SAFETY DATA SHEET Anastrozole. 1. Identification of the Substance/Mixture and of the Company/Undertaking. 2. Hazards Identification

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1 Page: 1 Cayman Chemical Company 1180 E. Ellsworth Rd. Ann Arbor, MI Product Code: 1. Identification of the Substance/Mixture and of the Company/Undertaking Product Name: Synonyms: Intended Use:.alpha.1,.alpha.1,.alpha.3,.alpha.3-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3- benzenediacetonitrile; Anastrol; Arimidex ; ICI-D 1033; ZD 1033; For research use only, not for human or veterinary use. Manufacturer Information Company Name: Emergency Contact: Alternate Emergency Contact: Information: Web site address: Cayman Chemical Company CHEMTREC Within USA and Canada: +1 (800) CHEMTREC Outside USA and Canada: +1 (703) Cayman Chemical Company +1 (734) Hazards Identification GHS Classification Acute Toxicity: Oral, Category 3 Acute Toxicity: Inhalation, Category 3 Carcinogenicty, Category 2 Toxic To Reproduction, Category 1B Target Organ Systemic Toxicity (repeated exposure), Category 1 GHS Hazard Phrases: GHS Precaution Phrases: GHS Response Phrases: GHS Storage and Disposal Phrases: Route(s) of Entry: Placard Skull and crossbones Skull and crossbones Key word Warning GHS Hazard Toxic if swallowed Toxic if inhaled Suspected of causing cancer May damage fertility or the unborn child Causes damage to {<target organs>} through prolonged or repeated exposure H301: Toxic if swallowed. H331: Toxic if inhaled. H351: Suspected of causing cancer. H360: May damage fertility or the unborn child. H372: Causes damage to organs through prolonged or repeated exposure. P264: Wash hands thoroughly after handling. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P : IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P330: Rinse mouth. P : IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P311: Call a POISON CENTER or doctor/physician. P : IF exposed or concerned: Get medical attention/advice. P314: Get medical attention/advice if you feel unwell. Please refer to Section 7 for Storage and Section 13 for Disposal information. Inhalation? Yes Skin? Yes Eyes? Yes Ingestion? Yes Other: Injection

2 Page: 2 Potential Health Effects (Acute and Chronic): Target Organs: Signs and Symptoms Of Exposure: Medical Conditions Generally Aggravated By Exposure: Material may be irritating to the mucous membranes and upper respiratory tract. May be harmful by skin absorption. May cause eye, skin, or respiratory system irritation. May damage fertility or the unborn child. Suspected of causing cancer. Toxic if swallowed or if inhaled. Ingestion may cause: gastrointestinal irritation, nausea, vomiting, and diarrhea. To the best of our knowledge, the toxicological properties have not been thoroughly investigated Emergency and First Aid Procedures: 3. Composition/Information on Ingredients Concentration EC# Risk Phrases RTECS # % R CZ First Aid Measures In Case of Inhalation: In Case of Skin Contact: In Case of Eye Contact: In Case of Ingestion: Indication of any immediate medical attention and special treatment needed: Suitable Extinguishing Media: Unsuitable Extinguishing Media: Flammable Properties and Hazards: Flash Pt: Autoignition Pt: Remove to fresh air. If not breathing, give artificial respiration or give oxygen by trained personnel. Get immediate medical attention. Immediately wash skin with soap and plenty of water for at least 20 minutes. Remove contaminated clothing. Get medical attention if symptoms occur. Wash clothing before reuse. Hold eyelids apart and flush eyes with plenty of water for at least 20 minutes. Have eyes examined and tested by medical personnel. Wash out mouth with water provided person is conscious. Never give anything by mouth to an unconscious person. Get medical attention. Do NOT induce vomiting unless directed to do so by medical personnel. 5. Fire Fighting Measures Use alcohol-resistant foam, carbon dioxide, water, or dry chemical spray. Use water spray to cool fire-exposed containers. A solid water stream may be inefficient. Explosive Limits: Hazardous Combustion Products: LEL: UEL: Fire Fighting Instructions: Protective Precautions, Protective Equipment and Emergency Procedures: Environmental Precautions: Steps To Be Taken In Case Material Is Released Or Spilled: As in any fire, wear self-contained breathing apparatus pressure-demand (NIOSH approved or equivalent), and full protective gear to prevent contact with skin and eyes. 6. Accidental Release Measures Avoid raising and breathing dust, and provide adequate ventilation. As conditions warrant, wear a NIOSH approved self-contained breathing apparatus, or respirator, and appropriate personal protection (rubber boots, safety goggles, and heavy rubber gloves). Take steps to avoid release into the environment, if safe to do so. Contain spill and collect, as appropriate. Transfer to a chemical waste container for disposal in accordance with local regulations.

