QPCR NGS Library Quant Kit - Illumina GA, Part Number G4880A

Transcription

1 Conforms to US OSHA Hazard Communication 29CFR Section 1. Identification 1.1 Product identifier Product name Supplier/Manufacturer SAFETY DATA SHEET QPCR NGS Library Quant Kit - Illumina GA, Part Number G4880A Part No. (Chemical Kit) Part No. QPCR NGS Library Quant Kit - Illumina GA, Part Number G4880A G4880A QPCR Master Mix Illumina GA Primer Mix pm Illumina DNA Standard Dilution Buffer Validation date 2/22/ Relevant identified uses of the substance or mixture and uses advised against Material uses Analytical chemistry. 1.3 Details of the supplier of the safety data sheet 50 Illumina GA Primer Mix 0.2 ml 100 pm Illumina DNA Standard 0.02 ml Agilent Technologies, Inc Stevens Creek Blvd Santa Clara, CA 95051, USA x 2.0 ml 0.1 ml 200 Dilution Buffer 2 x 0.5 ml 1 ml 1.4 Emergency telephone number In case of emergency CHEMTREC Section 2. Hazards identification 2.1 Classification of the substance or mixture OSHA/HCS status This material is considered hazardous by the OSHA Hazard Communication Standard (29 CFR ). While this material is not considered hazardous by the OSHA Hazard Communication Standard (29 CFR ), this SDS contains valuable information critical to the safe handling and proper use of the product. This SDS should be retained and available for employees and other users of this product. 50 Illumina GA Primer Mix While this material is not considered hazardous by the OSHA Hazard Communication Standard (29 CFR ), this SDS contains valuable information critical to the safe handling and proper use of the product. This SDS should be retained and available for employees and other users of this product. 100 pm Illumina DNA Standard While this material is not considered hazardous by the OSHA Hazard Communication Standard (29 CFR ), this SDS contains valuable information critical to the safe handling and proper use of the product. This Date of issue 02/22/2016 1/29

2 Section 2. Hazards identification SDS should be retained and available for employees and other users of this product. 200 Dilution Buffer While this material is not considered hazardous by the OSHA Hazard Communication Standard (29 CFR ), this SDS contains valuable information critical to the safe handling and proper use of the product. This SDS should be retained and available for employees and other users of this product. This material is considered hazardous by the OSHA Hazard Communication Standard (29 CFR ). Classification of the substance or mixture H320 EYE IRRITATION - Category 2B H302 ACUTE TOXICITY (oral) - Category 4 H320 EYE IRRITATION - Category 2B H373 SPECIFIC TARGET ORGAN TOXICITY (REPEATED EXPOSURE) (kidneys) - Category 2 Ingredients of unknown Not applicable. toxicity Percentage of the mixture consisting of ingredient (s) of unknown toxicity 2.4% 50 Illumina GA Primer Mix Not applicable. 100 pm Illumina DNA Standard Not applicable. 200 Dilution Buffer Percentage of the mixture consisting of ingredient (s) of unknown toxicity 10% Not applicable. 2.2 GHS label elements Hazard pictograms Signal word Warning No signal word. 50 Illumina GA Primer Mix No signal word. 100 pm Illumina DNA Standard No signal word. 200 Dilution Buffer No signal word. Warning Hazard statements H320 - Causes eye irritation. 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer GHS SYMBOL - Exclamation mark - Health hazard - H302 - Harmful if swallowed. H320 - Causes eye irritation. H373 - May cause damage to organs through prolonged or repeated exposure. (kidneys) Precautionary statements Date of issue 02/22/2016 2/29

