CARBON DIOXIDE METABOLISM AND CAPNOGRAPHY

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1 CARBON DIOXIDE METABOLISM AND CAPNOGRAPHY

2 CARBON DIOXIDE METABOLISM Production Transportation Elimination

3 Carbon Dioxide production CO 2 is the metabolite produced by the utilization by cells of oxygen and energy substrates ( glucose, lipids, proteins). The carbon dioxide daily production is 200ml/min CO 2 production (VCO 2 ) is correlated with O 2 consumption (VO 2 ).In an adult in basal conditions for a usual diet, VO 2 =250ml/min VCO 2 =200ml/min

4 RESPIRATORY QUOTIENT VCO 2 /VO 2 ratio is called the respiratory quotient It is equal to 0.82 Can be modified according to diet, anaerobic metabolism, excess of carbohydrates incomes

5 TRANSPORT OF CARBON DIOXIDE Bicarbonate(HCO 3 )- 60% formed when CO 2 (released by cells making ATP) combines with H 2 O (due to the enzyme in the red blood cells called carbonic anhydrase) Carbaminohemoglobin-30%-Formed when CO 2 combines with hemoglobin (Hemoglobin molecule that give up their oxygen) Dissolved in the plasma-10%(1.2mmol/l)

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8 BOHR AND HALDANE EFFECT Bohr Effect-Increased CO 2 in the blood enhances the o 2 release by hemoglobin: Positive effect at the tissue level CO 2 + H 2 O + HbO 2 HbH+ +HCO 3 +O 2 Haldane effect: Increased O 2 in the blood enhances the CO 2 release by hemoglobin: Positive effect at the lung level O 2 + HCO 3 + HbH + H 2 O + CO 2 + HbO 2

9 GAS EXCHANGE IN LUNGS Expired gas Inspired gas O Co 2 32 H N Right heart C02 40 H20 47 N2 573 Alveoli O Co H N Left heart O 2 40 C H N Veins O 2 40 Co 2 46 H N Artery Tissues O 2 95 Co 2 40 H N 2 573

10 CARBON DIOXIDE DISSOCIATION CURVE

11 CO2 Elimination

12 GAS EXCHANGE IN LUNGS Expired gas Inspired gas O Co 2 32 H N Right heart C02 40 H20 47 N2 573 Alveoli O Co H N Left heart O 2 40 C H N Veins O 2 40 Co 2 46 H N Artery Tissues O 2 95 Co 2 40 H N 2 573

13 HYPERCAPNIA Increase inpaco 2 >45mmHg PH <7.35 Paco 2 =VCO 2 /VA Any increase in VCO 2 or decrease in VA results in hypercapnia.

14 Airway obstruction Emesis with aspiration Bronchospasm Laryngospasm Respiratory center depression GA Sedative overdose or narcotic overdose Head injury Circulatory collapse Cardiac arrest Pulmonary edema Neurogenic causes Cervical spine injury Gullen barre Syndrome Mysthenic crisis Restrictive defects ARDS Flail chest Hemothorax or pneumothorax CAUSES (ACUTE)

15 Mechanism during anesthesia Hypoventilation Increased dead space ventilation Increased CO 2 production Low ventilator settings Circuit disconnection Ventilator Failure

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17 HYPOVENTILATION Abnormal surgical position Increased airway resistance (ETT obstruction) Decreased compliance Decreased respiratory drive due to Anesthetics

18 INCREASED CO 2 PRODUCTION Hyperthermia Shivering Catecholamine release during light anesthesia Hypertension Thyroid storm

19 RESPIRATORY EFFECTS Maximal effect attained by Paco 2 of 100mmHg Higher Paco 2 respiration ceases altogather. Co 2 narcosis at Paco 2 to more than 90 to 120mmHg. Bronchodilation. Pao 2 and PAO 2 may decrease

20 HYPOCAPNIA PH >7.45 Paco 2 less than 35mmHg

21 DIAGNOSIS Symptoms and signs ABGs Capnograph Other investigations

22 Capnography Capnometry

23 Methods of measurement Mass spectrometry Expensive, voluminous, time consuming,diffi. To use. Laser spectrometry Raman s principal,may measure gas &vapours,portable but voluminous. Infra red spectrometry Selective absorption by CO2 of 4.3um of selective infra red wavelenght Measure is made by reference to a caliberated cell containing a detrmined CO2 concentration.( mmhg, or percentage) Photo acoustic spectrography Uses an acoustic method instead of an optic technique, efficient,reliable and less ned for callibration and maintenance.

