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Noticias News Nouvelles The Centre for Mother, Infant, and Child Research Sunnybrook Health Sciences Centre C8-2075 Bayview Avenue, Toronto ON CANADA M4N 3M5 Tel: 1 416 480 5639 Fax: 1 416 480 5633 email: tbs@sw.ca website: www.cmicr.ca V O L U M E 1 0, I S S U E 5 M A Y 3 1, 2 0 1 1 TBS Data Campaign Please send us your data and queries today! Our overall current standings for complete and clean data are as follows: I N S I D E T H I S I S S U E Data Campaign Statistics Announcement: Final Meeting Date 1 1 Primary Data Received: 96% Queries Resolved: 88.6% Keep up the great work! Data Campaign 2 Centres: Complete and Clean What s New: Complete and Clean Report 2 3 Reminder: Clinician List and Follow-up 3 Follow-up Table 4

P A G E 2 The Data Campaign is Underway! Let s aim for 100% Complete and Clean! Data and query replies are continually coming in and we appreciate your hard work and diligence! Let s continue to focus our eforts on geting the data to the Coordinating Centre. Please SEND US YOUR DATA and QUERY REPLIES! Complete and Clean Data! Congratulations to the following centres that have reached 100% complete cases of primary data forms returned and all queries resolved: Hospital Angela Iglesia de Llano, Corrientes St George Hospital, Sydney Toowoomba Base Hospital, Toowoomba Monash Medical Centre, Clayton Logan Hospital, Meadowbrook Townsville Hospital, Townsville Women s and Children s Hospital, Adelaide Vrije Universiteit Brussel, Brussels IWK Health Centre, Halifax McMaster Univeresity Medical Centre, Hamilton Trillium Health Centre, Mississauga Mount Sinai Hospital, Toronto Foothills Medical Centre, Calgary SMBD Jewish General Hospital, Montreal North Bay General Hospital, North Bay Royal Columbian Hospital, New Westminster Royal University Hospital, Saskatoon Toronto East General, Toronto Women s Health Centre, St John s St Paul s Hospital, Vancouver York Central Hospital, Richmond Hill Sveti Duh Hospital, Zagreb Tartu University Hospital - Women s Clinic, Tartu Ludwig Maximilians University of Munich, Munich CUB - Benjamin Franklin, Berlin University of Debrecen, Debrecen Nazareth Hospital (EMMS), Nazareth Edith Wolfson Medical Center, Holon HaEmek Medical Center, Afula Poriya Government Hospital, Tiberias Bnai Zion Medical Center, Haifa University of Pharmacy and Medicine, Cluj-Napoca Complejo Hospitalario de Toledo, Toledo Atrium Medical Center, Heerlen Maaslandziekenhuis Sittard, Sittard Sint Lucas Andreas Ziekenhuis, Amsterdam Derriford Hospital, Plymouth Queen Elizabeth Hospital, King s Lynn Lewisham Hospital, London University of Miami, Miami University of South Carolina, Columbia Jamaica Hospital Medical Center, Jamaica Texas Tech UHSC, Lubbock University of Iowa Hospitals and Clinics, Iowa City

