2 Functions of the Respiratory System: 1) Air distribution / gaseous exchange; 2) Filter, warm & humidify air we breathe; 3) Influence speech; 4) Help maintain body s ph; 5) Make sense of smell possible.
3 **Gas exchange supplies O 2 for cellular respiration and disposes of CO 2.
4 ORGANS OF THE RESPIRATORY SYSTEM *The organs of the respiratory system can be divided into two groups: 1) Upper Respiratory Tract: nose, nasal cavity, sinuses, pharynx 2) Lower Respiratory Tract: larynx, trachea, bronchial tree, lungs, alveoli
7 SUMMARY OF PATHWAY OF AIR (OXYGEN) IN THE RESPIRATORY SYSTEM: Nostrils Nasal cavity Pharynx Glottis/epiglottis Larynx
8 Trachea Bronchi Bronchioles Alveoli Blood (capillaries) Body cells
9 NOSE supported by bone and cartilage openings for air: NOSTRILS
10 lined with mucous membrane to filter, warm, and moisten incoming air NASAL CAVITY CILIA carry particles trapped in the mucus to the pharynx, where they are swallowed
11 SINUSES spaces in the bones of the skull that open into the nasal cavity lined with mucous membranes
12 PHARYNX behind the oral cavity; between the nasal cavity and the larynx a.k.a. the throat
13 LARYNX conducts air and prevents foreign particles from entering trachea composed of muscles and cartilage; lined with mucous membrane the GLOTTIS and EPIGLOTTIS help prevent foods and liquids from entering the trachea contains the VOCAL CORDS
14 **VOCAL CORDS vibrate from side to side and produce sounds when air passes between them
15 TRACHEA extends into the thoracic cavity; in front of the esophagus divides into R and L BRONCHI
16 BRONCHIAL TREE consists of branched air passages that lead from the trachea to the air sacs ALVEOLI are at the distal ends of the narrowest tubes, the ALVEOLAR DUCTS
17 ALVEOLI: humans have approx. 300,000,000 of these microscopic air sacs; walls are only 1-2 cells thick
19 ALVEOLI O 2 dissolves in moist film covering epithelium & diffuses across to the capillaries covering each alveolus; CO 2 moves in opposite direction
21 LUNGS enclosed by the DIAPHRAGM and the thoracic cage closely surrounded by the PLEURAE
22 -VISCERAL PLEURA: attaches to the surface of the lungs -PARIETAL PLEURA: lines the thoracic cavity -PLEURAL CAVITY: the space between the two pleurae; contains fluid to lubricate and cushion lungs during breathing; fluid also holds the two pleurae together which aids in breathing
25 Gas Exchange and Transport
26 ALVEOLAR GAS EXCHANGES *Gas exchange between air and blood occurs in the alveoli.
27 ALVEOLAR GAS EXCHANGES Gases (O 2 and CO 2 ) diffuse from regions of HIGH concentration (and partial pressure) to regions of LOW concentration (partial pressure) OXYGEN diffuses from alveolar air into blood CARBON DIOXIDE diffuses from blood into alveolar air
28 Gas Partial Pressure in Blood Action Partial Pressure in Alveolar Space Carbon Dioxide 45 mm Hg exit 40 mm Hg Oxygen 40 mm Hg enter blood 104 mm Hg
30 GAS TRANSPORT IN THE BLOOD / BODY *Blood transports gases between the lungs and body cells.
31 OXYGEN TRANSPORT: oxygen binds to the protein hemoglobin in the blood (RBCs) the resulting molecule, oxyhemoglobin, is unstable and readily releases oxygen in regions where P O2 is low
32 OXYGEN TRANSPORT (continued) more oxygen will be released from oxyhemoglobin when: -CO 2 levels in the blood increase -blood becomes more acidic -blood temperature increases
34 CARBON DIOXIDE TRANSPORT: carbon dioxide may be carried: -in solution -bound to hemoglobin (different spot on molecule than where oxygen binds) **as a bicarbonate ion (HCO 3- ) MOST CO 2 is in this form!
36 CARBON DIOXIDE TRANSPORT: carbon dioxide reacts with water to form carbonic acid: CO 2 + H 2 O H 2 CO 3
38 CARBON DIOXIDE TRANSPORT: carbonic acid dissociates to release hydrogen ions and bicarbonate ions: H 2 CO 3 H + + HCO 3 -
41 Control of Breathing:
42 *Normal breathing is rhythmic and involuntary.
