Bupivacaine hydrochloride monohydrate. TSCA 8(b) inventory: No products were found. Not available. Not available. Solid. (Crystalline solid.
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1 API Chemicals The Chemical Company BUPIVACAINE HYDROCHLORIDE [CAS NO ] MSDS for BUPIVACAINE HYDROCHLORIDE CAS NO CAS No OTHER NAMES Bupivacaine hydrochloride monohydrate MOLECULAR FORMULA C18H28N2O.HCl.H2O Catalog Codes SLB1708 RTECS TK TSCA TSCA 8(b) inventory: No products were found. % by Weight 100 Chemical Name CI# Synonym 1-Butyl-N-(2,6-dimethylphenyl)-2- piperidinecarboxamide hydrochloride Physical state and appearance Solid. (Crystalline solid.) Odor Taste Molecular Weight g/mole Color White. ph (1% soln/water) Boiling Point Decomposes. Melting Point 255 C (491 F) Critical Temperature
2 Specific Gravity Vapor Pressure Not applicable. Vapor Density Volatility Odor Threshold Water/Oil Dist. Coeff. Ionicity (in Water) Dispersion Properties See solubility in water, methanol, diethyl ether. Solubility Easily soluble in methanol. Soluble in cold water. Partially soluble in diethyl ether Toxicological Data on Ingredients: Bupivacaine hydrochloride monohydrate: ORAL (LD50): Acute: 18 mg/kg [Rabbit]. Hazards Identification Potential Acute Health Effects: Very hazardous in case of ingestion. Hazardous in case of skin contact (irritant, permeator), of eye contact (irritant), of inhalation. Slightly hazardous in case of skin contact (sensitizer). Severe over-exposure can result in death. Potential Chronic Health Effects: CARCINOGENIC EFFECTS : MUTAGENIC EFFECTS : TERATOGENIC EFFECTS : DEVELOPMENTAL TOXICITY: The substance is toxic to blood, the nervous system, heart. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to a highly toxicmaterial may produce general deterioration of health by an accumulation in one or many human organs FIRST AID Measures Eye Contact: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention. Skin Contact: In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Cold water may be used.wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention. Serious Skin Contact: Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical attention.
3 Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious Inhalation: Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medical attention. Ingestion: If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately. Serious Ingestion: After contact with skin, wash immediately Fire Fighting Measures Flammability of the Product: May be combustible at high temperature. Auto-Ignition Temperature: Flash Points: Flammable Limits: Products of Combustion: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds. Fire Hazards in Presence of Various Substances: Explosion Hazards in Presence of Various Substances: Risks of explosion of the product in presence of mechanical impact: Risks of explosion of the product in presence of static discharge: Fire Fighting Media and Instructions: SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks on Fire Hazards: Special Remarks on Explosion Hazards: Extinguishing media: carbon dioxide, dry chemical powder, alcohol or polymer foam. Special fire-fighting procedures: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Unusual fire and explosion hazards/decomposition of product: emits toxic fumes under fire conditions. Accidental Release Measures Small Spill: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Large Spill: Poisonous solid. Stop leak if without risk. Do not get water inside container. Do not touch spilled
4 material. Use water spray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition sources. Call forassistance on disposal. Handling and Storage Precautions: Keep locked up.. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. Storage: Keep container tightly closed. Keep container in a cool, well-ventilated area. Exposure Controls, Personal Protection Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal Protection: Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of a Large Spill: Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure Limits: Stability and Reactivity Stability: The product is stable. Instability Temperature: Conditions of Instability: Incompatibility with various substances: Corrosivity: Non-corrosive in presence of glass. Special Remarks on Reactivity: Special Remarks on Corrosivity: Polymerization: Will not occur. Toxicological Information Routes of Entry: Dermal contact. Eye contact. Inhalation. Ingestion. Toxicity to Animals: Acute oral toxicity (LD50): 18 mg/kg [Rabbit]. Chronic Effects on Humans: Causes damage to the following organs: blood, the nervous system, heart. Other Toxic Effects on Humans: Very hazardous in case of ingestion. Hazardous in case of skin contact (irritant, permeator), of inhalation. Slightly hazardous in case of skin contact (sensitizer). Special Remarks on Toxicity to Animals: Special Remarks on Chronic Effects on Humans: Special Remarks on other Toxic Effects on Humans:
5 Ecological Information Ecotoxicity: BOD5 and COD: Products of Biodegradation: Possibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the Products of Biodegradation : The products of degradation are more toxic. Special Remarks on the Products of Biodegradation: Disposal Considerations Waste Disposal: Transport Information DOT Classification: CLASS 6.1: Poisonous material. Identification : Toxic solid, organic, n.o.s. (Bupivicaine hydrochloride) UNNA: UN2811 PG: III Special Provisions for Transport : Regulatory Information Federal and State Regulations: No products were found. Other Regulations: OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR ). Other Classifications: WHMIS (Canada): CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC). DSCL (EEC): R36/38- Irritating to eyes and skin. HMIS (U.S.A.):Health Hazard: 4 Fire Hazard: 1 Reactivity: 0 Personal Protection: E National Fire Protection Association (U.S.A.): Health: 4 Flammability: 1 Reactivity: 0 Specific hazard: Protective Equipment: Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Splash goggles. Additional Information References: Other Special Considerations: Created: 10/09/ :27 PM Last Updated: 11/01/ :00 PM The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.
6 *** Reproduction of any materials from the site is strictly forbidden without permission The above information is believed to be correct but does not purport to be all-inclusive and shall be used only as a guide. Shall not be held liable for any damage resulting from handling or from contact with the above product. apollo asia Division Mr.VipinSaxena CEO DIRECT: Wireline HELPDESK: Wireless HELPDESK: Chat: MSN Hotmail:VipinrSaxena Skype NAME:VipinrSaxena Rocketmail:VipinrSaxena Google mail:vipinrsaxena BlackBerry:28415C58 Regd. Office :- 1104, Maker Chamber V, Nariman Point Mumbai, INDIA Pin: Urban Office :- D-62, OIS, Oshiwara Industrial Centre, New Link Road, Goregoan West Mumbai, INDIA Pin: Manufacturing Unit Address: Plot No. 117A, Village: Chamble Near MonaTonaLimited.Wada, Maharashtra, PIN : INDIA in@apichemicals.in info@apichemicals.co.in apichemicals@hotmail.co.in
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