyl Diltiazem Dimenhydrinate (Diphenhydramine) LC/MS/MS Human EDTA Diosmetin Total; Hesperetin Total LC/MS/MS pg/ml; pg/ml Human EDTA Diosmetin-3'-O-Glucuronide LC/MS/MS pg/ml Human EDTA Dipyridamole LC/MS Human EDTA Donepezil LC/MS/MS Human EDTA Donepezil HPLC/FLR 2-50 Human EDTA Donepezil LC/MS/MS Human EDTA Donepezil ((+)-Donepezil; (-)- Donepezil) LC/MS/MS pg/ml ; pg/ml Human Sodium Heparinized Donepezil ((+)-Donepezil; (-)- Donepezil) LC/MS/MS pg/ml; pg/ml Human Sodium Heparinized Doxylamine LC/MS/MS Human EDTA Doxylamine (R-(-) Doxylamine ; S-(+) LC/MS/MS ; Human EDTA Doxylamine) Dronedarone ; N-Debutyl Dronedarone LC/MS/MS ; Human EDTA Drospirenone LC/MS/MS Human EDTA Drospirenone LC/MS/MS Human Breast Milk Duloxetine LC/MS/MS Human EDTA Duloxetine LC/MS/MS Human EDTA Dutasteride LC/MS/MS pg/ml Human EDTA Efavirenz LC/MS/MS Human EDTA Eletriptan; Desmethyl Eletriptan LC/MS/MS pg/ml; pg/ml Human EDTA Emoxypine (2-ethyl-6-methyl-3- LC/MS/MS Human EDTA hydroxypyridine) Emtricitabine LC/MS/MS Human EDTA Enalapril; Enalaprilat LC/MS/MS Human EDTA Enalapril; Enalaprilat LC/MS/MS Human EDTA Entacapone LC/MS/MS Human EDTA Entecavir LC/MS/MS pg/ml Human EDTA Entecavir LC/MS/MS pg/ml Human EDTA Eplerenone LC/MS/MS Human EDTA Eplerenone LC/MS/MS Human EDTA Eprosartan LC/MS/MS Human EDTA Erlotinib LC/MS/MS Human EDTA Erlotinib LC/MS/MS Human EDTA Escitalopram LC/MS/MS Human EDTA Page 7 / 18

8 Escitalopram LC/MS/MS Human EDTA Eslicarbazepine LC/MS/MS Human EDTA Esomeprazole LC/MS/MS Human EDTA Esomeprazole LC/MS/MS Human EDTA Esomeprazole LC/MS/MS Human EDTA Estradiol (Unconjugated); Estrone LC/MS/MS pg/ml; pg/ml Human EDTA (Unconjugated) Estradiol (Unconjugated); Estrone LC/MS/MS pg/ml; pg/ml Human EDTA (Unconjugated) Estrone (Total) LC/MS/MS pg/ml Human EDTA Ethinyl Estradiol LC/MS/MS pg/ml Human EDTA Ethinyl Estradiol; Gestodene LC/MS/MS pg/ml; pg/ml Human Serum Etodolac HPLC-UV μg/ml Human EDTA Etonogestrel (3-Ketodesogestrel) LC/MS/MS pg/ml Human EDTA Etoricoxib LC/MS/MS Human EDTA Exemestane LC/MS/MS Human EDTA Exemestane LC/MS/MS Human EDTA Exenatide LC/MS/MS pg/ml Human EDTA Ezetimibe (Total) LC/MS/MS Human EDTA Ezetimibe (Total) LC/MS/MS Human EDTA Ezetimibe (Unconjugated) LC/MS/MS pg/ml Human EDTA Famotidine LC/MS/MS Human EDTA Febuxostat LC/MS/MS Human EDTA Felodipine LC/MS/MS pg/ml Human EDTA Fenofibric Acid LC/MS/MS pg/ml Human EDTA Fentanyl LC/MS/MS pg/ml Human EDTA Fentanyl LC/MS/MS pg/ml Human EDTA Fesoterodine (refer to Tolterodine) Finasteride LC/MS/MS Human EDTA Fingolimod; Fingolimod Phosphate LC/MS/MS pg/ml ; pg/ml Human Whole Blood Flecainide LC/MS/MS Human EDTA Flecainide LC/MS/MS Human EDTA Flecainide LC/MS/MS Human EDTA Flopistrin; Linopristin; Linopristin Metabolite (RPR ) LC/MS/MS ; ; Human Lithium Heparanized Flopistrin; Linopristin; Linopristin LC/MS/MS ; ; Sodium Chloride (0,9%) Metabolite (RPR ) Fluoxetine LC/MS/MS 1-80 Human EDTA Fluoxetine LC/MS 1-30 Human EDTA Fluoxetine; Norfluoxetine LC/MS/MS 1-30 ; 2-60 Human EDTA Page 8 / 18

9 Fluoxetine; Norfluoxetine LC/MS/MS ; Human EDTA Flupirtine LC/MS/MS Human EDTA Flupirtine LC/MS/MS Human EDTA Fluticasone Propionate LC/MS/MS pg/ml Human EDTA Fluticasone Propionate LC/MS/MS pg/ml Human EDTA Fluvastatin LC-MS/MS Human Sodium Heparinized Fluvastatin ((+)-3R,5S-Fluvastatin ; (-) LC/MS/MS ; Human EDTA -3S, 5R-Fluvastatin) Fluvoxamine LC/MS/MS Human EDTA Formoterol LC/MS/MS pg/ml Human NaF/K2C2O4 Fosinopril LC/MS/MS ng/ ml Human EDTA Fosinoprilat LC/MS/MS Human EDTA Gabapentin LC/MS/MS Human EDTA Gabapentin LC/MS Human EDTA Galanthamine (with epigalanthamine LC/MS/MS Human EDTA separation) Gestodene LC/MS/MS pg/ml Human EDTA Glimepiride LC/MS/MS Human EDTA Glimepiride LC/MS/MS Human EDTA Glyburide LC/MS/MS Human EDTA Goserelin LC/MS/MS Human EDTA Granisetron LC/MS/MS pg/ml Human EDTA Haloperidol LC/MS/MS pg/ml Human EDTA Heparin/Enoxaparin/LMWH (refer to biomarkers Anti-FXa, Anti-FIIa and TFPI) Hydrochlorothiazide LC/MS/MS Human EDTA Hydrochlorothiazide LC/MS/MS Human EDTA Ibandronic acid LC/MS/MS Human EDTA Ibandronic Acid - Ibandronate LC/MS/MS Human EDTA Ibuprofen LC/MS/MS Human EDTA Ibuprofen HPLC/FLR Human EDTA Ibuprofen LC/MS/MS Human EDTA Ibuprofen LC/MS/MS Human EDTA Ibuprofen (R-(-)-ibuprofen; S-(+)- HPLC/FLR ; Human EDTA ibuprofen) Ibuprofen (R-(-)-ibuprofen; S-(+)- ibuprofen) HPLC/FLR ; Human EDTA Page 9 / 18

10 Ibuprofen (R-(-)-ibuprofen; S-(+)- LC/MS/MS ; Human EDTA ibuprofen) Ibuprofen (R-(-)-ibuprofen; S-(+)- LC/MS/MS ; Human EDTA ibuprofen) Idebenone (Total) LC/MS/MS Human EDTA Idebenone (Unconjugated) LC/MS/MS pg/ml Human EDTA Imatinib LC/MS/MS Human EDTA Imatinib; Desmethyl Imatinib LC/MS/MS ; Human EDTA Whole Blood Imatinib; Desmethyl Imatinib LC/MS/MS ; Human EDTA Indapamide LC/MS/MS Human EDTA Whole Blood Indapamide LC/MS/MS Human EDTA Whole Blood Irbesartan LC/MS/MS Human EDTA Irbesartan HPLC/FLR Human EDTA Irbesartan LC/MS/MS Human EDTA