3 Section 2. Hazards identification Prevention Response Storage Disposal Supplemental label elements 2.3 Other hazards P264 - Wash hands thoroughly after handling. Not applicable. 50 Illumina GA Primer Mix Not applicable. 100 pm Illumina DNA Standard Not applicable. 200 Dilution Buffer Not applicable. P260 - Do not breathe vapor. P270 - Do not eat, drink or smoke when using this product. P264 - Wash hands thoroughly after handling. Not applicable. 50 Illumina GA Primer Mix Not applicable. 100 pm Illumina DNA Standard Not applicable. 200 Dilution Buffer Not applicable. P305 + P351 + P338 - IF IN EYES Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337 + P313 - If eye irritation persists Get medical attention. P314 - Get medical attention if you feel unwell. P301 + P312 + P330 - IF SWALLOWED Call a POISON CENTER or physician if you feel unwell. Rinse mouth. P305 + P351 + P338 - IF IN EYES Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337 + P313 - If eye irritation persists Get medical attention. Not applicable. Not applicable. 50 Illumina GA Primer Mix Not applicable. 100 pm Illumina DNA Standard Not applicable. 200 Dilution Buffer Not applicable. Not applicable. Not applicable. Not applicable. 50 Illumina GA Primer Mix Not applicable. 100 pm Illumina DNA Standard Not applicable. 200 Dilution Buffer Not applicable. P501 - Dispose of contents and container in accordance with all local, regional, national and international regulations. None known. None known. 50 Illumina GA Primer Mix None known. 100 pm Illumina DNA Standard None known. 200 Dilution Buffer None known. None known. Date of issue 02/22/2016 3/29

4 Section 2. Hazards identification Hazards not otherwise classified None known. None known. 50 Illumina GA Primer Mix None known. 100 pm Illumina DNA Standard None known. 200 Dilution Buffer None known. None known. Section 3. Composition/information on ingredients Substance/mixture QPCR Mixture Master Mix Mixture 50 Illumina GA Primer Mix Mixture 100 pm Illumina DNA Standard Mixture 200 Dilution Buffer Mixture Mixture Ingredient name CAS number Glycerol Dimethyl sulfoxide Potassium chloride Potassium chloride Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride Ethanediol Any concentration shown as a range is to protect confidentiality or is due to batch variation. There are no additional ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section. Occupational exposure limits, if available, are listed in Section 8. Section 4. First aid measures 4.1 Description of necessary first aid measures Eye contact % Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes. If irritation persists, get medical attention. Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Get medical attention if irritation occurs. 50 Illumina GA Primer Mix Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Get medical attention if irritation occurs. 100 pm Illumina DNA Standard Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Get medical attention if irritation occurs. 200 Dilution Buffer Immediately flush eyes with plenty of water, Date of issue 02/22/2016 4/29

5 Section 4. First aid measures Inhalation Skin contact occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Get medical attention if irritation occurs. Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes. Get medical attention following exposure or if feeling unwell. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. Get medical attention if adverse health effects persist or are severe. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical attention if symptoms occur. In case of inhalation of decomposition products in a fire, symptoms may be delayed. The exposed person may need to be kept under medical surveillance for 48 hours. 50 Illumina GA Primer Mix Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical attention if symptoms occur. 100 pm Illumina DNA Standard Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical attention if symptoms occur. 200 Dilution Buffer Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical attention if symptoms occur. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. Get medical attention following exposure or if feeling unwell. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur. Wash clothing before reuse. Clean shoes thoroughly before reuse. Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur. 50 Illumina GA Primer Mix Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get Date of issue 02/22/2016 5/29

6 Section 4. First aid measures Ingestion medical attention if symptoms occur. 100 pm Illumina DNA Standard Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur. 200 Dilution Buffer Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur. Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Continue to rinse for at least 10 minutes. Get medical attention following exposure or if feeling unwell. Wash clothing before reuse. Clean shoes thoroughly before reuse. Wash out mouth with water. Remove dentures if any. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Get medical attention if adverse health effects persist or are severe. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. Wash out mouth with water. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Do not induce vomiting unless directed to do so by medical personnel. Get medical attention if symptoms occur. 50 Illumina GA Primer Mix Wash out mouth with water. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Do not induce vomiting unless directed to do so by medical personnel. Get medical attention if symptoms occur. 100 pm Illumina DNA Standard Wash out mouth with water. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Do not induce vomiting unless directed to do so by medical personnel. Get medical attention if symptoms occur. 200 Dilution Buffer Wash out mouth with water. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Do not induce vomiting unless directed to do so by medical personnel. Get medical attention if symptoms occur. Wash out mouth with water. Remove dentures if any. Remove victim to fresh air and keep at rest in Date of issue 02/22/2016 6/29

