Safety Data Sheet Methyl Isobutyl Ketone, ACS 1. PRODUCT AND COMPANY IDENTIFICATION Product Name: Methyl Isobutyl Ketone, ACS Synonyms/Generic Names: 4-Methylpentan-2-one; Isobutyl methyl ketone; Isopropylacetone Product Number: 3545 Product Use: Industrial, Manufacturing or Laboratory use Manufacturer: Columbus Chemical Industries, Inc. N4335 Temkin Rd. Columbus, WI. 53925 For More Information Call: 920-623-2140 (Monday-Friday 8:00-4:30) In Case of Emergency Call: CHEMTREC - 800-424-9300 or 703-527-3887 (24 Hours/Day, 7 Days/Week) 2. HAZARDS IDENTIFICATION OSHA Hazards: Flammable liquid, Carcinogen, Target organ effect, Irritant Target Organs: Nerves Signal Word: Danger Pictograms: GHS Classification: Flammable liquids Category 2 Acute toxicity, Inhalation Category 4 Eye irritation Category 2A Specific target organ toxicity - single exposure Category 3 GHS Label Elements, including precautionary statements: Hazard Statements: H225 Highly flammable liquid and vapor. H319 Causes serious eye irritation. H332 Harmful if inhaled. H335 May cause respiratory irritation. Precautionary Statements: P210 Keep away from heat/sparks/open flames/hot surfaces. No smoking. P233 Keep container tightly closed. Revised on 03/25/2015 Page 1 of 6
P240 P241 P242 P243 P261 P271 P280 P303+P361+P353 P304+P340 P305+P351+P338 P312 P337+P313 P370+P378 P403+P233 P405 P501 Ground/Bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/fume/gas/mist/vapors/spray. Use only outdoors or in a well-ventilated area. Wear protective gloves/eye protection/face protection. IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove person to fresh air and keep comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER/doctor/physician if you feel unwell. If eye irritation persists: Get medical advice/attention. In case of fire: Use appropriate media to extinguish. Store in a well-ventilated place. Keep container tightly closed. Store locked up. Dispose of contents/container in accordance with local regulations. Potential Health Effects Causes eye irritation. Inhalation May be fatal if inhaled. Causes respiratory tract irritation. May be harmful if absorbed through skin. Causes skin irritation. Ingestion May be harmful if swallowed. NFPA Ratings Health 2 Flammability 3 Reactivity 0 Specific hazard HMIS Ratings Health 2 Fire 3 Reactivity 0 Personal H 3. COMPOSITION/INFORMATION ON INGREDIENTS Component Weight % CAS # EINECS# / ELINCS# Formula Molecular Weight Methyl Isobutyl Ketone >99 108-10-1 203-550-1 C 6 H 12 O 100.16 g/mol 4. FIRST-AID MEASURES Inhalation Ingestion Rinse with plenty of water for at least 15 minutes and seek medical attention. Move casualty to fresh air and keep at rest. If breathing is difficult, give oxygen. If not breathing, give artificial respiration. Get medical attention. Flush with plenty of water for at least 15 minutes while removing contaminated clothing and wash using soap. Get medical attention. Do Not Induce Vomiting! Never give anything by mouth to an unconscious person. If conscious, wash out mouth with water. Get medical attention. 5. FIRE-FIGHTING MEASURES Suitable (and unsuitable) extinguishing media Product is flammable. Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Use appropriate media for adjacent fire. Cool containers with water. Revised on 03/25/2015 Page 2 of 6
