Noticias News Nouvelles The Centre for Mother, Infant, and Child Research 7 th Floor, 790 Bay Street Toronto ON CANADA M5G 1N8 Tel: 1 416 351 2533 Fax: 1 416 351 3771 email: tbs@sw.ca website: www.cmicr.ca/tbs V O L U M E 9, I S S U E 2 F E B R U A R Y 2 8, 2 0 1 0 Overall Total: 2266 Total this month: 44! I N S I D E T H I S I S S U E European & Middle Eastern Colaborators Meeting Argentina Meeting North American Colaborators Meeting Australian Meeting 1 1 2 2 Upcoming Meetings... European and Middle Eastern Meeting The European & Middle Eastern Colaborators Meeting is a few days away and final plans are being made for those participating in this meeting. An important email with final information regarding the agenda and dinner venue has been sent. If you did not receive this information, please contact the Data Coordinating Centre as soon as possible. Housekeeping 3 Recruitment Excellence Recruitment Table 2yr Table 3 4 7 Argentina Meeting Dr Mario Palermo of Posadas Hospital in Buenos Aires, Argentina, will be hosting a local TBS meeting on Thursday April 22nd, 2010. Dr Jon Barrett will be present at the meeting to discuss the study and answer any questions. If you are in Argentina and would like more information about this meeting, please contact Dr Palermo or the TBS Data Coordinating Centre.
P A G E 2 TBS Meetings (continued)... North American Meeting In case you missed the announcement in the last Newsletter, we will be hosting a Colaborators Meeting for our North American centres on October 17 18, 2010 in Banff, Canada. The meeting will be held at the Rimrock Hotel. We hope you have marked your calendars as we would like to see all our Canadian and American centres there! Australian Meeting We are in the early stages of planning a Colaborators meeting for our Australian centres. The meeting will take place on July 1st, 2010 in Sydney, Australia. Stay tuned for more information. Please mark your calendars and plan to join us!
P A G E 3 Housekeeping Please note the importance of obtaining an ultrasound within 7 days of randomization and record a valid date on Entry form, question 6. As a reminder, section 2.2.1 of the protocol states: An ultrasound should be performed within 7 days prior to randomisation to confirm that both fetuses are alive, determine the estimated fetal weights, the presentation of both fetuses, to rule out contraindications to labour or vaginal delivery and to confirm that twins are diamniotic if not previously determined. Recruitment Excellence Congratulations to Dr Maria Mohedano de Duhalde and the team at Hospital Avellaneda, Tucuman, Argentina; Dr Renato Augusto Moreira de Sa and the team at Maternidade Escola da UFRJ, Rio de Janeiro, Brazil; Dr Danielly Scaranello Nunes Santana and the team at Hospital Universitario de Jundiai, Jundiai, Brazil; Dr Luis Leighton and the team at Hospital Dr Gustavo Fricke, Vina del Mar, Chile; Dr Tamas Major and the team at University of Debrecen, Debrecen, Hungary; Dr Marwan Hakim and the team at Nazareth Hospital (EMMS), Nazareth, Israel; Dr Dalia Mansour-Schwake and the team at Holy Family Hospital, Nazareth, Israel; and Dr Jim Thornton and the team at Nottingham City Hospital, Nottingham, UK; Keep up the excellent work! We will be sending a gold seal to place on your Certificate of Achievement.
