Kent. ME11 5EL Tel. No: Emergency Telephone
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1 1 of 5 SAFETY DATA SHEET 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND COMPANY Product Name ISOFLURANE Chemical Name 1-CHLORO-2,2,2-TRIFLUOROETHYL DIFLUOROMETHYL ETHER Synonyms FORANE Manufacturer Name: Abbott Laboratories Ltd. Address: Queenborough, Kent. ME11 5EL Tel. No: Emergency Telephone COMPOSITION/INFORMATION ON INGREDIENTS Ingredient Name Cas No. % w/w Symbol R Phase ISOFLURANE >99.9 None None 3. HAZARDS IDENTIFICATION The major hazard of Isoflurane is its anaesthetic properties which will ultimately result in unconsciousness if a person is exposed to high concentrations. 4. FIRST AID MEASURES OBTAIN IMMEDIATE MEDICAL ATTENTION Treatment for inhalation over exposure should be given to any patient who has been exposed to Isoflurane. Accompany or transport patient to a medical centre, do not allow the patient to walk alone. Inhalation: Skin Contact: Eye Contact: Ingestion: Remove patient from exposure. Remove contaminated clothing. After contact with skin, wash immediately with plenty of water. Obtain medical attention. Immediately irrigate with eyewash solution or clean water, holding the eyelids apart, for at least 15 minutes. Obtain medical attention. Do not induce vomiting. Obtain medical attention.
2 2 of 5 5. FIRE-FIGHTING MEASURES Extinguishing Media: Not required - Isoflurane is not flammable. Special Hazards: Special Protective Equipment for Fire-Fighters: Possibility of thermal decomposition products such as carbon monoxide, carbon dioxide, hydrofluoric acid and hydrochloric acid under high temperature conditions. Self-contained breathing apparatus and full protective clothing. 6. ACCIDENTAL RELEASE MEASURES Personal Precautions: Remove all personnel from the area. Wear self-contained breathing apparatus or a breathable air supplied respirator together with protective clothing. Environmental Precautions: Do not allow to enter natural waters or soil. Methods of Clearing Up: See also Sections 8 and 13 for advice Absorb spillage onto inert absorbant and place in sealed containers for disposal. 7. HANDLING AND STORAGE Handling: Do not breathe vapour. Avoid contact with skin and eyes. Provide adequate ventilation, including appropriate local extraction to ensure that the defined occupational exposure limit is not exceeded. Storage: Keep container tightly closed and in a well ventilated place. Keep away from direct sunlight and maintain temperature at less than 30ºC. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Avoid exposure first of all by technical and/or organisational measures Respiratory Protection: Not necessary under well ventilated conditions. Wear respirator with filter suitable for organic vapour application with a normal boiling point less than 65ºC. Hand Protection: Plastic gloves. Eye Protection: Safety glasses or goggles. Skin Protection: Wear suitable protective clothing. Occupational Exposure Limits: UK : 50ppm 8 hr TWA (Source:EH40)
3 3 of 5 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance: Clear liquid Vapour Pressure: 330mmHg at 25ºC 760mmHg at 48.5ºC. Odour: Similar to chloroform Relative Vapour Density (to air): 6.4 ph: Not determined Flash Point: Not applicable Boiling Point: 48.5ºC Auto Ignition Temp: Not applicable Melting Point: Not determined Dust Explosion Not applicable Properties: Relative Density: Upper Explosion Not applicable Limit: Bulk Density: Not applicable Lower Explosion Limit: Not applicable Solubility in Water: Very small Minimum Ignition Energy: Not applicable Solubility in Not determined Oxidation Not determined other chemicals: Properties: Conductivity: Not determined Viscosity: Not determined 10. STABILITY AND REACTIVITY General: Stable under recommended storage conditions. Conditions to Avoid: Temperatures above 30ºC. Materials to Avoid: None known. Hazardous Decomposition Products: See Section 5 for hazardous decomposition products if Isoflurane is exposed to extreme temperatures. 11. TOXICOLOGICAL INFORMATION Acute Toxicity: Oral LD to 5080 mg/kg in rats and mice. Dermal Inhalation LC 50 15,300-16,800 ppm/3hrs in rats and mice. Irritation: Eyes Possible irritant. Skin Inhalation
4 4 of TOXICOLOGICAL INFORMATION (continued) Chronic Toxicity : Liver injury was found in a 10 week study in rats at a concentration of 12,000 ppm. Carcinogenicity : No tumour production was found in a 2 year study in rats at a concentration of 1,000 ppm. Mutagenicity : Negative in the AMES test, in a sex-linked recessive lethality test in drosophilia melogaster and in a test for chromatid exchanges in Chinese hamster ovary cells. Reproductive Toxicity : Maternal toxicity, fetotoxicity, cleft palette and impaired reproductive performance reported in animal studies at concentration of 600 ppm or more. 12. ECOLOGICAL INFORMATION 13. DISPOSAL CONSIDERATIONS Please check the requirements of your national or regional regulations on this product. Method of Disposal : High temperature incinceration is preferred. Dangers : Treat as Special/Hazardous Waste. 14. TRANSPORT INFORMATION UN No: 3334 Aviation Regulated Liquid N.O.S. AIR ICAO/IATA Class - primary : 9, Packing Instructions 906 SEA IMDG Class - primary : Non-Hazardous - subsidiary 1 : Non-Hazardous - subsidiary 2 : Non-Hazardous Marine Pollutant : Non-Hazardous Proper shipping name : Non-Hazardous ROAD/RAIL ADR/RID Class : Non-Hazardous ADR/RID Item No. : Non-Hazardous ADR SIN : Non-Hazardous
5 5 of REGULATORY INFORMATION EC Classification : CHIP Information Label Symbol(s) : None Risk Phrases : None Safety Phrases : None 16. OTHER INFORMATION The information contained in the Safety Data Sheet is, to the best of our knowledge, true and accurate, but any recommendations or suggestions which may be made are without guarantee since the conditions of use are beyond our control. Furthermore, nothing contained herein shall be construed as a recommendation to use any product in conflict with existing patients covering the material or its use. Revision No: 1 Date of Publication: April 1999 Last Revised: August 1998
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