Custom and standard isolators for analytical and QA laboratories Contained handling of samples for dispensing and analysis Integration of a wide range of different weigh scale systems and other instrumentation Provision of special atmospheres, such as inert, dry and gassed atmospheres Integration of work spaces, data hook up points and monitoring and recording instrumentation Integration with existing and new laboratory equipment ProSys Containment and Sampling Technology info@prosys.ie 732-364-1810 ProSys Laboratory Analytical Isolators
Custom gloveboxes to allow for contained small scale processing of HAPI compounds Gloveboxes may be linked directly to existing or new fume hoods via material transfer airlocks to segregate liquid processing within the fume hoods and solids handling within the glovebox Gloveboxes may contain a variety of different processing equipment, such as tray dryers, Nutsche filters, rotary evaporators, small scale reactors and crystallizers, etc. Dispensing and packaging of final solids compound may be carried out within the Glovebox ProSys Containment and Sampling Technology info@prosys.ie 732-364-1810 ProSys Laboratory Small Scale Isolators
Dry chamber glovebox for analytical QA facility Achieves less than 1% RH by continuous Dew Point analysis Fully integrated recirculation desiccator system Nitrogen purge facility for airlock chamber and working chamber Air purge system to remove all nitrogen from either chamber before windows are unlocked for opening Full touch screen HMI that allows for monitoring the running and maintenance status of the isolator as well as fault diagnostics 'Traffic Light' type indicator to allow quick status check of isolator Integrated power sockets, service hook up points and data transfer points ProSys Containment and Sampling Technology info@prosys.ie 732-364-1810 ProSys Dry Boxes
High Containment Isolator retrofits to existing processing equipment (e.g. Encapsulators, Tablet Presses, etc.) Fully contained powder infeed and final dosage form output Complete Project Management from Start to Finish, inclusive of any work being required from the OEM of the machine Integration and supply of ancillary equipment, like dust collectors, tablet samplers, dedusters, metal checkers, solids feed systems, etc. BEFORE AFTER ProSys Containment & Sampling Technology info@prosys.ie 732-364-1810 ProSys Encapsulator & Tablet Press Isolators
Multi-functional Glovebox system is integrated with the ProSys Recirculation Top Reactor Sampling System (RTRS) Multi-function glovebox that can be mounted either for liquids/solids charging directly into the sight-glass assembly of the RTRS or for the contained removal of samples from the RTRS Transfer in/out of the glovebox via Rapid Transfer Port Working chamber is nitrogen purged Internal safe change HEPA filters (removal via Rapid Transfer Port) Complete system can also be trolley mounted, when space on top of the reactor is limited ProSys Containment and Sampling Technology info@prosys.ie 732-364-1810 ProSys Sampling & Slurry Charging Gloveboxes
Isolator for sterility testing: greatly reduces the risk of false positives Can be customised to fit customer application Can be fully bio-decontaminated using vaporised Hydrogen Peroxide. Integration with Steris or Bioquell gas generators Validated fast gassing cycle on airlock ports (single or multiple transfer ports possible) H2O2 Cycle development and validation services offered Integrated pump for sterility testing, particle monitoring (viable and non viable), etc. info@prosysus.com 732-364-1810 ProSys Sterility Testing Isolators
Large scale vessel charging glovebox from drums and other types of containers Drum interface with glovebox is via a host container to permit handling of differently sized drums without the need for changeover parts Material entry via Rapid Transfer Port, drum docking hoist or through opened front window Nitrogen purged working chambers with cascading pressure Twin Chamber design to protect the drum docking point from powder contamination Internal safe change inlet and outlet HEPA filters (changed via Rapid Transfer Port) Single, double or triple chamber systems ProSys Containment & Sampling Technology info@prosys.ie 732-364-1810 ProSys Large Scale Reactor Charging Gloveboxes
Mobile slurry charging system for use with multiple process vessels 400mm height adjustability to provide optimum ergonomics for different height operators Solids enter the working chamber via Rapid Transfer Port Integrated pneumatic/magnetic stirrer for slurrying up of solids within the glovebox Pressure/vacuum transfer of slurry via disposable transfer lines Vacuum source, nitrogen purge for working chamber and slurrying bottle, low micron filtration of liquids and gasses are all integrated into the glovebox envelope Integrated flush/cleaning cycle for slurrying bottle and transfer lines Inlet and outlet HEPA filters are internal safe change (removal from glovebox via Rapid Transfer Port) ProSys Containment and Sampling Technology info@prosys.ie 732-364-1810 ProSys Mobile Seed Charging Gloveboxes www.prosysus..com