24 Types of Capnographs Main stream Capnographs Heavy, adds a dead space, adapted to high resp. frequencies >20 Side stream Capnographs Risk of under estimation, loss of ventilatory volume, can measure several gas simultaneously.

25 Normal Capnogram CONSTITUTED OF 4 PHASES

26 40

27 Phase -1 Basal level near at zero mmhg corresponding to the mechanic and anatomic dead space

28 Phase-11 The curve is increasing rapidly corresponding to the increasing concentration in CO2 due to the CO2 expiration in the mixture of alveolar and dead space.

29 40

30 Phase -3 Alveolar Plateau, slightly ascending to reach at the end the value of 40 mmhg corresponding to the EtCo2.

31 40

32 Phase -4 Inspiration starting just after the EtCo2 and producing a sharp decrease of Co2 concentration to reach the basal level.

33 40

34 Capnograph disturbances 1- Etco2 value 2- Morphology of the wave 3- The level of the base line 4- Modification of the respiratory rate 5- Trends- Etco2 decrease Etco2 increase

35 CAPNOGRAPHIC ALTERATIONS WITH EQUIPMENT High ETCO 2 Increased apparatus dead space Rebreathing with circle system Rebreathing with Mapleson system Rebreathing due to malfunctioning non rebreathing valve Low ETCO 2 Blockage of sampling line(absent) Leakage in sampling line Inadequate seal around tracheal device

36 Clinical applications 1-proof of adequate tracheal intubation 2-assesment of efficiency of cardiovascular maneuvers. 3- Apnea monitoring 4- Ventilation monitoring to: Asses ventlation efficiency Adapt ventillation parameters in neurosurgery,treatment of bronchospasm and acute asthma. Adjust the best PEEP Wean controlled ventillation. Control metabollic modifications Measure dead space, intrinsic PEEP.

37 REBREATHING

38 Baseline elevated 40 0 Incompetent expiratory valve Exhausted Co 2 absorbent Insufficient fresh gas flow to mapleson system Time

39 Elevated ETCO Time

40 A sudden rise in baseline Causes Exhausted CO 2 absorber Calibration error Stuck valve in circle absorber system Causes Sudden increase in CO 2 Gradual increase in CO 2 Release of a tourniquit Unclamping of major vessel Causes Hypoventilation Rapidly rising body temp Absorption of CO 2 from peritoneal cavity

41 MECHANISM of LOW EtCo2 DURING ANAESTHESIA Hyperventilation (spontaneous or controlled ventilation) Decreased VD ventilation Decreased CO 2 production

42 Low ETCO 2 40 CO2 0 Time

43 Slow decrease in CO 2 Causes Hyperventilation Fall in body temp Sudden drop of ETCO2 to zero Causes Esophageal intubation Complete breathing system disconnection Ventilator malfunction Totally obstructed tracheal tube

44 A sudden drop of ETCO 2 to non zero value Causes Poorly fitting tracheal tube A leak or partial disconnection in breathing system Partial obstruction of tracheal tube An exponential decrease in CO 2 Causes Sudden hypotension Pulmonary embolism Circulatory arrest

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46 Factors affecting EtCo2 Production --Metabolic Transportation --circulatory Elimination --ventilatory

47 New aplications of CO2 measurement 1- Volumetric capnography 2- Cardiac out put measurement based on Fick s principal 3- Gastric tonometry 4- Sublingual capnography(pslco2)

48 Conclusions Capnography is a sensitive and non invasive method which measures rapidly, easily and continuously expired Co2 at the bed side of the patient in clinical practice. Several clinical applications bring additional security. New derived techniques,such as tonometry, (both Gastric & sublingual )seem of interest.

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