P A G E 4 Twin Birth Study Recruitment (Projected sample size of 2800) February 28, 2010 Annual Jun Jul - Nov Jan Feb Grand Goal 2003 2004 2005 2006 2007 2008 2009 2009 2009 2010 2010 Total COUNTRY ARGENTINA 63 60 65 96 107 122 65 50 10 14 9 598 BRAZIL 73 2 44 71 54 63 42 44 11 3 11 345 CANADA 81 3 25 53 46 41 29 22 17 1 2 239 ISRAEL 46 21 27 16 14 32 15 23 4 2 5 159 POLAND 15 4 28 18 44 35 14 10 1 1 2 157 UK 63 2 2 15 18 16 11 18 2 3 5 92 CHILE 16 8 11 13 8 16 21 3 1 4 5 90 EGYPT 20 19 14 15 6 12 11 6 3 86 AUSTRALIA 32 2 15 12 17 14 5 1 2 1 69 SERBIA 11 27 15 8 1 1 1 53 USA 31 4 13 10 8 5 8 3 1 52 THE NETHERLANDS 10 7 9 17 6 6 3 1 1 50 JAMAICA 4 23 14 3 2 2 3 47 ESTONIA 3 5 12 8 7 7 5 2 1 47 SPAIN 5 2 6 10 9 8 5 1 1 2 44 JORDAN 9 5 5 8 9 8 4 2 1 42 HUNGARY 4 5 11 6 3 5 4 1 1 36 ROMANIA 3 2 5 2 4 3 1 17 GERMANY 9 3 4 4 3 1 15 BELGIUM 0 5 7 3 15 CROATIA 0 4 3 2 9 GREECE 0 1 3 4 Total 498 3 182 333 373 385 425 246 198 43 34 44 2266 CENTRES BY COUNTRY (Shaded area is prior to start-up) ARGENTINA Hospital LC Lagomaggiore, Mendoza 12 31 32 27 22 25 12 10 4 1 164 Hospital Posadas, Buenos Aires 6 22 28 17 19 6 11 4 3 1 111 Hospital Ramon Carrillo, Santiago del Estero 10 2 15 19 28 18 14 4 1 1 102 Hospital Avellaneda, Tucuman 6 2 11 13 13 6 4 2 3 54 Hospital JR Vidal, Corrientes 6 4 10 18 7 5 2 2 48 Hospital Penna, Bahia Blanca 4 12 10 6 3 2 2 35 Hospital Sarda, Buenos Aires 10 3 5 11 6 5 2 1 33 Hospital Angela Iglesia de Llano, Corrientes 3 5 9 2 2 2 20 Hospital Juan A Fernandez, Buenos Aires 4 12 1 1 14 Hospital Alvarez, Buenos Aires 2 1 2 4 7 Centre(s) that are no longer recruiting 0 10 BRAZIL University of Campinas, Campinas 5 2 17 15 17 13 11 3 2 2 82 Maternidade Escola da UFRJ, Rio de Janeiro 6 8 16 18 14 7 7 1 2 73 University of Pernambuco, Recife 7 13 14 10 17 1 1 56 Hospital Universitario de Jundiai, Jundiai 5 13 6 3 3 25 Maternidade Escola de Vila Nova Cachoeirinha, Sao Paulo 8 15 3 1 2 21 Hospital Universitario Antonio Pedro, Niteroi 5 1 10 5 2 2 1 21 Hospital Sao Lucas, Porto Alegre 5 5 3 7 1 1 1 18 Perinatal, Rio de Janeiro 8 8 3 1 1 1 14 ISCMPA-Maternidade Mario Totta, Porto Alegre 6 5 4 3 1 13 Botucatu Medical School, Botucatu 2 4 2 2 8 Hospital das Clinicas da UFPE, Recife 5 4 1 2 7 Hospital Materno Infantil, Goiania 3 2 2 2 6 Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife 8 1 1
