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Safety Data Sheet Issuing date data available Version 2 1. PRODUCT AND COMPANY IDENTIFICATION Product name UN/ID No Recommended use Mitomycin C (MMC) 2811 For research use only Supplier Address E-mail address Emergency telephone GHS - Classification Abcam Inc 1 Kendall Square, Ste 341 Cambridge, MA 02139-1517 USA Tel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free) Fax: (866) 739-9884 or (866) 457-9616 (both US toll free) technical@abcam.com Tel: (617)225-2272 or 888-77-ABCAM (22226) (US toll free) - Monday-Friday 8am-9pm EST 2. HAZARDS IDENTIFICATION Acute oral toxicity Category 2 Carcigenicity Category 2 GHS Label elements, including precautionary statements Signal Word Danger Hazard statements H300 - Fatal if swallowed H351 - Suspected of causing cancer Page 1 / 6

Precautionary Statements - EU ( 28, 1272/2008) P301 + P310 - IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician P308 + P313 - IF exposed or concerned: Get medical advice/ attention P281 - Use personal protective equipment as required P264 - Wash face, hands and any exposed skin thoroughly after handling P270 - Do t eat, drink or smoke when using this product P201 - Obtain special instructions before use P202 - Do t handle until all safety precautions have been read and understood P330 - Rinse mouth P501 - Dispose of contents/ container to an approved waste disposal plant P405 - Store locked up Other information Caution - substance t yet tested completely 3.1 Substances 3. COMPOSITION/INFORMATION ON INGREDIENTS Chemical Name Mitomycin C CAS-No Weight % Classification (Reg. 1272/2008) 50-07-7 60-100 Acute Tox. 2 (H300) Carc. 2 (H351) For the full text of the H-Statements mentioned in this Section, see Section 16 4. FIRST AID MEASURES General advice Eye contact Skin contact Inhalation Ingestion Notes to physician Protection of first-aiders Immediate medical attention is required. Immediately flush with plenty of water. After initial flushing, remove any contact lenses and continue flushing for at least 15 minutes. Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. Move to fresh air. Rinse mouth. Do t induce vomiting without medical advice. Never give anything by mouth to an unconscious person. Call a physician or poison control center immediately. Treat symptomatically. Use personal protective equipment. Ensure that medical personnel are aware of the material(s) involved, and take precautions to protect themselves. 5. FIRE-FIGHTING MEASURES Flammable properties Flash point Suitable extinguishing media Not flammable. t determined Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Page 2 / 6

Explosion Data Sensitivity to Mechanical Impact Sensitivity to Static Discharge Protective equipment and precautions for firefighters ne. ne. As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. 6. ACCIDENTAL RELEASE MEASURES Personal precautions Environmental precautions Methods for containment Methods for cleaning up Other information Use personal protective equipment. Avoid contact with the skin and the eyes. Avoid dust formation. Ensure adequate ventilation. Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak. Try to prevent the material from entering drains or water courses. Prevent further leakage or spillage if safe to do so. Cover powder spill with plastic sheet or tarp to minimize spreading. Dike far ahead of liquid spill for later disposal. Use personal protective equipment. Cover powder spill with plastic sheet or tarp to minimize spreading and keep powder dry. Take up mechanically and collect in suitable container for disposal. Avoid dust formation. Clean contaminated surface thoroughly. Refer to protective measures listed in sections 7 and 8. 7. HANDLING AND STORAGE Advice on safe handling Technical measures/storage conditions Wear personal protective equipment. Avoid contact with skin, eyes and clothing. Avoid dust formation. Use only in area provided with appropriate exhaust ventilation. Do t eat, drink or smoke when using this product. Remove and wash contaminated clothing before re-use. Keep containers tightly closed in a dry, cool and well-ventilated place. Keep out of the reach of children. Keep in properly labeled containers. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Exposure Guidelines Engineering measures Personal protective equipment Eye/face protection Skin and body protection Respiratory protection Hygiene measures This product does t contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies. Showers Eyewash stations Ventilation systems Tightly fitting safety goggles. No special protective equipment required. If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved respiratory protection should be worn. Positive-pressure supplied air respirators may be required for high airborne contaminant concentrations. Respiratory protection must be provided in accordance with current local regulations. When using, do t eat, drink or smoke. Remove and wash contaminated clothing before re-use. Provide regular cleaning of equipment, work area and clothing. Wash hands before breaks and immediately after handling the product. Keep away from food, drink and animal feeding stuffs. Page 3 / 6