7 Section 4. First aid measures a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Get medical attention. If necessary, call a poison center or physician. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. 4.2 Most important symptoms/effects, acute and delayed Potential acute health effects Eye contact Inhalation Skin contact Causes eye irritation. 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer Causes eye irritation. 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer Ingestion 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer Harmful if swallowed. Over-exposure signs/symptoms Eye contact Adverse symptoms may include the following irritation watering redness 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer Adverse symptoms may include the following irritation Date of issue 02/22/2016 7/29

8 Section 4. First aid measures Inhalation Skin contact Ingestion watering redness 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 4.3 Indication of immediate medical attention and special treatment needed, if necessary Notes to physician Specific treatments Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled. In case of inhalation of decomposition products in a fire, symptoms may be delayed. The exposed person may need to be kept under medical surveillance for 48 hours. 50 Illumina GA Primer Mix Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled. 100 pm Illumina DNA Standard Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled. 200 Dilution Buffer Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled. No specific treatment. No specific treatment. 50 Illumina GA Primer Mix No specific treatment. 100 pm Illumina DNA Standard No specific treatment. 200 Dilution Buffer No specific treatment. No specific treatment. Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled. Date of issue 02/22/2016 8/29

9 Section 4. First aid measures Protection of first-aiders No action shall be taken involving any personal risk or without suitable training. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. No action shall be taken involving any personal risk or without suitable training. 50 Illumina GA Primer Mix No action shall be taken involving any personal risk or without suitable training. 100 pm Illumina DNA Standard No action shall be taken involving any personal risk or without suitable training. 200 Dilution Buffer No action shall be taken involving any personal risk or without suitable training. No action shall be taken involving any personal risk or without suitable training. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. See toxicological information (Section 11) Section 5. Fire-fighting measures 5.1 Extinguishing media Suitable extinguishing media Unsuitable extinguishing media Use an extinguishing agent suitable for the surrounding fire. Use an extinguishing agent suitable for the surrounding fire. 50 Illumina GA Primer Mix Use an extinguishing agent suitable for the surrounding fire. 100 pm Illumina DNA Standard Use an extinguishing agent suitable for the surrounding fire. 200 Dilution Buffer Use an extinguishing agent suitable for the surrounding fire. None known. None known. 50 Illumina GA Primer Mix None known. 100 pm Illumina DNA Standard None known. 200 Dilution Buffer None known. None known. Use an extinguishing agent suitable for the surrounding fire. 5.2 Special hazards arising from the substance or mixture Specific hazards arising from the chemical In a fire or if heated, a pressure increase will occur and the container may burst. In a fire or if heated, a pressure increase will occur and the container may burst. 50 Illumina GA Primer Mix In a fire or if heated, a pressure increase will occur and the container may burst. 100 pm Illumina DNA Standard In a fire or if heated, a pressure increase will occur and the container may burst. 200 Dilution Buffer In a fire or if heated, a pressure increase will occur and the container may burst. In a fire or if heated, a pressure increase will occur and the container may burst. Date of issue 02/22/2016 9/29

