The Acute Stage of Ventilation: Supplying Ventilation to the Lungs in Patients With ARDS

Transcription

1 CoverArticle Mechanical Ventilation of Patients With Acute Respiratory Distress Syndrome and Patients Requiring Weaning The Evidence Guiding Practice CE Continuing Education Suzanne M. Burns, RN, MSN, RRT, ACNP, CCRN Mechanical ventilation is one of the most commonly used technologies in critical care. Despite the prevalence of ventilators, care planning is heavily influenced by anecdote and clinical preference. A vast array of ventilator modes and mode options exist, and claims of what works and what does not abound. Critical care nurses knowledge and understanding of mechanical ventilation are central to ensuring patients safe passage from the acute stage of ventilation to weaning. Of key importance is the use of evidence that may improve patients outcomes. To that end, in this article, I discuss the science related to mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) and in patients who require weaning. The Acute Stage of Ventilation: Supplying Ventilation to the Lungs in Patients With ARDS The acute stage of ventilation is described as that stage at which the patients require a high level of ventilatory support and their hemodynamic status is often unstable. 1-5 A variety of volume and pressure modes of ventilation are used in an effort to * This article has been designated for CE credit. A closed-book, multiple-choice examination follows this article, which tests your knowledge of the following objectives: 1. Identify lung-protective strategies in acute respiratory distress syndrome (ARDS) 2. Describe the benefits of low-tidal-volume ventilation in ARDS 3. Discuss evidence-based guidelines of mechanical ventilation in ARDS Author Suzanne M. Burns is a professor of nursing and an advanced practice nurse in the medical intensive care unit at the University of Virginia in Charlottesville. To purchase reprints, contact The InnoVision Group, 101 Columbia, Aliso Viejo, CA Phone, (800) or (949) (ext 532); fax, (949) ; , reprints@aacn.org. 14 CRITICALCARENURSE Vol 25, No. 4, AUGUST 2005

2 improve oxygenation, ventilation, and acid-base status. The results of recent research in patients with ARDS are dramatically affecting how we use mechanical ventilation in such patients and how clinical end points of mechanical ventilation are selected. The concept of lung-protective strategies, which include low-tidalvolume ventilation, positive endexpiratory pressure (PEEP), and prone positioning of patients, has emerged along with a renewed interest in the potential efficacy of highfrequency oscillation. A discussion focused on the evidence related to the use of such therapies follows. Are Volume or Pressure Modes Better for Patients With ARDS? Investigators 6-11 have shown that animals with induced ARDS, treated with mechanical ventilation with traditional (ie, large) ventilator volumes experience more lung injury than do similar animals treated with mechanical ventilation with lower ventilator volumes. 6,7 In these animals, plateau pressures of 35 cm H 2 O or greater for 72 hours resulted in alveolar fractures and increased alveolar flooding The term volutrauma was coined to describe injuries due to the large traditional volumes, although questions remained about whether the tidal volumes or the resultant distending (plateau) pressures were actually responsible for the lung injury. Because the potential for volutrauma in humans was recognized, recommendations for the use of smaller tidal volumes began to emerge 12,13 and studies in humans followed In a study by Hickling et al, 14 a total of 53 patients with ARDS were treated with mechanical ventilation at low volumes (7 ml/kg) in an attempt to maintain peak airway pressures less than 30 cm H 2 O. Hospital mortality for the patients was significantly lower than the mean mortality predicted on the basis of on Acute Physiology and Chronic Health Evaluation II scores. After this study, the ARDS Network 16 reported on the results of a randomized controlled trial designed to compare clinical outcomes of patients with ARDS who were assigned to low-volume (6 ml/kg) versus traditional-volume (12 ml/kg) ventilation. The study was stopped after a preliminary analysis of 861 patients indicated that mortality in the low-tidal-volume group was significantly lower than that in the control group (31.0% vs 39.8%, P =.007). Of interest, the plateau pressures when the tidal volume of 6 ml/kg was used were in the range of 26 to 30 cm H 2 O. 16 This pressure was far lower than the plateau pressure (<35 cm H 2 O) that had been suggested as potentially lung protective in the animal studies. But, the ARDS Network s study 16 has been criticized. For example, some have noted that volumes between 6 and 12 ml/kg (ie, 7, 8, 9, 10, and 11 ml/kg) were not tested, yet those