Special protective equipment and precautions for firefighters Specific hazards arising from the chemical Wear self-contained, approved breathing apparatus and full protective clothing, including eye protection and boots. Emits toxic fumes (carbon oxides) under fire conditions. (See also Stability and Reactivity section). 6. ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Environmental precautions Methods and materials for containment and cleaning up See section 8 for recommendations on the use of personal protective equipment. Prevent spillage from entering drains. Any release to the environment may be subject to federal/national or local reporting requirements. Absorb spill with noncombustible absorbent material, then place in a suitable container for disposal. Clean surfaces thoroughly with water to remove residual contamination. Dispose of all waste and cleanup materials in accordance with regulations. 7. HANDLING AND STORAGE Precautions for safe handling See section 8 for recommendations on the use of personal protective equipment. Use with adequate ventilation. Use explosion-proof equipment. Keep away from sources of ignition - No smoking. Take measures to prevent the build-up of electrostatic charge. Wash thoroughly after using. Keep container closed when not in use. Avoid formation of aerosols. Conditions for safe storage, including any incompatibilities Store in cool, dry well ventilated area. Keep away from incompatible materials (see section 10 for incompatibilities). 8. EXPOSURE CONTROLS / PERSONAL PROTECTION Occupational exposure controls: Ventilation and appropriate grounding of containers. Component Exposure Limits Basis Entity TLV ACGIH Methyl Isobutyl Ketone 50 ppm 205 mg/m 3 75 ppm STEL ACGIH 307 mg/m 3 100 ppm PEL OSHA 410 mg/m 3 50 ppm REL NIOSH 205 mg/m 3 75 ppm STEL NIOSH 300 mg/m 3 TWA: Time Weighted Average over 8 hours of work. TLV: Threshold Limit Value over 8 hours of work. REL: Recommended Exposure Limit PEL: Permissible Exposure Limit STEL: Short Term Exposure Limit during x minutes. IDLH: Immediately Dangerous to Life or Health WEEL: Workplace Environmental Exposure Levels CEIL: Ceiling Revised on 03/25/2015 Page 3 of 6
Personal Protection Wear chemical safety glasses or goggles, and face shield. Inhalation Provide local exhaust, preferably mechanical. If exposure levels are excessive, use an approved respirator. Wear nitrile or rubber gloves, and full body covering. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Other Other Recommendations Provide eyewash stations, quick-drench showers and washing facilities accessible to areas of use and handling. 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance (physical state, color, etc.) Liquid. Odor Odor threshold 0.1 ppm ph Melting point/freezing point -84 C (-119.2 F) Initial boiling point and boiling range 115.9 C (240.6 F) Flash point CLOSED CUP: 14 C (57.2 F) OPEN CUP: 23 C (73.4 F) Evaporation rate Flammability (solid, gas) Flammable Upper/lower flammability or explosive limit LOWER: 1.4% UPPER: 7.5% Vapor pressure 15.7 mm of Hg (@ 20 C) Vapor density 3.45 (Air = 1) Density 0.802 (Water = 1) Solubility (ies) Partially soluble in cold water. Partition coefficient: n-octanol/water log Pow: 1.31 Auto-ignition temperature 460 C (860 F) Decomposition temperature 10. STABILITY AND REACTIVITY Chemical Stability Possibility of Hazardous Reactions Conditions to Avoid Incompatible Materials Hazardous Decomposition Products Stable Will not occur. Heat, flames and sparks. Extremes of temperature and direct sunlight. Oxidizing agents, strong bases. Carbon oxides. 11. TOXICOLOGICAL INFORMATION Acute Toxicity Methyl Isobutyl Ketone LD50 Dermal - rabbit - > 16,000 mg/kg Respiratory LC50 Inhalation - rat - 4 h - 8.2-16.4 mg/m3 Ingestion LD50 Oral - rat - 2,080 mg/kg Revised on 03/25/2015 Page 4 of 6
