Foot plantar pressure is the pressure field that

Article Offloading of diabetic foot ulcers: The role of the physiotherapist as part of a multidisciplinary team Lyndsay Orr Citation: Orr L (2015) Offloading of diabetic foot ulcers: The role of the physiotherapist as part of a multidisciplinary team. Diabetic Foot Canada 3: 18 22 Article points 1. Offloading is vital in the management of people with diabetic foot ulcers. 2. Physiotherapists are not generally involved in the care of people with diabetic foot ulcers who require offloading. 3. However, physiotherapists are able to assess these patients offer strategies to manage offloading while keeping them mobile. Key words - Foot ulcers - Offloading - Peak plantar pressure Author Lyndsay Orr, BScPT, MClSc (Wound Healing), Rehab First Inc. Effective diabetic foot ulcer (DFU) offloading, which is the ability to reduce pressure forces over the wound site, is the key to managing patients with DFUs (Botros et al, 2010; RNAO, 2013). Failure to provide intensive offloading to patients with DFUs can lead to further trauma, infection, and ultimately amputation. Protection of the wound and foot is essential as the wound heals. As part of the multidisciplinary healthcare team, physiotherapists are able to assess patients with DFUs and offer strategies to manage offloading while mobilizing. This paper is a narrative review of key studies supporting the physiotherapist role for offloading of DFUs using gait aids and gait patterns which reduce peak plantar pressures (PPP) while ambulating. Foot plantar pressure is the pressure field that acts between the foot and the support surface during every day locomotor activities (Razak et al, 2013). Pecoraro et al (1990) investigated the effects of foot plantar pressures, over a 30-month period, by following 80 patients with diabetes mellitus (DM) who had a lower limb amputation due to a diabetic foot ulcer (DFU). The investigators used a synthesis of various objective and subjective data to define causal pathways that led to the amputation. They concluded that patients with DM and peripheral neuropathy (PN) are at high risk for plantar ulcers over the metatarsal heads due to excessive pressure and insensate skin. The causal sequence of minor trauma, cutaneous ulceration, and wound-healing failure applied to 72% of the amputations, often with the additional association of infection and gangrene. An episode involving minor trauma that caused cutaneous injury, such as increased plantar pressures in inappropriate footwear, preceded 69 of 80 amputations which they felt was an identifiable and potentially preventable event. Assessing the peak plantar pressures (PPP) using in-shoe insole pressure sensors is often used as a surrogate measure for studying the risk of skin breakdown (Cavanagh et al, 1997; Ahroni et al, 1999), and elevated plantar pressure is a significant risk factor for foot complications (Lavery et al, 2003). Minimizing PPP in at risk populations could prevent the need for future amputations. Many strategies are used with the DFU population for the management of PPP with the goal of DFU healing. Among these is the use of specialized footwear, which is commonly referred to in the literature as footwear for pressure redistribution and to increase the area of weight bearing. Total contact casting (TCC) and removable walkers are very effective in reducing PPP at sites of ulceration and high plantar pressure in the diabetic neuropathic foot. Offloading shoes also reduce peak pressure significantly, but not as much as TCC and removable walkers, which is likely to contribute to the lesser clinical effectiveness of these devices (Bus et al, 2008). Although effective, TCC and removable walkers can be expensive for patients and their families, and may be limited in availability depending on the services and professional support in the patients local community. Although there is no clear percentage of effective offloading that is needed to avoid skin damage and maximize wound healing in DFU (Beuker et al, 2005), it can be presumed that the maximal amount of offloading would be of most benefit. 18 Diabetic Foot Canada Volume 3 No 1 2015

