4 Oxygen Dissolved in the Blood Plasma Dissolve means that the gas maintains its precise molecular structure About.003 ml of O 2 will dissolve in 100 ml of blood for every 1 mm Hg of PO 2 Thus, a PaO 2 of 100 = 0.3 ml
5 Oxygen Dissolved in the Blood Plasma Written as 0.3 volumes percent (Vol%) Vol% represents amount of O 2 (in ml) that is in 100 ml of blood
6 Oxygen Dissolved in the Blood Plasma For example: 10 vol% of O 2 means that there are 10 ml of O 2 in 100 ml of blood Relatively small percentage of oxygen is transported in the form of dissolved oxygen
7 Oxygen Bound to Hemoglobin Each RBC contains about 280 million hemoglobin (Hb) molecules Normal adult Hb (Hb A) consists of: 4 heme groups (iron portion of the Hb) 4 amino acid chains: 2 alpha and 2 beta
8 Hemoglobin Molecule Fig Schematic illustration of a hemoglobin molecule.
9 Oxygen Bound to Hemoglobin
10 Oxygen Bound to Hemoglobin Oxyhemoglobin Hemoglobin bound with oxygen Reduced hemoglobin or deoxyhemoglobin Hemoglobin not bound with oxygen
11 Oxygen Bound to Hemoglobin Normal adult male Hb value: g/100 ml Normal adult female Hb value: g/100 ml
12 Oxygen Bound to Hemoglobin Clinically, the weight measurement of hemoglobin, in reference to 100 ml of blood, is referred to as either: Gram percent of hemoglobin (g% Hb), or Grams per deciliter (g/dl)
13 Quantity of Oxygen Bound to Hemoglobin Each g% Hb can carry 1.34 ml of oxygen Thus, if Hb level is 15 g%, and if Hb is fully saturated, about 20.1 vol% of O 2 will be bound to the Hb
14 Quantity of Oxygen Bound to Hemoglobin At a normal PaO 2 of 100 mm Hg, however, the Hb saturation (SaO 2 ) is only about 97% due to the following three normal physiologic shunts
15 Quantity of Oxygen Bound to Hemoglobin Thebesian venous drainage into the left atrium Bronchial venous drainage into pulmonary veins Alveoli that are under ventilated dead space ventilation
16 Quantity of Oxygen Bound to Hemoglobin Thus, the amount of arterial oxygen in the preceding equation must be adjusted to 97 percent:
17 Total Oxygen Content To determine the total amount of oxygen in 100 ml of blood, the following must be added together: Dissolved oxygen Oxygen bound to hemoglobin
18 Total Oxygen Content The following case study summarizes the calculations required to compute an individual s total oxygen content
19 Case Study Anemic Patient 27-year-old woman Long history of anemia (decreased hemoglobin concentration) Showing signs of respiratory distress Respiratory rate 36 breaths/min Heart rate 130 beats/min Blood pressure 155/90 mm Hg
20 Case Study Anemic Patient Hemoglobin concentration is 6 g% PaO 2 is 80 mm Hg (SaO 2 90%)
21 Case Study Anemic Patient Based on this information, the patient s total oxygen content is computed as follows:
22 Case Study - Anemic Patient 2. Oxygen Bound to Hemoglobin: 6 g% Hb x 1.34 (O 2 bound to Hb factor) 8.04 vol% O 2 (at SaO 2 of 100%) 8.04 vol% O 2 x 0.90 SaO vol% O 2
23 Case Study Anemic Patient 3. Total oxygen content: vol% O 2 (bound to hemoglobin) vol% O 2 (dissolved O 2 ) vol% O 2 (total amount of O 2 /100 ml of blood)
24 Case Study Anemic Patient Note: Patient s total arterial oxygen content is less than 50 percent of normal Her hemoglobin concentration, which is the primary mechanism for transporting oxygen, is very low Once problem is corrected, respiratory distress should no longer be present
25 Total Oxygen Content Calculated for following: Arterial Oxygen Content (CaO 2 ) Mixed Venous Oxygen Content (CvO 2 ) Oxygen Content of Pulmonary Capillary Blood (CcO 2 )
26 Total Oxygen Content of Arterial Blood CaO 2 = Oxygen content of arterial blood
27 Total Oxygen Content of Mixed Venous Blood CvO 2 = Oxygen content of mixed venous blood
28 Total Oxygen Content of Pulmonary Capillary Blood CcO 2 = Oxygen content of pulmonary capillary blood
29 Total Oxygen Content It will be shown later how various mathematical manipulations of the CaO 2, CvO 2, and CcO 2 values are used in different oxygen transport studies to reflect important factors concerning the patient s cardiac and ventilatory status.