PAGE 5 Annual Jun Jul - Nov Jan Feb Grand Goal 2003 2004 2005 2006 2007 2008 2009 2009 2009 2010 2010 Total CANADA Sunnybrook Health Sciences Centre, Toronto 5 3 14 11 13 18 8 5 3 1 1 77 IWK Health Centre, Halifax 7 1 4 6 4 6 3 3 27 Regina General Hospital, Regina 5 5 7 3 2 2 4 23 Trillium Health Centre, Mississauga 6 6 4 6 1 17 Lions Gate Hospital, Vancouver 3 6 1 2 1 1 11 Foothills Medical Centre, Calgary 7 1 5 1 1 1 9 St Joseph's Health Care, London 9 1 3 3 1 8 SMBD Jewish General Hospital, Montreal 6 2 4 2 8 Royal University Hospital, Saskatoon 6 4 1 1 6 Royal Columbian Hospital, New Westminster 5 3 3 6 North Bay General Hospital, North Bay 2 3 2 5 Women s Health Centre, St John's 4 1 2 3 Toronto East General, Toronto 5 1 1 2 Children's & Women's Health Centre of BC, Vancouver 11 1 1 Centre(s) that are no longer recruiting 0 36 ISRAEL Nazareth Hospital (EMMS), Nazareth 3 18 6 10 3 1 2 40 Ma'ayney HaYeshua Medical Center, Bnei Brak 10 5 4 5 4 5 3 4 1 31 Edith Wolfson Medical Center, Holon 5 11 6 6 4 2 1 1 31 Holy Family Hospital, Nazareth 3 2 8 1 2 13 HaEmek Medical Center, Afula 7 1 7 2 2 12 Poriya Government Hospital, Tiberias 4 3 3 1 4 1 12 Bnai Zion Medical Center, Haifa 8 4 7 11 Hillel Yaffe Medical Center, Hadera 6 3 3 2 1 9 POLAND University School of Medical Sciences, Poznan 8 3 24 15 33 26 12 9 1 1 2 126 Polish Mothers Memorial Hospital, Lodz 5 1 2 10 8 2 23 Medical University of Gdansk, Gdansk 2 1 3 1 1 1 1 8 UK Bradford Royal Infirmary, Bradford 8 8 4 2 4 10 1 1 30 Nottingham City Hospital, Nottingham 9 2 2 3 2 7 1 4 21 Basildon & Thurrock University, Basildon 6 1 5 3 9 Derriford Hospital, Plymouth 6 1 2 1 1 3 8 Liverpool Women's Hospital, Liverpool 12 5 1 6 Queens Medical Centre, Nottingham 6 4 2 6 Queen Elizabeth Hospital, King's Lynn 3 3 2 5 University Hospital of North Staffordshire, Stoke-on-Trent 8 3 1 4 Lewisham Hospital, London 5 3 3 CHILE Hospital Dr Gustavo Fricke, Vina del Mar 5 8 11 8 6 12 8 2 1 3 2 61 Hospital Dr Sotero del Rio, Puente Alto 11 5 2 4 13 1 1 3 29 EGYPT Assiut University Hospital, Assiut 20 19 14 15 6 12 11 6 3 86 AUSTRALIA Ipswich Hospital, Ipswich 3 1 12 9 1 1 24 Mater Mothers' Hospital, Brisbane 6 2 3 3 1 5 1 15 St George Hospital, Sydney 3 2 5 1 3 1 12 Toowoomba Base Hospital, Toowoomba 2 4 2 6 Monash Medical Centre, Clayton 4 4 1 5 Logan Hospital, Meadowbrook 5 3 1 4 Townsville Hospital, Townsville 3 1 1 2 Women's and Children's Hospital, Adelaide 6 1 1 SERBIA University of Belgrade, Belgrade 11 27 15 8 1 1 1 53 USA East Bay Perinatal Medical Associates, Oakland 7 9 5 4 1 1 20 University of Miami, Miami 9 1 7 3 11 Maricopa Medical Center, Phoenix 8 3 3 2 1 9 University of South Carolina, Columbia 4 1 2 3 6 University of Iowa Hospitals and Clinics, Iowa City 3 1 1 2 Centre(s) that are no longer recruiting 0 4
