Document Type WPNA - Canada and Mexico Revision date 29-Dec-2016 Version 4

Transcription

1 SAFETY DATA SHEET Document Type WPNA - Canada and Mexico Revision date 29-Dec-2016 Version 4 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE COMPANY/UNDERTAKING Product name Product No S-adenosylmethionine B9003 Recommended use of the chemical and restrictions on use Recommended use This product is for research and development only Uses advised against Details of the supplier of the safety data sheet Supplier Address New England BioLabs 240 County Road Ipswich, MA USA Company Phone Number (toll free) Telefax address info@neb.com Emergency telephone number Emergency telephone (toll free) 9:00am - 5:00pm Monday-Friday EST Specification No Page 1 / 8

2 2. HAZARDS IDENTIFICATION CAUTION Emergency Overview May cause central nervous system depression COMBUSTIBLE LIQUID AND VAPOR Appearance Colorless Physical state Liquid Odor Mild Principle Routes of Exposure Acute toxicity Inhalation May be harmful if inhaled. May cause irritation of respiratory tract. Eyes May cause irritation. Skin May cause irritation. Ingestion Ingestion may cause irritation to mucous membranes. Chronic Effects Chronic toxicity Symptoms Aggravated Medical Conditions Interactions with Other Chemicals May cause adverse effects on the bone marrow and blood-forming system May cause adverse liver effects Contains a known or suspected reproductive toxin. Central nervous system. Preexisting eye disorders. Blood disorders. Liver disorders. Overexposure may cause female and male reproductive disorder(s). Skin disorders. Respiratory disorders. Reproductive toxicity. Use of alcoholic beverages may enhance toxic effects Environmental hazard See Section 12: ECOLOGICAL INFORMATION 3. COMPOSITION/INFORMATION ON INGREDIENTS General advice If symptoms persist, call a physician. 4. FIRST AID MEASURES Eye contact Immediately flush with plenty of water. After initial flushing, remove any contact lenses and continue flushing for at least 15 minutes. Keep eye wide open while rinsing. If symptoms persist, call a physician. Skin contact Immediate medical attention is not required. Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. If skin irritation persists, call a physician. Inhalation Immediate medical attention is not required. If symptoms persist, call a physician. Move to fresh air in case of accidental inhalation of vapors or decomposition products. Ingestion Clean mouth with water and drink afterwards plenty of water. Never give anything by mouth to an unconscious person. Do NOT induce vomiting. Call a physician. Specification No Page 2 / 8

3 Note to physicians Treat symptomatically Self-protection of the first aider Use personal protective equipment as required 5. FIRE-FIGHTING MEASURES Flammable properties Combustible liquid Flash point 120 F / 49 C Method Suitable extinguishing media Use. Dry chemical. Carbon dioxide (CO2). Water spray (fog). Alcohol resistant foam. Unsuitable extinguishing media None. Specific hazards arising from the chemical Keep product and empty container away from heat and sources of ignition Risk of ignition Protective equipment and precautions for firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. NFPA Health hazards 2 Flammability 2 Stability 0 Special Hazard - HMIS Health hazards 2 Flammability 2 Physical hazards 0 Personal protection - 6. ACCIDENTAL RELEASE MEASURES Personal precautions Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak. Remove all sources of ignition. Pay attention to flashback. Take precautionary measures against static discharges. Use personal protective equipment as required. Personal protective equipment [PPE] Use personal protection recommended in Section 8. Environmental precautions See Section 12 for additional Ecological Information. Prevent further leakage or spillage if safe to do so. Prevent product from entering drains. Methods for containment Not applicable. Methods for cleaning up Dam up. Soak up with inert absorbent material. Pick up and transfer to properly labeled containers. Take precautionary measures against static discharges. 7. HANDLING AND STORAGE Advice on safe handling Use with local exhaust ventilation. All equipment used when handling the product must be grounded. Keep away from heat/sparks/openflames/hotsurfaces. Nosmoking.Usepersonalprotectiveequipmentasrequired.Donotbreathe dust/fume/gas/mist/vapors/spray. Take necessary action to avoid static electricity discharge (which might cause ignition of organic vapors). Storage temperature. Specification No Page 3 / 8

4 Storage Conditions Keep containers tightly closed in a cool, well-ventilated place. Keep away from heat. Keep in properly labeled containers. Incompatible materials None known based on information supplied. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Chemical Name ACGIH TLV OSHA PEL NIOSH IDLH Ethanol STEL: 1000 ppm Sulfuric Acid TWA: 0.2 mg/m 3 thoracic particulate matter NIOSH IDLH Immediately Dangerous to Life or Health TWA: 1000 ppm TWA: 1900 mg/m 3 (vacated) TWA: 1000 ppm (vacated) TWA: 1900 mg/m 3 IDLH: 3300 ppm TWA: 1000 ppm TWA: 1900 mg/m 3 TWA: 1 mg/m 3 IDLH: 15 mg/m 3 (vacated) TWA: 1 mg/m 3 TWA: 1 mg/m 3 Other information Vacated limits revoked by the Court of Appeals decision in AFL-CIO v. OSHA, 965 F.2d 962 (11th Cir., 1992) Engineering controls Showers. Eyewash stations. Personal protective equipment (PPE) Eye/face protection Tight sealing safety goggles. Skin and body protection Suitable protective clothing. Wear chemical resistant clothing such as gloves, apron, boots or whole bodysuits made from neoprene, as appropriate. Antistatic footwear. Gloves made of plastic or rubber. Respiratory protection Not applicable. General hygiene considerations When using do not eat, drink or smoke. Regular cleaning of equipment, work area and clothing is recommended. Information on basic physical and chemical properties 9. PHYSICAL AND CHEMICAL PROPERTIES Physical state Appearance Odor Liquid Colorless Mild Property Remarks Method ph Not applicable Melting point / freezing point Boiling point / boiling range Flash point 49 C / 120 F Evaporation rate Flammability (solid, gas) Flammability Limit in Air Upper flammability limit Lower flammability limit Vapor pressure Vapor density Relative density Specification No Page 4 / 8