3 Page: 3 Precautions To Be Taken in Handling: Precautions To Be Taken in Storing: Hazard Label Information: 7. Handling and Storage Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid prolonged or repeated exposure. Keep container tightly closed. Store in accordance with information listed on the product insert. Avoid contact with skin and eyes. Do not reuse this container. Use with adequate ventilation. Wash thoroughly after handling. 8. Exposure Controls/Personal Protection OSHA PEL ACGIH TLV Other Limits Britain EH40 France VL Europe Protective Equipment Summary - Hazard Compatible chemical-resistant gloves Eye wash station in work area Lab coat Safety Label Information: glasses Safety shower in work area Vent Hood Engineering Controls (Ventilation etc.): Eye Protection: Protective Gloves: Other Protective Clothing: Respiratory Equipment (Specify Type): Work/Hygienic/Maintenance Practices: Environmental Exposure Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to control airborne levels below recommended exposure limits. Safety glasses Compatible chemical-resistant gloves Lab coat NIOSH approved respirator, as conditions warrant. Do not take internally. Facilities storing or utilizing this material should be equipped with an eyewash and a safety shower. Wash thoroughly after handling. Information on Basic Physical and Chemical Properties 9. Physical and Chemical Properties Physical States: Appearance and Odor: Melting Point: Boiling Point: Flash Pt: Evaporation Rate: Vapor Pressure (vs. Air or mm Hg): Vapor Density (vs. Air = 1): Specific Gravity (Water = 1): Solubility in Water: Solubility tes: Autoignition Pt: Explosive Properties: Oxidizing Properties: [ ] Gas [ ] Liquid [ X ] Solid A crystalline solid ~0.1 mg/ml in 1:9 EtOH:PBS (ph 7.2); ~20, 13, and 14 mg/ml in EtOH, DMSO, & DMF; Other Information Percent Volatile:

4 Page: 4 Formula: Molecular Weight: Reactivity: Stability: Stability te(s): Conditions To Avoid: Polymerization: Incompatibility - Materials To Avoid: Hazardous Decomposition Or Byproducts: Toxicological Information: Chronic Toxicological Effects: C17H19N Stability and Reactivity Unstable [ ] Stable [ X ] Stable if stored in accordance with information listed on the product insert. Will occur [ ] Will not occur [ X ] carbon dioxide carbon monoxide nitrogen oxides General Ecological Information: Waste Disposal Method: 11. Toxicological Information The toxicological effects of this product have not been thoroughly studied. - Investigated as a mutagen, reproductive effector, and tumorigen. Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here. See actual entry in RTECS for complete information. RTECS Number: CZ NTP IARC ACGIH OSHA 12. Ecological Information Avoid release into the environment. Runoff from fire control or dilution water may cause pollution. 13. Disposal Considerations Dispose in accordance with local, state, and federal regulations. 14. Transport Information Globally Harmonized System of Classification and Labelling Acute Toxicity: Oral, Category 3 -! Toxic if swallowed Acute Toxicity: Inhalation, Category 3 -! Toxic if inhaled Carcinogenicty, Category 2 - Warning! Suspected of causing cancer Toxic To Reproduction, Category 1B -! May damage fertility or the unborn child Target Organ Systemic Toxicity (repeated exposure), Category 1 -! Causes damage to {<target organs>} through prolonged or repeated exposure LAND TRANSPORT (US DOT) DOT Proper Shipping Name LAND TRANSPORT (European ADR/RID) ADR/RID Shipping Name AIR TRANSPORT (ICAO/IATA) ICAO/IATA Shipping Name Additional Transport Information: European Community Hazard Symbol codes t dangerous goods. t dangerous goods. t dangerous goods. Transport in accordance with local, state, and federal regulations. 15. Regulatory Information T: Toxic; Carcinogenic Hazard: 3; Reproductive Hazard: 2 European Community Risk and Safety Phrases

5 Page: 5 R23 - Toxic by inhalation. R25 - Toxic if swallowed. R40 - Limited evidence of a carcinogenic effect R48 - of serious damage to health by prolonged exposure. R60 - May impair fertility. R61 - May cause harm to the unborn child. S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) US EPA SARA Title III Other US EPA or State Lists Sec.302 (EHS) Sec.304 RQ Sec.313 (TRI) Sec.110 CAA HAP,ODC CWA NPDES TSCA CA PROP Regulatory Information Statement: This SDS was prepared in accordance with 29 CFR , Regulation (EC).1272/2008, and European Directive 67/548/EEC as amended. 16. Other Information Revision Date: 03/05/2013 Company Policy or Disclaimer For research use only, not for human or veterinary use. DISCLAIMER: This information is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. N.A.=t available, N.P.=t applicable, N.D.=t determined, N.E.=t established, N.R.=t required