PAGE 6 Annual Jun Jul - Nov Jan Feb Grand Goal 2003 2004 2005 2006 2007 2008 2009 2009 2009 2010 2010 Total THE NETHERLANDS Atrium Medical Center, Heerlen 3 4 5 7 5 6 2 29 Academisch Ziekenhuis Maastricht, Maastricht 2 3 2 1 1 7 Sint Lucas Andreas Ziekenhuis, Amsterdam 2 4 1 5 Maxima Medical Centre, Veldhoven 3 1 1 2 Centre(s) that are no longer recruiting 0 7 JAMAICA University Hospital of the West Indies, Kingston 4 23 14 3 2 2 3 47 ESTONIA Tartu University Hospital - Women's Clinic, Tartu 3 5 12 8 7 7 5 2 1 47 SPAIN Hospital Clinic-University of Barcelona, Barcelona 5 2 6 10 9 8 5 1 1 2 44 JORDAN Islamic Hospital, Amman 9 5 5 8 9 8 4 2 1 42 HUNGARY University of Debrecen, Debrecen 4 5 11 6 3 5 4 1 1 36 ROMANIA University of Pharmacy and Medicine, Cluj-Napoca 3 2 5 2 4 3 1 17 GERMANY Ludwig Maximilians University of Munich, Munich 2 1 4 3 1 9 CUB - Virchow Klinikum, Berlin 5 3 3 CUB - Benjamin Franklin, Berlin 2 2 1 3 BELGIUM Centre(s) that are no longer recruiting 0 15 CROATIA Centre(s) that are no longer recruiting 0 9 GREECE Centre(s) that are no longer recruiting 0 4 Centres awaiting first patient: [COUNTRY: Hospital, City (annual goal)] [month/year start-up package sent] ARGENTINA: Hospital JM Cullen, Santa Fe (4) [01/10]; AUSTRALIA: Royal North Shore, St Leonards (3) [11/06]; CANADA:St Paul s Hospital, Vancouver (3) [01/09]; QATAR: Hamad Medical Corporation, Doha (23) [11/09]; UK: Aberdeen Maternity, Aberdeen (6) [11/06]; USA: Washington University, St Louis (5) [01/07];
PAGE 7 TBS 2 Year Follow-up The status of the TBS 2 Year Follow-up is displayed in the following table for centres that recruited patients. Centres are listed according to the total number of recruits by country and centre. See below for the number of follow-up assessments performed by your centre! Let's aim for 100% follow-up!! Status 2003 2004 2005 2006 2007 2008 2009 2010 Totals As of February 2010 COUNTRY ARGENTINA 60 51 65 58 96 87 107 96 122 4 125 23 598 296 BRAZIL 2 2 44 36 71 54 54 24 63 2 97 14 345 118 CANADA 3 3 25 22 53 47 46 37 41 31 29 1 40 2 239 141 ISRAEL 21 21 27 23 16 16 14 8 32 42 7 159 68 POLAND 4 4 28 26 18 15 44 33 35 1 25 3 157 79 UK 2 2 2 2 15 6 18 8 16 31 8 92 18 CHILE 8 8 11 11 13 13 8 6 16 25 9 90 38 EGYPT 19 19 14 14 15 15 6 6 12 1 20 86 55 AUSTRALIA 2 2 15 10 12 7 17 16 14 8 1 69 35 SERBIA 27 3 24 2 53 3 USA 4 2 13 7 10 3 8 4 5 11 1 52 16 THE NETHERLANDS 7 7 9 9 17 14 6 5 6 5 50 35 JAMAICA 23 12 14 7 3 47 12 ESTONIA 5 5 12 12 8 8 7 7 7 7 1 47 32 SPAIN 2 2 6 6 10 10 9 9 8 1 7 2 44 28 JORDAN 5 5 5 5 8 8 9 7 8 6 1 42 25 HUNGARY 5 5 11 4 6 3 5 5 1 36 9 ROMANIA 2 2 5 5 2 2 4 4 3 1 17 13 BELGIUM 5 7 3 15 GERMANY 3 2 4 4 4 2 3 1 15 8 CROATIA 4 4 3 2 2 2 9 8 GREECE 1 3 4 Total 3 3 182 163 333 279 373 301 385 278 425 13 487 78 2266 1037 100.0% 89.6% 83.8% 80.7% 72.2% 3.1% 46% CENTRES BY COUNTRY (Shaded area is prior to start-up) ARGENTINA Hospital LC Lagomaggiore, Mendoza 