Nicotine MSDS Name: l-nicotine Material Safety Data Sheet Synonym: S-(-)-Nicotine; B-Pyridyl-a-N-Methylpyrrolidine CAS: 54-11-5 Section 1 - Chemical Product MSDS Name: l-nicotine Synonym: S-(-)-Nicotine; B-Pyridyl-a-N-Methylpyrrolidine. Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name EINECS# 54-11-5 Nicotine 200-193-3 Hazard Symbols: T+ Risk Phrases: 25 27 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Toxic if swallowed. Very toxic in contact with skin.hygroscopic (absorbs moisture from the air). Potential Health Effects Eye: May cause eye irritation. May cause skin irritation. May be fatal if absorbed through the skin. Ingestion: May be fatal if swallowed. May cause adverse effects of the musculature. May cause severe digestive tract irritation with abdominal pain, nausea, vomiting and diarrhea. May cause tremors and convulsions. May cause muscle paralysis, respiratory failure, and possible death. Inhalation: May cause effects similar to those described for ingestion. Chronic: May cause digestive tract and cardiac disturbances. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Discard contaminated clothing in a manner which limits further exposure. Destroy contaminated shoes. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Can form explosive mixtures at temperatures above the flashpoint. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Extinguishing Media: For small fires, use water spray, dry chemical, carbon dioxide or chemical foam. Water or foam may cause frothing. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Avoid runoff into storm sewers and ditches which lead to waterways. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section). Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as sawdust. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not reuse this container. Do not get on skin or in eyes. Do not ingest or inhale. Storage: Keep away from sources of ignition. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from strong acids. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Exposure Limits CAS# 54-11-5: United Kingdom, WEL - TWA: 0.5 mg/m3 TWA United Kingdom, WEL - STEL: 1.5 ppm STEL United States OSHA: 0.5 mg/m3 TWA Belgium - TWA: 0.5 mg/m3 VLE France - VME: 0.5 mg/m3 VME Germany: 0.07 ppm TWA; 0.47 mg/m3 TWA Germany: Skin absorber Malaysia: 0.5 mg/m3 TWA Netherlands: 0.07 ppm MAC; 0.5 mg/m3 MAC Spain: 0.5 mg/m3 VLA-ED Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Wear impervious gloves. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Liquid Color: colorless to light yellow Odor: Slight fish odor when warm. ph: 10.2 Vapor Pressure: 1 mm Hg @ 61.8C Viscosity: exposure to air Boiling Point: 247 deg C @ 760.00mm Hg Freezing/Melting Point: -80 deg C Autoignition Temperature: 240 deg C ( 464.00 deg F) Flash Point: 101 deg C ( 213.80 deg F) Explosion Limits, lower:.70 vol % Explosion Limits, upper: 4.00 vol % Decomposition Temperature: Solubility in water: IN WATER: MISCIBLE BELOW 60 C Specific Gravity/Density: 1.0100g/cm3 Molecular Formula: C10H14N2 Molecular Weight: 162.23 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong acids, strong oxidizers. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 54-11-5: QS5250000 LD50/LC50: CAS# 54-11-5: Oral, mouse: LD50 = 3340 ug/kg; Oral, rat: LD50 = 50 mg/kg; Skin, rabbit: LD50 = 50 mg/kg; Skin, rat: LD50 = 140 mg/kg. Carcinogenicity: Nicotine - Not listed by ACGIH, IARC, or NTP. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Ecotoxicity: Fish (fresh water) 3-29ppm toxic (time period not specified). Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Packing Group: II IMO Packing Group: II RID/ADR Packing group: II USA RQ: CAS# 54-11-5: 100 lb final RQ; 45.4 kg final RQ Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: T+
Risk Phrases: R 25 Toxic if swallowed. R 27 Very toxic in contact with skin. Safety Phrases: S 36/37 Wear suitable protective clothing and gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 54-11-5: No information available. Canada CAS# 54-11-5 is listed on Canada's DSL List. CAS# 54-11-5 is listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 54-11-5 is listed on the TSCA inventory.