Advancing the Gold Standard of Care to the Next Generation GOLD Standard of Care TCC wound healing rate 1, 2 Quicker application, Greater comfort. Total Contact Casting is recognized as the GOLD Standard of Care for off-loading diabetic foot ulcers. 1-17 Fast and Effective Healing 1 Shown to reduce cost of care by half 17 Significantly improve patient outcomes by decreasing infection and amputation rates 19 Enforce Patient Compliance TCC-EZ offers a one-piece, roll-on, light weight, woven design that simplifies the application process while reducing the potential for causing additional tissue damage. The result is now an application process that can be completed in under 10 minutes while providing greater patient comfort. 18 TCC-EZ offers a complete, ready-to-go system with all accessories included. Easy 1-2-3 prep, roll, apply and set process For more information, please contact us at: 800.387.5302 or via email customerservice@dermasciences.com or visit www.tccez.com or www.tccpatient.com Takes about ¼ the amount of time of traditional systems 18 Ease of application helps decrease potential of causing tissue damage 18 Required minimal training time 18 Light-weight woven design offers a more comfortable fit 1. Armstrong DG, et al. Off-loading the diabetic foot wound. Diabetes Care 24:1019-1022, 2001 2. Bloomgarden ZT: American Diabetes Association 60th Scientific Sessions, 2000. Diabetes Care 24:946-951, 2001. 3. American Diabetes Association: Consensus Development Conference on Diabetic Foot Wound Care. Diabetes Care 22:1354 1360, 1999 4. Coleman W, Brand PW, Birke JA: The total contact cast, a therapy for plantar ulceration on insensitive feet. J Am Podiatr Med Assoc 74:548 552, 1984 5. Helm PA, Walker SC, Pulliam G: Total contact casting in diabetic patients with neuropathic foot ulcerations. Arch Phys Med Rehabil 65:691 693, 1984 6. Baker RE: Total contact casting. J Am Podiatr Med Assoc 85:172 176, 1995 7. Sinacore DR, Mueller MJ, Diamond JE: Diabetic plantar ulcers treated by total contact casting. Phys Ther 67:1543 1547,1987 8. Myerson M, Papa J, Eaton K, Wilson K: The total contact cast for management of neuropathic plantar ulceration of the foot. J Bone Joint Surg 74A:261 269, 1992 9. Walker SC, Helm PA, Pulliam G: Chronic diabetic neuropathic foot ulcerations and total contact casting: healing effectiveness and outcome probability (Abstract). Arch Phys Med Rehabil 66:574, 1985 10. Mueller MJ, Diamond JE, Sinacore DR, Delitto A, Blair VPD, Drury DA, Rose SJ: Total contact casting in treatment of diabetic plantar ulcers: controlled clinical trial. Diabetes Care 12:384 388, 1989 11. Liang PW, Cogley DI, Klenerman L: Neuropathic ulcers treated by total contact casts. J Bone Joint Surg 74B:133 136, 1991 12. Walker SC, Helm PA, Pulliam G: Total contact casting and chronic diabetic neuropathic foot ulcerations: healing rates by wound location. Arch Phys Med Rehabil 68:217 221, 1987 13. Armstrong DG, Lavery LA, Bushman TR: Peak foot pressures influence the healing time of diabetic foot ulcers treated with total contact casts. J Rehabil Res Dev 35: 1 5, 1998 14. Lavery LA, Vela SA, Lavery DC, Quebedeaux TL: Reducing dynamic foot pressures in high-risk diabetic subjects with foot ulcerations: a comparison of treatments. Diabetes Care 19:818 821, 1996 15. Lavery LA, Armstrong DG, Walker SC: Healing rates of diabetic foot ulcers associated with midfoot fracture due to Charcot s arthropathy. Diabet Med 14:46 49, 1997 16. Lavery LA, Vela SA, Lavery DC, Quebedeaux TL: Total contact casts: pressure reduction at ulcer sites and the effect on the contralateral foot. Arch Phys Med Rehabil 78:1268 1271, 1997 17. Fife CE; Carter MJ, Walker D: Why is it so hard to do the right thing in wound care? Wound Rep Reg 18: 154 158, 2010. 18. Jensen J, Jaakola E, Gillin B, et al: TCC-EZ Total Contact Casting System Overcoming the Barriers to Utilizing a Proven Gold Standard Treatment. DF Con. 2008. 19. C. E. Fife, MD, et all, Diabetic foot ulcer off-loading: The Gap Between Evidence and Practice: Data from the U.S. Wound Registry. Advances in Skin and Wound Care, 27(7) p. 310-316, 2014. 2015 Derma Sciences, Inc. All rights reserved.