31 27 32 31 27 27 22 21 25 1 26 1 164 107 Hospital Posadas, Buenos Aires 22 22 28 23 17 17 19 17 6 15 4 111 79 Hospital Ramon Carrillo, Santiago del Estero 2 2 15 15 19 19 28 2 36 2 102 38 Hospital Avellaneda, Tucuman 2 2 11 11 13 12 13 10 5 54 25 Hospital JR Vidal, Corrientes 4 4 10 5 18 14 2 48 9 Hospital Penna, Bahia Blanca 12 9 10 8 6 3 4 35 17 Hospital Sarda, Buenos Aires 3 5 5 11 1 11 3 33 6 Hospital Angela Iglesia de Llano, Corrientes 5 4 9 9 2 2 2 20 13 Hospital Juan A Fernandez, Buenos Aires 12 2 14 Hospital Ramos Mejia, Buenos Aires 7 2 1 2 10 2 Hospital Alvarez, Buenos Aires 1 6 7 BRAZIL University of Campinas, Campinas 2 2 17 11 15 6 17 2 13 16 2 82 21 Maternidade Escola da UFRJ, Rio de Janeiro 8 8 16 15 18 13 14 15 2 73 36 University of Pernambuco, Recife 13 12 14 13 10 9 17 2 2 56 36 Hospital Universitario de Jundiai, Jundiai 22 3 25 Maternidade Escola de Vila Nova Cachoeirinha, Sao Paulo 18 3 21 Hospital Universitario Antonio Pedro, Niteroi 1 1 10 9 5 2 2 1 21 10 Hospital Sao Lucas, Porto Alegre 5 11 2 18 Perinatal, Rio de Janeiro 8 7 3 1 2 14 7 ISCMPA-Maternidade Mario Totta, Porto Alegre 5 4 4 4 3 1 13 8 Botucatu Medical School, Botucatu 4 4 8 Hospital das Clinicas da UFPE, Recife 4 1 2 7 Hospital Materno Infantil, Goiania 2 4 6 Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife 1 1 CANADA Sunnybrook Health Sciences Centre, Toronto 3 3 14 14 11 10 13 12 18 16 8 9 1 77 55 IWK Health Centre, Halifax 1 1 4 4 6 6 4 3 6 6 27 14 McMaster University Medical Centre, Hamilton 10 10 7 7 4 4 4 25 21 Regina General Hospital, Regina 5 4 7 7 3 2 2 6 23 13 Trillium Health Centre, Mississauga 6 4 4 6 3 1 17 7 Lions Gate Hospital, Vancouver 6 6 1 1 2 1 2 11 8 Mount Sinai Hospital, Toronto 5 3 2 1 3 3 10 7 Foothills Medical Centre, Calgary 1 1 5 4 1 1 1 1 9 6 St Joseph's Health Care, London 1 6 1 8 SMBD Jewish General Hospital, Montreal 2 4 2 8 Royal Columbian Hospital, New Westminster 3 3 3 3 6 6 Royal University Hospital, Saskatoon 4 1 1 6 North Bay General Hospital, North Bay 5 5 Women s Health Centre, St John's 1 1 2 2 3 3 Toronto East General, Toronto 1 1 1 2 1 York Central Hospital, Richmond Hill 1 1 Children's & Women's Health Centre of BC, Vancouver 1 1 ISRAEL Nazareth Hospital (EMMS), Nazareth 18 19 3 40 Ma'ayney HaYeshua Medical Center, Bnei Brak 5 5 4 4 5 5 4 1 5 8 31 15 Edith Wolfson Medical Center, Holon 11 11 6 6 6 6 4 3 2 2 31 26 Holy Family Hospital, Nazareth 10 3 13 HaEmek Medical Center, Afula 1 1 7 6 2 2 2 1 12 10 Poriya Government Hospital, Tiberias 3 3 3 1 4 1 12 3 Bnai Zion Medical Center, Haifa 4 4 7 7 11 11 Hillel Yaffe Medical Center, Hadera 3 3 3 2 1 9 3 POLAND Univ School of Medicine, Poznan 3 3 24 24 15 14 33 32 26 1 22 3 126 74 Polish Mothers Memorial Hospital, Lodz 1 2 10 8 2 23 Medical University of Gdansk, Gdansk 1 1 3 2 1 1 1 1 1 1 8 5 UK Bradford Royal Infirmary, Bradford 8 4 4 3 2 15 1 30 7 Nottingham City Hospital, Nottingham 2 2 2 2 3 2 2 2 7 1 4 21 8 Basildon & Thurrock University, Basildon 1 5 1 3 9 1 Derriford Hospital, Plymouth 1 1 2 2 3 8 1 Liverpool Women's Hospital, Liverpool 6 6