9. PHYSICAL AND CHEMICAL PROPERTIES Appearance Odor Threshold ph Flash point Decomposition temperature Melting point/range Explosion limits Violet. Odor Physical State @20 C Autoignition temperature Boiling point/boiling range Flammability Limits in Air. Solid Specific Gravity Evaporation rate VOC Content(%) data available t applicable solubility Vapor density Dimethylsulfoxide. data available 10. STABILITY AND REACTIVITY Stability Incompatible products Conditions to avoid Stable under recommended storage conditions. None kwn based on information supplied. None kwn based on information supplied. Hazardous decomposition products Carbon moxide (CO). Carbon dioxide (CO2). Nitrogen oxides (NOx). Hazardous polymerization Hazardous polymerization does t occur. 11. TOXICOLOGICAL INFORMATION Acute toxicity Product Information Ingestion Product is toxic by ingestion. Toxic if swallowed Chronic toxicity Carcigenicity Limited evidence of a carcigenic effect. This product contains one or more substances which are classified by IARC as carcigenic to humans (Group I), probably carcigenic to humans (Group 2A) or possibly carcigenic to humans (Group 2B) - California - Proposition 65 - Carcigens List Target Organ Effects None kwn. 12. ECOLOGICAL INFORMATION Ecotoxicity The environmental impact of this product has t been fully investigated. Page 4 / 6

13. DISPOSAL CONSIDERATIONS Waste disposal methods Contaminated packaging This material, as supplied, is t a hazardous waste according to Federal regulations (40 CFR 261). This material could become a hazardous waste if it is mixed with or otherwise comes in contact with a hazardous waste, if chemical additions are made to this material, or if the material is processed or otherwise altered. Consult 40 CFR 261 to determine whether the altered material is a hazardous waste. Consult the appropriate state, regional, or local regulations for additional requirements. Do t re-use empty containers. 14. TRANSPORT INFORMATION DOT Excepted Quantity Proper shipping name Toxic solid, organic, n.o.s. (Mitomycin C) Hazard class 6.1 UN/ID No 2811 Packing group II IATA Excepted Quantity UN/ID No 2811 Proper shipping name Toxic solid, organic, n.o.s. (Mitomycin C) Hazard class 6.1 Packing group II ADR Excepted Quantity Proper shipping name Toxic solid, organic, n.o.s. (Mitomycin C) Hazard class 6.1 UN/ID No 2811 Packing group II U.S. Federal Regulations 15. REGULATORY INFORMATION SARA 313 Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does t contain any chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372. SARA 311/312 Hazard Categories Acute Health Hazard Chronic Health Hazard Fire Hazard Sudden Release of Pressure Hazard Reactive Hazard Clean Water Act This product does t contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40 CFR 122.42). CERCLA This material, as supplied, does t contain any substances regulated as hazardous substances under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments and Reauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state level pertaining to releases of this material. U.S. State Regulations Page 5 / 6

California Proposition 65 This product does t contain any Proposition 65 chemicals. U.S. State Right-to-Kw Regulations International Regulations Mexico - Grade Serious risk, Grade 3 WHMIS Note: This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all the information required by the CPR. Full text of H-Statements referred to under sections 2 and 3 H300 - Fatal if swallowed H351 - Suspected of causing cancer 16. OTHER INFORMATION Hazard statements H300 - Fatal if swallowed H351 - Suspected of causing cancer Revision Date Revision Note 13-Jul-2015. Disclaimer The information provided in this Safety Data Sheet is correct to the best of our kwledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is t to be considered a warranty or quality specification. The information relates only to the specific material designated and may t be valid for such material used in combination with any other materials or in any process, unless specified in the text. End of MSDS Page 6 / 6