SAFETY DATA SHEET according to Regulation (EC) No. 1907/2006

Transcription

1 SAFETY DATA SHEET Revision Date Identification of the substance/mixture and of the company/undertaking Product Information Use of the Substance/Mixture Reagent for analysis, Chemical production, Pharmaceutical production and analysis Regional representation: Merck Chemicals Ltd * Boulevard Industrial Park * Padge Road * Beeston * Nottingham * NG9 2JR * Tel * information@merckchem.co.uk. Emergency telephone: +49 (0) Responsible/issuing person: EQ-EPS * prodsafe@merck.de 2. Hazards identification GHS Classification Flammable liquid, Category 3 Acute toxicity, Category 4, Dermal Acute toxicity, Category 4, Inhalation Skin irritation, Category 2 EC Classification R10 Xn; R20/21 H226: Flammable liquid and vapour. H312: Harmful in contact with skin. H332: Harmful if inhaled. H315: Causes skin irritation. Xi; R38 For the full text of the R-phrases mentioned in this Section, see Section Composition/information on ingredients Formula C₆H₄(CH₃)₂ C₈H₁₀ (Hill) CAS-No Index-No EC-No Molar mass 106,17 g/mol 4. First aid measures After inhalation: fresh air. If breathing stops: mouth-to-mouth respiration or mechanical ventilation. Oxygen mask if necessary! Immediately call in physician. After skin contact: wash off with plenty of water. Remove contaminated clothing. Get medical attention. After eye contact: rinse out with plenty of water with the eyelid held wide open. Call in ophthalmologist if necessary. Page 1 of 8

2 If swallowed Caution Aspiration hazard Keep respiratory tract clear. Call a physician immediately. Subsequently administer: activated charcoal (20-40 g in 10% slurry). More severe effects if alcohol is consumed. 5. Fire-fighting measures Suitable extinguishing media Carbon dioxide (CO2), Foam, Dry powder Specific hazards during fire fighting Combustible material, Vapours are heavier than air and may spread along floors. Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at elevated temperatures. Special protective equipment for fire-fighters Do not stay in dangerous zone without self-contained breathing apparatus. In order to avoid contact with skin, keep a safety distance and wear suitable protective clothing. Further information Prevent fire extinguishing water from contaminating surface water or the ground water system. 6. Accidental release measures Personal precautions Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation. Environmental precautions Do not empty into drains. Explosive properties Methods for cleaning up Take up with liquid-absorbent material (e.g. Chemizorb ). Forward for disposal. Clean up affected area. 7. Handling and storage Handling Advice on protection against fire and explosion Keep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharge. Storage Further information on storage conditions Keep away from heat and sources of ignition. Keep container tightly closed in a dry and wellventilated place. Without limitations. Page 2 of 8

3 8. Exposure controls/personal protection Components with workplace control parameters Components Basis Value Control parameters Ceiling Limit Value, Remarks Xylene (mixture of isomers) ( ) ECTLV Short Term Exposure Limit (STEL): 100 ppm 442 mg/m3 Skin designation: Can be absorbed through the skin. EH40 WEL Time Weighted Average (TWA): Short Term Exposure Limit (STEL): Time Weighted Average (TWA): 50 ppm 221 mg/m3 100 ppm 441 mg/m3 50 ppm 220 mg/m3 Skin designation: Can be absorbed through the skin. Personal protective equipment Protective clothing should be selected specifically for the working place, depending on concentration and quantity of the hazardous substances handled. The resistance of the protective clothing to chemicals should be ascertained with the respective supplier. Respiratory protection required when vapours/aerosols are generated. Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds Hand protection full contact: splash contact: Glove material: Glove thickness: Break through time: Glove material: Glove thickness: Break through time: Viton (R) 0,70 mm > 480 min Nitrile rubber 0,40 mm > 30 min The protective gloves to be used must comply with the specifications of EC irective 89/686/EEC and he resultant standard EN374, for example. KCL 890 Vitoject (full contact), KCL 730 Camatril -Velours (splash contact). The breakthrough times stated above were determined by KCL in laboratory tests acc. to EN374 with samples of the recommended glove types. This recommendation applies only to the product stated in the safety data sheet and supplied by us as well as to the purpose specified by us. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CEapproved gloves (e.g. KCL GmbH, D Eichenzell, Internet: Eye protection Tightly fitting safety goggles Protective measures Flame retardant antistatic protective clothing Page 3 of 8

4 Hygiene measures Immediately change contaminated clothing. Apply skin- protective barrier cream. Wash hands and face after working with substance. 9. Physical and chemical properties Form Colour Odour ph Viscosity, dynamic liquid colourless aromatic not applicable ca.0,6 mpa.s at 20 C Melting point > -34 C Boiling point/boiling range C Ignition temperature ca. 465 C Method: DIN Flash point 25 C Method: c.c. Oxidizing properties Flammability Lower explosion limit Upper explosion limit Vapour pressure no data available no data available 1,0 %(V) 7,0 %(V) 10 hpa at 20 C Relative vapour density 3,7 Density Solubility/qualitative Water solubility Partition coefficient: n- octanol/water Evaporation rate 0,86 g/cm3 at 20 C no data available 0,2 g/l at 20 C log Pow: 3,12 Method: (experimental) (Lit.) An appreciable bioaccumulation potential is to be expected (log Po/w >3). no data available Page 4 of 8

