W. SCHANZER H. GEYER A. GOTZMANN U. MARECK-ENGELKE (Editors) RECENT ADVANCES IN DOPING ANALYSIS (4) Proceedings of the Manfred Donike Workshop 14th Cologne Workshop on Dope Analysis 17th to 22nd March 1996 SPORT und BUCH Straufi Koln 1997
Table of Contents Obituary: Prof. Dr. rer. nat. Manfred Donike I Biochemical Aspects of Steroid Hormones V. ROGOZKIN, B. FELDKOREN: Feasible Mechanism of the Testosterone Anabolic Action 13 S. RENDIC: Drug Interactions in Biosynthesis and Metabolism of Steroid Hormones: The Role of Human Cytochrome P450s 21 II Anabolic Androgenic Steroids W. SCHANZER, S. HORNING, G. OPFERMANN, M. DONIKE: Gas Chromatography/Mass Spectrometry Identification of Long-term Excreted Metabolites of the Anabolic Steroid 4-Chloro-l,2-dehydro-17amethyltestosterone in Humans 33 V.P. URALETS, P.A. GILLETTE, R.K. LATVEN: Occurrence of 19-Nordehydro-Androsterone/Etiocholanolone in Nandrolone Positive Specimens 35 D. THIEME, J. GROSSE, R.K. MUELLER: Observations on new Metabolites of Clostebol by High-Resolution-MS 43 III Steroid Profile X. DE LA TORRE, J.A. PASCUAL, J. ORTUNO, J. SEGURA: Steroid Profile and Sports A Cluster Analysis of Samples from Barcelona '92 Olympic Games 59 X. DE LA TORRE,J. SEGURA, Z. YANG, Y. LI, M. WU: Testosterone Detection in Different Ethnic Groups 71 C. AYOTTE, A. CHARLEBOIS: T/E Values: Measurements and Observations 91
P. HEMMERSBACH, K.I. BIRKELAND, H.R. NORLI, S.H. RINGERTZ: Urine Storage Conditions and Steroid Profile Analysis 99 H. GEYER, U. MARECK-ENGELKE, W. SCHANZER, M. DONIKE: The Cologne Protocol to Follow up High Testosterone / Epitestosterone Ratios 107 C. AYOTTE, A. CHARLEBOIS, S. LAPOINTE, D. BARRIAULT, M. SYLVESTRE: Validity of Urine Samples: Microbial Degradation 127 U. MARECK-ENGELKE, U. FLENKER, W. SCHANZER: Stability of Steroid Profiles (6): The Influence of Oral Contraceptives on Steroid Profiles 139 C. SCHWEIZER, C. CARDIS, M. CAUDERAY, L. RIVIER, M. SAUGY: T/E Ratio Variations through Puberty in Male Adolescents 159 SB. COUTTS, A.T. KICMAN, D.A. COWAN: Intramuscular Administration of 5a-Dihydrotestosterone Heptanoate: Changes in the Urinary Hormone Profile 173 W. SCHANZER: Metabolism of Anabolic Androgenic Steroids: 5a- and 5P-Reduction of 3-Keto-4-ene Steroids I 85 U. FLENKER, E. NOLTEERNSTING, W. SCHANZER, M. DONIKE: Detection and Classification of Different Male Steroid Profiles by Means of Multivariate Statistics 203 IV Sample Preparation PH. DELAHAUT: Immunoassays and Immunoaffinity Chromatography for the Detection of Drug Residues 211 M. MACHNIK, P. DELAHAUT, S. HORNING, W. SCHANZER: Purification and Concentration of Anabolic Steroids by Immuno Affinity Chromatography (IAC) 223
A. GOTZMANN, H. GEYER, W. SCHANZER: HPLC Clean-up for Urine Samples with Disturbing Background for Confirmation of 17B-methyl-5B-androst-l-ene-3a,17a-diol (Epimetenediol) 239 G. OPFERMANN, W. SCHANZER: Trimethylsilylation - Aspects for Derivatisation 247 V Techniques of MS Detection S. HORNING, W. SCHANZER: Basics of High Resolution Mass Sectrometry 253 S. HORNING, W. SCHANZER: Steroid Screening Using GC/HRMS 261 M. GARLE: Ion Trap - Different Problems and Discussion 271 S. HORNING, H. GEYER, M. MACHNIK, W. SCHANZER, A. HILKERT, J. OEBELMANN: Detection of Exogenous Testosterone by 13c/l 2 C Analysis 275 VI Peptide Hormones P. LAIDLER, DA. COWAN, R.C. HIDER, AT. KICMAN: Qualitative Analysis of hcg for Confirmatory Purposes 285 C. CARDIS, C. SCHWEIZER, M. SAUGY, L. RIVIER: Ketoconazole Test: Blood versus Urine Values 305 A. BREIDBACH, P. PLATEN, W. SCHANZER: Erythropoietin - Influence of Physical Strain and Application on Concentrations in Blood and Urine 319 VII Improvement of Detection A. DURUSSEL, C. CARDIS, C. SCHWEIZER, L. RIVIER, G. BRISSON, M. SAUGY: Influence of Creatine Intake upon Biochemical Parameters in Urine 323
E. UMPIERREZ, D. LORENZO: Three Cases of Misleading Results in Drug Analysis re-analyzed by GC/MS 335 R. VENTURA, G. GONZALEZ, M.T. SMEYERS, R. DE LA TORE, J. SEGURA: Screening of B-Adrenergic Antagonists in Human Urine by ELISA Techniques 343 D. DE BOER, M. VAN BEEK, C.H.J. BEKKERS, R.A.A. MAES: The Detection of the Administration of Salmeterol in Urine after Inhalation 357 S. ZHU, S. YANG: Determination of Benzthiazide in Human Urine by HPLC-ES/MS *) 371 S. YANG, S. ZHU, Z. YANG: Detection of Mesocarb in Human Urine by HPLC-Electrospray / Mass Spectrometry *) 377 VIII Organisation of Doping Control FT. DELBEKE: Doping Control in Flanders: Facts, Results and Statistics 385 E. NOLTEERNSTING, I. MATONDO, E. MURWISI, W. SCHANZER: Brief Report of the Doping Analyses during the 6th All Africa Games in Harare 1995 (September, 13th - 24th) 403 *) These papers were presented during the 13th Cologne Workshop on Dope Analysis 12th to 17th March, 1995. As a matter of fact they were not published in the Proceedings connected to this Workshop: 'Recent Advances in Doping Analysis (3). Koln 1996'. We apologize for this misunderstanding. The Editors