10 Section 5. Fire-fighting measures Hazardous thermal decomposition products Decomposition products may include the following materials carbon dioxide carbon monoxide sulfur oxides halogenated compounds metal oxide/oxides Decomposition products may include the following materials carbon dioxide carbon monoxide nitrogen oxides halogenated compounds metal oxide/oxides 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer Decomposition products may include the following materials carbon dioxide carbon monoxide Decomposition products may include the following materials carbon dioxide carbon monoxide 5.3 Advice for firefighters Special protective actions for fire-fighters Special protective equipment for fire-fighters Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. 50 Illumina GA Primer Mix Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. 100 pm Illumina DNA Standard Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. 200 Dilution Buffer Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. Date of issue 02/22/ /29

11 Section 5. Fire-fighting measures Section 6. Accidental release measures 50 Illumina GA Primer Mix Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. 100 pm Illumina DNA Standard Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. 200 Dilution Buffer Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. 6.1 Personal precautions, protective equipment and emergency procedures For non-emergency personnel No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Avoid breathing vapor or mist. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment. No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Put on appropriate personal protective equipment. 50 Illumina GA Primer Mix No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Put on appropriate personal protective equipment. 100 pm Illumina DNA Standard No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Put on appropriate personal protective equipment. 200 Dilution Buffer No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Put on appropriate personal protective equipment. No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilled material. Avoid breathing vapor or mist. Provide adequate Date of issue 02/22/ /29

12 Section 6. Accidental release measures For emergency responders ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment. If specialized clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel". If specialized clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel". 50 Illumina GA Primer Mix If specialized clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel". 100 pm Illumina DNA Standard If specialized clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel". 200 Dilution Buffer If specialized clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel". If specialized clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel". 6.2 Environmental precautions Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). 50 Illumina GA Primer Mix Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). 100 pm Illumina DNA Standard Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). 200 Dilution Buffer Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Date of issue 02/22/ /29

13 Section 6. Accidental release measures 6.3 Methods and materials for containment and cleaning up Methods for cleaning up Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor. Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor. 50 Illumina GA Primer Mix Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor. 100 pm Illumina DNA Standard Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor. 200 Dilution Buffer Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor. Section 7. Handling and storage 7.1 Precautions for safe handling Protective measures Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor. Put on appropriate personal protective equipment (see Section 8). Do not ingest. Avoid contact with eyes, skin and clothing. Avoid breathing vapor or mist. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Empty containers retain product residue and can be hazardous. Do not reuse container. Put on appropriate personal protective equipment (see Section 8). 50 Illumina GA Primer Mix Put on appropriate personal protective equipment (see Section 8). 100 pm Illumina DNA Standard Put on appropriate personal protective equipment (see Section 8). 200 Dilution Buffer Put on appropriate personal protective equipment (see Section 8). Date of issue 02/22/ /29

14 Section 7. Handling and storage Advice on general occupational hygiene Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures. Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures. 50 Illumina GA Primer Mix Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures. 100 pm Illumina DNA Standard Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures. 200 Dilution Buffer Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures. Put on appropriate personal protective equipment (see Section 8). Do not breathe vapor or mist. Do not ingest. Avoid contact with eyes, skin and clothing. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Empty containers retain product residue and can be hazardous. Do not reuse container. Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures. 7.2 Conditions for safe storage, including any incompatibilities Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright Date of issue 02/22/ /29

15 Section 7. Handling and storage to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination. Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination. 50 Illumina GA Primer Mix Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination. 100 pm Illumina DNA Standard Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination. 200 Dilution Buffer Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination. Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabeled containers. Use appropriate containment to avoid environmental contamination. 7.3 Specific end use(s) Date of issue 02/22/ /29