5 10. Stability and reactivity Conditions to avoid Heating. A range from approx. 15 Kelvin below the flash point is to be rated as critical. Materials to avoid Violent reactions possible with: Strong oxidizing agents, conc. sulfuric acid, sulfur Risk of explosion with: Nitric acid, uranium hexafluoride Hazardous decomposition products no information available Further information incompatible with: Light metals, rubber, various plastics Vapour/air-mixtures are explosive at intense warming. 11. Toxicological information Acute oral toxicity LD50 rat Dose: mg/kg (External MSDS) Symptoms: Gastrointestinal disturbance, Risk of aspiration upon vomiting. Acute inhalation toxicity LC50 rat Dose: 28 mg/l, 4 h Symptoms: absorption, Inhalation may lead to the formation of oedemas in the respiratory tract. Acute dermal toxicity LD50 rabbit Dose: > mg/kg Symptoms: absorption, Drying-out effect resulting in rough and chapped skin. Skin irritation rabbit Result: Irritations Eye irritation rabbit Result: slight irritation Genotoxicity in vitro Mutagenicity (mammal cell test): chromosome aberration. Result: negative (National Toxicology Program) Mutagenicity (mammal cell test): micronucleus. Result: negative Page 5 of 8

6 Ames test Result: negative Carcinogenicity No indication of carcinogenic activity. Further information After long-term exposure to the chemical: Dermatitis After absorption of toxic quantities: Systemic effects: Headache, drowziness, Dizziness, euphoria, agitation, spasms, narcosis Effect potentiated by: ethanol Damage of: Kidney, Central nervous system, Liver Further data: Handle in accordance with good industrial hygiene and safety practice. 12. Ecological information Ecotoxicity Toxicity to fish LC50 Species: Oncorhynchus mykiss (rainbow trout) Dose: 8,2 mg/l Exposure time: 96 h (ECOTOX Database) Toxicity to daphnia and other aquatic invertebrates. EC50 Species: Daphnia magna (Water flea) Dose: 75,5 mg/l Exposure time: 24 h (ECOTOX Database) Mobility Henry constant 772Pa*m3/mol Method: (experimental) (Lit.) Passage from aqueous solution into the atmosphere is not to be expected. Partition coefficient: n-octanol/water log Pow: 3,12 Method: (experimental) (Lit.) An appreciable bioaccumulation potential is to be expected (log Po/w >3). Additional ecological information Do not allow to enter waters, waste water, or soil! Page 6 of 8

7 13. Disposal considerations Product Chemicals must be disposed of in compliance with the respective national regulations. Under you will find country- and substance-specific information as well as contact partners. Packaging Merck product packaging must be disposed of in compliance with the country-specific regulations or must be passed to a packaging return system. Under you will find special information on the respective national conditions as well as contact partners. 14. Transport information ADR/RID UN 1307 XYLENES, 3, III IATA UN 1307 XYLENES, 3, III IMDG UN 1307 XYLENES, 3, III EmS F-E S-D The transport regulations re cited according to international regulations and in the form applicable in Germany. Possible national deviations in other countries are not considered. 15. Regulatory information GHS-Labelling Hazard pictograms Signal word Warning Hazard statements H226: Flammable liquid and vapour. H332: Harmful if inhaled. H312: Harmful in contact with skin. H315: Causes skin irritation. Precautionary statements P302 + P352: IF ON SKIN: Wash with plenty of soap and water. Reduced labelling ( 125 ml) Hazard pictograms Signal word Page 7 of 8

8 Warning Index-No Labelling according to EC Directives Symbol(s): Xn Harmful R-phrase(s): 10-20/21-38 Flammable. Harmful by inhalation and in contact with skin. Irritating to skin. S-phrase(s): 25 Avoid contact with eyes. EC-No EC Label Reduced labelling ( 125 ml) Symbol(s): Xn Harmful R-phrase(s): 10-20/21 Flammable. Harmful by inhalation and in contact with skin. National legislation Storage class VCI: Major Accident Hazard Legislation: Other regulations: 3 Flammable Liquids 96/82/EC Update: 2003 Flammable. 6 Quantity 1: t Quantity 2: t Take note of Dir 94/33/EC on the protection of young people at work. Take note of Dir 92/85/EEC on the safety and health at work of pregnant workers. 16. Other information Full text of R-phrases referred to under sections 2 and 3 R10 Flammable. R20/21 Harmful by inhalation and in contact with skin. R38 Irritating to skin. The information contained herein is based on the present state of our knowledge. It characterizes the product with regard to the appropriate safety precautions. It does not represent a guarantee of the properties of the product. Page 8 of 8