MANUFACTURING PROBLEMS AS OF 11th January 2018

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3 MANUFACTURING PROBLEMS AS OF 11th January 2018 If you know of any stock Issues that are not on this list please get in touch at ahope@nhs.net Dumfries and Galloway on the date displayed and may not apply to other regions. Drug Manufacturer Brand Name Comments Adalat Retard Bayer n/a 10mg oos - Expected start of January 2018 Suggested Alternatives Date of first reported issue Alzain 50mg, Dr Reddys n/a Ambrix GSK n/a Avaxim Vaccine MSD n/a Bactroban Cream 15g GSK n/a Casresense Lancets spirit healthcare n/a 50mg pack size 56 are currently oos - Pack size 84 are available Expected start of January 2018 All other strengths are available - 17/07/2017 Currently available - Restriction on quantity Currently oos - Expected March 2018 Out of stock - Expected Quarter 12018 Ointment is available Alliance are re - ordering and should have stock by w/b 18/12/17 - AAH Glsgow do not stock them but orders should be automatically fulfilled by the Warrington branch Colestyramine sachets x 50 Teva n/a Out of stock - Quality Issue - Until July/September 2018 Questran Sachets available (formulary choice)

Cyclimorph 10 Injection Concordia n/a Out- of Stock - Expected Mid January 2018 Cyclimorph 15 Injection Concordia n/a Out of stock - No date as yet Diamox Sr 250mg Prolonged Release Capsules Concordia n/a Out of stock - Expected by Q2 2018 Dilzem Sr 60mg Cap Teva n/a Out of Stock - Expected January/ March 2018 use other brand Distamine 250mg Tablets Alliance Pharma n/a Discontinued 125mg Tablets available Elleste Duet 1mg Mylan n/a OOS - Expected new stock to arrive w/c 8.1.18 - orders can be placed after that and supply to all AAH, Alliance & Pheonix 03.01.2018 Emulsifying Ointment Almus n/a Currently oos - no date as yet 14/12/2017 Erythormycin 2% Solution x 50ml GSK Stiemycin Discontinued Engerix B Paed GSK n/a In stock 07/08/2017 Engerix B Vial 1 & 10 GSK n/a restriction applies for post exposed or as per guidence 16/06/2017 Engerix B x 1 PFS NFN GSK n/a restriction applies for post exposed or as per guidence 16/06/2017 Engerix PF Syringe Adult 1 x 10 restriction applies for post GSK n/a dose exposed or as per guidence 16/06/2017 Epilim Chrono 500mg Sanofi n/a Out of stock - expected w/s 8/1/18-200mg back in stock Fendrick Vaccine GSK n/a restriction applies for renal patients as per guidence

Forceval Alliance Pharma n/a capsules oos expected early February 2018 - soluble in stock Refer to guideline 'BOMSS Guideline on perioperative and postoperative biochemical monitoring and micronutrient replacement for patients undergoing bariatric surgery.' Patients can also try to use an A-Z such as Sanatogen, Centrum or supermarket own brand. Fortipine LA 40mg Modified Release Tablets Havrix Monodose PFS 1 & 10'S GSK n/a Concordia n/a Out of stock - No date as yet Out of stock - expected Q1 2018 Paediatric Intermittent Supply available 16/06/2017 Insumin Insulin Sanofi n/a Sanofi are currently investigating this issue internally to discover the reason why the two wholesalers are in short supply. 13/12/2017

Ipinnia XL 6mg & 8mg Tablets Ethypharm n/a Temporarily out of stock - No date as yet - Still more cost effective to prescribe as Ipinnia xl 2 x3 mg for 6mg dose or 2 x 4mg for an 8mg dose extensive list for patients following Gastric bypass and Sleeve. Ayr recommend Forceval specifically as 19/12/2017 Isopto Alkaline eye drop 10ml Alcon n/a Discontinued by supplier 17/07/2017 Longtec Qdem n/a was OOS but issue been resolved with all strengths - should be available from wholesalers from w/b 18/12/17 Isotrex Gel x 30g GSK n/a Discontinued Navispare Tablet Amco / Mercury n/a Temporary Discontinued - Unsure at present if will be manufactured again These patients are also on Adcal D3, Vitamin B12 injections and iron. Orphenadrine 50mg Tablets Teva n/a Teva have Discontinued - Pavacol D Alliance Pharma n/a Discontinued- Both 300ml & 600ml Phenindione 50mg Tablet Concordia n/a Discontinued 17/07/2017 Ponstan 250mg Chemidex n/a OOS No date as yet 13/12/2017 Ponstan Forte 500mg Chemidex n/a Limited stock - No date as yet Potassium Chloride 600mg SR Tablets Alliance Pharma Slow K Discontinued by Alliance Pharma 03/12/2017 Pred Forte eye drops Allergan n/a Out of stock - 10ml will not be available all 2017 5ml in stock at present although low stock levels -

Prednisolone 2.5mg & 5mg ec tablets Alliance Pharma Deltacortril Discontinued by manufacturers - Alliance Pharma do a generic Predniolone ec tablet 2.5mg & 5mg in packs of 30's now - Both in stock Premique tablets 0.625mg/5mg Pfizer n/a Discontinued Premique low dose Pfizer N/a OOS - Expected end of January 2018 13/12/2017 Prempak-C 0.625mg Pfizer n/a Discontinued both strengths Quetiapine tablets various n/a Quinaderm 5% cream x 50g Alliance Pharma N/A Raw material problem - Not expecetd untill 2019 Quinaderm 10% cream 25g & 50g Alliance Pharma n/a Raw material problem - Not expected untill 2019 Respontin Nebules 1ml & 2ml GSK n/a Discontinued Rabies Vaccine BP Sanofi n/a Out of Stock - No date as yet 12/10/2017 Revaxis Injection Sanofi n/a Out of Stock - No date as yet 12/10/2017 Sukkarto Tablets Morningside n/a Out of stock - Expected January 2018 Synflorix vaccine 1PFS GSK n/a Out of stock - Expected 2019 16/06/2017 Traxam Pain Relief 3% gel 100g Concordia n/a Out of stock - Technical Issue - non formulary use expected Quarter 12018 ibuprofen gel Traxam 3% gel 30g concordia n/a Out of stock - Technical Issue - non formulary use expected Quarter 12018 ibuprofen gel Trimovate Cream 30g GSK N/A Out of Stock - Expected Quarter 12018 16/06/2017 Twinrix PFS 1 & 10'S GSK N/A Expected Quarter 12018 Twinrix Paediatric 1 Dose GSK n/a In stock 07/08/2017 Typherix Vaccine 1 & 10 PFS GSK n/a Out of Stock - Expected 2019 07/08/2017

Vaqta Vaccine MSD n/a Zantac Tablets 150mg & 300mg GSK n/a Paediatric avialable - Adult currently oos Out of Stock - Expected Quarter 32018 Switch to generic