: L-Asparagine/L-Glutamine/Ammonia Assay Kit

Transcription

1 L-Asparagine/L-Glutamine/Ammonia Assay Kit Kit Safety Information Sheet Date of issue: 05/06/2013 Revision date: 19/01/2018 Supersedes: 03/03/2017 Version: 1.3 SECTION 1: Kit identification 1.1. Kit identifier Product name Product code : L-Asparagine/L-Glutamine/Ammonia Assay Kit : K-ASNAM 1.2. Details of the supplier of the KIT safety information sheet Megazyme Bray Business Park A98 YV29 Bray - Ireland T F cs@megazyme.com - SECTION 2: General information This product is a Kit which consists of several independently packaged components This Kit should be handled in accordance with good laboratory practices and appropriate personal protective equipment should be used SECTION 3: Kit contents Name General description Quantity Unit Classification according to Regulation (EC) No. 1272/2008 [CLP] L-Asparagine/L- Glutamine/Ammonia Assay Kit (Rapid) (Bottle 2) L-Asparagine/L- Glutamine/Ammonia Assay Kit (Rapid) (Bottle 4) L-Asparagine/L- Glutamine/Ammonia Assay Kit (Rapid) (Bottle 5) L-Asparagine/L- Glutamine/Ammonia Assay Kit (Rapid) (Bottle 6) L-Asparagine/L- Glutamine/Ammonia Assay Kit (Rapid) (Bottle 3) Reagent 2 pcs (pieces) Skin Irrit. 2, H315 Eye Irrit. 2, H319 Repr. 1B, H360 Reagent 1 pcs (pieces) Eye Irrit. 2, H319 Repr. 2, H361 Lact., H362 Aquatic Chronic 3, H412 Reagent 1 pcs (pieces) Acute Tox. 4 (Oral), H302 Eye Irrit. 2, H319 Repr. 2, H361 Lact., H362 Aquatic Chronic 3, H412 Reagent 1 pcs (pieces) Eye Irrit. 2, H319 Resp. Sens. 1, H334 Skin Sens. 1, H317 Repr. 2, H361 Lact., H362 Aquatic Chronic 3, H412 Reagent 2 pcs (pieces) Acute Tox. 4 (Oral), H302 Aquatic Chronic 3, H412 No substance or mixture included in the following Kit components is hazardous according to Regulation (EC) No. 1272/2008 [CLP] and therefore the requirements of Regulation (EU) 2015/830 do not apply Name General description Quantity Unit L-Asparagine/L- Glutamine/Ammonia Assay Kit (Rapid) (Bottle 1) L-Asparagine/L- Glutamine/Ammonia Assay Kit (Rapid) (Bottle 8) L-Asparagine/L- Glutamine/Ammonia Assay Kit (Rapid) (Bottle 7) SECTION 4: General advice No data available SECTION 5: Safe handling advice Buffer 1 pcs (pieces) Reagent 1 pcs (pieces) Reagent 1 pcs (pieces) 12/03/2018 EN (English) 1/50

2 L-Asparagine/L-Glutamine/Ammonia Assay Kit Kit Safety Information Sheet General measures Environmental precautions Storage conditions Precautions for safe handling : Do not handle until all safety precautions have been read and understood. : Avoid release to the environment : Store in a well-ventilated place. Keep cool. Store in a well-ventilated place. Keep cool. : Ensure good ventilation of the work station Wear personal protective equipment SECTION 6: First aid measures First-aid measures after eye contact First-aid measures after ingestion First-aid measures after inhalation First-aid measures after skin contact Other medical advice or treatment : Rinse eyes with water as a precaution : Call a poison center or a doctor if you feel unwell : Remove person to fresh air and keep comfortable for breathing. : Wash skin with plenty of water : Treat symptomatically SECTION 7: Fire fighting measures Protection during firefighting Hazardous decomposition products in case of fire : Do not attempt to take action without suitable protective equipment Self-contained breathing apparatus Complete protective clothing : Toxic fumes may be released SECTION 8: Other information No data available 12/03/2018 EN (English) 2/50

3 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 8) Date of issue: 05/06/2013 Revision date: 19/01/2018 Supersedes: 03/03/2017 Version: 1.3 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier Product form : Mixture Product name : L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 8) Product code : K-ASNAM (Bottle 8) 1.2. Relevant identified uses of the substance or mixture and uses advised against Relevant identified uses Industrial/Professional use spec Use of the substance/mixture : For professional use only : Use as laboratory reagent Uses advised against 1.3. Details of the supplier of the safety data sheet Megazyme Bray Business Park A98 YV29 Bray - Ireland T F cs@megazyme.com Emergency telephone number Emergency number : [9 am to 5 pm GMT - Monday to Friday] SECTION 2: Hazards identification 2.1. Classification of the substance or mixture Classification according to Regulation (EC) No. 1272/2008 [CLP] Not classified Adverse physicochemical, human health and environmental effects To our knowledge, this product does not present any particular risk, provided it is handled in accordance with good occupational hygiene and safety practice Label elements Labelling according to Regulation (EC) No. 1272/2008 [CLP] Extra labelling to displayextra classification(s) to display No labelling applicable Labelling according to: exemption for inner packaging where the contents do not exceed 10ml No labelling required 2.3. Other hazards SECTION 3: Composition/information on ingredients 3.1. Substances 3.2. Mixtures This mixture does not contain any substances to be mentioned according to the criteria of section 3.2 of REACH annex II SECTION 4: First aid measures 4.1. Description of first aid measures First-aid measures after inhalation First-aid measures after skin contact First-aid measures after eye contact First-aid measures after ingestion : Remove person to fresh air and keep comfortable for breathing. : Wash skin with plenty of water. : Rinse eyes with water as a precaution. : Call a poison center or a doctor if you feel unwell. 12/03/2018 EN (English) 3/50

4 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 8) 4.2. Most important symptoms and effects, both acute and delayed 4.3. Indication of any immediate medical attention and special treatment needed Treat symptomatically. SECTION 5: Firefighting measures 5.1. Extinguishing media Suitable extinguishing media : Water spray. Dry powder. Foam Special hazards arising from the substance or mixture Hazardous decomposition products in case of fire : Toxic fumes may be released Advice for firefighters Protection during firefighting : Do not attempt to take action without suitable protective equipment. Self-contained breathing apparatus. Complete protective clothing. SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures For non-emergency personnel Emergency procedures For emergency responders Protective equipment : Ventilate spillage area. : Do not attempt to take action without suitable protective equipment. For further information refer to section 8: "Exposure controls/personal protection" Environmental precautions Avoid release to the environment Methods and material for containment and cleaning up Methods for cleaning up : Mechanically recover the product. Other information : Dispose of materials or solid residues at an authorized site Reference to other sections For further information refer to section 13. SECTION 7: Handling and storage 7.1. Precautions for safe handling Precautions for safe handling Hygiene measures : Ensure good ventilation of the work station. Wear personal protective equipment. : Do not eat, drink or smoke when using this product. Always wash hands after handling the product Conditions for safe storage, including any incompatibilities Storage conditions : Store in a well-ventilated place. Keep cool Specific end use(s) SECTION 8: Exposure controls/personal protection 8.1. Control parameters 8.2. Exposure controls Appropriate engineering controls: Ensure good ventilation of the work station. Hand protection: Protective gloves Type Material Permeation Thickness (mm) Penetration Standard Disposable gloves Nitrile rubber (NBR) 3 (> 60 minutes) 2 (< 1.5) EN Eye protection: Safety glasses 12/03/2018 EN (English) 4/50

5 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 8) Type Use Characteristics Standard Safety glasses Dust With side shields, clear EN 166 Skin and body protection: Wear suitable protective clothing Type Standard Lab coat Respiratory protection: In case of insufficient ventilation, wear suitable respiratory equipment Device Filter type Condition Standard Dust mask Type P1 Protection for Solid particles EN 143, EN 149 Environmental exposure controls: Avoid release to the environment. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties Physical state : Solid Colour on colour. Odour : None. Odour threshold ph Relative evaporation rate (butylacetate=1) Melting point Freezing point : Boiling point Flash point : Auto-ignition temperature : Decomposition temperature Flammability (solid, gas) : Non flammable. Vapour pressure Relative vapour density at 20 C Relative density : Solubility : Soluble in water. Log Pow Viscosity, kinematic : Viscosity, dynamic Explosive properties Oxidising properties Explosive limits : 9.2. Other information SECTION 10: Stability and reactivity Reactivity The product is non-reactive under normal conditions of use, storage and transport Chemical stability Stable under normal conditions Possibility of hazardous reactions No dangerous reactions known under normal conditions of use. 12/03/2018 EN (English) 5/50

6 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 8) Conditions to avoid None under recommended storage and handling conditions (see section 7) Incompatible materials Hazardous decomposition products Under normal conditions of storage and use, hazardous decomposition products should not be produced. SECTION 11: Toxicological information Information on toxicological effects Acute toxicity (oral) Acute toxicity (dermal) Acute toxicity (inhalation) Skin corrosion/irritation Serious eye damage/irritation Respiratory or skin sensitisation Germ cell mutagenicity Carcinogenicity Reproductive toxicity STOT-single exposure STOT-repeated exposure Aspiration hazard SECTION 12: Ecological information Toxicity Ecology - general Acute aquatic toxicity Chronic aquatic toxicity : The product is not considered harmful to aquatic organisms nor to cause long-term adverse effects in the environment Persistence and degradability Bioaccumulative potential Mobility in soil Results of PBT and vpvb assessment Other adverse effects SECTION 13: Disposal considerations Waste treatment methods Waste treatment methods : Dispose of contents/container in accordance with licensed collector s sorting instructions. SECTION 14: Transport information In accordance with ADR / RID / IMDG / IATA / ADN ADR UN number UN proper shipping name Transport hazard class(es) IATA 12/03/2018 EN (English) 6/50

