What our equipment teaches us

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What our equipment teaches us James H. Philip, ME(E), MD, CCE Brigham and Women s Hospital Anesthesiologist, Director of Anesthesia Clinical Bioengineering Professor of Anaesthesia, Harvard Medical School Presented at ISO TC 121 Panel on Anesthesia Technology and Innovation May 24, 2017 Copyright 2016-2017, James H. Philip, all rights reserved.

J Philip

My story I began my education as an Engineer (Cornell U I learned it well I entered a field of medicine I chose Anesthesiology because it needed the most engineering Each problem I encountered led me to an Engineering Solution I have had the the opportunity to Engineer for Life I have had the opportunity to observe and encourage others to innovate

Practice-Based Learning PBL is a key element of continuing graduate medical education In anesthesia, we can learn from everything we do We give medicines and techniques that move in seconds and act in minutes Each drug or technique acts on each patient in a variable way We are there to act and watch If we have the right tools and insights We can observe, analyze, synthesize, generalize, and have a model We can use what we learn from one patient on the next patient We can learn what to look for in each new patient to refine our model Eventually we do an IRB-approved study to prove to ourselves and others that what we learned is right, valuable, and should be done and taught by others. Or to learn to stop doing what we thought was so good

E We have a myriad of tools around us

GE Aisys Draeger Apollo GS 2017 state-of-the-art USA

Mindray A7 Draeger Perseus 2017 new to the USA

Products to hold ET constant exist in most countries but not yet in USA Draeger Zeus GE Aisys ETC Maquet Flow-i

Innovative companies need to Meet the Standards Meet the desires of the market Meet the needs of the market Meet the constraints of the payers Provide the tools for innovative physicians to explore and expand the limits of patient care If Standards block our path, we must revise them after due consideration of safety

Clinical Situation Obese female for robot-assisted hysterectomy General Anesthesia, Steep Trendelenburg position Peritoneal insufflation 30 mmhg High CO2 absorption -> Need higher MV (minute ventilation) VCV with P max > 40 cmh2o sounds P max alarms and quits breath How can we ventilate? Is patient being harmed by the high pressure? Need to test Want to know pressure the lung feels and make sure it is safe Conservative estimate will be Tube Tip Pressure (TTP) Case is underway and everyone is worried 30 o

Pressure connections made for this patient during this case P TT Gas Sample Line P Y

Volume Controlled Ventilation VCV Peak Pressure is maximum pressure reached Inspiratory pause (% of inspiratory time) is set Here, Inspiratory Pause is set to 20% TIP:TI (Time of Inspiratory Pause/Time of Inspiration) Draeger acronym for pause Pressure during pause is called Plateau Pressure (Draeger) Pause Pressure (GE)

TT and Y(wye) Pressure Monitoring Focus on this Y Pressure

TT and Y Pressure Monitoring Focus on this Y Pressure TT Transducer switched on to show TT Pressure

TT and Y Pressure Monitoring Note TT pressure reaches Inspiratory Pause pressure and no more Also, these pressures are mmhg for vascular monitoring. We are using mmhg for airway pressure Not the usual cmh2o

Where is the pressure drop? Where is the pressure drop between Y and TT? Pull back the Tube Pressure monitoring tube Measure pressure at several locations Most of the pressure drop is at tube connector Actually known for 40 years, but long forgotten

Resistance should be computed and monitored Only the machine knows the inspiratory flow rate Only the machine can compute inspiratory resistance R = DP / DF Anesthesiologist will be confused each time any of these are changed RR, I/E time ratio, Set TV They all will affect PP TTP None will affect Resistance measured during inspiratory flow, R i If R insp does go up, ET Tube is probably kinked and should be adjusted Philip JH. Anesthesia Machine as a Monitor. In: Ehrenfeld J, Cannesson M. Monitoring Technologies in Acute Care Environments, Springer, 2014, 197-201.

PCV Pressure Note that P TT never reaches P Y Y TT

Plot graph of Cost and determinants

Plot graph of Cost and determinants, like Gas Man does Compute and Display great graphs FGF Philip JH. Gas Man - An example of goal oriented computerassisted teaching which results in learning. In: J Clin Monit & Comp. 1986;3:165-173. PMID: 3540162 www.gasmanweb.com www.medmansimulations.org Download Gas man free Cost

Show us breath-by-breath when w need it High FGF and vaporizer setting

Second Breath, Inspired = Vaporizer setting

Give us great time-aligned graphic trends to tell most of the story SpO2 PR BP I&E O2 I&E Agent I&E CO2 MV RR

A better data set and temporal graphic display might look like this, or might look however the clinician or data analyst wanted to view it on the way to computer analysis Careful temporal alignment of graphic trends will uncover causal relationships that the human mind might overlook

Request of Standards writers Please keep creating Standards that assure product safety and efficacy Whenever possible, add additional measures and temporally aligned graphic trend displays that will allow patient care providers the provide the safest, best, and most educational care Require that machine error logs be readable by Qualified Service Personnel (like Hospital CEs and BMETs)

Thank you For more information and posted lectures, look here http://tinyurl.com/jhphilip http://tinyurl.com/jhphilip