volumes may be more reflective of common practice patterns. Others contended that the control group assignment of 12 ml/kg was excessively high and that the principle of scientific equipoise (ie, that genuine uncertainty exists about what treatment is best) may have been violated. Rubenfeld et al 17 and Weinert et al 18 subsequently examined practice patterns in the selection of tidal volume at academic institutions where clinicians were aware of the results of the ARDS Network s study. Their results 17,18 indicated that com- monly selected tidal volumes were not in the range of 6 ml/kg but were rather in a higher range, findings that somewhat dispelled the validity of the concerns. Regardless, questions persist about the effect of tidal volumes from 7 to 11 ml/kg and about the use of pressure modes to control plateau pressures in patients with ARDS. 19,20 Because pressure modes of ventilation have characteristics that make them attractive for use in patients with noncompliant lungs, many wonder if pressure-targeted ventilation might be a comparable substitute for volume-targeted ventilation in patients with ARDS. Some of the characteristics of pressure-targeted ventilation are discussed next. The decelerating flow pattern associated with pressure modes is thought to provide better gas distribution than volume ventilation does In addition, plateau pressure can be reliably limited by using pressure modes. Although some might assume that using pressure ventilation in patients with stiff lungs (in order to ensure a low plateau pressure) might result in outcomes similar to those found in the ARDS Network s trial, much remains to be determined. For example, volumes delivered with pressure ventilation are affected by compliance (lung and chest wall) and resistance. Using a plateau pressure to ensure lung protection may not ensure volumes comparable to the tidal volume of 6 ml/kg used in the ARDS Network s study. The superiority of selected new pressure modes, such as pressurerelease ventilation, for use in ARDS also has not been established. Randomized controlled trials comparing the modes with low-volume targeted CRITICALCARENURSE Vol 25, No. 4, AUGUST

3 ventilation will be necessary before the new pressure modes can be widely endorsed. To date, the study by the ARDS Network, 16 in which tidal volumes of 6 ml/kg were used, is the only study that has demonstrated a change in mortality. Until the effects of other modes of mechanical ventilation on the outcomes of patients with ARDS are clarified, the use of low-volume targeted ventilation rather than pressure-targeted ventilation is the suggested ventilatory strategy for protecting the lungs of these patients. What About PEEP Levels? In a randomized controlled trial of patients with ARDS, Amato et al 24 studied outcomes associated with different levels of PEEP. The optimal level was determined by measuring lung compliance at increasing levels of PEEP. A level just above the lower inflection point (that level that resulted in an increase in compliance with a given level of PEEP) was selected as the lung recruitment PEEP for the intervention group. Findings of the study suggested that levels of PEEP of about 14 to 16 cm H 2 O (ie, higher than levels generally selected) were necessary to prevent derecruitment (lung closure). Unfortunately, measurement of the inflection point at the bedside is technically difficult, and this method is unlikely to be widely used in clinical practice. Although the results of Amato et al 24 suggest that PEEP levels of 14 to 16 cm H 2 O are required to open the lung in patients with ARDS, definitive methods for determining the appropriate level of required PEEP are unknown. In the ARDS Network study, 16 an algorithmic approach was used to assign levels of PEEP. Unfortunately, auto-peep (occult PEEP due to inadequate expiratory time) also occurred in many of the patients (eg, those with Until the effects of other modes of mechanical ventilation on the outcomes of patients with ARDS are clarified, the use of low-volume targeted ventilation rather than pressure-targeted ventilation is the suggested ventilatory strategy for protecting the lungs of these patients. high respiratory rates and high minute volumes), making accurate assessment of the total level of PEEP difficult. Some have suggested that the auto-peep may have recruited the lung, perhaps contributing to the beneficial outcomes described by the investigators. 