Safety Data Sheet CHROMATOGRAPHY SOLVENT

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1 Safety Data Sheet dated 9/8/2017, version 1 1. IDENTIFICATION Product identifier Mixture identification: Trade name: Other means of identification: Product codes: , , , Recommended use of the chemical and restrictions on use Recommended use: FOR PROFESSIONAL USE Restrictions on use: Name, address, and telephone number of the chemical manufacturer, importer, or other responsible party Company: Enartis USA Inc Bell Road Windsor CA Competent person responsible for the safety data sheet: compliance@enartis.com Emergency phone number Phone: +1 (707) Fax: +1 (707) HAZARD(S) IDENTIFICATION Classification of the chemical Warning, Flam. Liq. 3, Flammable liquid and vapour. Warning, Acute Tox. 4, Harmful if swallowed. Danger, Skin Corr. 1A, Causes severe skin burns and eye damage. Danger, Eye Dam. 1, Causes serious eye damage. Warning, STOT SE 3, May cause respiratory irritation. Warning, STOT SE 3, May cause drowsiness or dizziness. Warning, STOT RE 2, May cause damage to organs through prolonged or repeated exposure. Label elements Hazard pictograms: Danger Hazard statements: H226 Flammable liquid and vapour. H302 Harmful if swallowed. H314 Causes severe skin burns and eye damage. H318 Causes serious eye damage. H335 May cause respiratory irritation. H336 May cause drowsiness or dizziness. H373 May cause damage to organs through prolonged or repeated exposure. Page n. 1 of 9

2 Precautionary statements: P210 Keep away from heat/sparks/open flames/hot surfaces. No smoking. P242 Use only non-sparking tools. P243 Take precautionary measures against static discharge. P260 Do not breathe vapours. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P301+P312 IF SWALLOWED: Call a doctor if you feel unwell. P301+P330+P331 IF SWALLOWED: rinse mouth. Do NOT induce vomiting. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P310 Immediately call a doctor. P403+P233 Store in a well-ventilated place. Keep container tightly closed. Special Provisions: Hazards not otherwise classified identified during the classification process: Ingredient(s) with unknown acute toxicity:. 3. COMPOSITION/INFORMATION ON INGREDIENTS Substances Mixtures Hazardous components within the meaning of 29 CFR and related classification: >= 40% - < 50% butan-1-ol Index number: , CAS: , EC: B.6/3 Flam. Liq. 3 H226 A.8/3 STOT SE 3 H335 A.2/2 Skin Irrit. 2 H315 A.3/2A Eye Irrit. 2A H319 A.9/2 STOT RE 2 H373 A.1/4/Oral Acute Tox. 4 H302 A.8/3 STOT SE 3 H336 >= 5% - < 7% Formic Acid Index number: , CAS: , EC: A.1/4/Oral Acute Tox. 4 H302 A.2/1A Skin Corr. 1A H314 A.3/1 Eye Dam. 1 H318 A.8/3 STOT SE 3 H335 B.16/1 Met. Corr. 1 H290 B.6/3 Flam. Liq. 3 H FIRST-AID MEASURES Description of necessary measures In case of skin contact: Immediately take off all contaminated clothing. OBTAIN IMMEDIATE MEDICAL ATTENTION. Remove contaminated clothing immediately and dispose off safely. After contact with skin, wash immediately with soap and plenty of water. In case of eyes contact: After contact with the eyes, rinse with water with the eyelids open for a sufficient length of time, Page n. 2 of 9

