Noticias News Nouvelles The Centre for Mother, Infant, and Child Research 7 th Floor, 790 Bay Street Toronto ON CANADA M5G 1N8 Tel: 1 416 351 2533 Fax: 1 416 351 3771 email: tbs@sw.ca website: www.cmicr.ca/tbs V O L U M E 8, I S S U E 7 J U L Y 3 1, 2 0 0 9 Overall Total: 2001 Total this month: 54 I N S I D E T H I S I S S U E Recruitment Record 2000 Recruits! 1 Reminder: Interim Analysis 1 Query Tutorial 2 Interim Analysis & Data Campaign 1 3 Recruitment Record! We have set a new monthly recruitment record! Thank you to all of our recruiting centres for making this milestone possible. Excellent work! 2000 Recruits! Congratulations to Dr George Carson and the team at Regina General Hospital in Regina, Canada for recruiting the 2000th patient into the Twin Birth Study. Let s aim to complete our recruitment goal of 2800 recruits by this time next year! Monthly Feature Congratulations Dr Raquel Martin Congratulations 1st Recruit Recruitment Excellence Recruitment Table 2yr Table 4 5 5 5 6 8 Reminder: 2 nd Interim Analysis Please send any outstanding primary data to the Data Coordinating Centre by courier and send any queries by email or fax today. The interim analysis begins at the end of August and the Data Safety and Monitoring Board will meet in November to review the results. Your help in sending the outstanding primary data is greatly appreciated!
P A G E 2 Query Tutorial Page 2 of the Clinical Neurodevelopmental Assessment Form, please note that if the child does not have cerebral palsy you do not need to complete the rest of the form. Please do not continue to question 7b.
P A G E 3 Data campaign for the interim analysis Again this month we are recognizing centres with 100% complete and clean data. We look forward to adding more centres to this list. If your centre has any outstanding data and/or queries, please send them to the Data Coordinating Centre as soon as possible. Congratulations to the following centres with 100% complete and clean data for the first 1800 recruits! COUNTRY CITY CENTRE ARGENTINA Bahia Blanca Hospital Penna Santiago del Estero Hospital Ramon Carrillo AUSTRALIA Adelaide Women's and Children's Hospital Clayton Monash Medical Centre Ipswich Ipswich Hospital Meadowbrook Logan Hospital Sydney St George Hospital Toowoomba Toowoomba Base Hospital Townsville Townsville Hospital BRAZIL Goiania Hospital Materno Infantil Porto Alegre ISCMPA-Maternidade Mario Totta CANADA Calgary Foothills Medical Centre Halifax IWK Health Centre Hamilton McMaster University Medical Centre London St Joseph's Health Care Mississauga Trillium Health Centre New Westminster Royal Columbian Hospital North Bay North Bay General Hospital Regina Regina General Hospital Saskatoon Royal University Hospital St John's Eastern Health Toronto Mount Sinai Hospital Vancouver Lions Gate Hospital CHILE Vina del Mar Hospital Dr Gustavo Fricke CROATIA Zagreb Sveti Duh Hospital ESTONIA Tartu Tartu University Hospital GERMANY Berlin CUB - Benjamin Franklin Munich Ludwig Maximilians University of Munich ISRAEL Afula HaEmek Medical Center Hadera Hillel Yaffe Medical Center Haifa Bnai Zion Medical Center Nazareth Nazareth Hospital (EMMS) (Continued on page 4)
P A G E 4 (Continued from Data Campaign for the Interim Analysis page 3) COUNTRY CITY CENTRE ISRAEL Tiberias Poriya Government Hospital SPAIN Barcelona Hospital Clinic-University of Barcelona THE NETHERLANDS Amsterdam Sint Lucas Andreas Ziekenhuis Heerlen Maastricht Atrium Medical Center Academisch Ziekenhuis Maastricht UK Bradford Bradford Royal Infirmary London Nottingham Plymouth Lewisham Hospital Derriford Hospital USA Columbia University of South Carolina Iowa City Miami Nottingham City Hospital University of Iowa Hospitals and Clinics University of Miami Oakland Phoenix Monthly Feature East Bay Perinatal Medical Associates Maricopa Medical Center This month, we feature Laura Kennedy, the coordinator from St Joseph's Health Care in London, Canada. St Joseph s Health Centre became active in October 2008 and has already recruited 5 patients into TBS. We congratulate the team for a job well done! Laura writes: I am very excited to be a part of the Twin Birth Study! This is the first international clinical trial that I have been involved with and it was great to meet collaborators from around the world at the New Investigators Meeting in April. Although it can be difficult to recruit for this study, I know that each woman who joins is helping to answer a vital question that may change the practice of physicians around the world. That makes each recruitment at our site very rewarding. I enjoy meeting and developing a relationship with the patients and their families and look forward to enrolling many more women in this important study!