25 How best to apply PEEP to recruit the lung and prevent derecruitment is not yet clear. Regardless, an understanding of these concepts is helpful for focusing clinical interventions. Recruiting the Lungs and Keeping Them Open (Preventing Derecruitment) In patients with ARDS, noncompliant lungs tend to collapse, and once collapsed, high inflation pressures are necessary to reopen the lungs. Knowledge of how the lungs in patients with ARDS inflate during mechanical ventilation is essential to our understanding of recruitment. Computed tomography scans of patients with ARDS have improved our understanding of the alveolar filling patterns associated with ARDS. 26,27 Once thought to be homogeneous, the pattern of alveolar filling in ARDS is actually heterogeneous. Some areas of the lung are open and others are closed. In the areas of aerated lung, the entire brunt of a tidal volume breath is experienced by the compliant (and open) lung tissue. Unfortunately, this small area of the lung (also called baby lung ) is at increased risk of injury from overdistention and the shear forces of repetitive opening and closing with tidal breathing. The stress on the lungs from the tidal breath may be an important mechanism associated with volutrauma. The closed lung parenchyma of patients with ARDS cannot be recruited without applying a critical opening pressure (ie, a pressure high enough to open closed alveoli). Further, once opened, the lung tissue is at risk of closing again (derecruitment) if optimal levels of PEEP or other strategies are not applied. Thus the concepts of lung recruitment and derecruitment are integrally related. The use of PEEP levels from 14 to 16 cm H 2 O, as described by Amato et al, 24 is suggested as one way to open the lungs. Another method is to provide periodic episodes of super-high levels of PEEP. Referred to as 40/40 or 60/60 maneuvers (eg, 40 cm H 2 O of PEEP for 40 seconds), these techniques have been used in a number 16 CRITICALCARENURSE Vol 25, No. 4, AUGUST 2005

4 of studies, but they are associated with a risk of barotrauma. 24,27-29 Once the Lungs Are Opened, How Are They Kept Open? Unfortunately, it is unclear how to select a level of PEEP to stabilize ventilation once a recruitment maneuver is completed Although monitoring the effects of the selected settings on oxygenation and ventilation is a generally accepted way of deciding if the settings are preventing derecruitment over time, oxygenation may not be the best indicator. Oxygenation, traditionally used to assess the adequacy of PEEP, is unreliable because the increase in oxygenation may be the result of either recruitment or redistribution of blood flow to aerated areas of the lung (thus decreasing the shunt and improving oxygenation). Identification of a PEEP level that recruits lung and prevents repetitive opening injury associated with tidal breathing is thus an elusive clinical goal. Investigators have used computed tomography to compare lung recruitment when different ventilatory maneuvers are used. 27,33 Although this method is accurate, it is impractical for use in most clinical settings and widespread use of it is unlikely. Theoretically, another way to assess recruitment is to increase the level of PEEP and monitor the difference between the plateau pressure and the PEEP level. If the addition of PEEP results in recruitment of lung, the plateau pressure should not change; however, if PEEP is adding to alveolar overdistention, the plateau pressure will increase. Although we have learned much about the effectiveness of PEEP in treating ARDS, much remains to be elucidated. To date, definitive methods of applying PEEP to ensure lung protection and to prevent derecruitment have not been clearly identified. Regardless, arbitrary selection of a PEEP level is unlikely to accomplish the goal. Other Ways to Recruit the Lungs: What About High-Frequency Oscillation and Prone Positioning of Patients? Unlike traditional ventilatory modes, high-frequency oscillation does not require bulk movement of volume in and out of the lungs; rather, a bias flow of gases is provided and an oscillator disperses the gases throughout the lung at very high frequencies in what has been called augmented dispersion. The lungs are recruited and a mean airway pressure sufficient to cause a chest vibration (or wiggle ) is maintained. 34 Although some think that this mode of ventilation may recruit the lungs and prevent tidal stress (damage due to tidal volume and repetitive opening of the stiff alveoli), to date only a single randomized controlled trial has been completed. The Multicenter Oscillatory Ventilation for Acute Respiratory Distress Syndrome Trial 34 was designed to test the safety and efficacy of a specific ventilator for high-frequency oscillation. The results indicated a positive but nonsignificant trend in 30-day mortality in patients receiving mechanical ventilation with high-frequency oscillation. Unfortunately, the tidal volumes in the control group were not maintained in the protective range, a situation that makes it difficult to interpret the results. An additional concern is that patients generally require heavy sedation and often require paralytic agents to ensure compliance with high-frequency oscillation. Prone positioning is useful in recruiting lung tissue. Studies in animal models and patients with ARDS in the prone position have revealed a number of responsible mechanisms Blood flow and gas distribution in the lungs are affected by gravity. When patients are supine, the alveoli in the dependent parts of the lungs (ie, the back) fill with fluid and collapse. When patients are turned to the prone position, the effect of gravity is reversed and lung tissue is recruited. 