The Art of. Flow Restoration. Raiden3. Non-Compliant PTCA Balloon

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1 The Art of Flow Restoration Raiden3

2 Japan s Recognized PCI Technology Raiden3 For Both Everyday and Complex Cases Manufactured by Kaneka Corporation, one of Japan s leading providers of interventional devices. Now part of the PTCA balloon portfolio of Cordis, a Cardinal Health Company. High Quality Japanese Balloon Design Engineered for smaller and narrower lesions. *Challenging lesions such as calcified or tortuous lesions may not be crossed with this catheter. The physician in charge of the procedure should determine whether this catheter is applicable based on his/her past experiences.

3 UP TO The Highest RBP Available Advancing Crossability Performance High Pressure, Noncompliant Balloon for Confidence in Preserving Post-Dilatation Accuracy Innovative Japanese technology and renown durability. Powerful atm RBP, the highest on the market.* Low compliance facilitates post-dilatation accuracy. Engineered for strength and puncture resistance. Next-Generation TR2 Hydrophilic Coating Improves lubricity, thereby reducing resistance. Tapered Balloon Shape Features a long, smooth tip, and a low profile engineered to prevent buckling and facilitate crossing. 1. mm Higher pressure facilitates stent tacking. Balloon Strength Unique Tri-fold Wrapping Technology Optimized balloon-wrapping technology. Lowest-Profile 1.mm Diameter Post-Dilatation Balloon Available* Cross confidently with the lowest profile currently available. Balloon Working Range: NP RBP (atm)** Kaneka Raiden3 TM ** Crossability of 3.0mm Post-Dilatation Products** Medtronic NC Euphora TM 0 Boston Scientific NC Emerge TM Abbott NC Trek TM Biotronik Pantera Leo TM OrbusNeich Sapphire NC TM Terumo Accuforce TM Lowest pressure in the graph refers to NP and highest one to RBP. Crossing Force Lower Force - Higher Crossing Force *Compared to products shown in the chart on this page. **RBP: atm (ø mm; atm for Ø1.-2.0mm mm). *Source: Data on file at Kaneka, compared to 1.mm Abbott. **Products are the same as those in the previous slide. Kaneka Raiden3 TM Boston Scientific NC Emerge Abbott TREK NC

4 Balloon Diameter (mm) Balloon Length (mm) Compatibility Sheath Nominal Pressure (atm) Rated Burst Pressure (atm) Catalog Reference Number Tip Radiopaque Marker Balloon KANEKA CORPORATION Distal Shaft Product Overview and Ordering Corewire Effective Length: Radiopaque Markers: Max Guide Wire Size: Balloon Folds: Accessories: Guide Wire Port Key Specifications 146cm Mid Shaft 1 (ø mm) 2 (ø2.0-4.mm) fold (ø1. ~ 1.7mm) 3-fold (ø2 ~ 4.mm) Proximal Shaft Flushing Needle and Rewrap Tool Included RD3-- RD3--17 RD3--0 RD3--0 RD3--0 RD3-1-0 RD3--0 RD3-- RD3-- RD3-1- RD3-- RD3-- RD3-- RD3-- RD3-1- RD3-- RD3-- RD3--27 RD3--27 RD RD3--27 RD3--0 RD3--0 RD3--0 RD3-1-0 RD3--0 RD3--0 RD3--32 RD3--32 RD RD3--32 RD3-- RD3-- RD3-- RD3-1- RD3-- RD3-- RD3--37 RD3--37 RD RD3--37 RD RD RD RD RD RD RD3--42 RD RD3--40 RD3--40 RD RD3--40

5 Raiden3 For healthcare professionals only. 17 Cardinal Health. All Rights Reserved. Prior to use, refer to the Instructions for Use supplied with this device for indications, contraindications, side effects, suggested procedure, warnings, and precautions. Third party trademarks are the trademarks of respective owners. Not available for sale in the United States and certain other countries. Raiden3 is a trademark of Kaneka Corporation, the legal manufacturer of Raiden3 and distributed by Cordis Corporation. CORDIS and the Cordis LOGO are trademarks of Cardinal Health and may be registered in the US and/or in other countries. All other marks are the property of their respective owners. EU73-2 9/17. WARNINGS : STERILE product, to be for one-time use only. Re-sterilizing or re-using may compromise the structural integrity of the device and may create a risk of contamination which, in turn, may result in health risks to patients. The inflated diameter of the balloon should correspond to the diameter of the vessel for treatment PTCA = Percutaneous Transluminal Coronary Angioplasty, NP = Nominal Pressure, RBP = Rated Burst Pressure PCI = Percutaneous Coronary Intervention

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