3. This solution retains potency for 2 8 hours at room temperature after reconstitution.

Transcription

1 1 CHAPTER 10 Reconstitution of Powdered Drugs Problems 10.1 (page 124) 1. The drug should be stored at or below 86 F (30 C). 2. This drug is administered IM or IV. 3. This solution retains potency for 2 8 hours at room temperature after reconstitution. 4. This solution retains potency for hours, if refrigerated. 5. If reconstituted at 10:10 am on October 3, the label should read: Exp. Oct. 4 10:10 am to Oct. 6 10:10 am. 6. Your initials should be printed on the label. 7. The total dosage strength of this reconstituted IV cefuroxime solution is 1.5 g. Problems 10.2 (page 124) 1. You will need 75 ml diluent. 2. The diluent to be used is water. 3. Slowly add water, partially fill bottle and shake vigorously. Add remaining water and shake. 4. No, this is an oral medication. 5. The dosage strength of the prepared solution is 250 mg/5 ml.

2 SECTION 3 READING MEDICATION LABELS AND SYRINGE CALIBRATIONS 2 6. If this drug is reconstituted on March 15 at 4:40 pm, the expiration label is: Exp. March 29 4:40 pm. 7. Reconstituted solution must be stored in a refrigerator. 8. Dosage ordered: 125 mg Dosage available: 250 mg/5 ml 1 5mL ml = 125 mg = 2.5 ml 250 mg 2 9. Dosage ordered: 500 mg Dosage available: 250 mg/5 ml 2 5mL ml = 500 mg = 10 ml 250 mg 10. There will be 400,000 units in a 5 ml dose You shake well before administering. 12. Her initials should be printed on the label. Problems 10.3 (page 126) 1. The total dosage strength of this vial is 500 mg. 2. You will use 1 ml for IM reconstitution. 3. The diluent to be used is 1% lidocaine hydrochloride injection or sterile water for injection ml solution of IM reconstitution contains 350 mg. 5. The generic name of this drug is ceftriaxone.

3 3 6. Add 4.8 ml for IV reconstitution. 7. You look for information on the kind of diluent to use for IV reconstitution on the package insert ml reconstitution of IV solution contains 100 mg. 9. Storage and expiration details are found on the package insert. 10. Print your initials on the label. Problems 10.4 (page 126) 1. The total dosage of this vial is 9 g. 2. Locate the instructions on the package insert. 3. The reconstituted solution may be used for 4 hours ml of volume will contain 900 mg. 9g 1000 mg mg = 6mL = 900 mg 60 ml 1g 5. Dosage ordered: 1500 mg Dosage available: 9 g/60 ml 1g 60 ml ml = 1500 mg = 10 ml 1000 mg 9g 6. The strength of this reconstituted solution is 150 mg/ml. 7. This drug is administered by IV.

4 SECTION 3 READING MEDICATION LABELS AND SYRINGE CALIBRATIONS 4 Problems 10.5 (page 127) 1. The total dosage strength of this vial is 1 g. 2. Add 10 ml diluent for reconstitution. 3. The dosage strength per ml of the reconstituted solution is 100 mg per ml. 4. The type of diluent to be used is bacteriostatic water. 5. The reconstituted solution will retain its potency for 48 hours. 6. This medication is administered intravenously, subcutaneously, or intrathecally. Problems 10.6 (page 127) 1. The total dosage strength of this vial is 500 mg. 2. Add 10 ml diluent for reconstitution. 3. The dosage per ml of the reconstituted solution is 50 mg/ml. 4. The expiration time of the reconstituted solution is 48 hours. 5. The diluent that must be used is bacteriostatic water USP with benzyl alcohol. Problems 10.7 (page 128) 1. The types of diluent that may by used for reconstitution under the section labeled For Intramuscular Use are sterile water for injection or bacteriostatic water for injection. 2. The volume of diluent specified for a 250 mg vial is 0.9 ml.

5 5 3. The diluent required for a 500 mg vial is 1.7 ml. 4. The diluent required for a 1 g vial is 3.4 ml. 5. The diluent required for a 2 g vial is 6.8 ml. 6. The dosage strength of all four reconstituted solutions is 250 mg/ml. 7. The amount of diluent required under For Direct Intravenous Use is 5 ml for either 250 mg or 500 mg vials. 8. For direct IV administration of the 250 mg and 500 mg reconstituted solution, inject slowly over 3 to 5 minutes. 9. The caution pertaining to rapid IV administration is that rapid administration may result in seizures. Problems 10.8 (page 130) 1. The dosage strength when adding 75 ml of diluent is 250,000 units/ml. 2. Yes, this prepared solution requires refrigeration. 3. If you reconstitute on June 1 at 2 pm, the label should read: Exp. June 8 2 pm. 4. The total dosage strength of this vial is 20 million units (20,000,000 units). 5. Your initials should be printed on the label. 6. To locate the diluent to be used, see the package insert.