16 Section 7. Handling and storage Recommendations Industrial sector specific solutions Industrial applications, Professional applications. Industrial applications, Professional applications. 50 Illumina GA Primer Mix Industrial applications, Professional applications. 100 pm Illumina DNA Standard Industrial applications, Professional applications. 200 Dilution Buffer Industrial applications, Professional applications. Industrial applications, Professional applications. Not applicable. Not applicable. 50 Illumina GA Primer Mix Not applicable. 100 pm Illumina DNA Standard Not applicable. 200 Dilution Buffer Not applicable. Not applicable. Section 8. Exposure controls/personal protection 8.1 Control parameters Occupational exposure limits Ingredient name Exposure limits Glycerol OSHA PEL 1989 (United States, 3/1989). TWA 5 mg/m³ 8 hours. Form Respirable fraction TWA 10 mg/m³ 8 hours. Form Total dust OSHA PEL (United States, 2/2013). TWA 5 mg/m³ 8 hours. Form Respirable fraction TWA 15 mg/m³ 8 hours. Form Total dust Dimethyl sulfoxide AIHA WEEL (United States, 10/2011). TWA 250 ppm 8 hours. Potassium chloride None. Potassium chloride 2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride None. None. Ethanediol ACGIH TLV (United States, 3/2015). C 100 mg/m³ Form Aerosol OSHA PEL 1989 (United States, 3/1989). CEIL 50 ppm CEIL 125 mg/m³ 8.2 Exposure controls Appropriate engineering controls Environmental exposure controls If user operations generate dust, fumes, gas, vapor or mist, use process enclosures, local exhaust ventilation or other engineering controls to keep worker exposure to airborne contaminants below any recommended or statutory limits. Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels. Individual protection measures Date of issue 02/22/ /29

17 Section 8. Exposure controls/personal protection Hygiene measures Eye/face protection Skin protection Hand protection Body protection Other skin protection Respiratory protection Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location. Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists, gases or dusts. If contact is possible, the following protection should be worn, unless the assessment indicates a higher degree of protection chemical splash goggles. Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. Considering the parameters specified by the glove manufacturer, check during use that the gloves are still retaining their protective properties. It should be noted that the time to breakthrough for any glove material may be different for different glove manufacturers. In the case of mixtures, consisting of several substances, the protection time of the gloves cannot be accurately estimated. Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product. Appropriate footwear and any additional skin protection measures should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product. Based on the hazard and potential for exposure, select a respirator that meets the appropriate standard or certification. Respirators must be used according to a respiratory protection program to ensure proper fitting, training, and other important aspects of use. Section 9. Physical and chemical properties 9.1 Information on basic physical and chemical properties Appearance Physical state Color Odor Liquid. Liquid. 50 Illumina GA Primer Mix Liquid. 100 pm Illumina DNA Standard Liquid. 200 Dilution Buffer Liquid. Liquid. 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer Date of issue 02/22/ /29

18 Section 9. Physical and chemical properties Odor threshold ph Melting point Boiling point Flash point Evaporation rate Flammability (solid, gas) Lower and upper explosive (flammable) limits 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 0 C (32 F) 50 Illumina GA Primer Mix 0 C (32 F) 100 pm Illumina DNA Standard 0 C (32 F) 200 Dilution Buffer 100 C (212 F) 50 Illumina GA Primer Mix 100 C (212 F) 100 pm Illumina DNA Standard 100 C (212 F) 200 Dilution Buffer 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer Not applicable. Not applicable. 50 Illumina GA Primer Mix Not applicable. 100 pm Illumina DNA Standard Not applicable. 200 Dilution Buffer Not applicable. Not applicable. 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer Date of issue 02/22/ /29

19 Section 9. Physical and chemical properties Vapor pressure Vapor density Relative density Solubility Partition coefficient n- octanol/water Auto-ignition temperature Decomposition temperature 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer Soluble in the following materials cold water and hot water. Easily soluble in the following materials cold water and hot water. 50 Illumina GA Primer Mix Easily soluble in the following materials cold water and hot water. 100 pm Illumina DNA Standard Easily soluble in the following materials cold water and hot water. 200 Dilution Buffer Easily soluble in the following materials cold water and hot water. 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 2 Brilliant III Ultra-Fast SYBR Green Reference dye, 1mM 50 Illumina GA Primer Mix 100 pm Illumina GA Standard 200 Dilution Buffer 10 GC-Additive Soluble in the following materials cold water and hot water. Date of issue 02/22/ /29