Congratulations! P A G E 5 We wish to congratulate Dr Raquel Martin at Hospital LC Lagomaggiore in Mendoza, Argentina for recruiting the centre s 150th patient! Great work! Congratulations on your first recruits We send congratulations to Dr Nelson Sass and the team at Maternidade Escola de Vila Nova Cachoeirinha in Sao Paulo, Brazil. Congratulations on recruiting four patients within one month of becoming active! Excellent job! Recruitment Excellence Congratulations to Dr Jesus Daniel Aguirre and the team at Hospital JR Vidal, Corrientes, Argentina; Dr Caio Coelho Marques and the team at University Hospital Sao Lucas, Porto Alegre, Brazil; Dr Danielly Scaranello Nunes Santana and the team at Hospital Universitario de Jundiai, Jundiai, Brazil; Dr George Carson and the team at Regina General Hospital, Regina, Canada; Dr Ramesh Kulkarni and the team at North Bay General Hospital, North Bay, Canada; Dr Fred Kirss and the team at Tartu University Hospital - Women s Clinic, Tartu, Estonia; Dr Dalia Mansour-Schwake and the team at Holy Family Hospital, Nazareth, Israel; and Prof Miroslava Gojnic and the team at University of Belgrade, Belgrade, Serbia. Keep up the excellent work! We will be sending a gold seal to place on your Certificate of Achievement.
Twin Birth Study Recruitment (Projected sample size of 2800) as of July 31, 2009 Annual Jun Jul - Apr May June July Grand Goal 2003 2004 2005 2006 2007 2008 2008 2009 2009 2009 2009 Total COUNTRY ARGENTINA 63 60 65 96 107 54 68 39 13 13 15 530 BRAZIL 65 2 44 71 54 35 28 30 5 7 12 288 CANADA 97 3 25 53 46 41 11 18 15 3 4 6 225 POLAND 15 4 28 18 44 14 21 14 2 145 ISRAEL 46 21 27 16 14 10 22 11 2 2 6 131 EGYPT 20 19 14 15 6 9 3 6 1 4 2 79 CHILE 16 8 11 13 8 5 11 14 7 77 UK 51 2 2 15 18 7 9 8 2 1 3 67 AUSTRALIA 32 2 15 12 17 10 4 3 2 65 THE NETHERLANDS 10 7 9 17 6 4 2 2 1 48 ESTONIA 3 5 12 8 7 4 3 3 2 1 45 SERBIA 11 9 18 11 3 1 2 44 USA 31 4 13 10 8 3 2 2 42 SPAIN 5 2 6 10 9 5 3 3 1 1 40 JAMAICA 4 23 5 9 3 40 JORDAN 9 5 5 8 9 6 2 4 1 40 HUNGARY 4 5 11 6 3 3 2 3 1 1 35 ROMANIA 3 2 5 2 4 2 1 1 17 BELGIUM 3 5 7 3 15 GERMANY 9 3 4 4 3 1 15 CROATIA 4 4 3 2 9 GREECE 6 1 3 4 Total 507 3 182 333 373 385 199 226 169 41 36 54 2001 CENTRES BY COUNTRY (Shaded area is prior to start-up) ARGENTINA Hospital LC Lagomaggiore, Mendoza 12 31 32 27 22 10 15 7 1 4 2 151 Hospital Posadas, Buenos Aires 6 22 28 17 19 4 2 7 3 1 2 105 Hospital Ramon Carrillo, Santiago del Estero 10 2 15 19 12 16 11 5 2 4 86 Hospital Avellaneda, Tucuman 6 2 11 13 4 9 1 1 4 1 46 Hospital JR Vidal, Corrientes 6 4 10 9 9 5 2 3 42 Hospital Penna, Bahia Blanca 4 12 10 4 2 1 29 Hospital Sarda, Buenos Aires 10 3 5 6 5 6 1 26 Hospital Angela Iglesia de Llano, Corrientes 3 5 9 1 1 2 18 Hospital Juan A Fernandez, Buenos Aires 4 4 8 1 1 14 Hospital Alvarez, Buenos Aires 2 1 1 1 3 