3 then consult an opthalmologist immediately. Protect uninjured eye. In case of Ingestion: Do not under any circumstances induce vomiting. OBTAIN A MEDICAL EXAMINATION IMMEDIATELY. Give nothing to eat or drink. In case of Inhalation: In case of inhalation, consult a doctor immediately and show him packing or label. Most important symptoms/effects, acute and delayed Indication of immediate medical attention and special treatment needed In case of accident or unwellness, seek medical advice immediately (show directions for use or safety data sheet if possible). Treatment: 5. FIRE-FIGHTING MEASURES Suitable extinguishing media: CO2 or Dry chemical fire extinguisher. Unsuitable extinguishing media: in particular. Specific hazards arising from the chemical Do not inhale explosion and combustion gases. Hazardous combustion products: Explosive properties: Oxidizing properties: Special protective equipment and precautions for fire-fighters Use suitable breathing apparatus. Collect contaminated fire extinguishing water separately. This must not be discharged into drains. Move undamaged containers from immediate hazard area if it can be done safely. 6. ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment, and emergency procedures Wear personal protection equipment. Remove all sources of ignition. Wear breathing apparatus if exposed to vapours/dusts/aerosols. Provide adequate ventilation. Remove persons to safety. Use appropriate respiratory protection. See protective measures under point 7 and 8. Methods and materials for containment and cleaning up Wash with plenty of water. 7. HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes, inhalation of vapours and mists. Do not use on extensive surface areas in premises where there are occupants. Use localized ventilation system. Don't use empty container before they have been cleaned. Before making transfer operations, assure that there aren't any incompatible material residuals in the containers. Contamined clothing should be changed before entering eating areas. Do not eat or drink while working. See also section 8 for recommended protective equipment. Page n. 3 of 9

4 Conditions for safe storage, including any incompatibilities Always keep in a well ventilated place. Keep away from unguarded flame, sparks, and heat sources. Avoid direct exposure to sunlight. Avoid accumulating electrostatic charge. Keep away from food, drink and feed. Incompatible materials: in particular. Instructions as regards storage premises: Cool and adequately ventilated. Safety electric system. Storage temperature: Store at ambient temperature. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters butan-1-ol - CAS: OSHA - TWA: 300 mg/m3, 100 ppm - Notes: US. OSHA Table Z-1 Limits for Air Contaminants (29 CFR ) ( ) ACGIH - TWA(8h): 20 ppm - Notes: US. ACGIH Threshold Limit Values (2011) NIOSH - TWA: 150 mg/m3, 50 ppm - Notes: US. NIOSH: Pocket Guide to Chemical Hazards (2010) National - TWA: 150 mg/m3, 50 ppm - Notes: US. California Code of Regulations, Title 8, Section Airborne Contaminants ( ) Formic Acid - CAS: OSHA - TWA: 9 mg/m3, 5 ppm - Notes: US. OSHA Table Z-1-A (29 CFR ) (1989) EU - TWA(8h): 9 mg/m3, 5 ppm ACGIH - TWA: 5 ppm - STEL: 10 ppm - Notes: US. ACGIH Threshold Limit Values (2011) Appropriate engineering controls: Individual protection measures Eye protection: Eye glasses with side protection. Protection for skin: Use clothing that provides comprehensive protection to the skin, e.g. cotton, rubber, PVC or viton. Protection for hands: Use protective gloves that provides comprehensive protection. Respiratory protection: Gas filtering device (DIN EN 141). Thermal Hazards: 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance and colour: Liquid Odour: Characteristic Odour threshold: ph: Melting point / freezing point: c Initial boiling point and boiling range: 118 C Solid/gas flammability: Upper/lower flammability or explosive limits: Vapour density: 2.6 Flash point: 37 C F Evaporation rate: Vapour pressure: Page n. 4 of 9