7 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 8) ADR Packing group Environmental hazards IATA No supplementary information available Special precautions for user - Overland transport - Air transport Transport in bulk according to Annex II of Marpol and the IBC Code SECTION 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture EU-Regulations Contains no REACH substances with Annex XVII restrictions Contains no substance on the REACH candidate list Contains no REACH Annex XIV substances National regulations Chemical safety assessment No chemical safety assessment has been carried out SECTION 16: Other information SDS EU (REACH Annex II) This information is based on our current knowledge and is intended to describe the product for the purposes of health, safety and environmental requirements only. It should not therefore be construed as guaranteeing any specific property of the product. 12/03/2018 EN (English) 7/50

8 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 7) Date of issue: 05/06/2013 Revision date: 19/01/2018 Supersedes: 03/03/2017 Version: 1.3 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier Product form : Mixture Product name : L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 7) Product code : K-ASNAM (Bottle 7) 1.2. Relevant identified uses of the substance or mixture and uses advised against Relevant identified uses Industrial/Professional use spec Use of the substance/mixture : For professional use only : Use as laboratory reagent Uses advised against 1.3. Details of the supplier of the safety data sheet Megazyme Bray Business Park A98 YV29 Bray - Ireland T F cs@megazyme.com Emergency telephone number Emergency number : [9 am to 5 pm GMT - Monday to Friday] SECTION 2: Hazards identification 2.1. Classification of the substance or mixture Classification according to Regulation (EC) No. 1272/2008 [CLP] Not classified Adverse physicochemical, human health and environmental effects To our knowledge, this product does not present any particular risk, provided it is handled in accordance with good occupational hygiene and safety practice Label elements Labelling according to Regulation (EC) No. 1272/2008 [CLP] Extra labelling to displayextra classification(s) to display EUH-statements : EUH032 - Contact with acids liberates very toxic gas. Labelling according to: exemption for inner packaging where the contents do not exceed 10ml No labelling required 2.3. Other hazards SECTION 3: Composition/information on ingredients 3.1. Substances 3.2. Mixtures This mixture does not contain any substances to be mentioned according to the criteria of section 3.2 of REACH annex II SECTION 4: First aid measures 4.1. Description of first aid measures First-aid measures after inhalation First-aid measures after skin contact First-aid measures after eye contact First-aid measures after ingestion : Remove person to fresh air and keep comfortable for breathing. : Wash skin with plenty of water. : Rinse eyes with water as a precaution. : Call a poison center or a doctor if you feel unwell. 12/03/2018 EN (English) 8/50

9 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 7) 4.2. Most important symptoms and effects, both acute and delayed 4.3. Indication of any immediate medical attention and special treatment needed Treat symptomatically. SECTION 5: Firefighting measures 5.1. Extinguishing media Suitable extinguishing media 5.2. Special hazards arising from the substance or mixture Hazardous decomposition products in case of fire : Water spray. Dry powder. Foam. Carbon dioxide. : Toxic fumes may be released Advice for firefighters Protection during firefighting : Do not attempt to take action without suitable protective equipment. Self-contained breathing apparatus. Complete protective clothing. SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures For non-emergency personnel Emergency procedures For emergency responders Protective equipment : Ventilate spillage area. : Do not attempt to take action without suitable protective equipment. For further information refer to section 8: "Exposure controls/personal protection" Environmental precautions Avoid release to the environment Methods and material for containment and cleaning up Methods for cleaning up : Take up liquid spill into absorbent material. Other information : Dispose of materials or solid residues at an authorized site Reference to other sections For further information refer to section 13. SECTION 7: Handling and storage 7.1. Precautions for safe handling Precautions for safe handling Hygiene measures : Ensure good ventilation of the work station. Wear personal protective equipment. : Do not eat, drink or smoke when using this product. Always wash hands after handling the product Conditions for safe storage, including any incompatibilities Storage conditions : Store in a well-ventilated place. Keep cool Specific end use(s) SECTION 8: Exposure controls/personal protection 8.1. Control parameters 8.2. Exposure controls Appropriate engineering controls: Ensure good ventilation of the work station. Hand protection: Protective gloves Type Material Permeation Thickness (mm) Penetration Standard Disposable gloves Nitrile rubber (NBR) 3 (> 60 minutes) 2 (< 1.5) EN Eye protection: Safety glasses 12/03/2018 EN (English) 9/50

10 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 7) Type Use Characteristics Standard Safety glasses Droplet With side shields, clear EN 166 Skin and body protection: Wear suitable protective clothing Type Standard Lab coat Respiratory protection: In case of insufficient ventilation, wear suitable respiratory equipment Device Filter type Condition Standard Dust mask Type P1 Protection for Liquid particles EN 143, EN 149 Environmental exposure controls: Avoid release to the environment. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties Physical state : Liquid Colour on colour. Odour : None. Odour threshold ph Relative evaporation rate (butylacetate=1) Melting point : Freezing point Boiling point Flash point Auto-ignition temperature Decomposition temperature Flammability (solid, gas) : Vapour pressure Relative vapour density at 20 C Relative density Solubility : Soluble in water. Log Pow Viscosity, kinematic Viscosity, dynamic Explosive properties Oxidising properties Explosive limits : 9.2. Other information SECTION 10: Stability and reactivity Reactivity The product is non-reactive under normal conditions of use, storage and transport Chemical stability Stable under normal conditions Possibility of hazardous reactions Contact with acids liberates very toxic gas. 12/03/2018 EN (English) 10/50

11 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 7) Conditions to avoid None under recommended storage and handling conditions (see section 7) Incompatible materials Acids Hazardous decomposition products Under normal conditions of storage and use, hazardous decomposition products should not be produced. SECTION 11: Toxicological information Information on toxicological effects Acute toxicity (oral) Acute toxicity (dermal) Acute toxicity (inhalation) Skin corrosion/irritation Serious eye damage/irritation Respiratory or skin sensitisation Germ cell mutagenicity Carcinogenicity Reproductive toxicity STOT-single exposure STOT-repeated exposure Aspiration hazard SECTION 12: Ecological information Toxicity Ecology - general Acute aquatic toxicity Chronic aquatic toxicity : The product is not considered harmful to aquatic organisms nor to cause long-term adverse effects in the environment Persistence and degradability Bioaccumulative potential Mobility in soil Results of PBT and vpvb assessment Other adverse effects SECTION 13: Disposal considerations Waste treatment methods Waste treatment methods : Dispose of contents/container in accordance with licensed collector s sorting instructions. SECTION 14: Transport information In accordance with ADR / RID / IMDG / IATA / ADN ADR UN number UN proper shipping name Transport hazard class(es) IATA 12/03/2018 EN (English) 11/50

12 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 7) ADR Packing group Environmental hazards IATA No supplementary information available Special precautions for user - Overland transport - Air transport Transport in bulk according to Annex II of Marpol and the IBC Code SECTION 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture EU-Regulations Contains no REACH substances with Annex XVII restrictions Contains no substance on the REACH candidate list Contains no REACH Annex XIV substances National regulations Chemical safety assessment No chemical safety assessment has been carried out SECTION 16: Other information Full text of H- and EUH-statements: EUH032 Contact with acids liberates very toxic gas. SDS EU (REACH Annex II) This information is based on our current knowledge and is intended to describe the product for the purposes of health, safety and environmental requirements only. It should not therefore be construed as guaranteeing any specific property of the product. 12/03/2018 EN (English) 12/50

13 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 6) Date of issue: 05/06/2013 Revision date: 19/01/2018 Supersedes: 03/03/2017 Version: 1.3 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier Product form : Mixture Product name : L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 6) Product code : K-ASNAM (Bottle 6) 1.2. Relevant identified uses of the substance or mixture and uses advised against Relevant identified uses Industrial/Professional use spec Use of the substance/mixture : For professional use only : Use as laboratory reagent Uses advised against 1.3. Details of the supplier of the safety data sheet Megazyme Bray Business Park A98 YV29 Bray - Ireland T F cs@megazyme.com Emergency telephone number Emergency number : [9 am to 5 pm GMT - Monday to Friday] SECTION 2: Hazards identification 2.1. Classification of the substance or mixture Classification according to Regulation (EC) No. 1272/2008 [CLP] Serious eye damage/eye irritation, Category H319 2 Respiratory sensitisation, Category 1 H334 Skin sensitisation, Category 1 Reproductive toxicity, Category 2 Reproductive toxicity, Additional category, Effects on or via lactation Hazardous to the aquatic environment Chronic Hazard, Category 3 Full text of H statements : see section 16 H317 H361 H362 H412 Adverse physicochemical, human health and environmental effects May cause harm to breast-fed children. Suspected of damaging fertility or the unborn child. May cause an allergic skin reaction. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Harmful to aquatic life with long lasting effects Label elements Labelling according to Regulation (EC) No. 1272/2008 [CLP] Extra labelling to displayextra classification(s) to display Hazard pictograms (CLP) : Signal word (CLP) Hazardous ingredients Hazard statements (CLP) Precautionary statements (CLP) : Danger GHS08 : Asparaginase; lithium sulfate : H317 - May cause an allergic skin reaction. H319 - Causes serious eye irritation H334 - May cause allergy or asthma symptoms or breathing difficulties if inhaled. H361 - Suspected of damaging fertility or the unborn child. H362 - May cause harm to breast-fed children. H412 - Harmful to aquatic life with long lasting effects. : P201 - Obtain special instructions before use. P202 - Do not handle until all safety precautions have been read and understood. P260 - Do not breathe mist, spray, vapours. 12/03/2018 EN (English) 13/50