Irbesartan LC/MS/MS Human EDTA Irinotecan ; SN-38 LC/MS/MS ; Human EDTA Isotretinoin LC/MS Human EDTA Isotretinoin LC/MS/MS Human EDTA Isradipine LC/MS/MS pg/ml Human EDTA Itraconazole HPLC/FLR Human EDTA Ivabradine LC/MS/MS Human EDTA Ivabradine LC/MS/MS Human EDTA Ivermectine B1a LC/MS/MS Human EDTA Ivermectine B1a LC/MS/MS Human EDTA Ivermectine B1a LC/MS/MS Human EDTA Ivermectine B1b LC/MS/MS pg/ml Human EDTA Ivermectine B1b LC/MS/MS pg/ml Human EDTA Ketamine (refer to S-Ketamine) Ketoconazole LC/MS/MS Human Sodium Heparinized Ketoprofen LC/MS/MS Human EDTA Lanreotide LC/MS/MS Rat Lanreotide LC/MS/MS Beagle Dog Lansoprazole LC/MS/MS Human EDTA Lapatinib LC/MS/MS μg/ml Human EDTA Leflunomide LC-MS/MS pg/ml Human EDTA Leflunomide metabolite (A ) LC-MS/MS Human EDTA Leflunomide metabolite (A ) LC/MS/MS Human EDTA Lenalidomide LC/MS/MS Human EDTA Lercanidipine LC/MS/MS Human EDTA Page 10 / 18

11 Lercanidipine ((-)-R-Lercanidipine; (+)- LC-MS/MS pg/ml; pg/ml Human EDTA S-Lercanipidine) Letrozole LC/MS/MS Human EDTA Letrozole LC/MS/MS Human EDTA Leuprolide LC/MS/MS pg/ml Rat EDTA Leuprolide LC/MS/MS pg/ml Rat EDTA Leuprorelin (refer to Leuprolide) Levetiracetam LC/MS/MS μg /ml Human EDTA Levetiracetam LC/MS/MS μg/ml Human EDTA plasma Levodopa LC/MS/MS Human EDTA Levofloxacin HPLC/FLR Human Serum Levofloxacin HPLC/FLR Human Urine Levonorgestrel LC/MS/MS pg/ml Human EDTA Levonorgestrel LC/MS/MS Human EDTA Levonorgestrel LC/MS/MS pg/ml Human EDTA Levonorgestrel LC/MS/MS pg/ml Human EDTA Linagliptin LC/MS/MS pg/ml Human EDTA Linezolid LC/MS/MS μg/ml Human EDTA Linopristin, Linopristin Metabolite (RPR ); Flopristin LC/MS/MS ; ; Human Lithium Heparinized Linopristin, Linopristin Metabolite (RPR LC/MS/MS ; ; Sodium Chloride (0,9%) ); Flopristin Lisinopril LC/MS/MS Human EDTA Loratadine; Descarboethoxy LC/MS/MS pg/ml; pg/ml Human EDTA Loratadine Lorazepam HPLC/MS/MS Human EDTA Lornoxicam LC/MS/MS Human EDTA Losartan LC/MS/MS Human EDTA Losartan; Losartan Carboxy Acid LC-MS/MS ng/ ml; ng/ ml Human EDTA Losartan; Losartan Carboxy Acid LC/MS/MS ; Human EDTA Losartan; Losartan Carboxy Acid LC-MS/MS ; Human Lithium Heparinized Losartan; Losartan Carboxy Acid LC-MS/MS ; Human EDTA Medroxyprogesterone Acetate LC/MS/MS pg/ml Human EDTA Meloxicam LC/MS/MS Human EDTA Memantine LC/MS/MS pg/ml; pg/ml Human EDTA Memantine LC/MS/MS Human EDTA Memantine LC/MS/MS Human EDTA Mercaptopurine LC/MS/MS Human EDTA Mesalamine LC/MS/MS Human EDTA Page 11 / 18