Soft tissue thickness and arch height were found to be the best predictors of increased pressure. Predicting plantar pressures In a study by Cavanagh et al (1997) the team took radiographic images of the feet of 50 healthy subjects to identify what measurements could be utilized as predictors of PPP. They found that only 31% of the heel and 38% of the first metatarsal head PPP variance could be explained by the measurements of foot structure derived from the radiographs. Soft tissue thickness and arch height were found to be the best predictors of increased pressure. Given that foot anatomy can only account for approximately 40% of pressure differences, their findings implied that dynamics of gait exert the major influence on plantar pressure during walking. As well, Mueller et al (2003) examined forefoot structure as a predictor of PPP during walking, and compared 20 people with DM and PN to 20 people without DM. Measures of foot structure were taken from three dimensional images. They found that hammer toe deformity, soft tissue thickness, hallux valgus, and forefoot arthropathy accounted for 47 71% of the PPP variance in the DM group and 52 83% of the variance in the control group. Given this wide margin, the source of PPP are multifactorial. Gait aids and gait patterns need to be considered along with foot deformity when evaluating risk for DFU in DM patients. Gait patterns and their effect on plantar pressures The assessment of gait in a person with diabetes is recommended to establish a person s risk of falling, abnormal weight bearing and alterations in gait pattern. Assessment of gait can also be utilized to determine changes in plantar pressures while walking. The effect of walking cadences on in-shoe plantar pressures in eight able-bodied subjects was evaluated by Zhu et al (1995). With increasing cadence, mean pressure-time integral continuously decreased (45% at 120 steps/minute), mean foot to floor contact durations continuously decreased (64% at 120 steps/ minute), and mean peak plantar pressures increased (119% at 120 steps/minute). These percentages were compared to the subjects at a cadence speed of 70 steps/minute. The results showed that the greater the walking speed, the greater the PPP. The authors then challenged whether decreased PPP with gait aids are due to the device itself or the decrease in cadence of patients using these devices. Given that patients using TCC and other therapeutic footwear would also likely have a decrease in cadence, it is difficult to attribute decreased PPP to the footwear alone. Encouraging patients to slow their gait speed while walking may result in decreased PPP and decrease their risk of minor trauma. Zhu et al (1991) also studied gait patterns in 10 healthy males, and reported the effect of shuffling gait patterns on plantar pressures. PPPs decreased at the first and second metatarsal heads and the hallux by up to 57.8% and 63.2% respectively. Again, the question of whether the pressure change was due to less of a push off versus decreased walking speed could not be determined. The risk of friction and shear causing cutaneous injury with shuffle type gait was also not addressed, but needs to be a clinical consideration with this gait pattern. Gait patterns in patients with DM and PN were studied in comparison to healthy subjects (Mueller et al, 1994). Limited plantar flexion muscle torque secondary to peripheral neuropathy was found in the group with DM. The authors suggest that emphasizing hip pull-off for patients may decrease pressure under the metatarsal heads. Mueller et al (1994) tested this hypothesis with seven male subjects who had diabetes mellitus and peripheral neuropathy. They were asked to emphasize a hip pull-off gait pattern by decreasing their push-off at the ankle, pull their legs forward from the hips, and shorten their steps but not slow their walking speed. Compared to normal ankle push-off, the hip pull-off pattern showed a 27% decrease in forefoot peak plantar pressures and a 24% increase in heel peak plantar pressures. It was recognized that further studies would need to be conducted to determine if this increase in heel pressure is more of a risk for patients than the benefit of decreased forefoot pressure. Though this is a small study, it reminds us that when pressure is decreased in one segment of the foot it is potentially increased in a secondary segment which would then be at increased risk for breakdown due to high plantar pressures. Step to pattern of gait was researched by Brown and Mueller (1998) in 10 healthy subjects and one subject who lived with DM and PN. The researchers compared step to gait with and without a cane and step through gait with and without a cane in both groups. Peak plantar pressures decreased 53% in the 20 Diabetic Foot Canada Volume 3 No 1 2015