Centres that are no longer recruiting 0 10 BRAZIL University of Campinas, Campinas 5 2 17 15 17 6 7 7 1 3 1 76 Maternidade Escola da UFRJ, Rio de Janeiro 6 8 16 18 8 6 3 2 2 63 University of Pernambuco, Recife 7 13 14 10 12 5 1 55 Hospital Universitario Antonio Pedro, Niteroi 5 1 10 5 1 1 2 20 Hospital Universitario de Jundiai, Jundiai 5 9 2 2 2 15 Perinatal, Rio de Janeiro 8 8 3 1 1 13 ISCMPA-Maternidade Mario Totta, Porto Alegre 6 5 4 2 1 12 Hospital Sao Lucas, Porto Alegre 5 2 3 3 4 12 Hospital das Clinicas da UFPE, Recife 5 4 1 2 7 Botucatu Medical School, Botucatu 2 2 2 2 1 7 Maternidade Escola de Vila Nova Cachoeirinha, Sao Paulo 8 4 4 Hospital Materno Infantil, Goiania 3 2 2 4 CANADA Sunnybrook Health Sciences Centre, Toronto 5 3 14 11 13 18 1 7 3 2 72 McMaster University Medical Centre, Hamilton 5 10 7 4 2 2 25 IWK Health Centre, Halifax 7 1 4 6 4 3 3 2 1 24 Regina General Hospital, Regina 5 5 7 3 2 2 2 21 Trillium Health Centre, Mississauga 6 6 4 6 1 17 Lions Gate Hospital, Vancouver 3 6 1 1 1 1 10 Mount Sinai Hospital, Toronto 11 5 2 3 10 Foothills Medical Centre, Calgary 7 1 5 1 1 1 9 SMBD Jewish General Hospital, Montreal 6 2 2 2 2 8 Royal Columbian Hospital, New Westminster 5 3 3 6 Royal University Hospital, Saskatoon 6 4 1 1 6 St Joseph's Health Care, London 9 1 2 1 2 6 North Bay General Hospital, North Bay 2 3 1 4 Eastern Health, St John's 4 1 2 3 Toronto East General, Toronto 5 1 1 2 Children's & Women's Health Centre of BC, Vancouver 11 1 1 Centres that are no longer recruiting 0 1 POLAND University School of Medical Sciences, Poznan 8 3 24 15 33 8 18 12 2 115 Polish Mothers Memorial Hospital, Lodz 5 1 2 10 6 2 2 23 Medical University of Gdansk, Gdansk 2 1 3 1 1 1 7 ISRAEL Edith Wolfson Medical Center, Holon 5 11 6 6 4 2 1 30 Ma'ayney HaYeshua Medical Center, Bnei Brak 10 5 4 5 4 1 4 1 1 1 1 27 Nazareth Hospital (EMMS), Nazareth 3 5 13 5 1 2 26 HaEmek Medical Center, Afula 7 1 7 2 2 12 Poriya Government Hospital, Tiberias 4 3 3 1 4 1 12
Annual Jun Jul - Apr May June July Grand Goal 2003 2004 2005 2006 2007 2008 2008 2009 2009 2009 2009 Total Bnai Zion Medical Center, Haifa 8 4 7 11 Hillel Yaffe Medical Center, Hadera 6 3 2 1 2 8 Holy Family Hospital, Nazareth 3 1 1 3 5 EGYPT Assiut University Hospital, Assiut 20 19 14 15 6 9 3 6 1 4 2 79 CHILE Hospital Dr Gustavo Fricke, Vina del Mar 5 8 11 8 6 3 9 6 2 53 Hospital Dr Sotero del Rio, Puente Alto 11 5 2 2 2 8 5 24 UK Bradford Royal Infirmary, Bradford 8 8 4 1 1 2 2 3 21 Nottingham City Hospital, Nottingham 9 2 2 3 2 2 5 1 17 Basildon & Thurrock University, Basildon 6 1 5 2 1 9 Queen Elizabeth Hospital, King's Lynn 3 3 1 1 5 Queens Medical Centre, Nottingham 6 3 1 4 Derriford Hospital, Plymouth 6 1 1 1 1 4 University Hospital of North Staffordshire, Stoke-on-Trent 8 3 1 4 Lewisham Hospital, London 5 3 