NEXUS TKO. Specialty Neonatal/Pediatric. Safety Infusion Sets. Blood Reflux Protection 24/7! Anti-Reflux Technology Provides

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Specialty Neonatal/Pediatric Safety Infusion Sets Anti-Reflux Technology Provides Blood Reflux Protection 24/7! NEXUS TKO TECHNOLOGY THAT NEVER SLEEPS!

Nexus TKO Neonatal Safety Catheter Nexus Tri-Seal Microbial Barrier Protection 96-Activation Microbial Barrier Performance Study6 Tri-Seal Design Provides (3) Levels of Validated Microbial Ingress Protection3,6 1 st Level of Protection A 360 compression seal between the septum and the rigid needle-free connector housing provides a 360 barrier of protection from microbial ingress3,6 2 nd Level of Protection A smooth, easy to disinfect septum surface with our exclusive Slit-Lock technology assures the septum slit is fully locked and sealed, which provides a safe and effective microbial barrier seal3,6 3 rd Level of Protection The Slit-Lock septum remains closed until the male luer fully compresses the locked septum slit inside the needle free housing, further protecting the internal fluid path from microbial ingress3,6 Patented Clear, Single Piece Technology Nexus TKO Anti-Reflux technology, delivers IV Catheter Patency 24/7! with a single crystal clear silicone Anti-Reflux valve Blood Reflux Protection 24/7! Nexus TKO technology decreases the risk of infection by preventing blood reflux; a known contributor to catheter related blood stream infections CRBSI s3,5 To Keep Open Catheter Patency Technology Patented 3 position Anti Reflux technology provides IV Catheter Patency 24/7! Normal Closed Position The TKO valve provides Blood Reflux Protection 24/7! Flush/Infusion The TKO valve opens forward with normal gravity pressure Blood Sample/Patency Check The TKO valve opens in reverse for easy blood draw Nexus Medical, LLC 11315 Strang Line Road Lenexa Kansas 66215

Specialty Neonatal IV Sets Extension Sets & T-Site Extension Sets Safety Connections Spin-Lock Male Luer Male Luer Lock Spin-Lock T-Site Slip Luer T-Site All Specialty Neonatal IV Sets are manufactured with our Nexus TKO Anti-Reflux technology. Our innovative safety IV sets assure catheter patency is achieved and the risk of CRBSI s due to blood reflux is reduced3,5. The TKO Anti-Reflux valve is normally closed but automatically opens towards the patient with the smallest amount of infusion pressure. When fluid pressure drops due to physiological changes (such as patient movement, crying, sneezing, coughing, venous spasms, or venous pressure) or mechanical changes (such as infusion pump fill cycles, syringe plunger reflux, IV bag run dry, luer connections, disconnections, roller clamping, or external pressure changes from ventilators) the TKO Anti-Reflux valve will automatically close to prevent blood from refluxing into the patient s catheter. The Nexus TKO valve will remain closed against vascular pressure ensuring IV Catheter Patency 24/7! 2. Nexus TKO Specialty Neonatal IV Sets are designed exclusively for Neonatal Intensive Care Extension Sets and T-Sites with Spin-Lock or Slip Luers in various tubing sizes to fit the need for low medication priming volume Multiple tubing set lengths from 3 to 60 with Multi-Color Pinch or Slide Clamps Manufactured from Non-DEHP and Latex Free materials Phone - 866.336.3987 Fax - 913.451.2363 www.nexusmedical.com Lever Lock Cannula

Nexus TKO Bi-Fuse, Tri-Fuse & Nexus TKO Multi-Access Neonatal Safety IV Sets Provide Protection Against Touch Contamination Provide Protection Against Drug Mixing Nexus TKO Anti-Reflux Technology provides Blood Reflux Protection 24/7! and the associated risk of CRBSI s3,5 Reduce the Risk of CRBSI s from Blood Reflux by using the Nexus TKO Anti-Reflux valve coupled with our Multi-Access Neonatal Safety IV Sets. These safety sets will assure catheter patency is achieved and the risk of CRBSI s due to blood reflux are reduced3,5 Reduced Risk of CRBSI s from Touch Contamination with pre-assembled and patient ready Nexus TKO Multi-Access Neonatal Safety IV Sets, designed to deliver a standardized safety solution by reducing the total number of line connections/disconnections and the potential unwanted risk of touch contamination which is proven to cause CRBSI s7 Standardized Protection and Safety Solution is achieved with Nexus TKO Multi-Access Neonatal Safety IV Sets by allowing the Clinician to choose the most efficient configuration to safely deliver the patient s specific pharmaceutical formulary. Nexus Neonatal Safety IV Sets are designed with optimum tubing lengths, priming volumes and filtration for your patient s protection Nexus TKO Provides Protection against Medication Mixing with pre-assembled IV sets offering a new level of safety by reducing drug, medication and nutrition line mixing. Nexus TKO Anti-Reflux valve technology automatically closes when fluid pressures drop from multiple pump infusions then reopens when fluid pressures resume6. Minimize Potential Costly Drug Waste and Drug Incompatibility with our Nexus TKO Bi-Fuse, Tri-Fuse and Quad-Fuse Multi-Access Neonatal IV Sets, designed to provide added safety and protection Low Priming Volumes provide a design solution for low drug waste concerns Safety Color Coded Clamps provide a visual aid to the Clinician to distinguish between specific IV lines; drugs, medications and nutrients Non-DEHP and Latex Free Nexus Medical, LLC 11315 Strang Line Road Lenexa Kansas 66215