35 In addition, pleural pressures are more uniform in the dorsal than in the ventral position, so lung recruitment is enhanced The third mechanism is a mechanical one. With prone positioning, the heart rests against the sternum (rather than against the lungs) and the abdomen moves away from the lungs. 38,42-44 As much as a third of the posterior part of the lungs may be recruited when patients are prone. 42 Last, the anterior part of the chest, normally the most mobile part of the chest, is slightly restricted when patients are prone. Consequently, when the lungs are ventilated in a patient who is prone, the air is redistributed more evenly throughout the chest, including the dependent regions. 45 The effect of prone positioning of patients on outcomes in ARDS is as yet unclear. Although our understanding of how prone positioning improves lung recruitment is fairly good, to date the only randomized controlled trial of prone positioning in patients with ARDS did not show a change in mortality. 46 Patients in the study were maintained in a 18 CRITICALCARENURSE Vol 25, No. 4, AUGUST 2005

5 prone position for at least 6 hours a day for 10 days. The study was done before the results of the ARDS study on ventilation with low lung volumes were published, 27 however, so volumes were not controlled. Of interest, in the sickest cohort of patients in the study, patients with a ratio of PaO 2 to fraction of inspired oxygen of less than 88 (a ratio <200 is defined as ARDS), those assigned to the prone position had a better 10-day survival rate than did those who remained supine. Perhaps the most important fact associated with positioning patients prone is that it is a relatively safe intervention compared with other techniques (albeit a time- and effortintensive one) that recruits lung and assists with drainage of secretions. 47,48 Although studies are needed to definitively determine the importance of prone positioning in the management of ARDS, the use of this position may be less risky than use of some of the other recruitment maneuvers described. What Ventilation, Oxygenation, and Acid-Base Thresholds Should Be Used With Protective Ventilatory Strategies? Use of low-volume ventilation may result in significant hypercarbia. 7,14,15,49-53 In the past, ventilator settings were adjusted to attain eucarbia and a normal ph. Because the goal is to protect the lung, such an end point may not be possible. Instead, the goal should be to ensure that volutrauma does not occur. Because low-volume ventilation results in decreased alveolar ventilation, hypercarbia is expected. Called permissive hypercarbia, the goal for acid-base status is to maintain a reasonable ph (approximately 7.25). 7,14,15,49-53 Bicarbonate infusions may be used if necessary in patients whose ph is lower and thought to be potentially harmful ,49 Although it is generally tolerated well in most patients, permissive hypercarbia is not appropriate for all patients. Examples include patients with elevated intracranial pressures and patients with some cardiac conditions The Weaning Stage of Mechanical Ventilation The weaning stage of mechanical ventilation is described as that time when the patient s physiological status is stable and progressive liberation from mechanical ventilation is possible. 1-5 Various mechanical ventilatory modes and methods are used to ensure an expeditious process. Recent research on weaning has elucidated the importance of approaches in which protocols and comprehensive multidisciplinary processes of care delivery are used. Mechanical Ventilation in the Weaning Stage: What Works? To date, no mode of weaning has been shown to be superior to the others, yet how the various methods of weaning are used does seem to make a difference in clinical outcomes. In randomized controlled trials by Brochard et al 54 and Esteban et al, 55 patients were selected on the basis of entry criteria that established the subjects readiness to be weaned. If patients met the readiness criteria, they were assigned to a 2-hour spontaneous breathing trial during which they were monitored for signs of intolerance to the trial. If signs of intolerance emerged, the weaning trial was classified as a failure and the patient was randomly assigned to a weaning protocol. In the study by Esteban et al, 55 patients who successfully sustained the 2-hour trial were extubated; the reintubation rate was 20%. The protocol