forefoot and increased 14% in the heel with step to gait regardless of whether the cane was used or not. These results were compared with results from the PN subject, who had an 87% decrease in forefoot pressures and 46% increase in heel pressures with step to gait when compared to step through gait. Step through with the cane decreased the peak plantar pressure on the forefoot by 84% and increased peak plantar pressure on the heel by 39%. The authors concluded that the cane did not significantly reduce pressure in the healthy subject s forefeet or the heels using the step to pattern, but there was a decrease in plantar pressures with use of a cane in the patient with DM and PN. This was attributed to the ineffective use of the cane by healthy subjects. Literature on the use of gait aids and their effect on PPP are discussed in the following section. Gait aids and their effect on plantar pressures In order to explore gait aids and their effect on plantar pressure, Youdas et al (2005) studied 10 healthy subjects to determine if subjects can offload target amounts of weight using a wheeled walker, cane, crutches and forearm crutches. Subjects were trained by a physiotherapist to offload the right lower extremity by 50% using an assistive device and a bathroom scale for feedback on weight reduction. Vertical ground reaction force was measured by using forceplates while subjects walked at a selfselected speed using a three-point partial weightbearing pattern. The authors found that the axillary crutches were most effective in consistently decreasing weightbearing to 50% of body weight. Forearm crutches achieved 56% offloading, wheeled walker 36%, and the straight cane 24%. This study concluded that even though patients are taught to offload their lower extremity with a gait aid, the amount of offloading may also depend on the gait aid provided in order to achieve consistent offloading. Nordic pole walking has become more popular in recent years as a means of low risk and highly practical aerobic exercise. Patients with DM and PN are asked to decrease plantar pressures for DFU prevention, but it is important for overall health and glucose management to keep an active lifestyle. Pérez-Soriano et al (2001) recognized the need for a safe aerobic exercise for patients with DM and PN, and researched the option of using Nordic pole walking for this population. Fifty healthy subjects were recruited and the plantar pressures of experienced pole walkers and inexperienced pole walkers with and without use of the Nordic poles were evaluated. Participants walked along a 12 metre walkway at the participants preferred speed and a speed 20% faster. Their findings showed that Nordic walking experience significantly modified the plantar pressure pattern, reducing the load on the second and third metatarsals by approximately 50%; 45% on the medial metatarsal, and 40% on the second and third metatarsal heads not only during Nordic walking but also during normal walking. Despite the greater speeds in Nordic walking, there was no significant increase in heel and first toe plantar pressures which has been recorded by previous studies when cadence is increased. They did find an increase in medial heel pressures in the experienced group with Nordic walking of 25% for the preferred speed and 23% for the fast speed which was statistically significant. Given their findings, the authors suggest that Nordic walking could be beneficial prophylactically for patient populations who are at risk for forefoot ulcers such as the diabetic neuropathic foot. As walkers gain more experience with pole walking, they also modified their pressure pattern during walking without poles and reduced pressure on the metatarsals by 30 50%. Lee et al (2011) recognized that foot pressure is widely used for the evaluation of gait and studied the fluctuating changes of foot pressure with normal, two-point, and four-point crutch walking in healthy volunteers. PPP parameters were collected using a force plate during gait with or without a crutch. The regional plantar forefoot pressure significantly decreased during two-point and four-point crutch (67.36 +/- 4.61 kpa; 63.82 +/- 4.51 kpa respectively) walking compared with normal gait (79.73 +/- 4.08 kpa). However, the regional plantar foot pressure of the midfoot and the rearfoot were not altered by gait type. Healthy subjects were also tested and compared with ipsilateral and contralateral cane use for peak vertical plantar force (Aragaki et al, 2009). The researchers collected data using a force plate from subjects walking in three different conditions relative Axillary crutches were most effective in consistently decreasing weightbearing to 50% of body weight. Diabetic Foot Canada Volume 3 No 1 2015 21

Pecoraro RE, Reiber GE, Burgess EM (1990) Pathways to diabetic limb amputation: basis for prevention. Diabetes Care 13(5): 513 21 Pérez-Soriano P, Llana-Belloch S, Martinez-Nova A et al (2011) Nordic walking practice might improve plantar pressure distribution. Res Q Exerc Sport 82(4): 593 9 Razak AH, Zayegh A, Begg RK, Wahab Y (2012) Foot plantar pressure measurement system: a review. Sensors (Basel) 12(7): 9884 912 Registered Nurses Association of Ontario (2013) Assessment and Management of Foot Ulcers for People with Diabetes. (2nd ed.). Registered Nurses Association of Ontario, Toronto. Youdas JW, Kotajarvi BJ, Padgett DJ, Kaufman KR (2005) Partial weightbearing gait using conventional assistive devices. Arch Phys Med Rehabil 86(3): 394 8 Zhu HS, Wertsch JJ, Harris GF et al (1991) Foot pressure distribution during walking and shuffling. Arch Phys Med Rehabil 72(6): 390 7 Zhu H, Wertsch JJ, Harris GF, Alba HM (1995) Walking cadence effect on plantar pressures. Arch Phys Med Rehabil 76(11): 1000 5 to a randomly