3 AUSTRALIA Ipswich Hospital, Ipswich 3 1 12 7 2 22 Mater Mothers' Hospital, Brisbane 6 2 3 3 1 3 2 14 St George Hospital, Sydney 3 2 5 1 2 1 11 Toowoomba Base Hospital, Toowoomba 2 4 2 6 Monash Medical Centre, Clayton 4 4 1 5 Logan Hospital, Meadowbrook 5 3 1 4 Townsville Hospital, Townsville 3 1 1 2 Women's and Children's Hospital, Adelaide 6 1 1 THE NETHERLANDS Atrium Medical Center, Heerlen 3 4 5 7 5 4 2 2 29 Academisch Ziekenhuis Maastricht, Maastricht 2 3 2 1 6 Sint Lucas Andreas Ziekenhuis, Amsterdam 2 4 1 5 Maxima Medical Centre, Veldhoven 3 1 1 Centres that are no longer recruiting 0 7 ESTONIA Tartu University Hospital - Women's Clinic, Tartu 3 5 12 8 7 4 3 3 2 1 45 SERBIA University of Belgrade, Belgrade 11 9 18 11 3 1 2 44 USA East Bay Perinatal Medical Associates, Oakland 7 9 5 4 1 19 Maricopa Medical Center, Phoenix 8 3 3 2 8 University of South Carolina, Columbia 4 1 2 3 6 University of Miami, Miami 9 1 2 3 University of Iowa Hospitals and Clinics, Iowa City 3 1 1 2 Centres that are no longer recruiting 0 4 JORDAN Islamic Hospital, Amman 9 5 5 8 9 6 2 4 1 40 JAMAICA University Hospital of the West Indies, Kingston 4 23 5 9 3 40 SPAIN Hospital Clinic-University of Barcelona, Barcelona 5 2 6 10 9 5 3 3 1 1 40 HUNGARY University of Debrecen, Debrecen 4 5 11 6 3 3 2 3 1 1 35 ROMANIA University of Pharmacy and Medicine, Cluj-Napoca 3 2 5 2 4 2 1 1 17 BELGIUM Vrije Universiteit Brussel, Brussels 3 5 7 3 15 GERMANY Ludwig Maximilians University of Munich, Munich 2 1 4 3 1 9 CUB - Virchow Klinikum, Berlin 5 3 3 CUB - Benjamin Franklin, Berlin 2 2 1 3 CROATIA Sveti Duh Hospital, Zagreb 4 4 3 2 9 GREECE Alexandra Maternity, Athens 6 1 3 4 Centres awaiting first patient: [COUNTRY: Hospital, City (annual goal)] [month/year start-up package sent] AUSTRALIA: Royal North Shore, St Leonards (3) [11/06]; CANADA:St Paul s Hospital, Vancouver (3) [01/09]; UK: Aberdeen Maternity, Aberdeen (6) [11/06], Liverpool Women's Hospital, Liverpool (12) [05/07]; USA: Washington University, St Louis (5) [01/07];
TBS 2 Year Follow-up The status of the TBS 2 Year Follow-up is displayed in the following table for centres that recruited patients. Centres are listed according to the total number of recruits by country and centre. See below for the number of follow-up assessments performed by your centre! Let's aim for 100% follow-up!! Status 2003 2004 2005 2006 2007 2008 2009 Totals As of July 2009 COUNTRY ARGENTINA 60 51 65 58 96 84 107 44 122 80 530 237 BRAZIL 2 2 44 36 71 54 54 7 63 54 288 99 CANADA 3 3 25 22 53 44 46 34 41 13 29 28 225 116 POLAND 4 4 28 26 18 14 44 11 35 16 145 55 ISRAEL 21 21 27 23 16 16 14 3 32 21 131 63 EGYPT 19 19 14 14 15 5 6 12 13 79 38 CHILE 8 8 11 11 13 13 8 3 16 21 77 35 UK 2 2 2 2 15 5 18 3 16 14 67 12 AUSTRALIA 2 2 15 10 12 7 17 9 14 5 65 28 THE NETHERLANDS 