32 Clinical Significance of the Flat Portion of the Curve PO 2 can fall from 60 to 100 mm Hg and the hemoglobin will still be 90 percent saturated with oxygen Excellent safety zone
33 Clinical Significance of the Flat Portion of the Curve As the Hb moves through the A-C system, a significant partial pressure difference continues to exist between the alveolar gas and blood, even after most O 2 has transferred This enhances the diffusion of O 2
34 Clinical Significance of the Flat Portion of the Curve Increasing PO 2 beyond 100 mm Hg adds very little O 2 to the blood Dissolved O 2 only (PO 2 x = dissolved O 2 )
35 Clinical Significance of the Flat Portion of the Curve A reduction of PO 2 below 60 mm Hg causes a rapid decrease in amount of O 2 bound to hemoglobin However, diffusion of oxygen from hemoglobin to tissue cells is enhanced
36 The P 50 P 50 represents the partial pressure at which the hemoglobin is 50 percent saturated with oxygen Normally, P 50 is about 27 mm Hg
37 The P 50 Fig The P 50 represents the partial pressure at which hemoglobin is 50 percent saturated with oxygen.
38 Factors that Shift Oxygen Dissociation Curve ph Temperature Carbon Dioxide 2,3-DPG Fetal Hemoglobin Carbon Monoxide Hemoglobin
39 Oxygen Dissociation Curve Fig Factors that shift the oxygen dissociation curve to the right and left.
40 CLINICAL SIGNIFICANCE OF SHIFTS IN THE O 2 DISSOCIATION CURVE
41 The O 2 Dissociation Curve When an individual s blood PaO 2 is within normal limits ( mm Hg): Shift of oxygen dissociation curve to the right or left does not significantly affect hemoglobin s ability to transport oxygen to the peripheral tissues.
42 The O 2 Dissociation Curve However, when an individual s blood PaO 2 falls below the normal range: A shift to the right or left can have a remarkable effect on the hemoglobin s ability to pick up and release oxygen. This is because shifts below the normal range occur on the steep portion of the curve.
43 The O 2 Dissociation Curve For example, consider the loading and unloading of oxygen during the following clinical conditions:
44 Right Shifts: Loading of Oxygen in Lungs Picture the loading of oxygen onto hemoglobin as blood passes through the alveolar-capillary system at a time when the alveolar oxygen tension (PaO 2 ) is moderately low, around 60 mm Hg.
45 Right Shifts: Loading of Oxygen in Lungs Fig Normally, when the PaO 2 is 60 mm Hg, the plasma PO 2 is about 60 mm Hg, and Hb is about 90% saturated.
46 Right Shifts: Loading of Oxygen in Lungs If, however, the oxygen dissociation curve shifts to the right, as indicated in Figure 6-6, the hemoglobin will be only about 75 percent saturated with oxygen as it leaves the alveoli.
47 Right Shifts: Loading of Oxygen in Lungs Fig When the PAO 2 is 60 mm Hg at a time when the curve has shifted to the right because of a ph of 7.1.
48 Right Shifts: Loading of Oxygen in Lungs In view of this gas transport phenomenon, it should be stressed that: Total oxygen delivery may be much lower than indicated by a particular PaO 2 value when a disease process is present that causes the oxygen dissociation curve to shift to the right.