P A G E 3 Complete and Clean Report Beginning in July, each centre that recruited patients will receive a monthly email of the Complete and Clean Data Report. This report wil provide updates on the status of the data received to date. We look forward to seeing your centre reach 100% complete and clean status. Keep up the great work! REMINDERS Clinician List We still need your Clinician List updates. Please continue to respond to our requests for updates because this information is still needed while we are collecting data. If you have any questions about this, please contact the Coordinating Centre. Follow-up Please remember, in addition to obtaining the primary data, it is also important to remember the importance of completing the follow-up phase of the study. The 3 month postpartum questionnaire, Ages and Stages Questionnaire, 2-year Maternal Questionnaire and (if needed), the Neurodevelopmental Assessment Form will be assessed after the primary data has been analyzed and the follow-up portion of the study is over. Therefore, please do not delay getting these forms from your patients. Let s aim for 100% folow-up! You must give some time to your felow men. Even if it's a litle thing, do something for others - something for which you get no pay but the privilege of doing it. ~Albert Schweitzer

PAGE 4 TBS 2 Year Follow-up The status of the TBS 2 Year Follow-up is displayed in the following table for centres that recruited patients. Centres are listed according to the total number of recruits by country and centre. See below for the number of follow-up assessments performed by your centre! Let's aim for 100% follow-up!! Status 2003 2004 2005 2006 2007 2008 2009 2010 2011 Totals As of May 2011 COUNTRY ARGENTINA 60 51 65 58 96 87 107 100 122 92 125 23 123 34 732 411 BRAZIL 2 2 44 36 71 56 54 35 63 37 97 6 69 14 414 172 CANADA 3 3 25 22 53 47 46 37 41 33 29 25 40 8 16 7 260 175 ISRAEL 21 21 27 23 16 16 14 14 32 31 42 2 39 10 201 107 POLAND 4 4 28 26 18 15 44 34 35 21 25 10 3 167 100 UK 2 2 2 2 15 6 18 13 16 9 31 2 30 12 126 34 CHILE 8 8 11 11 13 13 8 7 16 12 25 10 20 13 114 61 SPAIN 2 2 6 6 10 10 9 9 8 8 7 3 49 17 108 38 EGYPT 19 19 14 14 15 15 6 6 12 1 20 3 89 55 AUSTRALIA 2 2 15 10 12 7 17 16 14 13 8 1 10 1 79 49 THE NETHERLANDS 7 7 9 9 17 14 6 5 6 6 5 2 13 63 43 SERBIA 27 22 24 6 6 1 58 28 USA 4 2 13 8 10 3 8 5 5 3 11 6 57 21 JORDAN 5 5 5 5 8 8 9 9 8 8 6 4 14 1 56 39 JAMAICA 23 16 14 5 7 8 2 54 21 ESTONIA 5 5 12 12 8 8 7 7 7 7 7 3 7 53 42 QATAR 35 7 42 HUNGARY 5 5 11 9 6 6 3 3 5 3 5 3 1 39 26 OMAN 17 4 21 ROMANIA 2 2 5 5 2 2 4 4 3 3 1 1 18 16 GERMANY 3 2 4 4 4 2 3 1 15 8 BELGIUM 5 4 7 7 3 2 15 13 URUGUAY 4 6 10 CROATIA 4 4 3 2 2 2 9 8 GREECE 1 3 4 Total 3 3 182 167 333 292 373 311 385 318 425 306 487 70 483 133 2804 1467 100.0% 91.8% 87.7% 83.4% 82.6% 72.0% 14.4% 52% CENTRES BY COUNTRY (Shaded area is prior to start-up) ARGENTINA Hospital LC Lagomaggiore, Mendoza 31 27 32 31 27 27 22 22 25 25 26 5 24 10 197 137 Hospital Ramon Carrillo, Santiagodel Estero 2 2 15 15 19 19 28 28 36 9 27 13 140 73 Hospital Posadas, Buenos Aires 22 