methods to which patients were randomly assigned included pressure-support ventilation, intermittent mandatory ventilation, and spontaneous breathing trials. Although Brochard et al 54 found that pressure-support ventilation resulted in faster weaning and Esteban et al 55 found that spontaneous breathing trials once per day were superior, both groups of investigators used similar protocols for assessing Recent research on weaning has elucidated the importance of approaches in which protocols and comprehensive multidisciplinary processes of care delivery are used. weaning readiness, advancing weaning trials, and defining success (tolerance) or failure (intolerance). The results of those 2 studies 54,55 stimulated interest in testing the efficacy and safety of weaning protocols. In studies by Ely et al 56 and Kollef et al, 57 patients were randomly assigned either to a weaning protocol managed by a nurse and respiratory 20 CRITICALCARENURSE Vol 25, No. 4, AUGUST 2005

6 therapist or to a traditional weaning plan designed by a physician. Compared with weaning according to the physician s plan, weaning via the protocol resulted in significantly shorter durations of mechanical ventilation in both studies and a significantly shorter stay in the intensive care unit (ICU) in the study by Kollef et al. 57 The usefulness of protocols in decreasing variation in processes of care is not restricted to weaning trials. The use of sedatives in patients receiving mechanical ventilation has been associated with prolonged duration of mechanical ventilation and prolonged stays in the ICU and hospital. 57 In randomized controlled trials, the algorithmic management of sedation 58 and use of a protocol to wean patients off infusions of sedatives 59 resulted in significantly shorter duration of mechanical ventilation and shorter stays in the ICU and in the hospital. The use of protocols is linked to improved outcomes. However, the results of a study by Ely et al 60 suggest that protocols must be applied carefully. Ely et al sought to implement a protocol for weaning in surgical units that involved spontaneous breathing trials. The protocol had been previously tested in a study of patients in a medical ICU and coronary care unit. 56 Components of the protocol included a weaning readiness screening, a spontaneous breathing trial, and end points for stopping the trial. Educational sessions were used to update clinicians about the study, and respiratory care practitioners implemented the protocol. The spontaneous breathing trials were implemented only 10% of the time initially, but implementation increased to 30% with additional educational sessions. One of the major reasons for the lack of compliance with the protocol was that the protocol was not managed by any specific person (as it had been during the original study). 60 Other methods of improving weaning outcomes for patients treated with mechanical ventilation include systematic comprehensive initiatives in which multiple evidence-based interventions are applied together in a single approach The interventions include clinical pathways, methods for evaluating progress, specific elements of care (eg, deep vein prophylaxis, nutrition, mobility) and protocols for weaning trials. Two prospective system initiatives indicate the effectiveness of the more comprehensive approaches. Smyrnios et al 67 designed a largescale multidisciplinary approach to care of patients receiving mechanical ventilation in a medical ICU, a surgical ICU, and a coronary care unit. The initiative consisted of using a weaning algorithm and a nurse clinician to ensure compliance with the processes of care. Duration of mechanical ventilation, length of stay in the ICU, and length of stay in the hospital all improved significantly when the care initiative was used. Financial gains also occurred; however, mortality was not affected. In another study, 68 all adult patients in 5 critical care units (medical ICU, coronary care unit, thoraciccardiovascular ICU, surgical-trauma ICU, and neurological ICU) who required mechanical ventilation for more than 3 consecutive days were managed and monitored by 4 advanced practice nurses for 1 year. The process consisted of an evidencebased clinical pathway, protocols for weaning trials and sedation management, and a standardized weaning assessment tool (Burns Wean Assessment Program). Results of the intervention were compared with outcomes prospectively collected before implementation of the approach. The findings included significant reductions in duration of mechanical ventilation, lengths of stay in the ICU and hospital, and mortality in the managed group. The beneficial outcomes were attributed to the management and monitoring of the process by the advanced practice nurses and the systematic multidisciplinary evidence-based approach to care of the patients. Conclusions and Summary To achieve the best outcomes, we must have an in-depth understanding of the evidence related to appropriate use of mechanical ventilation in patients with ARDS and in patients who require weaning. We have learned much from studies conducted in such patients, yet many questions about how best to apply the therapy remain unanswered. Low-volume lung ventilation is associated with decreased mortality as applied in the ARDS Network s study. 