Carcinogenicity IARC ACGIH NTP OSHA 2B - Group 2B: Possibly carcinogenic to humans (4-Methylpentan-2-one). No components of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH. No components of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP. No components of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA. Signs & Symptoms of Exposure Irritation, redness, itchiness, dermatitis. Irritation, redness, watering eyes, itchiness, blurred vision. Respiratory Irritation, coughing, wheezing. Ingestion Irritation, nausea, vomiting, diarrhea. Chronic Toxicity Teratogenicity Mutagenicity Embryotoxicity Specific Target Organ Toxicity Reproductive Toxicity Respiratory/ Sensitization The substance is toxic to lungs, the nervous system, mucous membranes -Developmental Toxicity - mouse - Inhalation Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death. -Developmental Toxicity - mouse - Inhalation Specific Developmental Abnormalities: Central nervous system. Specific -Developmental Abnormalities: Musculoskeletal system. Specific Developmental Abnormalities: Cardiovascular (circulatory) system Passes through the placental barrier in human. May cause respiratory irritation. 12. ECOLOGICAL INFORMATION Ecotoxicity Methyl Isobutyl Ketone Aquatic Vertebrate Aquatic Invertebrate Terrestrial LC0 - Leuciscus idus melanotus - 480 mg/l - 48 h EC50 - Daphnia magna (Water flea) - 1,550-3,623 mg/l - 24 h EC50 - Desmodesmus subspicatus (green algae) - 980-2,000 mg/l - 48 h Persistence and Degradability Bioaccumulative Potential Mobility in Soil PBT and vpvb Assessment Other Adverse Effects Biotic/Aerobic 13. DISPOSAL CONSIDERATIONS Waste Product or Residues Product Containers Users should review their operations in terms of the applicable federal/national or local regulations and consult with appropriate regulatory agencies if necessary before disposing of waste product or residue. Users should review their operations in terms of the applicable federal/national or local regulations and consult with appropriate regulatory agencies if necessary before disposing of waste product container. Revised on 03/25/2015 Page 5 of 6
The information offered in section 13 is for the product as shipped. Use and/or alterations to the product may significantly change the characteristics of the material and alter the waste classification and proper disposal methods. 14. TRANSPORTATION INFORMATION US DOT TDG IMDG Marine Pollutant IATA/ICAO UN1245, Methyl isobutyl ketone, 3, pg II UN1245, METHYL ISOBUTYL KETONE, 3, pg II UN1245, METHYL ISOBUTYL KETONE, 3, pg II No UN1245, Methyl isobutyl ketone, 3, pg II 15. REGULATORY INFORMATION TSCA Inventory Status DSCL (EEC) California Proposition 65 SARA 302 SARA 304 SARA 311 SARA 312 SARA 313 WHMIS Canada All ingredients are listed on the TSCA inventory. All ingredients are listed on the DSCL inventory. Listed: 4-Methylpentan-2-one Not Listed Not Listed Fire Hazard, Acute Health Hazard, Chronic Health Hazard Fire Hazard, Acute Health Hazard, Chronic Health Hazard Listed: 4-Methylpentan-2-one Class B-2 - Flammable and combustible material - Flammable liquid Class D-2A - Poisonous and infectious material - Other effects - Very toxic 16. OTHER INFORMATION Revision Date Revision 1 07-31-2012 Revision 2 08/05/2013 Revision 3 03/25/2015 Disclaimer: Columbus Chemical Industries, Inc. ( Columbus ) believes that the information herein is factual but is not intended to be all inclusive. The information relates only to the specific material designated and does not relate to its use in combination with other materials or its use as to any particular process. Because safety standards and regulations are subject to change and because Columbus has no continuing control over the material, those handling, storing or using the material should satisfy themselves that they have current information regarding the particular way the material is handled, stored or used and that the same is done in accordance with federal, state and local law. COLUMBUS MAKES NO WARRANTY, EXPRESS OR IMPLIED, INCLUDING (WITHOUT LIMITATION) WARRANTIES WITH RESPECT TO THE COMPLETENESS OR CONTINUING ACCURACY OF THE INFORMATION CONTAINED HEREIN OR WITH RESPECT TO FITNESS FOR ANY PARTICULAR USE. Revised on 03/25/2015 Page 6 of 6