22 28 23 17 17 19 18 6 6 15 3 11 3 121 89 Hospital Avellaneda, Tucuman 2 2 11 11 13 12 13 13 10 20 1 70 38 Hospital JR Vidal, Corrientes 4 4 10 6 18 2 14 16 2 64 12 Hospital Sarda, Buenos Aires 3 5 5 11 11 11 6 9 3 42 22 Hospital Penna, BahiaBlanca 12 9 10 9 6 5 3 9 40 23 Hospital AngelaIglesiadeLlano, Corrientes 5 4 9 9 2 2 2 3 21 15 Hospital Juan A Fernandez, Buenos Aires 12 2 14 Hospital Ramos Mejia, Buenos Aires 7 2 1 2 10 2 Hospital Alvarez, Buenos Aires 1 6 1 8 Hospital JM Cullen, SantaFe 3 2 5 BRAZIL University of Campinas, Campinas 2 2 17 11 15 6 17 2 13 5 16 1 9 2 91 27 Maternidade Escola da UFRJ, Rio de Janeiro 8 8 16 15 18 18 14 12 15 2 12 7 90 55 University of Pernambuco, Recife 13 12 14 13 10 9 17 13 2 56 47 Maternidade Escola de Vila Nova Cachoeirinha, Sao Paulo 18 19 1 38 Hospital UniversitariodeJundiai, Jundiai 22 5 27 Hospital SaoLucas, PortoAlegre 5 11 10 1 27 Hospital UniversitarioAntonioPedro, Niteroi 1 1 10 10 5 5 2 2 2 1 5 25 19 Perinatal, Rio de Janeiro 8 8 3 1 1 2 3 17 9 ISCMPA-Maternidade Mario Totta, Porto Alegre 5 4 4 4 3 3 1 13 11 Botucatu Medical School, Botucatu 4 4 3 1 12 Hospital MaternoInfantil, Goiania 2 2 4 2 2 2 10 4 Hospital das Clinicas da UFPE, Recife 4 1 2 7 InstitutodeMedicinaIntegral Prof. FernandoFigueira (IMIP), Recife 1 1 CANADA Sunnybrook Health Sciences Centre, Toronto 3 3 14 14 11 10 13 12 18 17 8 7 9 1 5 3 84 64 IWK Health Centre, Halifax 1 1 4 4 6 6 4 4 6 6 6 2 2 29 23 ReginaGeneral Hospital, Regina 5 4 7 7 3 2 2 2 6 1 1 1 25 16 McMaster University Medical Centre, Hamilton 10 10 7 7 4 4 4 4 25 25 Trillium Health Centre, Mississauga 6 4 4 6 3 1 17 7 Lion's Gate Hospital, Vancouver 6 6 1 1 2 2 2 3 2 16 9 St Joseph's Health Care, London 1 1 6 1 2 1 10 2 Mount Sinai Hospital, Toronto 5 3 2 1 3 3 10 7 Foothills Medical Centre, Calgary 1 1 5 4 1 1 1 1 1 9 7 SMBD Jewish General Hospital, Montreal 2 4 1 2 8 1 North Bay General Hospital, North Bay 5 2 1 6 2 Royal Columbian Hospital, NewWestminster 3 3 3 3 6 6 Royal University Hospital, Saskatoon 4 1 1 1 6 1 Women s Health Centre, St John's 1 1 2 2 3 3 TorontoEast General, Toronto 1 1 1 1 1 3 2 St Paul's Hospital, Vancouver 1 1 Children's & Women's Health Centre of BC, Vancouver 1 1 York Central Hospital, RichmondHill 1 1 ISRAEL Nazareth Hospital (EMMS), Nazareth 18 18 19 2 17 3 57 20 Ma'ayney HaYeshuaMedical Center, Bnei Brak 5 5 4 4 5 5 4 4 5 5 8 3 1 35 23 Edith Wolfson Medical Center, Holon 11 11 6 6 6 6 4 4 2 2 2 31 29 Holy Family Hospital, Nazareth 10 15 5 30 HaEmek Medical Center, Afula 1 1 7 6 2 2 2 2 1 13 11 Hillel YaffeMedical Center, Hadera 3 3 3 2 2 3 1 12 5 PoriyaGovernment Hospital, Tiberias 3 3 3 1 1 4 4 1 12 8 Bnai Zion Medical Center, Haifa 4 4 7 7 11 11 POLAND Univ School of Medicine, Poznan 3 3 24 24 15 14 33 33 26 21 22 7 3 133 95 Polish Mother's Memorial Hospital, Lodz 1 2 10 8 2 3 26 Medical University of Gdansk, Gdansk 1 1 3 2 1 1 1 1 1 1 8 5