12 Mesalamine (5-Amino Salicylic Acid_5- HPLC/FLR ; Human EDTA Acetylamino Salicylic Acid) Mesalazine (refer to Mesalamine) Metamizol metabolite (4- LC/MS/MS µg/ml Human EDTA methylaminoantipyrine) Metformin LC/MS/MS Human EDTA Metformin LC/MS/MS Human EDTA Methotrexate LC/MS/MS Human EDTA Methylphenidate; Ritalinic Acid LC/MS/MS ; Human EDTA Methylphenidate; Ritalinic Acid LC/MS/MS ; Human EDTA Methylprednisolone LC/MS/MS Human EDTA Metoprolol LC/MS/MS Human EDTA Metoprolol ((+)-R-Metoprolol; (-)-S- LC/MS/MS ; Human EDTA Metoprolol) Midazolam LC/MS/MS Human EDTA Mifepristone LC/MS/MS Human EDTA Mirtazapine LC/MS/MS Human EDTA Mirtazapine LC/MS/MS Human EDTA Misoprostol Acid LC/MS/MS pg/ml Human EDTA Misoprostol Acid LC/MS/MS pg/ml Human EDTA Misoprostol Acid LC/MS/MS pg/ml Human EDTA Montelukast LC/MS/MS Human EDTA Montelukast LC/MS/MS Human EDTA Morphine, Morphine-3-beta-Dglucoronide; LC/MS/MS ; ; Human EDTA Morphine-6-beta-D- glucoronide Moxifloxacin LC/MS/MS Human Lithium Heparinized Mycophenolate Mofetil LC/MS/MS pg/ml Human EDTA Mycophenolic acid LC/MS/MS Human EDTA N-Acetylcysteine LC/MS/MS Human EDTA N-Acetylcysteine LC/MS/MS Human EDTA N-mono-desmethyl-sibutramine; N-didesmethyl-sibutramine LC/MS/MS 0.1-5, Human Sodium Heparinized Nadolol LC/MS/MS Human EDTA Naloxone (Unconjugated) LC/MS/MS Human EDTA Naproxen LC/MS/MS Human EDTA Naratriptan LC/MS/MS pg/ml Human EDTA Nateglinide LC/MS/MS Human EDTA Nateglinide LC/MS/MS Human EDTA Page 12 / 18

13 Nebivolol LC/MS/MS pg/ml Human EDTA Nebivolol LC/MS/MS pg/ml Human EDTA Nevirapine LC/MS Human EDTA Nicorandil LC/MS/MS Human EDTA Nicorandil LC/MS/MS Human EDTA Nicotine LC/MS/MS Human EDTA Nifedipine LC/MS/MS Human EDTA Nilotinib LC/MS/MS Human EDTA Nilotinib LC/MS/MS Human EDTA Nitrofurantoin LC/MS/MS Human EDTA NP LC/MS/MS pg/ml Human EDTA NP LC/MS/MS pg/ml Human EDTA Octopamine LC/MS/MS 1-30 µg/ml Human Lithium Heparinized Octreotide LC/MS/MS pg/ml Human EDTA Octreotide LC/MS/MS pg/ml Rat Olanzapine LC/MS/MS pg/ml Human EDTA Olanzapine LC/MS/MS Human EDTA Olanzapine LC/MS/MS Human EDTA Olanzapine LC/MS/MS pg/ml Human EDTA Olmesartan LC/MS/MS Human EDTA Olmesartan LC/MS/MS Human EDTA Omeprazole LC/MS/MS Human EDTA Omeprazole LC/MS/MS Dog Ondasetron LC/MS/MS Human EDTA Ondasetron LC/MS Human Lithium Heparinized Opipramol LC/MS/MS μg/ml Human EDTA Orlistat LC/MS/MS pg/ml Human EDTA Orlistat M1 LC/MS/MS pg/ml Human EDTA Oxcarbazepine LC/MS/MS Human EDTA Oxcarbazepine; 10- LC/MS/MS ; Human EDTA Hydroxycarbamazepine Oxycodone LC/MS/MS pg/ml Human EDTA Oxycodone LC/MS/MS Human EDTA Oxycodone LC/MS/MS Human EDTA Paliperidone ((-) Paliperidone; (+) LC/MS/MS pg/ml; pg/ml Human EDTA Paliperidone) Paliperidone (9-OH Risperidone) LC/MS/MS pg/ml Human EDTA Paliperidone (9-OH Risperidone) LC/MS/MS Human EDTA Page 13 / 18

