Page 1 of 6 SECTION 1: Identification of the substance/mixture and of the company/undertaking Product identifier Further trade names Succinimidyl 2,2,2-trichlororethyl carbonate, Troc-NHS, N- (2,2,2-Trichloroethoxycarbonyloxy)succinimide CAS No.: 66065-85-8 Relevant identified uses of the substance or mixture and uses advised against Details of the supplier of the safety data sheet Company name: Street: Place: Post-office box: Waldershofer Str. 49-51 D-95615 Marktredwitz 568 D-95615 Marktredwitz Telephone: +49 9231 9619 73 Telefax: +49 9231 9619 99 e-mail: Internet: Emergency telephone: SECTION 2: Hazards identification Classification of the substance or mixture info@iris-biotech.de www@iris-biotech.de +49 (0)89 19240 Indications of danger : Harmful, Irritant R-phrases: Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes and respiratory system. GHS classification Hazard categories: Acute toxicity: Acute Tox. 4 Serious eye damage/eye irritation: Eye Irrit. 2 Specific target organ toxicity - single exposure: STOT SE 3 Hazard Statements: Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. May cause respiratory irritation. Causes serious eye irritation. Label elements Signal word: Pictograms: Warning GHS07 Hazard statements H302 H312 H332 Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.
Page 2 of 6 H319 H335 Causes serious eye irritation. May cause respiratory irritation. Precautionary statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. SECTION 3: Composition/information on ingredients Substances Sum formula: C7H6Cl3NO5 Molecular weight: 290,49 Hazardous components EC No. CAS No. Index No. REACH No. 66065-85-8 Chemical name Classification GHS classification Xn, Xi R20/21/22-36/37 Acute Tox. 4, Eye Irrit. 2, STOT SE 3; H302 H312 H332 H335 H319 Quantity 100 % Full text of R- and H-phrases: see section 16. SECTION 4: First aid measures Description of first aid measures General information In case of accident or if you feel unwell, seek medical advice immediately (show safety data sheet if possible). After inhalation Remove casualty to fresh air and keep warm and at rest. In case of irregular breathing or respiratory arrest provide artificial respiration. In all cases of doubt, or when symptoms persist, seek medical advice. After contact with skin After contact with skin, wash immediately with plenty of water and soap. In all cases of doubt, or when symptoms persist, seek medical advice. After contact with eyes In case of contact with eyes, rinse immediately with plenty of flowing water for 10 to 15 minutes holding eyelids apart. Subsequently consult an ophthalmologist. After ingestion Rinse mouth thoroughly with water. Never give anything by mouth to an unconscious person or a person with cramps. In all cases of doubt, or when symptoms persist, seek medical advice. SECTION 5: Firefighting measures Extinguishing media Suitable extinguishing media Water spray. alcohol resistant foam. Dry extinguishing powder. Carbon dioxide (CO2). Sand. Special hazards arising from the substance or mixture Thermal decomposition can lead to the escape of irritating gases and vapours. Can be released in case of fire: Carbon dioxide (CO2). Carbon monoxide. Nitrogen oxides (NOx).
Page 3 of 6 Hydrogen chloride (HCl). Advice for firefighters Wear a self-contained breathing apparatus and chemical resistant suit. Additional information Usual measures for fire prevention. SECTION 6: Accidental release measures Personal precautions, protective equipment and emergency procedures Avoid breathing dust/fume/gas/mist/vapours/spray. Provide adequate ventilation. Avoid contact with skin, eye and clothing. Wear personal protection equipment. In case of fire: Evacuate area. Environmental precautions Do not allow to enter into soil/subsoil. Do not empty into drains or the aquatic environment. Methods and material for containment and cleaning up Remove mechanically, placing in appropriate containers for disposal. Avoid generation of dust. Clear contaminated area thoroughly. SECTION 7: Handling and storage Precautions for safe handling Advice on safe handling Avoid generation of dust. Avoid breathing dust/fume/gas/mist/vapours/spray. Provide adequate ventilation. Avoid contact with skin, eye and clothing. Advice on protection against fire and explosion Usual measures for fire prevention. Conditions for safe storage, including any incompatibilities Requirements for storage rooms and vessels Keep container tightly closed in a cool, well-ventilated place. Protect from moisture. Storage: Inert gas: nitrogen Recommended storage temperature: 2-8 C SECTION 8: Exposure controls/personal protection Control parameters Additional advice on limit values Exposure controls The receiver of our product is singulary responsible for adhering to existing laws and regulations. Protective and hygiene measures Avoid contact with skin, eye and clothing. Provide adequate ventilation. When using do not eat, drink or smoke. Wash hands before breaks and at the end of work. Respiratory protection Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Hand protection Wear suitable gloves.