14 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 6) EUH-statements P263 - Avoid contact during pregnancy and while nursing. P264 - Wash hands thoroughly after handling. P270 - Do not eat, drink or smoke when using this product. : EUH032 - Contact with acids liberates very toxic gas. Labelling according to: exemption for inner packaging where the contents do not exceed 10ml Hazard pictograms (CLP) : Hazardous ingredients GHS08 : Asparaginase; lithium sulfate 2.3. Other hazards SECTION 3: Composition/information on ingredients 3.1. Substances 3.2. Mixtures Name Product identifier % Classification according to Regulation (EC) No. 1272/2008 [CLP] lithium sulfate (CAS-No.) (EC-No.) Asparaginase (CAS-No.) (EC-No.) sodium azide substance with a Community workplace exposure limit Full text of H-statements: see section 16 (CAS-No.) (EC-No.) (EC Index-No.) Acute Tox. 4 (Oral), H302 Eye Irrit. 2, H319 Lact., H362 Repr. 2, H361 Aquatic Chronic 3, H Resp. Sens. 1, H334 Skin Sens. 1, H317 Repr. 2, H361 < 0.1 Acute Tox. 2 (Oral), H300 Aquatic Acute 1, H400 Aquatic Chronic 1, H410 SECTION 4: First aid measures 4.1. Description of first aid measures First-aid measures general First-aid measures after inhalation First-aid measures after skin contact First-aid measures after eye contact First-aid measures after ingestion : IF exposed or concerned: Get medical advice/attention. Call a poison center or a doctor if you feel unwell. : Remove person to fresh air and keep comfortable for breathing. If experiencing respiratory symptoms: Call a poison center or a doctor. : Wash skin with plenty of water. Take off contaminated clothing. If skin irritation or rash occurs: Get medical advice/attention. : Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. : Call a poison center or a doctor if you feel unwell Most important symptoms and effects, both acute and delayed Symptoms/effects after inhalation Symptoms/effects after skin contact Symptoms/effects after eye contact : May cause allergy or asthma symptoms or breathing difficulties if inhaled. : May cause an allergic skin reaction. : Eye irritation Indication of any immediate medical attention and special treatment needed Treat symptomatically. SECTION 5: Firefighting measures 5.1. Extinguishing media Suitable extinguishing media 5.2. Special hazards arising from the substance or mixture Hazardous decomposition products in case of fire : Water spray. Dry powder. Foam. Carbon dioxide. : Toxic fumes may be released. 12/03/2018 EN (English) 14/50

15 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 6) 5.3. Advice for firefighters Protection during firefighting : Do not attempt to take action without suitable protective equipment. Self-contained breathing apparatus. Complete protective clothing. SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures For non-emergency personnel Emergency procedures For emergency responders Protective equipment : Ventilate spillage area. Do not breathe mist, spray, vapours. Avoid contact with skin and eyes. : Do not attempt to take action without suitable protective equipment. For further information refer to section 8: "Exposure controls/personal protection" Environmental precautions Avoid release to the environment Methods and material for containment and cleaning up Methods for cleaning up Other information : Take up liquid spill into absorbent material. Notify authorities if product enters sewers or public waters. : Dispose of materials or solid residues at an authorized site Reference to other sections For further information refer to section 13. SECTION 7: Handling and storage 7.1. Precautions for safe handling Precautions for safe handling Hygiene measures : Ensure good ventilation of the work station. Obtain special instructions before use. Avoid contact during pregnancy/while nursing. Do not breathe mist, spray, vapours. Do not handle until all safety precautions have been read and understood. Wear personal protective equipment. Avoid contact with skin and eyes. : Do not eat, drink or smoke when using this product. Always wash hands after handling the product. Contaminated work clothing should not be allowed out of the workplace. Wash contaminated clothing before reuse Conditions for safe storage, including any incompatibilities Storage conditions 7.3. Specific end use(s) SECTION 8: Exposure controls/personal protection 8.1. Control parameters : Store locked up. Store in a well-ventilated place. Keep cool. sodium azide ( ) EU Local name Sodium azide EU IOELV TWA (mg/m³) 0.1 mg/m³ EU IOELV STEL (mg/m³) 0.3 mg/m³ EU Notes Skin EU Regulatory reference COMMISSION DIRECTIVE 2000/39/EC 8.2. Exposure controls Appropriate engineering controls: Ensure good ventilation of the work station. Hand protection: Protective gloves Type Material Permeation Thickness (mm) Penetration Standard Disposable gloves Nitrile rubber (NBR) 3 (> 60 minutes) 2 (< 1.5) EN Eye protection: Safety glasses Type Use Characteristics Standard Safety glasses Droplet With side shields, clear EN /03/2018 EN (English) 15/50

16 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 6) Skin and body protection: Wear suitable protective clothing Type Standard Lab coat Respiratory protection: [In case of inadequate ventilation] wear respiratory protection. Device Filter type Condition Standard Dust mask Type P1 Protection for Liquid particles EN 143, EN 149 Environmental exposure controls: Avoid release to the environment. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties Physical state : Liquid Colour on colour. Odour : None. Odour threshold ph Relative evaporation rate (butylacetate=1) Melting point : Freezing point Boiling point Flash point Auto-ignition temperature Decomposition temperature Flammability (solid, gas) : Vapour pressure Relative vapour density at 20 C Relative density Solubility : Soluble in water. Log Pow Viscosity, kinematic Viscosity, dynamic Explosive properties Oxidising properties Explosive limits : 9.2. Other information SECTION 10: Stability and reactivity Reactivity The product is non-reactive under normal conditions of use, storage and transport Chemical stability Stable under normal conditions Possibility of hazardous reactions Contact with acids liberates very toxic gas Conditions to avoid None under recommended storage and handling conditions (see section 7). 12/03/2018 EN (English) 16/50

17 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 6) Incompatible materials Acids Hazardous decomposition products Under normal conditions of storage and use, hazardous decomposition products should not be produced. SECTION 11: Toxicological information Information on toxicological effects Acute toxicity (oral) Acute toxicity (dermal) Acute toxicity (inhalation) lithium sulfate ( ) LD50 oral rat Skin corrosion/irritation Serious eye damage/irritation Respiratory or skin sensitisation Germ cell mutagenicity Carcinogenicity Reproductive toxicity 580 mg/kg rat : Causes serious eye irritation. : May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. : Suspected of damaging fertility or the unborn child. May cause harm to breast-fed children. STOT-single exposure STOT-repeated exposure Aspiration hazard SECTION 12: Ecological information Toxicity Ecology - general Acute aquatic toxicity Chronic aquatic toxicity : Harmful to aquatic life with long lasting effects. : Harmful to aquatic life with long lasting effects Persistence and degradability lithium sulfate ( ) Persistence and degradability Biochemical oxygen demand (BOD) Chemical oxygen demand (COD) ThOD BOD (% of ThOD) Bioaccumulative potential lithium sulfate ( ) Bioaccumulative potential Mobility in soil Biodegradability:. Not established Results of PBT and vpvb assessment Other adverse effects SECTION 13: Disposal considerations Waste treatment methods Waste treatment methods : Dispose of contents/container in accordance with licensed collector s sorting instructions. 12/03/2018 EN (English) 17/50

18 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 6) SECTION 14: Transport information In accordance with ADR / RID / IMDG / IATA / ADN ADR UN number UN proper shipping name Transport hazard class(es) Packing group Environmental hazards IATA No supplementary information available Special precautions for user - Overland transport - Air transport Transport in bulk according to Annex II of Marpol and the IBC Code SECTION 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture EU-Regulations Contains no REACH substances with Annex XVII restrictions Contains no substance on the REACH candidate list Contains no REACH Annex XIV substances National regulations Chemical safety assessment No chemical safety assessment has been carried out SECTION 16: Other information Full text of H- and EUH-statements: Acute Tox. 2 (Oral) Acute toxicity (oral), Category 2 Acute Tox. 4 (Oral) Acute toxicity (oral), Category 4 Aquatic Acute 1 Hazardous to the aquatic environment Acute Hazard, Category 1 Aquatic Chronic 1 Hazardous to the aquatic environment Chronic Hazard, Category 1 Aquatic Chronic 3 Hazardous to the aquatic environment Chronic Hazard, Category 3 Eye Irrit. 2 Serious eye damage/eye irritation, Category 2 Lact. Reproductive toxicity, Additional category, Effects on or via lactation Repr. 2 Reproductive toxicity, Category 2 Resp. Sens. 1 Respiratory sensitisation, Category 1 Skin Sens. 1 Skin sensitisation, Category 1 H300 Fatal if swallowed. H302 Harmful if swallowed. H317 May cause an allergic skin reaction. H319 Causes serious eye irritation H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H361 Suspected of damaging fertility or the unborn child. H362 May cause harm to breast-fed children. H400 Very toxic to aquatic life. 12/03/2018 EN (English) 18/50

19 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 6) H410 H412 EUH032 Very toxic to aquatic life with long lasting effects. Harmful to aquatic life with long lasting effects. Contact with acids liberates very toxic gas. SDS EU (REACH Annex II) This information is based on our current knowledge and is intended to describe the product for the purposes of health, safety and environmental requirements only. It should not therefore be construed as guaranteeing any specific property of the product. 12/03/2018 EN (English) 19/50