14 Paliperidone (9-OH Risperidone) LC/MS/MS Beagle Dog EDTA Pantoprazole LC/UV Human EDTA Pantoprazole LC/MS/MS Human EDTA Paracetamol/Acetaminophen LC/MS/MS µg/ml Human EDTA Paracetamol/Acetaminophen LC/MS/MS μg/ml Human EDTA Paricalcitol LC/MS/MS pg/ml Human EDTA Paricalcitol LC/MS/MS pg/ml Human EDTA Pentoxyfiline; Metabolite I; Metabolite LC/MS/MS ; ; Human EDTA V Perindopril; Perindoprilat LC/MS/MS ; Human EDTA Perindopril; Perindoprilat LC/MS/MS pg/ml ; pg/ml Human EDTA Phenylephrine LC/MS/MS pg/ml Human EDTA Pioglitazone LC/MS/MS Human EDTA Pioglitazone, Hydroxypioglitazone; LC/MS/MS ; ; Human EDTA Ketopioglitazone Pioglitazone; Hydropioglitazone LC/MS/MS ; Human EDTA Pioglitazone; Hydropioglitazone LC/MS/MS ; Human EDTA Piracetam LC/MS/MS µg/ml Human EDTA Pirlindole LC/MS/MS Human EDTA Pirlindole (R-(-)Pirlindole; S- LC/MS/MS ; Rat EDTA (+)Pirlindole) Pitavastatin LC/MS/MS Human EDTA Pramipexole LC/MS/MS pg/ml Human EDTA Pramipexole LC/MS/MS pg/ml Human EDTA Pramipexole LC/MS/MS pg/ml Human EDTA Prasugrel metabolite R LC/MS/MS Human EDTA Pravastatin LC/MS/MS Human EDTA Pravastatin; 3-α-Hydroxy Pravastatin LC/MS/MS ; Human EDTA Prednisolone LC/MS/MS Rat Sodium Heparinized Prednisone; Prednisolone LC/MS/MS 1-50 ; ng/ ml Human EDTA Pregabalin LC/MS/MS Human EDTA Pregabalin LC/MS/MS Human EDTA Progesterone LC/MS/MS pg/ml Human EDTA Progesterone LC/MS/MS pg/ml Human EDTA Propofol LC/MS Human EDTA Whole Blood Pseudoephedrine LC/MS/MS Human EDTA Pseudoephedrine (S,S(+)- LC/MS/MS Human EDTA Pseudoephedrine) Pyridoxine (Vitamin B6); Pyridoxal; Pyridoxal 5-phosphate LC/MS/MS ; ; Human EDTA Page 14 / 18

15 Quetiapine LC/MS/MS Human EDTA Quetiapine LC/MS/MS Human EDTA Quetiapine LC/MS/MS Human EDTA Quetiapine LC/MS/MS Human EDTA R (Prasugrel metabolite) LC/MS/MS Human EDTA Bicalutamide (R-(-)Bicalutamide) LC/MS/MS Human EDTA Rabeprazole LC/MS/MS Human EDTA Racecadotril (refer to Thiorphan) Raloxifene LC/MS/MS pg/ml Human EDTA Raloxifene-4-glucuronide; LC/MS/MS ; Human EDTA Raloxifene-6-glucuronide Ramipril LC/MS/MS Human EDTA Ramipril LC/MS/MS Human EDTA