20 Section 9. Physical and chemical properties Viscosity Section 10. Stability and reactivity 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 10.1 Reactivity No specific test data related to reactivity available for this product or its ingredients. No specific test data related to reactivity available for this product or its ingredients. 50 Illumina GA Primer Mix No specific test data related to reactivity available for this product or its ingredients. 100 pm Illumina DNA Standard No specific test data related to reactivity available for this product or its ingredients. 200 Dilution Buffer No specific test data related to reactivity available for this product or its ingredients. No specific test data related to reactivity available for this product or its ingredients Chemical stability The product is stable. The product is stable. 50 Illumina GA Primer Mix The product is stable. 100 pm Illumina DNA Standard The product is stable. 200 Dilution Buffer The product is stable. The product is stable Possibility of hazardous reactions Under normal conditions of storage and use, hazardous reactions will not occur. Under normal conditions of storage and use, hazardous reactions will not occur. 50 Illumina GA Primer Mix Under normal conditions of storage and use, hazardous reactions will not occur. 100 pm Illumina DNA Standard Under normal conditions of storage and use, hazardous reactions will not occur. 200 Dilution Buffer Under normal conditions of storage and use, hazardous reactions will not occur. Under normal conditions of storage and use, hazardous reactions will not occur Conditions to avoid 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer Date of issue 02/22/ /29

21 Section 10. Stability and reactivity 10.5 Incompatible materials 10.6 Hazardous decomposition products Under normal conditions of storage and use, hazardous decomposition products should not be produced. Under normal conditions of storage and use, hazardous decomposition products should not be produced. 50 Illumina GA Primer Mix Under normal conditions of storage and use, hazardous decomposition products should not be produced. 100 pm Illumina DNA Standard Under normal conditions of storage and use, hazardous decomposition products should not be produced. 200 Dilution Buffer Under normal conditions of storage and use, hazardous decomposition products should not be produced. May react or be incompatible with oxidizing materials. May react or be incompatible with oxidizing materials. 50 Illumina GA Primer Mix May react or be incompatible with oxidizing materials. 100 pm Illumina DNA Standard May react or be incompatible with oxidizing materials. 200 Dilution Buffer May react or be incompatible with oxidizing materials. Section 11. Toxicological information 11.1 Information on toxicological effects Acute toxicity May react or be incompatible with oxidizing materials. Under normal conditions of storage and use, hazardous decomposition products should not be produced. Product/ingredient name Result Species Dose Exposure 2X Brilliant III SYBR Green Glycerol LD50 Oral Rat mg/kg - Dimethyl sulfoxide LD50 Dermal Rat mg/kg - LD50 Oral Rat mg/kg - Potassium chloride LD50 Oral Rat 2600 mg/kg - Potassium chloride LD50 Oral Rat 2600 mg/kg - Ethanediol LD50 Oral Rat 4700 mg/kg - Irritation/Corrosion Date of issue 02/22/ /29

22 Section 11. Toxicological information Product/ingredient name Result Species Score Exposure Observation 2X Brilliant III SYBR Green Glycerol Eyes - Mild irritant Rabbit - 24 hours 500 milligrams Skin - Mild irritant Rabbit - 24 hours 500 milligrams Dimethyl sulfoxide Eyes - Mild irritant Rabbit - 24 hours 500 milligrams Eyes - Mild irritant Rabbit milligrams Skin - Mild irritant Rabbit - 24 hours 500 milligrams Skin - Mild irritant Rabbit milligrams Potassium chloride Eyes - Mild irritant Rabbit - 24 hours 500 milligrams Potassium chloride Eyes - Mild irritant Rabbit - 24 hours 500 milligrams Ethanediol Eyes - Mild irritant Rabbit - 24 hours 500 milligrams Eyes - Mild irritant Rabbit - 1 hours 100 milligrams Eyes - Moderate irritant Rabbit - 6 hours 1440 milligrams Skin - Mild irritant Rabbit milligrams Sensitization Mutagenicity Carcinogenicity Reproductive toxicity Teratogenicity Specific target organ toxicity (single exposure) Name Category Route of exposure 2-Amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride Category 3 Not applicable. Respiratory tract irritation Specific target organ toxicity (repeated exposure) Target organs Date of issue 02/22/ /29