5 Specific gravity Water solubility Solubility in other solvents Partition coefficient Autoignition temperature Decomposition temperature Kinematic viscosity Dynamic viscosity Explosive properties Oxidizing properties Other information Softening point Molecular weight VOC content (%) Density Bulk density 10. STABILITY AND REACTIVITY Reactivity No data available. Stability Stable under normal conditions. Possibility of hazardous reactions None under normal processing. Conditions to avoid Heat, flames and sparks. Incompatible materials None known based on information supplied. Hazardous decomposition products None known based on information supplied. Acute toxicity 11. TOXICOLOGICAL INFORMATION Product information Product does not present an acute toxicity hazard based on known or supplied information. Inhalation No known effect. Eye contact No known effect. Skin contact No known hazard in contact with skin. Ingestion No known effect. Specification No Page 5 / 8

6 Chronic toxicity Skin corrosion/irritation Serious eye damage/eye irritation Irritation Corrosivity Sensitization Skin Respiratory Germ cell mutagenicity Carcinogenicity Not applicable Not applicable Not applicable May cause irritation This product contains one or more substances which are classified by IARC as carcinogenic to humans (Group I), probably carcinogenic to humans (Group 2A) or possibly carcinogenic to humans (Group 2B) ACGIH (American Conference of Governmental Industrial Hygienists) A3 - Animal Carcinogen IARC (International Agency for Research on Cancer) Group 1 - Carcinogenic to Humans NTP (National Toxicology Program) Known - Known Carcinogen OSHA (Occupational Safety and Health Administration of the US Department of Labor) X - Present Reproductive toxicity Developmental toxicity Teratogenicity STOT - single exposure STOT - repeated exposure Chronic toxicity Subchronic toxicity Target organ effects Neurological effects Other adverse effects Aspiration hazard May cause adverse effects on the bone marrow and blood-forming system May cause adverse liver effects Contains a known or suspected reproductive toxin Blood, Central nervous system, Eyes, Liver, Reproductive System, Respiratory system, Skin. 12. ECOLOGICAL INFORMATION Marine pollutant Ecotoxicity Persistence and degradability Bioaccumulation Mobility Other adverse effects Ozone depletion potential (ODP) Specification No Page 6 / 8

7 13. DISPOSAL CONSIDERATIONS Disposal considerations Use a licensed professional waste disposal service to dispose of this product. Product may be dissolved in a combustible solvent or absorbed onto a combustible material and burned by a chemical incinerator. Contaminated packaging Empty containers must be tripled rinsed prior to disposal. US EPA Waste Number D001 This product contains one or more substances that are listed with the State of California as a hazardous waste. 14. TRANSPORT INFORMATION DOT TDG MEX ICAO (air) IATA IMDG RID ADR ADN 15. REGULATORY INFORMATION International Inventories TSCA - DSL - NDSL Complies Legend TSCA - United States Toxic Substances Control Act Section 8(b) Inventory DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List US Federal Regulations SARA 313 Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372 SARA 311/312 Hazard Categories Acute health hazard Chronic Health Hazard Fire hazard Sudden release of pressure hazard Reactive hazard Yes No Yes No No CWA (Clean Water Act) Specification No Page 7 / 8

8 This product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR and 40 CFR ) CERCLA This material, as supplied, does not contain any substances regulated as hazardous substances under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments and Reauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state level pertaining to releases of this material International Regulations Mexico - Grade Moderate risk, Grade 2 Canada This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all the information required by the CPR 16. OTHER INFORMATION Prepared by EH&S Manager Prepared by New England BioLabs Issue date No data available Revision note SDS is valid 3 years from revision date. Contact info@neb.com for latest revision Disclaimer IMPORTANT: The information in this SDS is provided in good faith based on our knowledge as of the issue date (or subsequent revision date, if any), and is to be used only as a guide. This SDS does not constitute a guarantee (express or implied) of any kind and we make no warranties or merchantability or fitness for a particular purpose. This information relates only to the designated product as shipped and may not be valid if the product is used in combination with any other materials or is not used in accordance with our instructions. It is the responsibility of the buyer/user to ensure that its activities comply with all applicable governmental requirements. Since conditions of use of the product are not under the control of New England Biolabs, it is the duty of the buyer/user to determine the necessary conditions for the safe use of the product. New England Biolabs will not be liable for any damages resulting from handling or contact with the product. End of Safety Data Sheet Specification No Page 8 / 8