20 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 5) Date of issue: 05/06/2013 Revision date: 19/01/2018 Supersedes: 03/03/2017 Version: 1.3 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier Product form : Mixture Product name : L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 5) Product code : K-ASNAM (Bottle 5) 1.2. Relevant identified uses of the substance or mixture and uses advised against Relevant identified uses Industrial/Professional use spec Use of the substance/mixture : For professional use only : Use as laboratory reagent Uses advised against 1.3. Details of the supplier of the safety data sheet Megazyme Bray Business Park A98 YV29 Bray - Ireland T F cs@megazyme.com Emergency telephone number Emergency number : [9 am to 5 pm GMT - Monday to Friday] SECTION 2: Hazards identification 2.1. Classification of the substance or mixture Classification according to Regulation (EC) No. 1272/2008 [CLP] Acute toxicity (oral), Category 4 H302 Serious eye damage/eye irritation, Category H319 2 Reproductive toxicity, Category 2 H361 Reproductive toxicity, Additional category, Effects on or via lactation Hazardous to the aquatic environment Chronic Hazard, Category 3 Full text of H statements : see section 16 H362 H412 Adverse physicochemical, human health and environmental effects May cause harm to breast-fed children. Suspected of damaging fertility or the unborn child. Harmful if swallowed. Causes serious eye irritation. Harmful to aquatic life with long lasting effects Label elements Labelling according to Regulation (EC) No. 1272/2008 [CLP] Extra labelling to displayextra classification(s) to display Hazard pictograms (CLP) : Signal word (CLP) Hazardous ingredients Hazard statements (CLP) Precautionary statements (CLP) GHS07 : Warning : lithium sulfate GHS08 : H302 - Harmful if swallowed. H319 - Causes serious eye irritation H361 - Suspected of damaging fertility or the unborn child. H362 - May cause harm to breast-fed children. H412 - Harmful to aquatic life with long lasting effects. : P201 - Obtain special instructions before use. P202 - Do not handle until all safety precautions have been read and understood. P260 - Do not breathe mist, spray, vapours. P263 - Avoid contact during pregnancy and while nursing. P264 - Wash hands thoroughly after handling. 12/03/2018 EN (English) 20/50

21 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 5) EUH-statements P270 - Do not eat, drink or smoke when using this product. : EUH032 - Contact with acids liberates very toxic gas. Labelling according to: exemption for inner packaging where the contents do not exceed 10ml Hazard pictograms (CLP) : Hazardous ingredients GHS08 : lithium sulfate 2.3. Other hazards SECTION 3: Composition/information on ingredients 3.1. Substances 3.2. Mixtures Name Product identifier % Classification according to Regulation (EC) No. 1272/2008 [CLP] lithium sulfate (CAS-No.) (EC-No.) sodium azide substance with a Community workplace exposure limit Full text of H-statements: see section 16 (CAS-No.) (EC-No.) (EC Index-No.) Acute Tox. 4 (Oral), H302 Eye Irrit. 2, H319 Lact., H362 Repr. 2, H361 Aquatic Chronic 3, H412 < 0.1 Acute Tox. 2 (Oral), H300 Aquatic Acute 1, H400 Aquatic Chronic 1, H410 SECTION 4: First aid measures 4.1. Description of first aid measures First-aid measures general First-aid measures after inhalation First-aid measures after skin contact First-aid measures after eye contact First-aid measures after ingestion : IF exposed or concerned: Get medical advice/attention. Call a poison center or a doctor if you feel unwell. : Remove person to fresh air and keep comfortable for breathing. : Wash skin with plenty of water. : Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. : Call a poison center or a doctor if you feel unwell. Rinse mouth Most important symptoms and effects, both acute and delayed Symptoms/effects after eye contact : Eye irritation Indication of any immediate medical attention and special treatment needed Treat symptomatically. SECTION 5: Firefighting measures 5.1. Extinguishing media Suitable extinguishing media 5.2. Special hazards arising from the substance or mixture Hazardous decomposition products in case of fire : Water spray. Dry powder. Foam. Carbon dioxide. : Toxic fumes may be released Advice for firefighters Protection during firefighting : Do not attempt to take action without suitable protective equipment. Self-contained breathing apparatus. Complete protective clothing. 12/03/2018 EN (English) 21/50

22 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 5) SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures For non-emergency personnel Emergency procedures For emergency responders Protective equipment : Ventilate spillage area. Do not breathe mist, spray, vapours. Avoid contact with skin and eyes. : Do not attempt to take action without suitable protective equipment. For further information refer to section 8: "Exposure controls/personal protection" Environmental precautions Avoid release to the environment Methods and material for containment and cleaning up Methods for cleaning up Other information : Take up liquid spill into absorbent material. Notify authorities if product enters sewers or public waters. : Dispose of materials or solid residues at an authorized site Reference to other sections For further information refer to section 13. SECTION 7: Handling and storage 7.1. Precautions for safe handling Precautions for safe handling Hygiene measures : Ensure good ventilation of the work station. Obtain special instructions before use. Avoid contact during pregnancy/while nursing. Do not breathe mist, spray, vapours. Do not handle until all safety precautions have been read and understood. Wear personal protective equipment. Avoid contact with skin and eyes. : Do not eat, drink or smoke when using this product. Always wash hands after handling the product Conditions for safe storage, including any incompatibilities Storage conditions 7.3. Specific end use(s) SECTION 8: Exposure controls/personal protection 8.1. Control parameters : Store locked up. Store in a well-ventilated place. Keep cool. sodium azide ( ) EU Local name Sodium azide EU IOELV TWA (mg/m³) 0.1 mg/m³ EU IOELV STEL (mg/m³) 0.3 mg/m³ EU Notes Skin EU Regulatory reference COMMISSION DIRECTIVE 2000/39/EC 8.2. Exposure controls Appropriate engineering controls: Ensure good ventilation of the work station. Hand protection: Protective gloves Type Material Permeation Thickness (mm) Penetration Standard Disposable gloves Nitrile rubber (NBR) 3 (> 60 minutes) 2 (< 1.5) EN Eye protection: Safety glasses Type Use Characteristics Standard Safety glasses Droplet With side shields, clear EN 166 Skin and body protection: Wear suitable protective clothing Type Standard Lab coat 12/03/2018 EN (English) 22/50

23 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 5) Respiratory protection: [In case of inadequate ventilation] wear respiratory protection. Device Filter type Condition Standard Dust mask Type P1 Protection for Liquid particles EN 143, EN 149 Environmental exposure controls: Avoid release to the environment. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties Physical state : Liquid Colour on colour. Odour : None. Odour threshold ph Relative evaporation rate (butylacetate=1) Melting point : Freezing point Boiling point Flash point Auto-ignition temperature Decomposition temperature Flammability (solid, gas) : Vapour pressure Relative vapour density at 20 C Relative density Solubility : Soluble in water. Log Pow Viscosity, kinematic Viscosity, dynamic Explosive properties Oxidising properties Explosive limits : 9.2. Other information SECTION 10: Stability and reactivity Reactivity The product is non-reactive under normal conditions of use, storage and transport Chemical stability Stable under normal conditions Possibility of hazardous reactions Contact with acids liberates very toxic gas Conditions to avoid None under recommended storage and handling conditions (see section 7) Incompatible materials Acids Hazardous decomposition products Under normal conditions of storage and use, hazardous decomposition products should not be produced. 12/03/2018 EN (English) 23/50

24 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 5) SECTION 11: Toxicological information Information on toxicological effects Acute toxicity (oral) : Oral: Harmful if swallowed. Acute toxicity (dermal) Acute toxicity (inhalation) ATE CLP (oral) lithium sulfate ( ) LD50 oral rat Skin corrosion/irritation Serious eye damage/irritation Respiratory or skin sensitisation Germ cell mutagenicity Carcinogenicity Reproductive toxicity 1160 mg/kg bodyweight 580 mg/kg rat : Causes serious eye irritation. : Suspected of damaging fertility or the unborn child. May cause harm to breast-fed children. STOT-single exposure STOT-repeated exposure Aspiration hazard SECTION 12: Ecological information Toxicity Ecology - general Acute aquatic toxicity Chronic aquatic toxicity : Harmful to aquatic life with long lasting effects. : Harmful to aquatic life with long lasting effects Persistence and degradability lithium sulfate ( ) Persistence and degradability Biochemical oxygen demand (BOD) Chemical oxygen demand (COD) ThOD BOD (% of ThOD) Biodegradability: Bioaccumulative potential lithium sulfate ( ) Bioaccumulative potential Not established Mobility in soil Results of PBT and vpvb assessment Other adverse effects SECTION 13: Disposal considerations Waste treatment methods Waste treatment methods : Dispose of contents/container in accordance with licensed collector s sorting instructions. SECTION 14: Transport information In accordance with ADR / RID / IMDG / IATA / ADN ADR UN number UN proper shipping name IATA 12/03/2018 EN (English) 24/50

25 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 5) ADR Transport hazard class(es) Packing group Environmental hazards IATA No supplementary information available Special precautions for user - Overland transport - Air transport Transport in bulk according to Annex II of Marpol and the IBC Code SECTION 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture EU-Regulations Contains no REACH substances with Annex XVII restrictions Contains no substance on the REACH candidate list Contains no REACH Annex XIV substances National regulations Chemical safety assessment No chemical safety assessment has been carried out SECTION 16: Other information Full text of H- and EUH-statements: Acute Tox. 2 (Oral) Acute toxicity (oral), Category 2 Acute Tox. 4 (Oral) Acute toxicity (oral), Category 4 Aquatic Acute 1 Hazardous to the aquatic environment Acute Hazard, Category 1 Aquatic Chronic 1 Hazardous to the aquatic environment Chronic Hazard, Category 1 Aquatic Chronic 3 Hazardous to the aquatic environment Chronic Hazard, Category 3 Eye Irrit. 2 Serious eye damage/eye irritation, Category 2 Lact. Reproductive toxicity, Additional category, Effects on or via lactation Repr. 2 Reproductive toxicity, Category 2 H300 Fatal if swallowed. H302 Harmful if swallowed. H319 Causes serious eye irritation H361 Suspected of damaging fertility or the unborn child. H362 May cause harm to breast-fed children. H400 Very toxic to aquatic life. H410 Very toxic to aquatic life with long lasting effects. H412 Harmful to aquatic life with long lasting effects. EUH032 Contact with acids liberates very toxic gas. SDS EU (REACH Annex II) This information is based on our current knowledge and is intended to describe the product for the purposes of health, safety and environmental requirements only. It should not therefore be construed as guaranteeing any specific property of the product. 12/03/2018 EN (English) 25/50