Ramipril; Ramiprilat LC/MS/MS ; Human EDTA Ranitidine LC/MS/MS Human EDTA Rasagiline LC/MS/MS pg/ml Human EDTA Repaglinide LC/MS/MS Human EDTA Rhein (Diacerein metabolite) LC/MS/MS Human EDTA Risedronic Acid LC/MS/MS Human EDTA Risedronic Acid LC/MS/MS Human EDTA Risedronic Acid LC/MS/MS Human Sodium Heparinized Risperidone; 9-OH-Risperidone LC/MS/MS pg/ml ; pg/ml Human EDTA Risperidone; 9-OH-Risperidone LC/MS/MS ; Beagle Dog EDTA Risperidone; 9-OH-Risperidone LC/MS/MS ; Human EDTA Rivaroxaban LC/MS/MS Human EDTA Rivaroxaban LC/MS/MS Human EDTA Rivastigmine LC/MS/MS Human EDTA Rivastigmine LC/MS/MS pg/ml Human EDTA Rivastigmine LC/MS/MS Human EDTA Rivastigmine LC/MS/MS Human EDTA Rivastigmine; NAP LC/MS/MS ; Human EDTA Rizatriptan LC/MS/MS Human EDTA Ropinirole LC/MS/MS pg/ml Human EDTA Ropinirole LC/MS/MS pg/ml Human EDTA Rosiglitazone LC/MS/MS Human EDTA Rosiglitazone LC/MS/MS Human EDTA Rosuvastatin LC/MS/MS pg/ml Human EDTA Rosuvastatin LC/MS/MS pg/ml Human EDTA Rosuvastatin LC/MS/MS pg/ml Human EDTA Page 15 / 18

16 Rupatadine LC/MS/MS pg/ml Human EDTA S-Ketamine ; S-Norketamine LC/MS/MS ; Human EDTA Salmeterol LC/MS/MS pg/ml Human EDTA Salmeterol LC/MS/MS pg/ml Human EDTA Sibutramine (R(+)-Sibutramine ; S(-)- Sibutramine) LC/MS/MS pg/ml ; pg/ml Human Sodium Heparinized Sibutramine (R(+)-Sibutramine ; S(-)- Sibutramine) LC/MS/MS pg/ml ; pg/ml Human Sodium Heparinized Sildenafil LC/MS/MS Human EDTA Sildenafil LC/MS/MS Human EDTA Sildenafil; desmethyl Sildenafil LC/MS/MS ; Human EDTA Silodosin LC/MS/MS Human EDTA Simvastatin LC/MS/MS pg/ml Human EDTA Simvastatin LC/MS/MS Human EDTA Simvastatin LC/MS/MS Human EDTA Simvastatin; b-hydroxy Acid LC/MS/MS ; Human EDTA Simvastatin Simvastatin; b-hydroxy Acid LC/MS/MS ; Human EDTA Simvastatin Sitagliptin LC/MS/MS Human EDTA Solifenacin LC/MS/MS Human EDTA Solifenacin LC/MS/MS Human EDTA Solifenacin LC/MS/MS Human EDTA Sorafenib LC/MS/MS Human EDTA Spironolactone; Canrenone LC/MS/MS ; Human EDTA Sumatriptan LC/MS/MS Human EDTA Sunitinib LC/MS/MS Human EDTA Tacrolimus LC/MS/MS Human EDTA Whole Blood Tacrolimus LC/MS/MS Human EDTA Whole Blood Tacrolimus LC/MS/MS pg/ml Human EDTA Whole Blood Tadalafil LC/MS/MS Human EDTA Tadalafil LC/MS/MS Human EDTA Tadalafil LC/MS/MS Human EDTA Tamoxifen; N-Desmethyl Tamoxifen LC/MS/MS ; Human EDTA. Tamsulosin LC/MS/MS pg/ml Human EDTA Tamsulosin LC/MS/MS Human EDTA Telmisartan LC/MS/MS Human EDTA Telmisartan LC/MS/MS Human EDTA Temozolomide LC/MS/MS Human EDTA Temozolomide LC/MS/MS μg/ml Human EDTA Page 16 / 18