16 Until additional studies of other modes (pressure modes and high-frequency oscillation) indicate comparable outcomes, use of lowvolume ventilation in patients with ARDS should be encouraged. Unfortunately, questions still abound related to how we might best recruit the lungs and keep them open (eg, optimal levels of PEEP, prone positioning). In the area of weaning, evidence indicates that it is not the mode used but rather the method, specifically the use of protocols, that results in improved clinical outcomes. Further, CRITICALCARENURSE Vol 25, No. 4, AUGUST

7 outcomes are likely to be improved by multidisciplinary system initiatives that provide systematic evidencebased care. References 1. Burns SM, Clochesy J, Goodnough- Hanneman SK, Ingersoll GE, Knebel AR, Shekleton ME. Weaning from long-term mechanical ventilation. Am J Crit Care. 1995;4: Knebel AR, Shekleton ME, Burns SM, Clochesy JM, Goodnough-Hanneman SK, Ingersoll GL. Weaning from mechanical ventilation: concept development. Am J Crit Care. 1994;3: Goodnough-Hanneman SK, Ingersoll GL, Knebel AR, Shekleton ME, Burns SM, Clochesy JM. Weaning from short-term mechanical ventilation: a review. Am J Crit Care. 1994;3: Burns SM, Ryan B, Burns JE. The weaning continuum: use of Apache III, BWAP, TISS, and WI scores to establish stages of weaning. Crit Care Med. 2000;28: Knebel A, Shekleton MD, Burns S, Clochesy JM, Hanneman SK. Weaning from mechanical ventilatory support: refinement of a model. Am J Crit Care. 1998;7: Dreyfuss D, Basset G, Soler P, Saumon G. 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Am Rev Respir Dis. 1990;141: Albert RK. Editorial: for every thing (turn turn turn..). Am J Respir Crit Care Med. 1997;155: Gattinoni L, Tognoni G, Pesenti A, et al. Effect of prone positioning on the survival of patients with acute respiratory failure. N Engl J Med. 2001;345: Douglas WW, Rehder K, Beynen FM, Sessler AD, Marsh HM. Improved oxygenation in patients with acute respiratory failure: the prone position. Am Rev Respir Dis. 1977;115: Curley MAQ. Prone positioning of patients 22 CRITICALCARENURSE Vol 25, No. 4, AUGUST 2005

8 with acute respiratory distress syndrome: a systematic review. Am J Crit Care. 1999;8: Menitove SM, Golring RA. Combined ventilator and bicarbonate strategy in the management of status asthmaticus. Am J Med. 1983;74: Darioli R, Perret C. Mechanical controlled hypoventilation in status asthmaticus. Am Rev Respir Dis. 1984;129: Tuxen D. Permissive hypercapnia. In: Tobin MJ, ed. Principles and Practice of Mechanical Ventilation. New York, NY: McGraw Hill; 1994: Bidani A, Tzouanakis AE, Cardenas VJ, Zwischenberger JB. Permissive hypercapnia in acute respiratory failure. JAMA. 1994;272: Bellomo R, Mclaughlin P, Tai E, Parkin G. Asthma requiring mechanical ventilation: a low morbidity approach. Chest. 1994;105: Brochard L, Ranes A, Benito S, et al. Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilators. Am J Respir Crit Care Med. 1994;150: Esteban A, Frutos F, Tobin MJ, et al. A comparison of four methods of weaning patients from mechanical ventilation: Spanish Lung Failure Collaborative Group. N Engl J Med. 1995;332: Ely EW, Baker AM, Dunagan DP, et al. Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med. 1996;335: Kollef MH, Shapiro SD, Silver P, et al. A randomized, controlled trial of protocoldirected versus physician-directed weaning from mechanical ventilation. Crit Care Med. 1997;25: Brook AD, Ahrens TS, Schaff R, et al. Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation. Crit Care Med. 1999;27: Kress JP, Pohlman AS, O Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med. 2000;342: Ely EW, Bennett PA, Bowton DL, Murphy SM, Florance AM, Haponick EF. Large-scale implementation of a respiratory therapistdriven protocol for ventilator weaning. Am J Respir Crit Care Med. 1999;159: Cohen IL, Bari N, Strosberg MA, et al. Reduction of duration and cost of mechanical ventilation in an intensive care unit by use of a ventilatory management team. Crit Care Med. 1991;19: Rudy FB, Daly BJ, Douglas S, Montenegro HD, Song R, Dyer MA. Patient outcomes for the chronically critically ill: special care unit versus intensive care unit. Nurs Res. 1995;44: Kite-Powell D, Sauban D, Ideno KT, et al. Optimizing outcomes in ventilator-dependent patients: challenging critical care practice. Crit Care Nurs Q. 1996;19: Burns SM, Marshall M, Burns JD, et