26 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 4) Date of issue: 05/06/2013 Revision date: 19/01/2018 Supersedes: 03/03/2017 Version: 1.3 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier Product form : Mixture Product name : L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 4) Product code : K-ASNAM (Bottle 4) 1.2. Relevant identified uses of the substance or mixture and uses advised against Relevant identified uses Industrial/Professional use spec Use of the substance/mixture : For professional use only : Use as laboratory reagent Uses advised against 1.3. Details of the supplier of the safety data sheet Megazyme Bray Business Park A98 YV29 Bray - Ireland T F cs@megazyme.com Emergency telephone number Emergency number : [9 am to 5 pm GMT - Monday to Friday] SECTION 2: Hazards identification 2.1. Classification of the substance or mixture Classification according to Regulation (EC) No. 1272/2008 [CLP] Serious eye damage/eye irritation, Category H319 2 Reproductive toxicity, Category 2 H361 Reproductive toxicity, Additional category, Effects on or via lactation Hazardous to the aquatic environment Chronic Hazard, Category 3 Full text of H statements : see section 16 H362 H412 Adverse physicochemical, human health and environmental effects May cause harm to breast-fed children. Suspected of damaging fertility or the unborn child. Causes serious eye irritation. Harmful to aquatic life with long lasting effects Label elements Labelling according to Regulation (EC) No. 1272/2008 [CLP] Extra labelling to displayextra classification(s) to display Hazard pictograms (CLP) : Signal word (CLP) Hazardous ingredients Hazard statements (CLP) Precautionary statements (CLP) EUH-statements GHS07 : Warning : lithium sulfate GHS08 : H319 - Causes serious eye irritation H361 - Suspected of damaging fertility or the unborn child. H362 - May cause harm to breast-fed children. H412 - Harmful to aquatic life with long lasting effects. : P201 - Obtain special instructions before use. P202 - Do not handle until all safety precautions have been read and understood. P260 - Do not breathe mist, spray, vapours. P263 - Avoid contact during pregnancy and while nursing. P264 - Wash hands thoroughly after handling. P270 - Do not eat, drink or smoke when using this product. : EUH208 - Contains Glutaminase, L-Glutamine amidohydrolase. May produce an allergic 12/03/2018 EN (English) 26/50

27 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 4) reaction. EUH032 - Contact with acids liberates very toxic gas. Labelling according to: exemption for inner packaging where the contents do not exceed 10ml Hazard pictograms (CLP) : Hazardous ingredients GHS08 : lithium sulfate 2.3. Other hazards SECTION 3: Composition/information on ingredients 3.1. Substances 3.2. Mixtures Name Product identifier % Classification according to Regulation (EC) No. 1272/2008 [CLP] lithium sulfate (CAS-No.) (EC-No.) Glutaminase, L-Glutamine amidohydrolase (CAS-No.) (EC-No.) sodium azide substance with a Community workplace exposure limit Full text of H-statements: see section 16 (CAS-No.) (EC-No.) (EC Index-No.) Acute Tox. 4 (Oral), H302 Eye Irrit. 2, H319 Lact., H362 Repr. 2, H361 Aquatic Chronic 3, H Resp. Sens. 1, H334 < 0.1 Acute Tox. 2 (Oral), H300 Aquatic Acute 1, H400 Aquatic Chronic 1, H410 SECTION 4: First aid measures 4.1. Description of first aid measures First-aid measures general First-aid measures after inhalation First-aid measures after skin contact First-aid measures after eye contact First-aid measures after ingestion : IF exposed or concerned: Get medical advice/attention. : Remove person to fresh air and keep comfortable for breathing. If experiencing respiratory symptoms: Call a poison center or a doctor. : Wash skin with plenty of water. : Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. : Call a poison center or a doctor if you feel unwell Most important symptoms and effects, both acute and delayed Symptoms/effects after inhalation Symptoms/effects after eye contact : May cause allergy or asthma symptoms or breathing difficulties if inhaled. : Eye irritation Indication of any immediate medical attention and special treatment needed Treat symptomatically. SECTION 5: Firefighting measures 5.1. Extinguishing media Suitable extinguishing media 5.2. Special hazards arising from the substance or mixture Hazardous decomposition products in case of fire : Water spray. Dry powder. Foam. Carbon dioxide. : Toxic fumes may be released Advice for firefighters Protection during firefighting : Do not attempt to take action without suitable protective equipment. Self-contained breathing apparatus. Complete protective clothing. 12/03/2018 EN (English) 27/50

28 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 4) SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures For non-emergency personnel Emergency procedures For emergency responders Protective equipment : Ventilate spillage area. Do not breathe mist, spray, vapours. Avoid contact with skin and eyes. : Do not attempt to take action without suitable protective equipment. For further information refer to section 8: "Exposure controls/personal protection" Environmental precautions Avoid release to the environment Methods and material for containment and cleaning up Methods for cleaning up Other information : Take up liquid spill into absorbent material. Notify authorities if product enters sewers or public waters. : Dispose of materials or solid residues at an authorized site Reference to other sections For further information refer to section 13. SECTION 7: Handling and storage 7.1. Precautions for safe handling Precautions for safe handling Hygiene measures : Ensure good ventilation of the work station. Obtain special instructions before use. Avoid contact during pregnancy/while nursing. Do not breathe dust/fume/gas/mist/vapours/spray. Do not handle until all safety precautions have been read and understood. Wear personal protective equipment. Avoid contact with skin and eyes. : Do not eat, drink or smoke when using this product. Always wash hands after handling the product Conditions for safe storage, including any incompatibilities Storage conditions 7.3. Specific end use(s) SECTION 8: Exposure controls/personal protection 8.1. Control parameters : Store locked up. Store in a well-ventilated place. Keep cool. sodium azide ( ) EU Local name Sodium azide EU IOELV TWA (mg/m³) 0.1 mg/m³ EU IOELV STEL (mg/m³) 0.3 mg/m³ EU Notes Skin EU Regulatory reference COMMISSION DIRECTIVE 2000/39/EC 8.2. Exposure controls Appropriate engineering controls: Ensure good ventilation of the work station. Hand protection: Protective gloves Type Material Permeation Thickness (mm) Penetration Standard Disposable gloves Nitrile rubber (NBR) 3 (> 60 minutes) 2 (< 1.5) EN Eye protection: Safety glasses Type Use Characteristics Standard Safety glasses Droplet With side shields, clear EN 166 Skin and body protection: Wear suitable protective clothing Type Standard Lab coat 12/03/2018 EN (English) 28/50

29 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 4) Respiratory protection: [In case of inadequate ventilation] wear respiratory protection. Device Filter type Condition Standard Dust mask Type P1 Protection for Liquid particles EN 143, EN 149 Environmental exposure controls: Avoid release to the environment. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties Physical state : Liquid Colour on colour. Odour : None. Odour threshold ph Relative evaporation rate (butylacetate=1) Melting point : Freezing point Boiling point Flash point Auto-ignition temperature Decomposition temperature Flammability (solid, gas) : Vapour pressure Relative vapour density at 20 C Relative density Solubility : Soluble in water. Log Pow Viscosity, kinematic Viscosity, dynamic Explosive properties Oxidising properties Explosive limits : 9.2. Other information SECTION 10: Stability and reactivity Reactivity The product is non-reactive under normal conditions of use, storage and transport Chemical stability Stable under normal conditions Possibility of hazardous reactions Contact with acids liberates very toxic gas Conditions to avoid None under recommended storage and handling conditions (see section 7) Incompatible materials Acids Hazardous decomposition products Under normal conditions of storage and use, hazardous decomposition products should not be produced. 12/03/2018 EN (English) 29/50

30 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 4) SECTION 11: Toxicological information Information on toxicological effects Acute toxicity (oral) Acute toxicity (dermal) Acute toxicity (inhalation) lithium sulfate ( ) LD50 oral rat Skin corrosion/irritation Serious eye damage/irritation Respiratory or skin sensitisation Germ cell mutagenicity Carcinogenicity Reproductive toxicity 580 mg/kg rat : Causes serious eye irritation. : Suspected of damaging fertility or the unborn child. May cause harm to breast-fed children. STOT-single exposure STOT-repeated exposure Aspiration hazard SECTION 12: Ecological information Toxicity Ecology - general Acute aquatic toxicity Chronic aquatic toxicity : Harmful to aquatic life with long lasting effects. : Harmful to aquatic life with long lasting effects Persistence and degradability lithium sulfate ( ) Persistence and degradability Biochemical oxygen demand (BOD) Chemical oxygen demand (COD) ThOD BOD (% of ThOD) Biodegradability: Bioaccumulative potential lithium sulfate ( ) Bioaccumulative potential Not established Mobility in soil Results of PBT and vpvb assessment Other adverse effects SECTION 13: Disposal considerations Waste treatment methods Waste treatment methods : Dispose of contents/container in accordance with licensed collector s sorting instructions. SECTION 14: Transport information In accordance with ADR / RID / IMDG / IATA / ADN ADR UN number UN proper shipping name Transport hazard class(es) IATA 12/03/2018 EN (English) 30/50

31 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 4) ADR Packing group Environmental hazards IATA No supplementary information available Special precautions for user - Overland transport - Air transport Transport in bulk according to Annex II of Marpol and the IBC Code SECTION 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture EU-Regulations Contains no REACH substances with Annex XVII restrictions Contains no substance on the REACH candidate list Contains no REACH Annex XIV substances National regulations Chemical safety assessment No chemical safety assessment has been carried out SECTION 16: Other information Full text of H- and EUH-statements: Acute Tox. 2 (Oral) Acute toxicity (oral), Category 2 Acute Tox. 4 (Oral) Acute toxicity (oral), Category 4 Aquatic Acute 1 Hazardous to the aquatic environment Acute Hazard, Category 1 Aquatic Chronic 1 Hazardous to the aquatic environment Chronic Hazard, Category 1 Aquatic Chronic 3 Hazardous to the aquatic environment Chronic Hazard, Category 3 Eye Irrit. 2 Serious eye damage/eye irritation, Category 2 Lact. Reproductive toxicity, Additional category, Effects on or via lactation Repr. 2 Reproductive toxicity, Category 2 Resp. Sens. 1 Respiratory sensitisation, Category 1 H300 Fatal if swallowed. H302 Harmful if swallowed. H319 Causes serious eye irritation H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. H361 Suspected of damaging fertility or the unborn child. H362 May cause harm to breast-fed children. H400 Very toxic to aquatic life. H410 Very toxic to aquatic life with long lasting effects. H412 Harmful to aquatic life with long lasting effects. EUH032 Contact with acids liberates very toxic gas. EUH208 Contains. May produce an allergic reaction. SDS EU (REACH Annex II) This information is based on our current knowledge and is intended to describe the product for the purposes of health, safety and environmental requirements only. It should not therefore be construed as guaranteeing any specific property of the product. 12/03/2018 EN (English) 31/50