PAGE 8 Status 2003 2004 2005 2006 2007 2008 2009 2010 Totals As of February 2010 Queens Medical Centre, Nottingham 6 6 Queen Elizabeth Hospital, King's Lynn 3 1 2 5 1 University Hospital of North Staffordshire, Stoke-on-Trent 3 1 4 Lewisham Hospital, London 3 3 CHILE Hospital Dr Gustavo Fricke, Vina del Mar 8 8 11 11 8 8 6 6 12 11 5 61 33 Hospital Dr Sotero del Rio, Puente Alto 5 5 2 4 14 4 29 5 EGYPT Assiut University Hospital, Assiut 19 19 14 14 15 15 6 6 12 1 20 86 55 AUSTRALIA Ipswich Hospital, Ipswich 1 1 12 12 9 1 1 24 13 Mater Mothers' Hospital, Brisbane 2 2 3 2 3 3 1 6 15 7 St George Hospital, Sydney 2 2 5 5 1 1 3 1 12 8 Toowoomba Base Hospital, Toowoomba 4 1 2 6 1 Monash Medical Centre, Clayton 4 2 1 5 2 Logan Hospital, Meadowbrook 3 1 1 1 4 2 Townsville Hospital, Townsville 1 1 1 1 2 2 Women's and Children's Hospital, Adelaide 1 1 SERBIA University of Belgrade, Belgrade 27 3 24 2 53 3 USA East Bay Perinatal Medical Associates, Oakland 9 4 5 1 4 1 1 20 5 University of Miami, Miami 1 10 11 Maricopa Medical Center, Phoenix 3 2 3 2 1 9 2 University of South Carolina, Columbia 1 1 2 2 3 3 6 6 Texas Tech UHSC, Lubbock 2 2 Jamaica Hospital Medical Center, Jamaica 2 2 2 2 University of Iowa Hospitals and Clinics, Iowa City 1 1 1 2 1 THE NETHERLANDS Atrium Medical Center, Heerlen 4 4 5 5 7 7 5 4 6 2 29 20 Academisch Ziekenhuis Maastricht, Maastricht 3 3 2 2 1 1 7 5 Maaslandziekenhuis Sittard, Sittard 2 2 5 5 7 7 Sint Lucas Andreas Ziekenhuis, Amsterdam 4 2 1 1 5 3 Maxima Medical Centre, Veldhoven 2 2 JAMAICA University Hospital of the West Indies, Kingston 23 12 14 7 3 47 12 ESTONIA Tartu University Hospital - Women's Clinic, Tartu 5 5 12 12 8 8 7 7 7 7 1 47 32 SPAIN Hospital Clinic-University of Barcelona, Barcelona 2 2 6 6 10 10 9 9 8 1 7 2 44 28 JORDAN Islamic Hospital, Amman 5 5 5 5 8 8 9 7 8 6 1 42 25 HUNGARY University of Debrecen, Debrecen 5 5 11 4 6 3 5 5 1 36 9 ROMANIA University of Pharmacy and Medicine, Cluj-Napoca 2 2 5 5 2 2 4 4 3 1 17 13 BELGIUM Vrije Universiteit Brussel, Brussels 5 7 3 15 GERMANY Ludwig Maximilians University of Munich, Munich 1 1 4 4 3 2 1 9 7 CUB - Virchow Klinikum, Berlin 3 3 CUB - Benjamin Franklin, Berlin 2 1 1 3 1 CROATIA Sveti Duh Hospital, Zagreb 4 4 3 2 2 2 9 8 GREECE Alexandra Maternity, Athens 1 3 4