60% 24h. [DOI] /j.issn Institute of Aviation Medicine, Air Force of China, Beijing , China

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1 [ ] 5 ( ) % ( % % ) 3 1h3 % 3 3h A 5 h [ ] [ ] R7. [ ] A [ ] 577-7(1)-33-7 [DOI] /j.issn Effects of breathing mixed gas with oxygen in different concentrations on delayed otic barotrauma WEN Dong-qing, GU Zhao, ZHENG Xue-wen, YU Li-hua, CHEN Xiao-qin, XIAO Hua-jun, LIU Xiao-peng, WANG Gui-you, XUE Li-hao, ZANG Bin, WANG Jie * Institute of Aviation Medicine, Air Force of China, Beijing 11, China * Corresponding author, kjzygdwk@13.com This work was supported by the Major Project of General Logistics Department (AKJ11J) [Abstract] Objective To investigate the delayed changes in middle ear function and audition after rapid changes in ambient pressure while breathing mixed gas with oxygen in different concentrations. Methods Five healthy male subjects, sitting in the hypobaric chamber breathed pure oxygen, % oxygen-rich air, or air respectively, one hour before hypobaric chamber test. The interval of two tests was longer than two weeks. After m/s rapid changes in the ambient pressure, all the three groups were tested with subjective symptoms, degree of congestion, middle ear function and audition at four timing. Results Just after test, the amount of symptomatic ears were, and 3 in pure oxygen group, % oxygen-rich air group and air group, respectively. Some subjects in pure oxygen group felt aural fullness and pain again 3 hours after tests. The amount of congestionearswas5,and 3 in each group respectively with no congestion aggravation. The amount of ears withatypetympanogramwas5,andineach group respectively. The extraction ratio of tympanogram and acoustic reflex incomplete in all groups recovered gradually to the initial value without obviously delayed data rebound. The middle ear pressure and pure-tone threshold in subjects of pure oxygen group changed more obviously and recovered more slowly. Conclusion In hypobaric chamber test, the incidence of otic barotrauma may increase in those subjects breathing pure oxygen with symptoms aggravation and repetition within h. [Key words] delayed otic barotrauma; altitude chamber; ear baric function; hearing [ ] (AKJ11J) [ ] [ ] 11 ( ) [ ] kjzygdwk@13.com [1]

2 Med J Chin PLA, Vol. 1, No., April 1, ~ 5~3kg 17~17cm 3 db( hearing level HL) 1. 5 ( ) % ( % % ) 3 m/s m 5min m/s 1.3 ( ) [] F-1D Madsen ZO91 ( ) Madsen ITERA ( ) 3dB HBP h 3h h (GBZ93-1) ( ) 15~Hz GB SPSS 13. x±s Bonferroni P< % 1 ( 1) 3 ( 5 1 ) 3h h % 3 h 3h ( 1). - ( 1) Tab. 1 Tympanic membrane congestion classification of each group after hypobaric chamber tests % oxygen-rich air group Subject (No.) R L R L R L R L R L R L R L R L R L 1 3 5

3 Amount of symptomatic ears Fullness % oxygen-rich air group Discomfort % oxygen-rich air group % oxygen-rich air group Symptom 1 Fig. 1 Amount of symptomatic ears after hypobaric chamber tests None Slight Mild Moderate Severe A. Amount of symptomatic ears during tests; B. Amount of symptomatic ears just after tests; C. Amount of symptomatic ears 3 hours after tests; D. Amount of symptomatic ears hours after tests Pain Hearing loss % oxygen-rich air group A B C D h ( ).3 5 A A B C Tab. Tympanogramtypeofeachgroupafterhypobaricchambertests % oxygen-rich air group Subject (No.) R L R L R L R L R L R L R L R L R L 1 B A A A A A C A C A C A B A C A A A C A C A A A B A C A A A B A A A A A 3 A A A A A A A A A A A A A A A A A A B B C C A A A C A A A A A B A A A A 5 C A A A A A C A A A A A C A C A A A

4 Med J Chin PLA, Vol. 1, No., April 1, R Before tests Just after tests 3 hours after tests hours after tests L A R L B R L C Fig. Changes of tympanic membrane congestion before and after hypobaric chamber tests A. Breathing pure oxygen tests; B. Breathing % oxygen-rich gas tests; C. Breathing air tests; R. Right tympanic membrane; L. Left tympanic membrane (P>.5) (P>.5 3). 75~1dBHL 5 1 Hz (P>.5) (P>.5 )

5 Difference value of middle ear pressure (dapa) A % oxygen-rich air group. Difference value of static compliance (ml) B Difference value of gradient C 3 Difference value of tympanogram width (dapa) compliance (ml) Fig. 3 Difference value of tympanogram parameter in each group before and after hypobaric chamber tests A. Difference value of middle ear pressure before and after hypobaric chamber tests; B. Difference value of static compliance at middle ear pressure before and after hypobaric chamber tests; C. Difference value of gradient before and after hypobaric chamber tests; D. Difference value of tympanogram width before and after hypobaric chamber tests D 3 [3]

6 Med J Chin PLA, Vol. 1, No., April 1, (% n=1) Tab. 3 Acoustic reflex in each group before and after hypobaric chamber tests (%, n=1) Parameter Pure oxygen group % oxygenrich air group Acoustic reflex extraction ratio Before tests 1 1 Just after tests 1 9 3h after tests 9 9 h after tests Acoustic reflex incomplete extraction ratio Before tests Just after tests h after tests 1 h after tests [3-].5~1 l [5-] 1 Difference value of reflex threshold (db) % oxygen-rich air group Fig. Difference value of acoustic reflex threshold in each group before and after hypobaric chamber tests (dbhl x±s n=1) Tab. Difference value of pure-tone threshold in each group after hypobaric chamber tests (dbhl, x±s, n=1) Group 15Hz 5Hz 5Hz 1Hz Hz 3Hz Hz Hz Hz Just after tests 3.5±7. 5.5±9.5 7.±1.5.5±.9 1.5±.1 3.5±.3.5± ± ± hours after tests.5±5.9.±5.1.5±.9 3.±5.37.5± ±3.37.± ±. 3.±7.15 hours after tests.5±..5±..5±1.5.±.3.5±.3 1.5±3.37.5±.3.±. 1.5±7.9 % oxygen-rich air group Just after tests.5±..±5.7 3.±5.37.± ±.75.5±7.17.5± ± ±1.3 3 hours after tests.±..5±. 1.5±3.37.±..5±3.9 1.±3.1.5±3.9 3.±9.19.±7.75 hours after tests.5±..5±1.5.5± ±..5±3.9.± ±.3.±.7 3.±7.15 Just after tests 1.±5.1.5±.5 3.5±.3 3.5±7.9.5±.97.±5.1.± ±.1 1.5±.51 3 hours after tests 1.5±..5±.3 1.±5.1 1.±5..±3.33.±. 1.5± ±3.9.5±5.99 hours after tests 1.±3.1.5±3.9.±..± ±3.37.5±3.9 1.±3.9 1.±7.3 1.±.59 [7] (N ) h A h

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