32 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 3) Date of issue: 05/06/2013 Revision date: 19/01/2018 Supersedes: 03/03/2017 Version: 1.3 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier Product form : Mixture Product name : L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 3) Product code : K-ASNAM (Bottle 3) 1.2. Relevant identified uses of the substance or mixture and uses advised against Relevant identified uses Industrial/Professional use spec Use of the substance/mixture : For professional use only : Use as laboratory reagent Uses advised against 1.3. Details of the supplier of the safety data sheet Megazyme Bray Business Park A98 YV29 Bray - Ireland T F cs@megazyme.com Emergency telephone number Emergency number : [9 am to 5 pm GMT - Monday to Friday] SECTION 2: Hazards identification 2.1. Classification of the substance or mixture Classification according to Regulation (EC) No. 1272/2008 [CLP] Acute toxicity (oral), Category 4 Hazardous to the aquatic environment Chronic Hazard, Category 3 Full text of H statements : see section 16 H302 H412 Adverse physicochemical, human health and environmental effects Harmful if swallowed. Harmful to aquatic life with long lasting effects Label elements Labelling according to Regulation (EC) No. 1272/2008 [CLP] Extra labelling to displayextra classification(s) to display Hazard pictograms (CLP) : Signal word (CLP) Hazardous ingredients Hazard statements (CLP) Precautionary statements (CLP) EUH-statements GHS07 : Warning : sodium azide : H302 - Harmful if swallowed. H412 - Harmful to aquatic life with long lasting effects. : P264 - Wash hands thoroughly after handling. P270 - Do not eat, drink or smoke when using this product. P273 - Avoid release to the environment. P301+P312 - IF SWALLOWED: Call a doctor, a POISON CENTER if you feel unwell. P330 - Rinse mouth. P501 - Dispose of contents/container to hazardous or special waste collection point, in accordance with local, regional, national and/or international regulation. : EUH032 - Contact with acids liberates very toxic gas. Labelling according to: exemption for inner packaging where the contents do not exceed 10ml Hazardous ingredients : sodium azide 12/03/2018 EN (English) 32/50

33 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 3) 2.3. Other hazards SECTION 3: Composition/information on ingredients 3.1. Substances 3.2. Mixtures Name Product identifier % Classification according to Regulation (EC) No. 1272/2008 [CLP] sodium azide (CAS-No.) (EC-No.) (EC Index-No.) Full text of H-statements: see section Acute Tox. 2 (Oral), H300 Aquatic Acute 1, H400 Aquatic Chronic 1, H410 SECTION 4: First aid measures 4.1. Description of first aid measures First-aid measures general First-aid measures after inhalation First-aid measures after skin contact First-aid measures after eye contact First-aid measures after ingestion : Call a poison center or a doctor if you feel unwell. : Remove person to fresh air and keep comfortable for breathing. : Wash skin with plenty of water. : Rinse eyes with water as a precaution. : Call a poison center or a doctor if you feel unwell. Rinse mouth Most important symptoms and effects, both acute and delayed 4.3. Indication of any immediate medical attention and special treatment needed Treat symptomatically. SECTION 5: Firefighting measures 5.1. Extinguishing media Suitable extinguishing media : Water spray. Dry powder. Foam Special hazards arising from the substance or mixture Hazardous decomposition products in case of fire : Toxic fumes may be released Advice for firefighters Protection during firefighting : Do not attempt to take action without suitable protective equipment. Self-contained breathing apparatus. Complete protective clothing. SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures For non-emergency personnel Emergency procedures For emergency responders Protective equipment : Ventilate spillage area. : Do not attempt to take action without suitable protective equipment. For further information refer to section 8: "Exposure controls/personal protection" Environmental precautions Avoid release to the environment Methods and material for containment and cleaning up Methods for cleaning up : Mechanically recover the product. Other information : Dispose of materials or solid residues at an authorized site Reference to other sections For further information refer to section 13. SECTION 7: Handling and storage 7.1. Precautions for safe handling Precautions for safe handling : Ensure good ventilation of the work station. Wear personal protective equipment. 12/03/2018 EN (English) 33/50

34 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 3) Hygiene measures : Do not eat, drink or smoke when using this product. Always wash hands after handling the product Conditions for safe storage, including any incompatibilities Storage conditions 7.3. Specific end use(s) SECTION 8: Exposure controls/personal protection 8.1. Control parameters : Store in a well-ventilated place. Keep cool. sodium azide ( ) EU Local name Sodium azide EU IOELV TWA (mg/m³) 0.1 mg/m³ EU IOELV STEL (mg/m³) 0.3 mg/m³ EU Notes Skin EU Regulatory reference COMMISSION DIRECTIVE 2000/39/EC 8.2. Exposure controls Appropriate engineering controls: Ensure good ventilation of the work station. Hand protection: Protective gloves Type Material Permeation Thickness (mm) Penetration Standard Disposable gloves Nitrile rubber (NBR) 3 (> 60 minutes) 2 (< 1.5) EN Eye protection: Safety glasses Type Use Characteristics Standard Safety glasses Dust With side shields, clear EN 166 Skin and body protection: Wear suitable protective clothing Type Standard Lab coat Respiratory protection: In case of insufficient ventilation, wear suitable respiratory equipment Device Filter type Condition Standard Dust mask Type P1 Protection for Solid particles EN 143, EN 149 Environmental exposure controls: Avoid release to the environment. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties Physical state : Solid Colour on colour. Odour : None. Odour threshold ph Relative evaporation rate (butylacetate=1) 12/03/2018 EN (English) 34/50

35 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 3) Melting point Freezing point Boiling point Flash point Auto-ignition temperature Decomposition temperature Flammability (solid, gas) Vapour pressure Relative vapour density at 20 C Relative density Solubility Log Pow Viscosity, kinematic Viscosity, dynamic Explosive properties Oxidising properties Explosive limits : : : : Non flammable. : : Soluble in water. : : 9.2. Other information SECTION 10: Stability and reactivity Reactivity The product is non-reactive under normal conditions of use, storage and transport Chemical stability Stable under normal conditions Possibility of hazardous reactions Contact with acids liberates very toxic gas Conditions to avoid None under recommended storage and handling conditions (see section 7) Incompatible materials Acids Hazardous decomposition products Under normal conditions of storage and use, hazardous decomposition products should not be produced. SECTION 11: Toxicological information Information on toxicological effects Acute toxicity (oral) : Oral: Harmful if swallowed. Acute toxicity (dermal) Acute toxicity (inhalation) ATE CLP (oral) mg/kg bodyweight Skin corrosion/irritation Serious eye damage/irritation Respiratory or skin sensitisation Germ cell mutagenicity Carcinogenicity Reproductive toxicity STOT-single exposure STOT-repeated exposure Aspiration hazard SECTION 12: Ecological information Toxicity Ecology - general : Harmful to aquatic life with long lasting effects. Harmful to aquatic life. 12/03/2018 EN (English) 35/50

36 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 3) Acute aquatic toxicity Chronic aquatic toxicity : Harmful to aquatic life with long lasting effects Persistence and degradability Bioaccumulative potential Mobility in soil Results of PBT and vpvb assessment Other adverse effects SECTION 13: Disposal considerations Waste treatment methods Waste treatment methods : Dispose of contents/container in accordance with licensed collector s sorting instructions. SECTION 14: Transport information In accordance with ADR / RID / IMDG / IATA / ADN ADR UN number UN proper shipping name Transport hazard class(es) Packing group Environmental hazards IATA No supplementary information available Special precautions for user - Overland transport - Air transport Transport in bulk according to Annex II of Marpol and the IBC Code SECTION 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture EU-Regulations Contains no REACH substances with Annex XVII restrictions Contains no substance on the REACH candidate list Contains no REACH Annex XIV substances National regulations Chemical safety assessment No chemical safety assessment has been carried out SECTION 16: Other information 12/03/2018 EN (English) 36/50

37 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 3) Full text of H- and EUH-statements: Acute Tox. 2 (Oral) Acute toxicity (oral), Category 2 Aquatic Acute 1 Hazardous to the aquatic environment Acute Hazard, Category 1 Aquatic Chronic 1 Hazardous to the aquatic environment Chronic Hazard, Category 1 H300 Fatal if swallowed. H302 Harmful if swallowed. H400 Very toxic to aquatic life. H410 Very toxic to aquatic life with long lasting effects. H412 Harmful to aquatic life with long lasting effects. EUH032 Contact with acids liberates very toxic gas. SDS EU (REACH Annex II) This information is based on our current knowledge and is intended to describe the product for the purposes of health, safety and environmental requirements only. It should not therefore be construed as guaranteeing any specific property of the product. 12/03/2018 EN (English) 37/50