43 Respiratory Center: the respiratory center is in the brain stem and includes portions of the PONS and MEDULLA OBLONGATA
44 FACTORS AFFECTING BREATHING: 1) respiratory center in the brain 2) chemical concentrations (gases, ions, ph, etc.) 3) stretching of lung tissue 4) emotional state
45 EXAMPLES: *when chemoreceptors in the walls of certain large arteries detect low O 2 levels (or high CO 2 levels), breathing rate increases *fear and pain typically increase the normal breathing pattern
46 CONTROL OF BREATHING -medulla control center also monitors blood biochemistry & ph of the spinal fluid; -as blood CO 2 concentrations increase, the ph drops (CO 2 combines with water to form carbonic acid); -when the medulla senses the drop in ph, the rate & depth of breathing are increased & excess CO 2 is removed in the exhaled air
47 CONTROL OF BREATHING -when oxygen concentration in blood becomes very low, oxygen sensors in aorta and carotid arteries send signals to the medulla and pons, which respond by increasing the breathing rate.
48 CONTROL OF BREATHING -breathing is an automatic action -we inhale when nerves in the breathing centers of the medulla oblongata & pons send impulses to the rib muscles or diaphragm stimulating the muscles to contract -when muscles contract, the volume of the chest cavity expands, pressure decreases, air from outside rushes in -this happens approx times per minute Negative Pressure Breathing
49 Breathing Mechanism
50 *Changes in the size of the thoracic cavity accompany INSPIRATION (inhaling) and EXPIRATION (exhaling).
51 Pressure *ATMOSPHERIC PRESSURE (the weight of the air) is the force that moves air into the lungs. *Air (gases) move from regions of HIGH PRESSURE to regions of LOW PRESSURE
52 INSPIRATION: if the pressure inside the lungs/alveoli decreases, atmospheric pressure will force air into the lungs
53 INSPIRATION: How does the pressure inside the lungs decrease??? > Diaphragm contracts (moves downward) > Thoracic cage moves upward and outward (external intercostal muscles contract)
55 INSPIRATION: the INCREASE IN VOLUME of the thoracic cavity causes a DECREASE IN PRESSURE
56 INSPIRATION: as the walls of the thoracic cavity expand, they pull on the parietal pleura the serous fluid in the pleural cavity holds the pleural membranes tightly together (much like a wet microscope slide will stick to another microscope slide) as the parietal pleura is pulled outward, the visceral pleura follows
58 INSPIRATION: the lungs expand in all directions and air is pulled inward!! **for a deeper breath, the diaphragm and intercostals muscles contract with more force
59 EXPIRATION: the forces for normal exhalation come from ELASTIC RECOIL of tissues the opposite pressure and volume changes occur pressure inside the lungs increases and forces air out
60 EXPIRATION: How does the pressure inside the lungs increase??? > Diaphragm relaxes (moves upward) > External intercostals muscles relax; thoracic cage moves downward and inward
61 EXPIRATION: Lungs and thoracic cage recoil and return to their original shape the DECREASE IN VOLUME of the thoracic cavity causes an INCREASE IN PRESSURE air is forced out!!
63 RESPIRATORY AIR VOLUMES AND CAPACITIES: *the amount of air inhaled and exhaled depends upon size, activity level and state of health.
64 TIDAL VOLUME = volume of air an animal inhales & exhales with each breath during normal, quiet breathing (Average = 500 ml in humans)
65 RESPIRATORY AIR VOLUMES AND CAPACITIES: even after forceful expiration, some air remains in the lungs (RESIDUAL VOLUME) why? -so that lungs don t collapse! (alveoli always stay partially inflated) -prevents the O 2 and CO 2 levels from fluctuating greatly ( new air always mixes with old air)
66 RESPIRATORY AIR VOLUMES AND CAPACITIES: VITAL CAPACITY = maximum air volume that can be inhaled & exhaled during forced breathing (Average = ml in humans) -loss of lung elasticity may result in collapse of bronchioles during exhalation -emphysema causes a decrease in vital capacity
67 TOTAL LUNG CAPACITY = VITAL + RESIDUAL CAPACITY VOLUME **all of these volumes/capacities vary with age, sex, and body size
68 Vital capacity
69 NONRESPIRATORY MOVEMENTS: used to clear passageways, or to express emotion COUGH - -may be produced through conscious effort -may be triggered by the presence of a foreign object -clears the object from the lower respiratory tract
70 SNEEZE - -clears the upper respiratory tract -a reflex triggered by a mild irritation in the lining of the nasal cavity -can propel a particle at 200 miles per hour!
71 LAUGHING - involves taking a breath and releasing it in a series of short expirations CRYING - similar to laughing in terms of mechanism HICCUP - a sudden inspiration to a spasmodic contraction of the diaphragm YAWN - may aid respiration by providing an occasional deep breath
72 Disorders and Diseases of the Respiratory System: Asthma Emphysema
73 Disorders and Diseases of the Cancer Respiratory System: Cystic fibrosis
74 Disorders and Diseases of the Respiratory System: Tuberculosis (TB) Pneumonia Common cold
75 Disorders and Diseases of the Flu Respiratory System: Whooping cough Plague
76 Disorders and Diseases of the Strep throat Respiratory System:
77 Disorders and Diseases of the Respiratory System: Bronchitis / laryngitis Normal vocal chords Inflamed vocal chords
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