Page 4 of 6 In the cases of special applications, it is recommended to check the chemical resistance with the manufacturer of the gloves. Eye protection Wear suitable protective clothing, gloves and eye/face protection. Skin protection Wear suitable protective clothing, gloves and eye/face protection. SECTION 9: Physical and chemical properties Information on basic physical and chemical properties Physical state: Colour: solid Test method Changes in the physical state Melting point: 111-113 C SECTION 10: Stability and reactivity Reactivity Chemical stability The product is stable under normal conditions (room temperature) Possibility of hazardous reactions Conditions to avoid Keep away from heat. Incompatible materials Oxidizing agents, strong. strong alkalis Hazardous decomposition products Thermal decomposition can lead to the escape of irritating gases and vapours. Can be released in case of fire: Carbon dioxide (CO2). Carbon monoxide. Nitrogen oxides (NOx). Hydrogen chloride (HCl). SECTION 11: Toxicological information Information on toxicological effects Toxicocinetics, metabolism and distribution Acute toxicity CAS No. Chemical name Exposure routes Method Dose Species h 66065-85-8 Acute oral toxicity Acute dermal toxicity ATE 500 mg/kg ATE 1100 mg/kg Specific effects in experiment on an animal Irritation and corrosivity Irritating to eyes, respiratory system and skin.
Page 5 of 6 Harmful if inhaled. May cause respiratory irritation. Harmful if swallowed. Harmful in contact with skin. Sensitizing effects Severe effects after repeated or prolonged exposure Carcinogenic/mutagenic/toxic effects for reproduction SECTION 12: Ecological information Toxicity Persistence and degradability Bioaccumulative potential Mobility in soil Results of PBT and vpvb assessment SECTION 13: Disposal considerations Waste treatment methods Advice on disposal Waste disposal according to official state regulations. Consult the local waste disposal expert about waste disposal. Handle contaminated packaging in the same way as the substance itself. SECTION 14: Transport information Land transport (ADR/RID) Inland waterways transport Marine transport Air transport UN/ID number: Transport hazard class(es): Not a hazardous material with respect to these transportation regulations. Not a hazardous material with respect to these transportation regulations. Not a hazardous material with respect to these transportation regulations. 3335 Hazard label: 9 Special Provisions: A27 - A48 Limited quantity Passenger: - IATA-packing instructions - Passenger: IATA-max. quantity - Passenger: IATA-packing instructions - Cargo: AVIATION REGULATED SOLID, N.O.S. (Succinimidyl 2,2,2-trichlororethyl carbonate) 9 906 100 kg 906
Page 6 of 6 IATA-max. quantity - Cargo: Other applicable information (air transport) E0 : - SECTION 15: Regulatory information 200 kg Safety, health and environmental regulations/legislation specific for the substance or mixture EU regulatory information Additional information Safety Data Sheet (REACH) National regulatory information Water contaminating class (D): Chemical Safety Assessment 3 - highly water contaminating For this substance a chemical safety assessment has not been carried out. SECTION 16: Other information Full text of R-phrases referred to under sections 2 and 3 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. 36/37 Irritating to eyes and respiratory system. Full text of H-Statements referred to under sections 2 and 3 H302 Harmful if swallowed. H312 Harmful in contact with skin. H319 Causes serious eye irritation. H332 Harmful if inhaled. H335 May cause respiratory irritation. Further Information Warning - substance not yet tested completely. The product is intended for research, analysis and scientific education. The receiver of our product is singulary responsible for adhering to existing laws and regulations. The information is based on present level of our knowledge. It does not, however, give assurances of product properties and establishes no contract legal rights. The above information describes exclusively the safety requirements of the product and is based on our present-day knowledge. The information is intended to give you advice about the safe handling of the product named in this safety data sheet, for storage, processing, transport and disposal. The information cannot be transferred to other products. In the case of mixing the product with other products or in the case of processing, the information on this safety data sheet is not necessarily valid for the new made-up material.