38 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 2) Date of issue: 05/06/2013 Revision date: 23/11/2017 Supersedes: 03/03/2017 Version: 1.3 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier Product form : Mixture Product name : L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 2) Product code : K-ASNAM (Bottle 2) Type of product Product group : Mixture : Trade product 1.2. Relevant identified uses of the substance or mixture and uses advised against Relevant identified uses Industrial/Professional use spec Use of the substance/mixture : For professional use only : Use as laboratory reagent Uses advised against 1.3. Details of the supplier of the safety data sheet Manufacturer Megazyme Bray Business Park A98 YV29 Bray - Ireland T F cs@megazyme.com Emergency telephone number Emergency number : [9 am to 5 pm GMT - Monday to Friday] SECTION 2: Hazards identification 2.1. Classification of the substance or mixture Classification according to Regulation (EC) No. 1272/2008 [CLP]Mixtures/Substances: SDS EU 2015: According to Regulation (EU) 2015/830 (REACH Annex II) Skin corrosion/irritation, Category 2 H315 Serious eye damage/eye irritation, Category H319 2 Reproductive toxicity, Category 1B H360 Full text of H statements : see section 16 Adverse physicochemical, human health and environmental effects May damage fertility or the unborn child. Causes skin irritation. Causes serious eye irritation Label elements Labelling according to Regulation (EC) No. 1272/2008 [CLP] Extra labelling to displayextra classification(s) to display Hazard pictograms (CLP) : Signal word (CLP) Hazardous ingredients Hazard statements (CLP) Precautionary statements (CLP) : Danger GHS07 : imidazole GHS08 : H315 - Causes skin irritation. H319 - Causes serious eye irritation H360 - May damage fertility or the unborn child. : P201 - Obtain special instructions before use. P202 - Do not handle until all safety precautions have been read and understood. P264 - Wash hands thoroughly after handling. P280 - Wear protective gloves/protective clothing/eye protection/face protection P302+P352 - IF ON SKIN: Wash with plenty of water. P305+P351+P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. 12/03/2018 EN (English) 38/50

39 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 2) EUH-statements : EUH032 - Contact with acids liberates very toxic gas. Labelling according to: exemption for packages of a capacity of 125ml or less Hazard pictograms (CLP) : Signal word (CLP) Hazardous ingredients Hazard statements (CLP) Precautionary statements (CLP) EUH-statements : Danger GHS07 : imidazole GHS08 : H360 - May damage fertility or the unborn child. : P201 - Obtain special instructions before use. P202 - Do not handle until all safety precautions have been read and understood. P280 - Wear protective gloves/protective clothing/eye protection/face protection : EUH032 - Contact with acids liberates very toxic gas Other hazards SECTION 3: Composition/information on ingredients 3.1. Substances 3.2. Mixtures Name Product identifier % Classification according to Regulation (EC) No. 1272/2008 [CLP] Triethanolamine substance with national workplace exposure limit(s) (IE) (CAS-No.) (EC-No.) (REACH-no) imidazole (CAS-No.) (EC-No.) (EC Index-No.) sodium azide substance with a Community workplace exposure limit Full text of H-statements: see section 16 (CAS-No.) (EC-No.) (EC Index-No.) Not classified 1-5 Acute Tox. 4 (Oral), H302 Skin Corr. 1C, H314 Repr. 1B, H360D < 0.1 Acute Tox. 2 (Oral), H300 Aquatic Acute 1, H400 Aquatic Chronic 1, H410 SECTION 4: First aid measures 4.1. Description of first aid measures First-aid measures general First-aid measures after inhalation First-aid measures after skin contact First-aid measures after eye contact First-aid measures after ingestion : Never give anything by mouth to an unconscious person. IF exposed or concerned: Get medical advice/attention. : Remove person to fresh air and keep comfortable for breathing. Assure fresh air breathing. Allow the victim to rest. Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTRE or doctor/physician. : Immediately call a POISON CENTRE or doctor/physician. Wash skin with plenty of water. Take off contaminated clothing. If skin irritation occurs: Get medical advice/attention. : Immediately call a POISON CENTRE or doctor/physician. Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If eye irritation persists: Get medical advice/attention. : Do NOT induce vomiting. Immediately call a POISON CENTRE or doctor/physician. Call a poison center or a doctor if you feel unwell Most important symptoms and effects, both acute and delayed Symptoms/effects Symptoms/effects after skin contact Symptoms/effects after eye contact : Causes severe skin burns and eye damage. Suspected of damaging fertility. May damage the unborn child. : Irritation. : Eye irritation Indication of any immediate medical attention and special treatment needed Treat symptomatically. 12/03/2018 EN (English) 39/50

40 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 2) SECTION 5: Firefighting measures 5.1. Extinguishing media Suitable extinguishing media Unsuitable extinguishing media : Sand. Water spray. Dry powder. Foam. Carbon dioxide. : Do not use a heavy water stream Special hazards arising from the substance or mixture Reactivity in case of fire Hazardous decomposition products in case of fire : Thermal decomposition generates : Corrosive vapours. : Toxic fumes may be released Advice for firefighters Firefighting instructions Protection during firefighting : Use water spray or fog for cooling exposed containers. Exercise caution when fighting any chemical fire. Avoid fire-fighting water entering the environment. : Do not enter fire area without proper protective equipment, including respiratory protection. Do not attempt to take action without suitable protective equipment. Self-contained breathing apparatus. Complete protective clothing. SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures For non-emergency personnel Emergency procedures For emergency responders Protective equipment Emergency procedures : Evacuate unnecessary personnel. Only qualified personnel equipped with suitable protective equipment may intervene. : Do not attempt to take action without suitable protective equipment. Equip cleanup crew with proper protection. For further information refer to section 8: "Exposure controls/personal protection". : Ventilate area Environmental precautions Avoid release to the environment. Prevent entry to sewers and public waters. Notify authorities if liquid enters sewers or public waters. Notify authorities if product enters sewers or public waters Methods and material for containment and cleaning up Methods for cleaning up Other information 6.4. Reference to other sections : Take up liquid spill into absorbent material. Soak up spills with inert solids, such as clay or diatomaceous earth as soon as possible. Collect spillage. Store away from other materials. Notify authorities if product enters sewers or public waters. : Dispose of materials or solid residues at an authorized site. See Heading 8. Exposure controls and personal protection. For further information refer to section 13. SECTION 7: Handling and storage 7.1. Precautions for safe handling Precautions for safe handling Hygiene measures 7.2. Conditions for safe storage, including any incompatibilities Technical measures Storage conditions Incompatible materials 7.3. Specific end use(s) SECTION 8: Exposure controls/personal protection 8.1. Control parameters : Ensure good ventilation of the work station. Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work. Provide good ventilation in process area to prevent formation of vapour. Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wear personal protective equipment. Avoid contact with skin and eyes. : Wash Wash hands and other exposed areas with mild soap and water before eating, drinking or smoking and when leaving work thoroughly after handling. Separate working clothes from town clothes. Launder separately. Wash contaminated clothing before reuse. Do not eat, drink or smoke when using this product. Always wash hands after handling the product. : Comply with applicable regulations. : Keep only in the original container in a cool, well ventilated place away from : Direct sunlight. Keep container closed when not in use. Store locked up. Store in a well-ventilated place. Keep cool. : Sources of ignition. Direct sunlight. Triethanolamine ( ) Ireland Local name Triethanolamine 12/03/2018 EN (English) 40/50

41 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 2) Triethanolamine ( ) Ireland OEL (8 hours ref) (mg/m³) 5 mg/m³ sodium azide ( ) EU Local name Sodium azide EU IOELV TWA (mg/m³) 0.1 mg/m³ EU IOELV STEL (mg/m³) 0.3 mg/m³ EU Notes Skin EU Regulatory reference COMMISSION DIRECTIVE 2000/39/EC 8.2. Exposure controls Appropriate engineering controls: Ensure good ventilation of the work station. Personal protective equipment: Avoid all unnecessary exposure. Materials for protective clothing: nitrile rubber Hand protection: Wear protective gloves. Type Material Permeation Thickness (mm) Penetration Standard Disposable gloves Nitrile rubber (NBR) 3 (> 60 minutes) 3 2 (< 1.5) EN 374 Eye protection: Chemical goggles or face shield. Safety glasses Type Use Characteristics Standard Safety glasses Droplet With side shields EN 166 Skin and body protection: Wear suitable protective clothing Respiratory protection: In case of insufficient ventilation, wear suitable respiratory equipment. [In case of inadequate ventilation] wear respiratory protection. Device Filter type Condition Standard Dust mask Type P1 Protection for Liquid particles EN 143, EN 149 Environmental exposure controls: Avoid release to the environment. Other information: Do not eat, drink or smoke during use. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties Physical state : Liquid Appearance : Clear, colorless liquid. Colour : Colourless. Odour : characteristic. Odour threshold ph Relative evaporation rate (butylacetate=1) Melting point : 12/03/2018 EN (English) 41/50

42 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 2) Freezing point Boiling point Flash point Auto-ignition temperature Decomposition temperature Flammability (solid, gas) Vapour pressure Relative vapour density at 20 C Relative density Solubility Log Pow Viscosity, kinematic Viscosity, dynamic Explosive properties Oxidising properties Explosive limits : 9.2. Other information SECTION 10: Stability and reactivity Reactivity Thermal decomposition generates : Corrosive vapours Chemical stability Not established Possibility of hazardous reactions Not established. Contact with acids liberates very toxic gas Conditions to avoid Direct sunlight. Extremely high or low temperatures Incompatible materials Strong bases. Acids Hazardous decomposition products fume. Carbon monoxide. Carbon dioxide. Thermal decomposition generates : Corrosive vapours. SECTION 11: Toxicological information Information on toxicological effects Acute toxicity (oral) Acute toxicity (dermal) Acute toxicity (inhalation) Triethanolamine ( ) LD50 oral rat LD50 oral LD50 dermal rat LD50 dermal rabbit LD50 dermal LC50 inhalation rat (Dust/Mist - mg/l/4h) Skin corrosion/irritation Additional information Serious eye damage/irritation Additional information Respiratory or skin sensitisation Additional information Germ cell mutagenicity Additional information > 5000 mg/kg (Rat; Equivalent or similar to OECD 401; Experimental value; 6400 mg/kg bodyweight; Rat) 8000 mg/kg bodyweight > 5000 mg/kg (Rat) > mg/kg (Rabbit; Experimental value; Equivalent or similar to OECD 402; >2000 mg/kg bodyweight; Rabbit) > mg/kg bodyweight > 1.8 mg/l : Causes skin irritation. : Causes severe skin burns and eye damage. : Causes serious eye irritation. : Causes severe skin burns and eye damage. : Based on available data, the classification criteria are not met : Based on available data, the classification criteria are not met 12/03/2018 EN (English) 42/50