49 Right Shifts: Loading of Oxygen in Lungs Although total oxygen delivery may be decreased in the above situation: Plasma PO 2 at the tissue sites does not have to fall as much to unload oxygen
50 Right Shifts: Unloading of Oxygen at the Tissues For example, if tissue cells metabolize 5 vol% oxygen at a time when the oxygen dissociation is in the normal position: Plasma PO 2 must fall from 60 mm Hg to about 35 mm Hg to free 5 vol% oxygen from the hemoglobin See Figure 6-7
51 Right Shifts: Unloading of Oxygen at the Tissues Fig Normally, when the plasma PO 2 is 60 mm Hg, the PO 2 must fall to about 35 mm Hg to free 5 vol% oxygen for metabolism.
52 Right Shifts: Unloading of Oxygen at the Tissues If, however, the curve shifts to the right in response to a ph of 7.1: Plasma PO 2 at tissue sites would only have to fall from 60 mm Hg to about 40 mm Hg to unload 5 vol% oxygen from the hemoglobin See Figure 6-8
53 Right Shifts: Unloading of Oxygen at the Tissues Fig When the plasma PO 2 is 60 mm Hg at a time when the curve is to the right because of ph of 7.1, the PO 2 must fall to about 40 mm Hg to free 5 vol% oxygen for metabolism.
54 Left Shifts: Loading of Oxygen in the Lungs If the oxygen dissociation curve shifts to left when the PAO 2 is 60 mm Hg at a time when the curve has shifted to the left because of a ph of 7.6: Hemoglobin will be about 95 percent saturated with oxygen See Figure 6-9
55 Left Shifts: Loading of Oxygen in the Lungs Fig When the PAO 2 is 60 mm Hg at a time when the curve has shifted to the left because of a ph of 7.6.
56 Left Shifts: Unloading of Oxygen at the Tissues Although total oxygen increases in the previously mentioned situation: Plasma PO 2 at the tissue sites must decrease more than normal in order for oxygen to dissociate from the hemoglobin
57 Left Shifts: Unloading of Oxygen at the Tissues For example, if the tissue cells require 5 vol% oxygen at a time when the oxygen dissociation curve is normal, the plasma PO 2 will fall from 60 mm Hg to about 35 mm Hg to free 5 vol% of oxygen from the hemoglobin See Figure 6-7
58 Oxygen for Metabolism Fig Normally, when the plasma PO 2 is 60 mm Hg, the PO 2 must fall to about 35 mm Hg to free 5 vol% oxygen for metabolism.
59 Left Shifts: Unloading of Oxygen at the Tissues If, however, the curve shifts to the left because of a ph of 7.6: Plasma PO 2 at tissue sites would have to fall from 60 mm Hg to about 30 mm Hg to unload 5 vol% oxygen from the hemoglobin See Figure 6-10
60 Left Shifts: Unloading of Oxygen at the Tissues Fig When the plasma PO 2 is 60 mm Hg at a time when the curve is to the left because of ph of 7.6, the PO 2 must fall to about 30 mm Hg to free 5 vol% oxygen for metabolism.
61 Oxygen Transport Calculations Total Oxygen Delivery Arterial-Venous Oxygen Content Difference Oxygen Consumption Oxygen Extraction Ratio Mixed Venous Oxygen Saturation Pulmonary Shunting
62 Total Oxygen Delivery: DO 2 = QT x (CaO 2 x 10) The total amount of oxygen delivered or transported to the peripheral tissues is dependent on 1. The body s ability to oxygenate blood 2. The hemoglobin concentration 3. The cardiac output
63 Total Oxygen Delivery (DO 2 ) is calculated as follows:
64 Total Oxygen Delivery For example: If a patient has a cardiac output of 5 L/min and a CaO 2 of 20 vol% DO 2 will be about 1000 ml of oxygen per minute:
65 Total Oxygen Delivery
66 Total Oxygen Delivery DO 2 decreases in response to: Low blood oxygenation Low PaO 2 Low SaO 2 Low hemoglobin concentration Low cardiac output
67 Total Oxygen Delivery DO 2 increases in response to increased blood oxygenation Increased PaO 2 Increased SaO 2 Increased hemoglobin concentration Increased cardiac output
68 Arterial-Venous Oxygen Content Difference The C(a-v)O 2 is the difference between the CaO 2 and the CvO 2
69 Arterial-Venous Oxygen Content Difference Normally, the CaO 2 is about 20 vol% and the CvO 2 is 15 vol%. Thus, the C(a-v)O 2 is about 5 vol%:
70 Arterial-Venous Oxygen Content Difference
71 Oxygen Dissociation Curve Fig Oxygen dissociation curve. Summary of important values.
72 Factors that Increase the C(a-v)O 2 Decreased cardiac output Periods of increased oxygen consumption Exercise Seizures Shivering Hyperthermia
73 Factors that Decrease the C(a-v)O 2 Increased cardiac output Skeletal relaxation Induced by drugs Peripheral shunting Sepsis, trauma
74 Factors that Decrease the C(a-v)O 2 Certain poisons Cyanide Hypothermia
75 Oxygen Consumption Amount of oxygen extracted by the peripheral tissues during the period of one minute Also called oxygen uptake (VO 2 )
76 Oxygen Consumption Calculated as follows: Case: If a patient has a cardiac output of 5 L/min and a C(a-v)O 2 of 5 vol%: What is the total amount of oxygen consumed by the tissue cells in one minute?
77 Oxygen Consumption For example: If an individual has a cardiac output of 5 L/min and a C(a-v)O 2 of 5 vol% Total amount of oxygen metabolized by the tissue cells in one minute will be 250 ml:
78 Oxygen Consumption
79 Factors that Increase VO 2 Exercise Seizures Shivering Hyperthermia Body Size
80 Factors that Decrease VO 2 Skeletal Muscle Relaxation Induced by drugs Peripheral shunting Sepsis, trauma Certain poisons Cyanide Hypothermia
81 Oxygen Extraction Ratio Oxygen extraction ratio (O 2 ER) is the amount of oxygen extracted by the peripheral tissues divided by the amount of oxygen delivered to the peripheral cells Also called: Oxygen coefficient ratio Oxygen utilization ratio
82 Oxygen Extraction Ratio Calculated as Follows:
83 Oxygen Extraction Ratio Calculated as Follows: In considering the normal CaO 2 of 20 vol% and the normal CvO 2 of 15 vol%: O 2 ER is about 25 percent
84 Oxygen Extraction Ratio
85 Oxygen Extraction Ratio O 2 ER provides an important view of the oxygen transport status when O 2 consumption remains the same For example, consider the following two cases with the same C(a-v)O 2 (5 vol%), but with different DO 2
86 Normal CaO 2 and CvO 2
87 Decreased CaO 2 and CvO 2
88 Factors that Increase O 2 ER Decreased cardiac output Periods of increased O 2 consumption Exercise Seizures Shivering Hyperthermia Anemia
89 Factors that Decrease O 2 ER Increased cardiac output Skeletal muscle relaxation Drug induced Peripheral shunting (e.g., sepsis)
90 Factors that Decrease O 2 ER Certain poisons Cyanide Hypothermia Increased Hb Increased arterial oxygenation (PaO 2 )
91 Mixed Venous Oxygen Saturation (SvO 2 ) Changes in the SvO 2 can be used to detect changes in the: C(a-v)O 2 VO 2 O 2 ER
92 Factors that Decrease the SvO 2 Decreased cardiac output Exercise Seizures Shivering Hyperthermia
93 Factors that Increase the SvO 2 Increased cardiac output Skeletal muscle relaxation Drug induced Peripheral shunting Sepsis
94 Factors that Increase the SvO 2 Certain poisons Cyanide Hypothermia
95 Oxygen Transport Calculations Table 6-10
96 Oxygen Transport Calculations Table 6-10
97 Oxygen Transport Calculations Table 6-10
98 Oxygen Transport Calculations Table 6-10
99 Oxygen Transport Calculations Table 6-10
100 Oxygen Transport Calculations Table 6-10
101 Oxygen Transport Calculations Table 6-10
102 Oxygen Transport Calculations Table 6-10
103 Pulmonary Shunting Portion of cardiac output that moves from the right side to the left side of the heart without being exposed to alveolar oxygen (PAO 2 ).