5 Relative density: (4 C) Solubility in water: 90 g/l Solubility in oil: Partition coefficient (n-octanol/water): 0.88 Auto-ignition temperature: 650 F Decomposition temperature: Viscosity: Miscibility: Fat Solubility: Conductivity: Substance Groups relevant properties 10. STABILITY AND REACTIVITY Reactivity It may generate dangerous reactions (See subsections below) Chemical stability It may generate dangerous reactions (See subsections below) Possibility of hazardous reactions Conditions to avoid Avoid accumulating electrostatic charge. Incompatible materials Avoid contact with combustible materials. The product could catch fire. Hazardous decomposition products. 11. TOXICOLOGICAL INFORMATION Information on toxicological effects Toxicological information of the product: Toxicological information of the main substances found in the product: butan-1-ol - CAS: a) acute toxicity: Test: LD50 - Route: Oral - Species: Rat = 790 mg/kg Test: LD50 - Route: Inhalation - Species: Rat = 8000 Ppm Test: LD50 - Route: Skin - Species: Rabbit = 3400 mg/kg b) skin corrosion/irritation: Test: Skin Irritant - Route: Skin Positive Test: Eye Corrosive Positive Formic Acid - CAS: a) acute toxicity: Test: LD50 - Route: Oral - Species: Rat = 730 mg/kg - Source: OECD Test Guideline 401 Test: LC50 - Route: Inhalation - Species: Rat = 7.4 mg/l - Duration: 4h Test: LC50 - Route: Inhalation - Species: Mouse = 6.2 mg/l - Notes: 15 min b) skin corrosion/irritation: Test: Skin Corrosive - Route: Skin Positive Test: Eye Corrosive Positive Substance(s) listed on the NTP report on Carcinogens:. Substance(s) listed on the IARC Monographs:. Substance(s) listed as OSHA Carcinogen(s):. Substance(s) listed as NIOSH Carcinogen(s):. Page n. 5 of 9

6 12. ECOLOGICAL INFORMATION Ecotoxicity Adopt good working practices, so that the product is not released into the environment. butan-1-ol - CAS: a) Aquatic acute toxicity: Endpoint: LC50 - Species: Fish > 100 mg/l - Duration h: 96 Endpoint: LC50 - Species: Fish = mg/l - Duration h: 96 Endpoint: LC50 - Species: Fish = mg/l - Duration h: 48 Endpoint: LC50 - Species: Daphnia = mg/l - Duration h: 24 Endpoint: LC50 - Species: Daphnia = mg/l - Duration h: 24 Formic Acid - CAS: a) Aquatic acute toxicity: Endpoint: LC50 - Species: Fish = 175 mg/l - Duration h: 24 Endpoint: EC50 - Species: Daphnia > 138 mg/l - Duration h: 48 Endpoint: LC50 - Species: Daphnia = 410 mg/l - Duration h: 24 Endpoint: LC50 - Species: Daphnia > 80 mg/l - Duration h: 48 Persistence and degradability Bioaccumulative potential Mobility in soil Other adverse effects 13. DISPOSAL CONSIDERATIONS Waste treatment and disposal methods Recover, if possible. Send to authorised disposal plants or for incineration under controlled conditions. In so doing, comply with the local and national regulations currently in force. 14. TRANSPORT INFORMATION UN number ADR-UN Number: 1120 DOT number: UN1120 IATA-UN Number: 1120 IMDG-UN Number: 1120 UN proper shipping name ADR-Shipping Name: BUTANOLS DOT-Shipping Name: Butanols IATA-Shipping Name: BUTANOLS IMDG-Shipping Name: BUTANOLS Transport hazard class(es) ADR-Class: 3 DOT Hazard Class: 3 IATA-Class: 3 IMDG-Class: 3 Packing group ADR-Packing Group: III DOT Packing group: III IATA-Packing group: III Page n. 6 of 9

7 IMDG-Packing group: III Environmental hazards ADR-Enviromental Pollutant: No IMDG-Marine pollutant: No Most important toxic component: Transport in bulk (according to Annex II of MARPOL 73/78 and the IBC Code) Special precautions DOT Special provisions: B1, IB3, T2, TP1 ADR-Subsidiary risks: - ADR-S.P.: - ADR-Transport category (Tunnel restriction code): 3 (D/E) IATA-Passenger Aircraft: 355 IATA-Subsidiary risks: - IATA-Cargo Aircraft: 366 IATA-S.P.: A3 IATA-ERG: 3L IMDG-EmS: F-E, S-D IMDG-Subsidiary risks: - IMDG-Stowage and handling: Category A IMDG-Segregation: REGULATORY INFORMATION USA - Federal regulations TSCA - Toxic Substances Control Act TSCA inventory: all the components are listed on the TSCA inventory. TSCA listed substances: butan-1-ol is listed in TSCA Section 12b Formic Acid is listed in TSCA Section 12b. SARA - Superfund Amendments and Reauthorization Act Section 302 Extremely Hazardous Substances: no substances listed. Section 304 Hazardous substances: butan-1-ol, Formic Acid. Section 313 Toxic chemical list: butan-1-ol, Formic Acid. CERCLA - Comprehensive Environmental Response, Compensation, and Liability Act Substance(s) listed under CERCLA: butan-1-ol - Reportable quantity: 5000 pounds Formic Acid - Reportable quantity: 5000 pounds. Reportable quantity for mixture: pounds. CAA - Clean Air Act CAA listed substances:. CWA - Clean Water Act CWA listed substances: Formic Acid is listed in CWA Section 311. USA - State specific regulations California Proposition 65 Substance(s) listed under California Proposition 65:. Massachusetts Right to know Substance(s) listed under Massachusetts Right to know: butan-1-ol Formic Acid. New Jersey Right to know Substance(s) listed under New Jersey Right to know: butan-1-ol Formic Acid. Pennsylvania Right to know Page n. 7 of 9