43 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 2) Carcinogenicity Additional information Reproductive toxicity Additional information : Based on available data, the classification criteria are not met : May damage fertility or the unborn child. : Suspected of damaging fertility or the unborn child. STOT-single exposure Additional information STOT-repeated exposure Additional information Aspiration hazard Additional information Potential adverse human health effects and symptoms SECTION 12: Ecological information Toxicity Ecology - general Acute aquatic toxicity Chronic aquatic toxicity Triethanolamine ( ) LC50 fish 1 LC50 fish 2 EC50 other aquatic organisms 1 EC50 other aquatic organisms 2 : Based on available data, the classification criteria are not met : Based on available data, the classification criteria are not met : Based on available data, the classification criteria are not met : Based on available data, the classification criteria are not met. : The product is not considered harmful to aquatic organisms nor to cause long-term adverse effects in the environment mg/l mg/l (LC50; 96 h; Lepomis macrochirus) 2038 mg/l waterflea 216 mg/l Persistence and degradability L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 2) Persistence and degradability Not established. Triethanolamine ( ) Persistence and degradability Biochemical oxygen demand (BOD) Chemical oxygen demand (COD) ThOD BOD (% of ThOD) Bioaccumulative potential Photolysis in the air. Readily biodegradable in water g O₂/g substance 1.5 g O₂/g substance 2.04 g O₂/g substance 0.02 % ThOD L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 2) Bioaccumulative potential Not established. Triethanolamine ( ) BCF fish 1 < 3.9 (Cyprinus carpio; TEST DURATION: 6 WEEKS) Log Pow Bioaccumulative potential Bioaccumulation unlikely Mobility in soil Results of PBT and vpvb assessment Other adverse effects Additional information : Avoid release to the environment. SECTION 13: Disposal considerations Waste treatment methods Waste treatment methods Product/Packaging disposal recommendations Ecology - waste materials : Dispose of contents/container in accordance with licensed collector s sorting instructions. : Dispose in a safe manner in accordance with local/national regulations. Dispose of contents/container to hazardous or special waste collection point, in accordance with local, regional, national and/or international regulation. : Avoid release to the environment. 12/03/2018 EN (English) 43/50

44 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 2) SECTION 14: Transport information In accordance with ADR / RID / IMDG / IATA / ADN ADR UN number Not regulated UN proper shipping name Not regulated Transport hazard class(es) Not regulated Packing group Not regulated Environmental hazards Not regulated IATA Not regulated Not regulated Not regulated Not regulated Not regulated No supplementary information available Special precautions for user - Overland transport Not regulated - Air transport Not regulated Transport in bulk according to Annex II of Marpol and the IBC Code SECTION 15: Regulatory information Safety, health and environmental regulations/legislation specific for the substance or mixture EU-Regulations The following restrictions are applicable according to Annex XVII of the REACH Regulation (EC) No 1907/2006: 3(b) Substances or mixtures fulfilling the criteria for any of the following L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 2) hazard classes or categories set out in Annex I to Regulation (EC) No 1272/2008: Hazard classes 3.1 to 3.6, 3.7 adverse effects on sexual function and fertility or on development, 3.8 effects other than narcotic effects, 3.9 and 3.10 Contains no substance on the REACH candidate list Contains no REACH Annex XIV substances National regulations Chemical safety assessment No chemical safety assessment has been carried out SECTION 16: Other information Indication of changes: Revision - See : *. Data sources Other information : REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006. : None. Full text of H- and EUH-statements: Acute Tox. 2 (Oral) Acute toxicity (oral), Category 2 Acute Tox. 4 (Oral) Acute toxicity (oral), Category 4 Aquatic Acute 1 Hazardous to the aquatic environment Acute Hazard, Category 1 Aquatic Chronic 1 Hazardous to the aquatic environment Chronic Hazard, Category 1 Repr. 1B Reproductive toxicity, Category 1B Skin Corr. 1C Skin corrosion/irritation, Category 1C H300 Fatal if swallowed. H302 Harmful if swallowed. 12/03/2018 EN (English) 44/50

45 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 2) H314 H315 H319 H360 H360D H400 H410 EUH032 Causes severe skin burns and eye damage. Causes skin irritation. Causes serious eye irritation May damage fertility or the unborn child. May damage the unborn child. Very toxic to aquatic life. Very toxic to aquatic life with long lasting effects. Contact with acids liberates very toxic gas. SDS EU (REACH Annex II) This information is based on our current knowledge and is intended to describe the product for the purposes of health, safety and environmental requirements only. It should not therefore be construed as guaranteeing any specific property of the product. 12/03/2018 EN (English) 45/50

46 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 1) Date of issue: 05/06/2013 Revision date: 19/01/2018 Supersedes: 03/03/2017 Version: 1.3 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. Product identifier Product form : Mixture Product name : L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 1) Product code : K-ASNAM (Bottle 1) 1.2. Relevant identified uses of the substance or mixture and uses advised against Relevant identified uses Industrial/Professional use spec Use of the substance/mixture : For professional use only : Use as laboratory reagent Uses advised against 1.3. Details of the supplier of the safety data sheet Megazyme Bray Business Park A98 YV29 Bray - Ireland T F cs@megazyme.com Emergency telephone number Emergency number : [9 am to 5 pm GMT - Monday to Friday] SECTION 2: Hazards identification 2.1. Classification of the substance or mixture Classification according to Regulation (EC) No. 1272/2008 [CLP] Not classified Adverse physicochemical, human health and environmental effects To our knowledge, this product does not present any particular risk, provided it is handled in accordance with good occupational hygiene and safety practice Label elements Labelling according to Regulation (EC) No. 1272/2008 [CLP] Extra labelling to displayextra classification(s) to display No labelling applicable 2.3. Other hazards SECTION 3: Composition/information on ingredients 3.1. Substances 3.2. Mixtures This mixture does not contain any substances to be mentioned according to the criteria of section 3.2 of REACH annex II SECTION 4: First aid measures 4.1. Description of first aid measures First-aid measures after inhalation First-aid measures after skin contact First-aid measures after eye contact First-aid measures after ingestion : Remove person to fresh air and keep comfortable for breathing. : Wash skin with plenty of water. : Rinse eyes with water as a precaution. : Call a poison center or a doctor if you feel unwell Most important symptoms and effects, both acute and delayed 12/03/2018 EN (English) 46/50

47 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 1) 4.3. Indication of any immediate medical attention and special treatment needed Treat symptomatically. SECTION 5: Firefighting measures 5.1. Extinguishing media Suitable extinguishing media 5.2. Special hazards arising from the substance or mixture Hazardous decomposition products in case of fire : Water spray. Dry powder. Foam. Carbon dioxide. : Toxic fumes may be released Advice for firefighters Protection during firefighting : Do not attempt to take action without suitable protective equipment. Self-contained breathing apparatus. Complete protective clothing. SECTION 6: Accidental release measures 6.1. Personal precautions, protective equipment and emergency procedures For non-emergency personnel Emergency procedures For emergency responders Protective equipment : Ventilate spillage area. : Do not attempt to take action without suitable protective equipment. For further information refer to section 8: "Exposure controls/personal protection" Environmental precautions Avoid release to the environment Methods and material for containment and cleaning up Methods for cleaning up : Take up liquid spill into absorbent material. Other information : Dispose of materials or solid residues at an authorized site Reference to other sections For further information refer to section 13. SECTION 7: Handling and storage 7.1. Precautions for safe handling Precautions for safe handling Hygiene measures : Ensure good ventilation of the work station. Wear personal protective equipment. : Do not eat, drink or smoke when using this product. Always wash hands after handling the product Conditions for safe storage, including any incompatibilities Storage conditions : Store in a well-ventilated place. Keep cool Specific end use(s) SECTION 8: Exposure controls/personal protection 8.1. Control parameters 8.2. Exposure controls Appropriate engineering controls: Ensure good ventilation of the work station. Hand protection: Protective gloves Type Material Permeation Thickness (mm) Penetration Standard Disposable gloves Nitrile rubber (NBR) 3 (> 60 minutes) 2 (< 1.5) EN Eye protection: Safety glasses Type Use Characteristics Standard Safety glasses Droplet With side shields, clear EN /03/2018 EN (English) 47/50

48 L-Asparagine/L-Glutamine/Ammonia Assay Kit (Rapid) (Bottle 1) Skin and body protection: Wear suitable protective clothing Type Standard Lab coat Respiratory protection: In case of insufficient ventilation, wear suitable respiratory equipment Device Filter type Condition Standard Dust mask Type P1 Protection for Liquid particles EN 143, EN 149 Environmental exposure controls: Avoid release to the environment. SECTION 9: Physical and chemical properties 9.1. Information on basic physical and chemical properties Physical state : Liquid Colour on colour. Odour : None. Odour threshold ph Relative evaporation rate (butylacetate=1) Melting point : Freezing point Boiling point Flash point Auto-ignition temperature Decomposition temperature Flammability (solid, gas) : Vapour pressure Relative vapour density at 20 C Relative density Solubility : Soluble in water. Log Pow Viscosity, kinematic Viscosity, dynamic Explosive properties Oxidising properties Explosive limits : 9.2. Other information SECTION 10: Stability and reactivity Reactivity The product is non-reactive under normal conditions of use, storage and transport Chemical stability Stable under normal conditions Possibility of hazardous reactions No dangerous reactions known under normal conditions of use Conditions to avoid None under recommended storage and handling conditions (see section 7). 12/03/2018 EN (English) 48/50