6 SECTION 3 READING MEDICATION LABELS AND SYRINGE CALIBRATIONS 6 Problems 10.9 (page 131) 1. The amount of diluent to reconstitute a 500 mg vial is 10 ml. 2. The amount of diluent to reconstitute a 1 g vial is 20 ml. 3. The kind of diluent to be used is sterile water for injection. 4. The reconstituted dosage per ml of both of these solutions is 50 mg/ml. 5. The solution can be stored in a refrigerator for 14 days. 6. If the drug is reconstituted on May 4 at 1350 the expiration label is Exp. May Print your initials on the label. Summary Self-Test (page 132) 1. The total dosage of the ceftriaxone vial is 1 g. 2. The volume of diluent that must be used for reconstitution is 2.1 ml. 3. The dosage strength of 1 ml of reconstituted solution is 350 mg/ml. 4. The dosage strength is 200 mcg; 0.2 mg. 5. The volume of diluent that must be added to prepare the solution for use is 5 ml. 6. The kind of diluent that must be added to prepare the solution is 0.9% sodium chloride. 7. The reconstituted solution must be used immediately.

7 7 8. The per ml strength is 40 mcg/ml. 9. You will find average dosage instructions in the package insert. 10. The amount of diluent needed to reconstitute solution is 10 ml. 11. The type of diluent is bacteriostatic water for injection with benzyl alcohol. 12. The total vial dosage is 1 gram. 13. This should be stored at 25 C (77 F) ml dosage will contain 100 mg/ml. 15. The expiration time of the solution is 48 hours. 16. If the solution is reconstituted on Feb 14 at 0840, the expiration date printed on the label is Exp. Feb The diluent required to reconstitute VFend IV solution is 19 ml. 18. The diluent specified for use is water for injection. 19. The strength of each 1 ml of the reconstituted solution is 10 mg/ml. 20. The total dosage of the vial of VFend is 200 mg. 21. The amount of diluent required to reconstitute Vantin oral suspension is 29 ml. 22. The type of diluent listed for reconstitution of Vantin oral suspension is distilled water.

8 SECTION 3 READING MEDICATION LABELS AND SYRINGE CALIBRATIONS To add this diluent, shake the bottle to loosen granules, add half (about 15 ml) of the distilled water, and shake vigorously to dissolve granules; add balance of water and shake vigorously. 24. The reconstituted dosage strength of Vantin oral suspension is 100 mg/5 ml. 25. The reconstituted Vantin solution will retain its potency for 14 days. 26. The total strength of cytarabine is 500 mg. 27. The diluent that must be used to reconstitute cytarabine is bacteriostatic water with benzyl alcohol. 28. The amount of diluent to reconstitute cytarabine is 10 ml. 29. The dosage per reconstituted ml is 50 mg/ml. 30. The reconstituted cytarabine solution will retain its potency at room temperature for 48 hours. 31. The type of diluent recommended for reconstitution of acyclovir is sterile water for injection. 32. The amount of diluent that must be added for preparation of acyclovir is 10 ml. 33. The total dosage strength of the vial of acyclovir is 500 mg. 34. This solution of acyclovir must be used within 12 hours. 35. The total dosage strength is 2 g. 36. The volume of diluent that must be added for use of cytarabine is 20 ml. 37. The diluent that must be used is bacteriostatic water for injection USP with benzyl alcohol. 38. The reconstituted dosage strength 100 mg/ml.

9 9 39. Reconstituted medication will retain its potency for 48 hours. 40. The total dosage strength of the penicillin G potassium vial is one million units (1,000,000 units). 41. The amount of diluent that must be added to prepare a 100,000 unit/ml strength of penicillin G potassium is 10 ml. 42. The amount of diluent that must be added to prepare a 500,000 units/ml strength of penicillin G potassium is 1.8 ml. 43. The amount of diluent that must be added to prepare a 50,000 unit/ml strength of penicillin G potassium is 20 ml. 44. You will find the information for the type of diluent to use on the package insert. 45. This solution of penicillin must be refrigerated. 46. If reconstituted at 1:10 am on December 18, print on the label Exp. December 25 1:10 am. 47. Print your initials on the label. 48. Print initials for space considerations and because handwriting is difficult to read. 49. The generic name for Zithromax is azithromycin. 50. The total dosage strength of the Zithromax vial is 500 mg. 51. The diluent specified for reconstitution of Zithromax is sterile water for injection. 52. The amount of diluent required for reconstitution of Zithromax is 4.8 ml. 53. The reconstituted dosage strength of Zithromax is 100 mg/ml.