assigned limb: contralateral cane, ipsilateral cane and no cane. Their results showed that compared to walking unaided, there was a 7% decrease in peak plantar vertical force with ipsilateral cane use and an 11% decrease with contralateral cane use. The authors concluded that both ipsilateral and contralateral cane use reduced peak plantar vertical pressures, but also decreased cadence by 13% which they believe was due to inexperienced cane users. Clinical implications While physiotherapists have traditionally been referred to for ambulatory aids and recommended alterations in gait patterns in the treatment of the orthopedic population to aid the healing of a bone or soft tissue injury in the foot, they are not typically referred to for equipment and weightbearing strategies in the DFU population. Physiotherapy assessment as part of the multidisciplinary team plan of care is imperative in the effective treatment of patients with diabetic foot ulcers, including developing tailored teaching plans related to effective ways to decrease offloading and assist in healing (Bakker and Schaper, 2012). Many approaches have been used to adapt footwear to decrease plantar pressures in the DFU population and such adaptations are able to reduce forefoot pressures by 37% 85% (Beuker et al, 2005). The above literature review shows that it is not only foot deformity and peripheral neuropathy that accounts for high peak plantar pressures leading to minor trauma, but also gait pattern, which therefore should be assessed. Gait aids can be used in isolation or in combination with therapeutic footwear to maximize offloading for patients who cannot comply with specialized footwear due to adherence, financial restraints, or contraindications. Combining multiple strategies for the offloading of DFUs will maximize healing. Physiotherapists need to be aware of their role in care of patients with DFU to augment offloading with recommendations related to gait, mobility and safe physical activity for overall health and safe glucose management. Conclusion The physiotherapist is a key member of the multidisciplinary team caring for patients with diabetes who may be in need of foot offloading. This narrative review of the literature supports the importance of the physiotherapist role in maximizing offloading interventions through attention to gait aids and gait training. Further research is needed to assess the long term effects of altered gait pattern on the musculoskeletal system. Offloading of the heel is also noted to be much more challenging than offloading of the forefoot. A number of studies commented on the increase in heel pressures with the decrease of forefoot pressures. A risk benefit analysis is clinically indicated for all DFU patients. The majority of studies found calculated the effects of gait patterns and gait aids on healthy volunteers. Further research in the DFU population is warranted. n Ahroni JH, Boyko EJ, Forsberg RC (1999) Clinical correlates of plantar pressure among diabetic veterans. Diabetes Care 22(6): 965 72 Aragaki DR, Nasmyth MC, Schultz SC et al (2009) Immediate effects of contralateral and ipsilateral cane use of normal adult gait. PM R 1(3): 208-213 Bakker K, Schaper NC, International Working Group on the Diabetic Foot Editorial Board (2012) The development of global consensus guidelines on the management and prevention of the diabetic foot 2011. Diabetes Metab Res Rev 28(Suppl 1): 116 8 Beuker BJ, Van Deursen RW, Price P et al (2005) Plantar pressure in off-loading devices used in diabetic ulcer treatment. Wound Rep Regen 13(6): 537 42 Botros M, Goetti K, Parsons L et al (2010) Best practice recommendations for the prevention, diagnosis and treatment of diabetic foot ulcers: update 2010. Wound Care Canada 8(4): 6-40 Brown HE, Mueller MJ (1998) A step-to gait decreases pressures on the forefoot. J Orthop Sports Phys Ther 28(3): 139 45 Bus SA, Valk GD, van Deursen RW et al (2008) The effectiveness of footwear and offloading interventions to prevent and heal foot ulcers and reduce plantar pressure in diabetes: a systematic review. Diabetes Metab Res Rev 24(Suppl 1): S162 180 Cavanagh PR, Morag E, Boulton AJ et al (1997) The relationship of static foot structure to dynamic foot function. J Biomech 30(3): 243 50 Lavery LA, Armstrong DG, Wunderlich RP et al (2003) Predictive value of foot pressure assessment as part of a population-based diabetes disease management program. Diabetes Care 26(4): 1069 73 Lee JU, Kim MY, Kim JH et al (2011) Analysis of plantar foot pressure during the non-crutch, two-point, and four-point crutch gait performed by healthy volunteers. Journal of Physical Therapy Science 23(3): 489 93 Mueller MJ, Minor SD, Sahrmann SA et al (1994) Differences in the gait characteristics of patients with diabetes and peripheral neuropathy compared to age-matched controls. Phys Ther 74(4): 299 313 Mueller MJ, Sinacore DR, Hoogstrate S, Daly L (1994) Hip and ankle walking strategies: effect on peak plantar pressures and implications for neuropathic ulceration. Arch Phys Med Rehabil 75(11): 1196 200 Mueller MJ, Hastings M, Commean PK et al (2003) Forefoot structural predictors of plantar pressures during walking in people with diabetes and peripheral neuropathy. J Biomech 36(7): 1009 17 22 Diabetic Foot Canada Volume 3 No 1 2015