7 7 9 9 17 14 6 1 6 3 48 31 ESTONIA 5 5 12 12 8 8 7 2 7 6 45 27 SERBIA 27 17 44 USA 4 2 13 7 10 3 8 3 5 2 42 15 JORDAN 5 5 5 5 8 8 9 2 8 5 40 20 JAMAICA 23 4 14 3 40 4 SPAIN 2 2 6 6 10 10 9 3 8 5 40 21 HUNGARY 5 5 11 4 6 3 5 5 35 9 ROMANIA 2 2 5 5 2 2 4 4 3 1 17 13 GERMANY 3 2 4 4 4 2 3 1 15 8 BELGIUM 5 7 3 15 CROATIA 4 4 3 2 2 2 9 8 GREECE 1 3 4 Total 3 3 182 163 333 276 373 283 385 114 425 300 2001 839 100.0% 89.6% 82.9% 75.9% 29.6% 42% CENTRES BY COUNTRY (Shaded area is prior to start-up) ARGENTINA Hospital LC Lagomaggiore, Mendoza 31 27 32 31 27 27 22 8 25 14 151 93 Hospital Posadas, Buenos Aires 22 22 28 23 17 16 19 11 6 13 105 72 Hospital Ramon Carrillo, Santiago del Estero 2 2 15 15 19 8 28 22 86 25 Hospital Avellaneda, Tucuman 2 2 11 11 13 7 13 7 46 20 Hospital JR Vidal, Corrientes 4 2 10 1 18 10 42 3 Hospital Penna, Bahia Blanca 12 9 10 1 6 1 29 10 Hospital Sarda, Buenos Aires 3 5 4 11 7 26 4 Hospital Angela Iglesia de Llano, Corrientes 5 4 9 4 2 2 18 8 Hospital Juan A Fernandez, Buenos Aires 12 2 14 Hospital Ramos Mejia, Buenos Aires 7 2 1 2 10 2 Hospital Alvarez, Buenos Aires 1 2 3 BRAZIL University of Campinas, Campinas 2 2 17 11 15 6 17 2 13 12 76 21 Maternidade Escola da UFRJ, Rio de Janeiro 8 8 16 15 18 2 14 7 63 25 University of Pernambuco, Recife 13 12 14 13 10 3 17 1 55 28 Hospital Universitario Antonio Pedro, Niteroi 1 1 10 9 5 2 2 20 10 Hospital Universitario de Jundiai, Jundiai 15 15 Perinatal, Rio de Janeiro 8 7 3 1 1 13 7 ISCMPA-Maternidade Mario Totta, Porto Alegre 5 4 4 4 3 12 8 Hospital Sao Lucas, Porto Alegre 5 7 12 Hospital das Clinicas da UFPE, Recife 4 1 2 7 Botucatu Medical School, Botucatu 4 3 7 Maternidade Escola de Vila Nova Cachoeirinha, Sao Paulo 4 4 Hospital Materno Infantil, Goiania 2 2 4 CANADA Sunnybrook Health Sciences Centre, Toronto 3 3 14 14 11 7 13 9 18 4 8 5 72 37 McMaster University Medical Centre, Hamilton 10 10 7 7 4 4 4 25 21 IWK Health Centre, Halifax 1 1 4 4 6 6 4 2 6 3 24 13 Regina General Hospital, Regina 5 4 7 7 3 1 2 4 21 12 Trillium Health Centre, Mississauga 6 4 4 6 1 1 17 5 Lions Gate Hospital, Vancouver 6 6 1 1 2 1 10 7 Mount Sinai Hospital, Toronto 5 3 2 1 3 3 10 7 Foothills Medical Centre, Calgary 1 1 5 4 1 1 1 1 9 6 SMBD Jewish General Hospital, Montreal 2 4 2 8 Royal Columbian Hospital, New Westminster 3 3 3 3 6 6 St Joseph's Health Care, London 1 5 6 Royal University Hospital, Saskatoon 4 1 1 6 North Bay General Hospital, North Bay 4 4 Eastern Health, St John's 1 1 2 3 1 Toronto East General, Toronto 1 1 1 2 1 York Central Hospital, Richmond Hill 1 1 Children's & Women's Health Centre of BC, Vancouver 1 1 POLAND Univ School of Medicine, Poznan 3 3 24 24 15 13 33 11 26 14 115 51 Polish Mothers Memorial Hospital, Lodz 1 2 10 8 2 23 Medical University of Gdansk, Gdansk 1 1 3 2 1 1 1 1 7 4 ISRAEL Edith Wolfson Medical Center, Holon 11 11 6 6 6 6 4 2 1 30 23 Ma'ayney HaYeshua Medical Center, Bnei Brak 5 5 4 4 5 5 4 1 5 4 27 15 Nazareth Hospital (EMMS), Nazareth 18 8 26 Poriya Government Hospital, Tiberias 3 3 3 1 4 1 12 3 HaEmek Medical Center, Afula 1 1 7 6 2 2 2 12 9 Bnai Zion Medical Center, Haifa 4 4 7 7 11 11