23 Section 11. Toxicological information Name Category Ethanediol Category 2 Not determined kidneys Aspiration hazard Route of exposure Target organs Information on the likely routes of exposure Potential acute health effects Eye contact Inhalation Skin contact Ingestion 200 Dilution Buffer Causes eye irritation. 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard Routes of entry anticipated Oral, Dermal, Inhalation. Routes of entry anticipated Oral, Dermal, Inhalation. 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer Routes of entry anticipated Oral, Dermal, Inhalation. Routes of entry anticipated Oral, Dermal, Inhalation. Causes eye irritation. 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer Harmful if swallowed. Symptoms related to the physical, chemical and toxicological characteristics Date of issue 02/22/ /29

24 Section 11. Toxicological information Eye contact Inhalation Skin contact Ingestion redness 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer Adverse symptoms may include the following irritation watering redness 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer Adverse symptoms may include the following irritation watering Delayed and immediate effects and also chronic effects from short and long term exposure Short term exposure Potential immediate effects Potential delayed effects Long term exposure Potential immediate effects Potential delayed effects Potential chronic health effects General 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer May cause damage to organs through prolonged or repeated exposure. Date of issue 02/22/ /29

25 Section 11. Toxicological information Carcinogenicity Mutagenicity Teratogenicity Developmental effects Fertility effects 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer 50 Illumina GA Primer Mix 100 pm Illumina DNA Standard 200 Dilution Buffer Numerical measures of toxicity Acute toxicity estimates Route Oral Oral Oral ATE value mg/kg mg/kg 956 mg/kg Date of issue 02/22/ /29

26 Section 12. Ecological information 12.1 Toxicity Product/ingredient name 2X Brilliant III SYBR Green Glycerol Acute LC mg/l Fresh water Fish - Oncorhynchus mykiss 96 hours Dimethyl sulfoxide Acute LC ppm Fresh water Daphnia - Daphnia magna - 48 hours Neonate Acute LC µg/l Fresh water Fish - Pimephales promelas 96 hours Chronic NOEC 100 ul/l Marine water Algae - Ulva lactuca 72 hours Potassium chloride Acute EC µg/l Fresh water Algae - Navicula seminulum 96 hours Acute EC g/l Fresh water Algae - Desmodesmus 72 hours subspicatus Acute EC µg/l Fresh water Daphnia - Daphnia magna 48 hours Acute LC µg/l Fresh water Fish - Pimephales promelas 96 hours Potassium chloride Acute EC µg/l Fresh water Algae - Navicula seminulum 96 hours Acute EC g/l Fresh water Algae - Desmodesmus 72 hours subspicatus Acute EC µg/l Fresh water Daphnia - Daphnia magna 48 hours Acute LC µg/l Fresh water Fish - Pimephales promelas 96 hours Ethanediol Acute LC µg/l Fresh water Crustaceans - Ceriodaphnia 48 hours dubia - Neonate Acute LC µg/l Fresh water Daphnia - Daphnia magna - 48 hours Neonate Acute LC µg/l Fresh water Fish - Pimephales promelas 96 hours Conclusion/Summary Result Species Exposure 12.2 Persistence and degradability Product/ingredient name Aquatic half-life Photolysis Biodegradability Ethanediol - - Readily 12.3 Bioaccumulative potential Product/ingredient name LogPow BCF Potential 2X Brilliant III SYBR Green Glycerol low Dimethyl sulfoxide low Potassium chloride low Potassium chloride low Ethanediol low 12.4 Mobility in soil Date of issue 02/22/ /29