104 Pulmonary Shunting Clinically, pulmonary shunting can be subdivided into: Absolute Shunt Also called True Shunt Relative Shunt Also called shunt-like effects
105 Absolute Shunt An anatomic shunt (true shunt) When blood flows from the right side of heart to the left side without coming in contact with an alveolus for gas exchange See Figure 6-12, A and B
106 Pulmonary Shunting Fig Pulmonary shunting.
107 Common Causes of Absolute Shunting Congenital heart disease Intrapulmonary fistula Vascular lung tumors
108 Common Causes of Absolute Shunting Capillary shunting is commonly caused by: Alveolar collapse or atelectasis Alveolar fluid accumulation Alveolar consolidation See Figure 6-12, C
109 Common Causes of Absolute Shunting When pulmonary capillary perfusion is in excess of alveolar ventilation, a relative or shunt-like effect is said to exist See Figure 6-12, D
110 Common Causes of This Form of Shunting Hypoventilation Ventilation/perfusion mismatches Chronic emphysema, bronchitis, asthma Alveolar-capillary diffusion defects Alveolar fibrosis or alveolar edema
111 Venous Admixture Venous mixture is the mixing of shunted, non-reoxygenated blood with reoxygenated blood distal to the alveoli Downstream in the pulmonary venous system See Figure 6-13
112 Venous Admixture Fig Venous admixture occurs when reoxygenated blood mixes with nonreoxygenated blood.
113 Pulmonary Equation
114 Shunt Equation Clinical Information Needed PB PaO 2 PaCO 2 PvO 2 Hb PAO 2 FIO 2
115 Case Study: Motorcycle Accident Victim A 38-year-old man is on a volume-cycled mechanical ventilator on a day when the barometric pressure is 750 mm Hg Patient is receiving an FIO 2 of.70 The following clinical data are obtained:
116 Case Study: Motorcycle Accident Victim Hb: 13 g% PaO 2 : 50 mm Hg (SaO 2 = 85%) PaCO 2 : 43 mm Hg PvO 2 : 37 mm Hg (SvO 2 = 65%)
117 Case Study: Motorcycle Accident Victim With this information, the patient s PAO 2, CcO 2, CaO 2, and CvO 2 can now be calculated
118 Case Study: Motorcycle Accident Victim
119 Case Study: Motorcycle Accident Victim
120 Case Study: Motorcycle Accident Victim
121 Case Study: Motorcycle Accident Victim
122 Case Study: Motorcycle Accident Victim Based on the previous calculation the patient s degree of pulmonary shunting can now be calculated: Q s = CcO 2 CaO 2 Q T CcO 2 CvO 2 = = = 0.515
123 Clinical Significance of Pulmonary Shunting <10% Normal status 10 to 20% Indicates intrapulmonary abnormality
124 Clinical Significance of Pulmonary Shunting 20 to 30% Significant intrapulmonary diseases > 30% Potentially life-threatening
125 Appendix V
127 HYPOXEMIA VERSUS HYPOXIA
128 Hypoxemia Abnormally low arterial oxygen tension (PaO 2 ) Frequently associated with hypoxia Which is an inadequate level of tissue oxygenation
129 Hypoxemia Classifications
130 Hypoxia Low or inadequate oxygen for cellular metabolism
131 Hypoxia There are four main types of hypoxia: Hypoxic Anemic Circulatory Histotoxic
132 Types of Hypoxia Hypoxic hypoxia Inadequate oxygen at tissue cells caused by low arterial oxygen tension (PaO 2 ) Common Causes Low PaO 2 caused by Hypoventilation High altitude
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Slide 1 BIOLOGY CONCEPTS & CONNECTIONS Fourth Edition Neil A. Campbell Jane B. Reece Lawrence G. Mitchell Martha R. Taylor CHAPTER 22 Respiration: The Exchange of Gases Modules 22.1 22.4 From PowerPoint
Computers in Biology and Medicine 31 (2001) 59 72 www.elsevier.com/locate/compbiomed Multiple modeling in the study of interaction of hemodynamics and gas exchange Anqi Qiu, Jing Bai Institute of Biomedical
High Altitude And Lung (Respiration Ser. 6) If searching for the book High Altitude and Lung (Respiration Ser. 6) in pdf form, then you've come to faithful site. We present the complete variant of this
inquiry question How does the respiratory system contribute to energy production for movement? chapter 7 Structure and functions of the respiratory system The respiratory system is the starting point for
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