Multi-Access Neonatal Safety IV Sets Quad-Fuse Safety IV Sets Safety Connections Bi Bi-Fuse Spin-Lock Connector Tri Tri-Fuse Spin-Lock Connector Quad Quad-Fuse Spin-Lock Connector HAL/TPN MED LIPID MED Colored Slide Clamps Nexus Medical designed a wide range of innovative Nexus TKO Multi-Access Neonatal IV Sets. Our innovative line of IV sets are pre-assembled with needle free Nexus TKO Anti-Reflux valve protection on each IV line whether you choose a bi, tri or quad configuration. This specialty designed group of IV sets handles the complex challenges of continuous IV nutrition therapy, drug therapy and intermittent IV delivery of low volume, small dosage medications and drugs. Nexus TKO Anti-Reflux technology extends catheter life by providing Blood Reflux Protection 24/7! for neonatal patients and their limited vasculature which is crucial to delivering life-sustaining nutrition, medications and drugs. Nexus TKO Anti-Reflux technology protects each IV line by reducing the risk of mixing during simultaneous infusions of nutrition, medication and drugs. Phone - 866.336.3987 Fax - 913.451.2363 www.nexusmedical.com.22 micron 1.2 micron Filters

Nexus TKO Bi-Fuse, Tri-Fuse & Nexus TKO Multi-Access Neonatal Closed Infusion System Designed to Protect Against CRBSI s by Reducing the Total Number of Line Connections/Disconnections and Touch Contamination 7 Comprehensive System to Assure Reductions in Line Openings and Line Violations The Nexus TKO Anti-Reflux Valve decreases the risk of infection by preventing Blood Reflux Protection 24/7, which is a known contributor to catheter related blood stream infections (CRBSIs) 3,5. The Patented Clear, Single Piece Nexus TKO Anti-Reflux Valve was designed to have three positions; the TKO valve will open toward the patient with the smallest amount of fluid pressure, close when not infusing to prevent blood reflux into your patient s catheter and open in reverse for easy blood sampling or patency check, but automatically reset into the closed position upon syringe disconnection. Nexus TKO technology has been proven to significantly increase IV catheter life by reducing blood reflux, which is the root cause of most thrombotic catheter occlusions 3,5. Nexus TKO valve will remain closed against vascular pressure, assuring your catheter remains patent 2. Nexus Fully Closed, Multi-Access Infusion Sets provide a completely sealed structure and clinical method for intermittent flushing and medication infusions. This system, when implemented provides a comprehensive Closed Multi-Access technique which can be used to assure a complete reduction in the overall number of line openings and line violations. Nexus Medical, LLC 11315 Strang Line Road Lenexa Kansas 66215

Multi-Access Neonatal Closed Infusion System Quad-Fuse Neonatal Closed Infusion Sets Safety Connections Vented Spike Pinch Clamp with Caution Label One Way Check Valve Nexus TKO Anti-Reflux Technology 2-Way Stop Cock Provides Blood Reflux Protection 24/7! Promotes IV Catheter Patency 24/7! Significantly reduces medication mixing by protecting each IV line separately Significantly reduces the risk of CRBSI s associated with unintentional blood reflux Increased catheter life by reducing unintentional blood reflux HAL/TPN MED Nexus TKO Neonatal Closed Infusion System Provides a significant reduction in the total number of line connections/disconnections through the use of a single, standardized closed system set Promotes standard of practice by providing a unique Closed System designed specifically for the IV nutrition and medication delivery your patient requires Safety color coded clamps provide a visual aid to the Clinician to distinguish between specific IV lines; drugs, medications and nutrients Phone - 866.336.3987 Fax - 913.451.2363 www.nexusmedical.com MED LIPID Colored Slide Clamps

Nexus TKO -6P Luer-Activated Anti-Reflux Device Nexus TKO -5 Split Septum Anti-Reflux Device NEXUS TKO TECHNOLOGY THAT NEVER SLEEPS! 1. Jasinksy LM, Wurster J. Occlusions Reduction and Heparin Elimination Trial using an Anti-Reflux Device on Peripheral and Central Intravenous Lines. Journal of Infusion Nursing, 2009; 32(1):33-39. Erratum: 2009; 32(4):194-195. 2. Mitch S. RN, CRNI, Brandmeyer B, RN, BSN. PICC and Midline Catheter Occlusion Rates: A Prospective Study Comparing the Interlink Split Septum Device versus Nexus TKO Split Septum Pressure Activated Anti-Reflux Valve. 3. Jarvis W, MD. Choosing the Best Design for Intravenous Needleless Connectors to Prevent HA-BSI. Infection Control Today, 2010 Aug. 4. Hadaway L, RN, C, CRNI, MEd. Reopening the Pipeline. Nursing, 2005; 35(8):54-61. 5. Timsit J, Misset B, Carlet J et.al. Central Vein Catheter-Related Thrombosis in Intensive Care Patients: Incidence, Risks Factors, and Relationship with Catheter-Related Sepsis. CHEST, 1998; 114(1):207-213. 6. 96-Activation Microbial Barrier Performance Study, GLP Laboratory Testing. Results on file at Nexus Medical LLC. 7. Aly H, Herson V, Duncan A et. al. Is Bloodstream Infection Preventable Among Premature Infants? A Tale of Two Cities. PEDIATRICS, 2005; 115(5):1513-1518. *additional references shown used in other Nexus literature found online at www.nexusmedical.com Nexus Medical, LLC 11315 Strang Line Road Lenexa Kansas 66215 Phone - 866.336.3987 Fax - 913.451.2363 www.nexusmedical.com