17 Tenofovir LC/MS/MS Human Serum Terbinafine LC/MS/MS Diluted Digested Human Nail Clippings Teriflunomide (refer to Leflunomide Metabolite) Testosterone LC/MS/MS Human Serum Tetrahydrocannabinol; 11-Hydroxy- LC/MS/MS ; ; Human EDTA. Tetrahydrocannabinol; Cannabidiol TFPI ELISA Human Citrate THC; OH-THC; CBD LC/MS/MS ; ; Human EDTA Thiorphan (Racecadotril) LC/MS/MS Human EDTA Tiagabine LC/MS/MS Human EDTA Tianeptine; Tianeptine MC5 Metabolite LC/MS/MS ; Human Sodium Heparinized Tibolone LC/MS/MS pg/ml Human EDTA. Ticagrelor LC/MS/MS Human EDTA Tiotropium LC/MS/MS pg/ml Human EDTA Tiotropium LC/MS/MS pg/ml Human EDTA Tolterodine; 5-hydroxymethyl LC/MS/MS pg/ml; pg/ml Human EDTA. Tolterodine Tolterodine; 5-hydroxymethyl LC/MS/MS pg/ml; pg/ml Human EDTA. Tolterodine Topiramate LC/MS/MS Human EDTA Topiramate LC/MS/MS Human EDTA Torasemide HPLC-UV Human Torsemide LC/MS/MS Human EDTA Tramadol; O-desmethyltramadol LC/MS/MS ; Human EDTA Trandolapril; Trandolaprilat LC/MS/MS pg/ml; pg/ml Human EDTA Trazodone LC/MS/MS Human EDTA Tretinoin LC/MS/MS Human EDTA Triamcinolone Acetonide LC-MS/MS pg/ml Human EDTA Trimetazidine LC-MS/MS Human EDTA Ursodiol, Glycoursodeoxycholic Acid; LC/MS/MS , ; Human EDTA Tauroursodeoxycholic Acid Valacyclovir LC/MS/MS Human EDTA Valganciclovir ; Ganciclovir LC/MS/MS ; Human EDTA Valproic Acid LC/MS/MS µg/ml Human EDTA Valsartan LC-MS/MS Human EDTA Valsartan LC/MS/MS Human EDTA Page 17 / 18

18 Valsartan LC/MS/MS Human EDTA Valsartan LC/MS/MS Human EDTA Vardenafil LC/MS/MS Human EDTA Venlafaxine; O-desmethylvenlafaxine LC/MS/MS ; Human EDTA Venlafaxine; O-desmethylvenlafaxine LC/MS/MS ; Human EDTA Venlafaxine; O-desmethylvenlafaxine LC/MS/MS ; Human EDTA Venlafaxine; O-desmethylvenlafaxine LC-MS/MS ; Human EDTA Verapamil ; Norverapamil LC/MS/MS ; Human EDTA Vildagliptin LC/MS/MS Human EDTA Voriconazole LC/MS/MS Human EDTA Warfarin HPLC/FLR Human EDTA Warfarin (R-(+) Warfarin, S-(-)- Warfarin) LC/MS/MS pg/ml; pg/ml Human Sodium Heparinized Warfarin (R-(+) Warfarin, S-(-)- Warfarin) LC/MS/MS pg/ml; pg/ml Human Sodium Heparinized Warfarin (R-(+) Warfarin, S-(-)- LC/MS/MS Human EDTA Warfarin) Ziprasidone LC/MS Human EDTA Zoledronic Acid LC/MS/MS Human Urine Zolmitriptan; N-desmethylzolmitriptan LC/MS/MS pg/ml; pg/ml Human EDTA Zolpidem LC/MS/MS Human EDTA Zonisamide LC/MS/MS Human Serum Zonisamide LC/MS/MS Human Serum Page 18 / 18