Status 2003 2004 2005 2006 2007 2008 2009 Totals As of July 2009 Hillel Yaffe Medical Center, Hadera 3 2 3 2 8 2 Holy Family Hospital, Nazareth 5 5 EGYPT Assiut University Hospital, Assiut 19 19 14 14 15 5 6 12 13 79 38 CHILE Hospital Dr Gustavo Fricke, Vina del Mar 8 8 11 11 8 8 6 3 12 8 53 30 Hospital Dr Sotero del Rio, Puente Alto 5 5 2 4 13 24 5 UK Bradford Royal Infirmary, Bradford 8 3 4 2 7 21 3 Nottingham City Hospital, Nottingham 2 2 2 2 3 2 2 1 7 1 17 7 Basildon & Thurrock University, Basildon 1 5 1 3 9 1 Queen Elizabeth Hospital, King's Lynn 3 2 5 Queens Medical Centre, Nottingham 4 4 Derriford Hospital, Plymouth 1 1 2 1 4 1 University Hospital of North Staffordshire, Stoke-on-Trent 3 1 4 Lewisham Hospital, London 3 3 AUSTRALIA Ipswich Hospital, Ipswich 1 1 12 7 9 22 8 Mater Mothers' Hospital, Brisbane 2 2 3 2 3 2 1 5 14 6 St George Hospital, Sydney 2 2 5 5 1 1 3 11 8 Toowoomba Base Hospital, Toowoomba 4 1 2 6 1 Monash Medical Centre, Clayton 4 2 1 5 2 Logan Hospital, Meadowbrook 3 1 1 1 4 2 Townsville Hospital, Townsville 1 1 1 2 1 Women's and Children's Hospital, Adelaide 1 1 THE NETHERLANDS Atrium Medical Center, Heerlen 4 4 5 5 7 7 5 1 6 2 29 17 Maaslandziekenhuis Sittard, Sittard 2 2 5 5 7 7 Academisch Ziekenhuis Maastricht, Maastricht 3 3 2 2 1 6 5 Sint Lucas Andreas Ziekenhuis, Amsterdam 4 2 1 5 2 Maxima Medical Centre, Veldhoven 1 1 ESTONIA Tartu University Hospital - Women's Clinic, Tartu 5 5 12 12 8 8 7 2 7 6 45 27 SERBIA University of Belgrade, Belgrade 27 17 44 USA East Bay Perinatal Medical Associates, Oakland 9 4 5 1 4 1 19 5 Maricopa Medical Center, Phoenix 3 2 3 2 8 2 University of South Carolina, Columbia 1 1 2 2 3 3 6 6 University of Miami, Miami 1 2 3 Jamaica Hospital Medical Center, Jamaica 2 2 2 2 Texas Tech UHSC, Lubbock 2 2 University of Iowa Hospitals and Clinics, Iowa City 1 1 2 JAMAICA University Hospital of the West Indies, Kingston 23 4 14 3 40 4 SPAIN Hospital Clinic-University of Barcelona, Barcelona 2 2 6 6 10 10 9 3 8 5 40 21 JORDAN Islamic Hospital, Amman 5 5 5 5 8 8 9 2 8 5 40 20 HUNGARY University of Debrecen, Debrecen 5 5 11 4 6 3 5 5 35 9 ROMANIA University of Pharmacy and Medicine, Cluj-Napoca 2 2 5 5 2 2 4 4 3 1 17 13 GERMANY Ludwig Maximilians University of Munich, Munich 1 1 4 4 3 2 1 9 7 CUB - Virchow Klinikum, Berlin 3 3 CUB - Benjamin Franklin, Berlin 2 1 1 3 1 BELGIUM Vrije Universiteit Brussel, Brussels 5 7 3 15 CROATIA Sveti Duh Hospital, Zagreb 4 4 3 2 2 2 9 8 GREECE Alexandra Maternity, Athens 1 3 4