8 Substance(s) listed under Pennsylvania Right to know: butan-1-ol Formic Acid. 16. OTHER INFORMATION Full text of phrases referred to in Section 3: H226 Flammable liquid and vapour. H335 May cause respiratory irritation. H315 Causes skin irritation. H319 Causes serious eye irritation. H373 May cause damage to organs through prolonged or repeated exposure. H302 Harmful if swallowed. H336 May cause drowsiness or dizziness. H314 Causes severe skin burns and eye damage. H318 Causes serious eye damage. H290 May be corrosive to metals. Safety Data Sheet dated 9/8/2017, version 1 Sections modified from the previous revision: 2. HAZARD(S) IDENTIFICATION 3. COMPOSITION/INFORMATION ON INGREDIENTS 5. FIRE-FIGHTING MEASURES 7. HANDLING AND STORAGE 8. EXPOSURE CONTROLS/PERSONAL PROTECTION 9. PHYSICAL AND CHEMICAL PROPERTIES 10. STABILITY AND REACTIVITY 11. TOXICOLOGICAL INFORMATION 12. ECOLOGICAL INFORMATION SECTION 14: Transport information 15. REGULATORY INFORMATION Disclaimer: The information contained herein is based on our state of knowledge at the above-specified date. It refers solely to the product indicated and constitutes no guarantee of particular quality. The information relates only to the specific material and may not be valid for such material used in combination with any other material or in any process. This Safety Data Sheet cancels and replaces any preceding release. ADR: CAS: CLP: DNEL: EINECS: GHS: HMIS: IARC: IATA: IATA-DGR: ICAO: ICAO-TI: Page n. 8 of 9 European Agreement concerning the International Carriage of Dangerous Goods by Road. Chemical Abstracts Service (division of the American Chemical Society). Classification, Labeling, Packaging. Derived No Effect Level. European Inventory of Existing Commercial Chemical Substances. Globally Harmonized System of Classification and Labeling of Chemicals. Hazardous Materials Identification System International Agency for Research on Cancer International Air Transport Association. Dangerous Goods Regulation by the "International Air Transport Association" (IATA). International Civil Aviation Organization. Technical Instructions by the "International Civil Aviation Organization"

9 IMDG: INCI: KSt: LC50: LD50: LTE: NFPA: NIOSH: NTP: OSHA: PNEC: RID: STE: STEL: STOT: TLV: TWATLV: (ICAO). International Maritime Code for Dangerous Goods. International Nomenclature of Cosmetic Ingredients. Explosion coefficient. Lethal concentration, for 50 percent of test population. Lethal dose, for 50 percent of test population. Long-term exposure. National Fire Protection Association National Institute for Occupational Safety and Health National Toxicology Program Occupational Safety and Health Administration Predicted No Effect Concentration. Regulation Concerning the International Transport of Dangerous Goods by Rail. Short-term exposure. Short Term Exposure limit. Specific Target Organ Toxicity. Threshold Limiting Value. Threshold Limit Value for the Time Weighted Average 8 hour day. (ACGIH Standard). Page n. 9 of 9