PAGE 5 Status 2003 2004 2005 2006 2007 2008 2009 2010 2011 Totals As of May 2011 UK BradfordRoyal Infirmary, Bradford 8 4 4 3 2 1 15 1 6 2 37 9 Nottingham City Hospital, Nottingham 2 2 2 2 3 2 2 2 7 4 1 7 2 26 12 Basildon & Thurrock University Hospital, Basildon 1 5 5 3 1 3 2 14 6 Liverpool Women's Hospital, Liverpool 6 6 12 Derriford Hospital, Plymouth 1 1 2 2 2 6 1 12 3 Queen's Medical Centre, Nottingham 6 1 1 1 8 1 City Hospitals Sunderland NHS Foundation Trust, Sunderland 1 4 5 Queen Elizabeth Hospital, King's Lynn 3 2 2 1 5 3 University Hospital of North Staffordshire, Stoke-on-Trent 3 1 4 Lewisham Hospital, London 3 3 CHILE Hospital Dr GustavoFricke, Vinadel Mar 8 8 11 11 8 8 6 6 12 11 11 6 14 3 73 50 Hospital Dr Soterodel Rio, PuenteAlto 5 5 2 1 4 1 14 4 6 10 41 11 SPAIN Hospital Clinic-University of Barcelona, Barcelona 2 2 6 6 10 10 9 9 8 8 7 3 9 1 52 38 Hospital LaPaz, Madrid 22 10 32 Hospital Vall d'hebron, Barcelona 12 4 16 Complejo Hospitalario de Toledo, Toledo 6 2 8 EGYPT Assiut University Hospital, Assiut 19 19 14 14 15 15 6 6 12 1 20 3 89 55 AUSTRALIA Ipswich Hospital, Ipswich 1 1 12 12 9 8 1 4 1 28 21 Mater Mothers' Hospital, Brisbane 2 2 3 2 3 3 1 1 6 1 5 20 9 St GeorgeHospital, Sydney 2 2 5 5 1 1 3 3 1 12 11 Toowoomba Base Hospital, Toowoomba 4 1 2 6 1 Monash Medical Centre, Clayton 4 2 1 5 2 Logan Hospital, Meadowbrook 3 1 1 1 4 2 Women's and Children's Hospital, Adelaide 1 1 1 2 1 Townsville Hospital, Townsville 1 1 1 1 2 2 THE NETHERLANDS AtriumMedical Center, Heerlen 4 4 5 5 7 7 5 4 6 6 2 2 5 34 28 Academisch Ziekenhuis Maastricht, Maastricht 3 3 2 2 1 1 3 10 5 MaximaMedical Centre, Veldhoven 2 5 7 Maaslandziekenhuis Sittard, Sittard 2 2 5 5 7 7 Sint Lucas Andreas Ziekenhuis, Amsterdam 4 2 1 1 5 3 SERBIA University of Belgrade, Belgrade 27 22 24 6 6 1 58 28 USA East Bay Perinatal Medical Associates, Oakland 9 5 5 1 4 1 1 3 22 7 MaricopaMedical Center, Phoenix 3 2 3 2 2 1 3 12 4 University of Miami, Miami 1 10 11 University of South Carolina, Columbia 1 1 2 2 3 3 6 6 Texas Tech UHSC, Lubbock 2 2 JamaicaHospital Medical Center, Jamaica 2 2 2 2 University of Iowa Hospitals and Clinics, Iowa City 1 1 1 1 2 2 JORDAN Islamic Hospital, Amman 5 5 5 5 8 8 9 9 8 8 6 4 14 1 56 39 JAMAICA University Hospital of thewest Indies, Kingston 23 16 14 5 7 8 2 54 21 ESTONIA Tartu University Hospital - Women's Clinic, Tartu 5 5 12 12 8 8 7 7 7 7 7 3 7 53 42 QATAR HamadMedical Corporation, Doha 35 7 42 HUNGARY University of Debrecen, Debrecen 5 5 11 9 6 6 3 3 5 3 5 3 1 39 26 OMAN Khoula Hospital, Muscat 17 4 21 ROMANIA University of Pharmacy and Medicine, Cluj-Napoca 2 2 5 5 2 2 4 4 3 3 1 1 18 16 GERMANY Ludwig Maximilians University of Munich, Munich 1 1 4 4 3 2 1 9 7 CUB - VirchowKlinikum, Berlin 3 3 CUB - Benjamin Franklin, Berlin 2 1 1 3 1 BELGIUM VrijeUniversiteit Brussel, Brussels 5 4 7 7 3 2 15 13 URUGUAY PereiraRossell Hospital, Montevideo 4 6 10 CROATIA Sveti Duh Hospital, Zagreb 4 4 3 2 2 2 9 8 GREECE Alexandra Maternity, Athens 1 3 4