al. Design, testing and results of an outcomes managed approach to patients requiring prolonged ventilation. Am J Crit Care. 1998;7: Henneman E, Dracup K, Ganz T, Molayeme O, Cooper C. Effect of a collaborattive weaning plan on patient outcome in the critical care setting. Crit Care Med. 2001;29: Henneman E, Dracup K, Ganz T, Molayeme O, Cooper CB. Using a collaborative weaning plan to decrease duration of mechanical ventilation and length of stay in the intensive care unit patients receiving long-term mechanical ventilation. Am J Crit Care. 2002;11: Smyrnios NA, Connolly A, Wilson MM, et al. Effects of a multifaceted, multidisciplinary, hospital-wide quality improvement program on weaning from mechanical ventilation. Crit Care Med. 2002;30: Burns SM, Earven D, Fisher C, et al. Implementation of an institutional program to improve clinical and financial outcomes of patients requiring mechanical ventilation: one year outcomes and lessons learned. Crit Care Med. 2003;31: CRITICALCARENURSE Vol 25, No. 4, AUGUST

9 CE Test Test ID C054: Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome and Patients Requiring Weaning: The Evidence Guiding our Practice Learning objectives: 1. Identify lung-protective strategies in acute respiratory distress syndrome (ARDS) 2. Describe the benefits of low-tidal-volume ventilation in ARDS 3. Discuss evidence-based guidelines of mechanical ventilation in ARDS 1. Which of the following is not a lung-protective strategy in the management of acute respiratory distress syndrome (ARDS)? a. Low-tidal-volume ventilation b. Positive end-expiratory pressure (PEEP) c. Lateral positioning of patients d. High-frequency oscillation 2. Which of the following tidal volumes contributed to a lower mortality rate in the ARDS Network s study? a. 4 ml/kg b. 6 ml/kg c. 8 ml/kg d. 10 ml/kg 3. Which of the following PEEP levels may be benef icial in preventing alveolar closure in ARDS? a. 10 to 12 cm H 2 O b. 12 to 14 cm H 2 O c. 14 to 16 cm H 2 O d. 16 to 18 cm H 2 O 4. Which of the following mechanisms of prone positioning is benef icial in recruiting lung in ARDS? a. Low pleural pressure b. Elevation of the diaphragm c. Low tidal volume d. Reversed gravity 5. Which of the following PaO 2 to fraction of inspired oxygen ratios is indicative of ARDS? a. Less than 200 b. Less than 250 c. Less than 300 d. Less than Which of the following is a goal of low-tidal-volume ventilation? a. Increased oxygenation b. Eucarbia c. Decreased volutrauma d. Normal ph 7. Low-tidal-volume ventilation may result in which of the following? a. Hypocarbia b. Eucarbia c. Hyperventilation d. Hypercarbia 8. The goal for acid-base status in ARDS is to maintain a ph at which of the following levels? a b c d Permissive hypercarbia should be avoided in which of the following? a. Increased intracranial pressure b. Decreased intracranial pressure c. Acute lung injury d. ARDS 10. Which of the following is not a component of a weaning protocol? a. Assessing weaning readiness b. Advancing spontaneous weaning trial c. Tolerance criteria d. Failure criteria 11. The use of a weaning protocol has been associated with which of the following? a. Decreased morbidity b. Decreased use of paralytics c. Decreased use of sedation d. Decreased ventilator days Test answers: Mark only one box for your answer to each question. You may photocopy this form. 1. a 2. a 3. a 4. a 5. a 6. a 7. a 8. a b b b b b b b b c c c c c c c c d d d d d d d d 9. a b c d 10. a b c d 11. a b c d Test ID: C054 Form expires: August 1, Contact hours: 2.0 Fee: $12 Passing score: 8 correct (73%) Category: A Test writer: John P. Harper, RN, MSN, BC Program evaluation Yes No Objective 1 was met Name Address Member # Objective 2 was met Objective 3 was met City State ZIP Content was relevant to my Country Phone Mail this entire page to: nursing practice My expectations were met AACN This method of CE is effective RN Lic. 1/St RN Lic. 2/St 101 Columbia for this content The level of difficulty of this test was: Payment by: Visa M/C AMEX Discover Check Aliso Viejo, CA easy medium difficult (800) To complete this program, Card # Expiration Date it took me hours/minutes. Signature 24 CRITICALCARENURSE Vol 25, No. 4, AUGUST 2005

10 Mechanical Ventilation of Patients With Acute Respiratory Distress Syndrome and Patients Requiring Weaning: The Evidence Guiding Practice Suzanne M. Burns Crit Care Nurse 2005; Copyright 2005 by the American Association of Critical-Care Nurses Published online Personal use only. For copyright permission information: Subscription Information Information for authors Submit a manuscript alerts Critical Care Nurse is an official peer-reviewed journal of the American Association of Critical-Care Nurses (AACN) published bimonthly by AACN, 101 Columbia, Aliso Viejo, CA Telephone: (800) , (949) , ext Fax: (949) Copyright 2016 by AACN. All rights reserved.