A few seconds after turning on, the screen changes to Set Up Screen Before adjusting the pressure, calibrate the O 2 sensors

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SiPAP Set-Up Plug into mains, air & O 2, then setup the circuit as shown below Set-up & test before spiking water bag A few seconds after turning on, the screen changes to Set Up Screen Before adjusting the pressure, calibrate the O 2 sensors O 2 Sensor Calibration 1. Enter the Calibration Screen from the Set Up Screen by pressing the CAL button on the lower right hand corner of the touch screen 2. Adjust the %O 2 control to 21% a. Allow the %O 2 display to stabilize b. Confirm by touching the associated flashing question mark c. Wait for egg-timer to disappear and a green tick to be shown 3. Adjust the %O 2 control to 100% a. Allow the %O 2 display to stabilize b. Confirm by touching the associated flashing question mark c. Wait for egg-timer to disappear and a green tick to be shown 4. Return to the Start up Screen by pressing the EXIT button 5. If calibration fails and returns an error code E5x a. Calibrate again b. If fails again, inform technician and switch to other SiPAP machine c. If no other available, press O 2 Disable to disable O 2 monitoring and read O 2 level from the dial 1

Leak Test 1. Connect the patient interface (prong or mask) to the generator and occlude the opening to the patient 2. Adjust the NCPAP / Pres Low flowmeter to 8 L/min a. Verify that the measured pressure is 5 ± 1 cmh 2 O b. Adjust pressure to R x lower CPAP level c. Touch the associated flashing question mark to confirm. 3. Adjust %O 2 control as R x for the current patient a. Verify that the blender setting, and the measured oxygen value, are within 3% b. Touch the associated flashing question mark to confirm. 4. Adjust the Pres High flowmeter as R x for the current patient a. Aim 3 cmh 2 O above lower CPAP b. Touch the associated flashing question mark to confirm. 5. Respiratory monitoring - a. Yes? - Connect the transducer to the front panel of the unit & associated respiratory sensor to baby i. The white arrow goes at the top please do not force it b. No? - Ensure the transducer is disconnected from the front panel c. Touch the associated flashing question mark to confirm d. The display screen changes to the Alarm Set/Confirm Screen 6. Press the NCPAP button or Alarm icon to set alarms and begin monitoring 7. Remove the occlusion to the patient interface a. The monitored CPAP display should be 0-2 cmh 2 O b. If not, check that the interface is not still occluded 2

Select therapy NCPAP continuous positive airway pressure based on clinician set pressure o Breath rate monitoring/alarm can be activated in this mode by selecting NCPAP + Apnoea mode BiPhasic time triggered pressure assists are delivered based on clinician set inspiratory time, rate and pressure criteria o Breath rate monitoring/alarm can be activated in this mode by selecting BiPhasic + Apnoea mode BiPhasic tr* patient triggered pressure assists delivered based on clinician set inspiratory time and pressure criteria o Breath rate monitoring/alarm and Apnoea backup breaths are automatically active in this mode. 3

Soft-key operation Changing a control When a control such as T i (inspiratory time) is selected, increase and decrease buttons appear & the control and the displayed value for the selected parameter are highlighted o Use the up or down arrows to adjust the parameter o Accept the action by pressing the control button again If a button for another control is pressed at any time during this procedure, the first control reverts to its original setting and the highlight changes to the newly selected control If no button is pressed for a period of 15s during this procedure, the highlighted controls are automatically de-selected and the screen is restored to its previous configuration If no screen interactions occur for a period of 2 minutes and there are no active alarms, the screen goes to a locked state to prevent inadvertent entries o To unlock the screen, press the screen lock button o In the case of a high priority alarm, the screen immediately unlocks to allow access to controls SiPAP, troubleshooting 02 sensor calibration failure / error code E5x Calibrate again If fails again, inform technician and switch to other SiPAP machine If no other available, press O 2 Disable to disable O 2 monitoring and read O 2 level from the dial 4

Points to consider Not achieving adequate pressure in set-up? o Check water bag spike is still in its holder Start high o Aim to use respiratory sensor to synchronize breaths / provide alarms o If no decent signal, then switch to mode without a need for a sensor, i.e - BiPhasic tr* > BiPhasic NCPAP + Apnoea > NCPAP If not achieving desired PIP & no leaks present, consider an increase it T i For early recognition of alarm state, consider reducing T apnoea to 10s Battery life Up to 2 hours The unit is designed to give 3 cmh 2 0 pressure above CPAP level o For this reason, the Pres High flowmeter only goes to 5Lmin -1 o It should not be used off the scale 5