Pharmaceutical active ingredients dispensing stations Designed to achieve an OEL of less than 1microgr/m 3 Fully automated nitrogen purge system and pressure control circuit Designed to dispense either into ILC Dover continuous liner or into Split Butterfly Valve (integrated into the base of the glovebox) Drum docking to the base of the glovebox for either the removal or addition of small quantities Integrated weighscales ProSys Containment & Sampling Technology info@prosys.ie 732-364-1810 ProSys Dispensing and Subdivision Isolators
Small scale vessel charging glovebox, e.g. Seed Charging, small liquid editions, etc. Material entry via Rapid Transfer Port, Airlock (Passbox) or through opened front window Nitrogen purged working chamber Material transfer via funnel allows for cleandown of the glovebox without draining into the process vessel Internal safe change inlet and outlet HEPA filters (change via Rapid Transfer Port, Continuous Liner Port or Airlock) Large radius corners and edges for ease of cleaning ProSys Containment & Sampling Technology info@prosys.ie 732-364-1810 ProSys Reactor Charging/Seeding Gloveboxes
Fully contained top vessel sampling station (solids and liquid sampling from reactors, dryers, etc.) Automated sample lance with removable and interchangeable sample cup arrangement Option for taking a fixed sample volume at a fixed level within the vessel Nitrogen purged glovebox chamber Sample transfer either via continuous liner system or via Rapid Transfer Port The top sampler principle has also been combined with pressure and vacuum rated cabinets and simple (non-glovebox) cabinets for non-toxic applications ProSys Containment and Sampling Technology info@prosys.ie 732-364-1810 ProSys Vessel Top Sampling Gloveboxes
Isolators for sampling, solids discharge and heel removal from Nutsche filters, dryers and filter dryers or a combination of all these functions into one system Isolators are purpose built to suit existing and new filtration & drying equipment Existing filter dryer discharge valves are replaced with integrated solids discharge doors to allow for contained access to the filter dryer interior via the glovebox system Assessment of existing filtration & drying equipment for suitability for containment carried out by ProSys experts Drum filling may be via continuous liner system, split butterfly valve, ILC Dover type bags or inflatable seal head interface Integration of special atmospheres, solids metering, weighing, particle size reduction (screening, milling, etc.) and more into the containment system is possible ProSys Containment & Sampling Technology info@prosys.ie 732-364-1810 ProSys Filter Dryer Heel Removal & Discharge Gloveboxes
Unloading of solids vessel to very low OEL's and high weighing accuracy Multiple filling heads for offloading into either single liners via inflatable sealhead, continuous liner or RTP Managed airflow throughout the system to prevent cross contamination between chambers or fully segregated chambers Options for manual or fully integraded solids dosing system to achieve very high filling accuracies Solids chute nitrogen purge and filtered extract options Integrated weigh system and roller track Optional pneumatic drum pusher to assist in removal of filled product drums ProSys Containment & Sampling Technology info@prosys.ie 732-364-1810 ProSys Solids Drum Filling Systems
Liquid drum unloading and sampling of toxic compounds Single chamber or multi chamber systems Small liquids additions or charges from large IBC s Simple manual dip pipes or fully automated, fully sealed dip pipes with integrated nitrogen blanketing and WIP, blow down and drying cycles Drum weigh systems and automated dosing of the liquid transfer Hastelloy product contact surfaces for highly corrosive liquids (e.g. Bromine) Dock Insert Tilt Purge ProSys Containment & Sampling Technology info@prosys.ie 732-364-1810 ProSys Liquid Drum Unloading & Sampling Gloveboxes
Contained systems for the safe removal of in-line cartridge filter elements Disposal of used filter cartridges via continuous linger system Nitrogen purge of working chamber Lift up windows for easy maintenance access to the filter housings Introduction of clean filter cartridges via airlock access Internal safe change HEPA filters (removal via continuous liner system) Optional integrated storage racks ProSys Containment and Sampling Technology info@prosys.ie 732-364-1810 ProSys In-Line Filter Change Gloveboxes