Material Safety Data Sheet Issuing Date 29-Jun-2007 MSDS PN: MIB31647 REV. K 1. PRODUCT AND COMPANY IDENTIFICATION Product Name HOAT Product Code(s) GEN076511, GEN076513, GEN076515, GEN076515C, GEN076517, GEN076517C, GEN759206, GEN759206N Trade Name(s) 1-HYDROXY-7-AZA-BENZOTRIAZOLE; 3-HYDROXY-3H-1,2,3-TRIZOLO(4,5-B)PYRIDINE Recommended Use For research use only. Not for use in diagnostic procedures. Supplier Address APPLIED BIOSYSTEMS 850 LINCOLN CENTRE DRIVE FOSTER CITY CA USA 94404 TELEPHONE: (650) 570-6667 (USA) Emergency Telephone Number CHEMTREC: +1-703-527-3887 (INTERNATIONAL) 1-800-424-9300 (NORTH AMERICA) 2. HAZARDS IDENTIFICATION DANGER! Emergency Overview Explosive Flammable solid May cause skin, eye, and respiratory tract irritation Appearance White to off-white Physical State Powder Odor No information available Potential Health Effects Principle Routes of Exposure Acute Toxicity Eyes Skin Inhalation Ingestion Chronic Effects Aggravated Medical Conditions Environmental Hazard Eye contact, Skin contact, Inhalation. May cause irritation. May cause irritation. Inhalation of dust in high concentration may cause irritation of respiratory system. Harmful if swallowed. Ingestion may cause gastrointestinal irritation, nausea, vomiting and diarrhea. Possible risks of irreversible effects. Skin disorders. See Section 12 for additional Ecological information. 3. COMPOSITION/INFORMATION ON INGREDIENTS Chemical Name CAS-No Weight % 1-hydroxy-7-azabenzotriazole 39968-33-7 60-100 Page 1 / 7
4. FIRST AID MEASURES General Advice Eye Contact Skin Contact Inhalation Ingestion Notes to Physician Protection of First-aiders In case of injury caused by fire:. Flush with plenty of water immediately. Continue flushing during transport to hospital or medical center. Immediately flush with plenty of water. After initial flushing, remove any contact lenses and continue flushing for at least 15 minutes. Keep eye wide open while rinsing. If symptoms persist, call a physician. Wash off immediately with soap and plenty of water for at least 15 minutes. Get medical attention if irritation develops and persists. Move to fresh air. If breathing is irregular or stopped, administer artificial respiration. Avoid direct contact with skin. Use barrier to give mouth-to-mouth resuscitation. If symptoms persist, call a physician. Rinse mouth. Drink plenty of water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Consult a physician if necessary. Treat symptomatically. Remove all sources of ignition. 5. FIRE-FIGHTING MEASURES Flammable Properties Flash Point Suitable Extinguishing Media Explosion Data Sensitivity to mechanical impact Sensitivity to static discharge HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. May explode from heat or contamination. No data available Water spray. Carbon dioxide (CO2). Foam. Dry powder... Specific Hazards Arising from the Chemical Risk of explosion by shock or heating under confinement. Dusts or fumes may form explosive mixtures in air. In the event of fire, cool tanks with water spray. Keep product and empty container away from heat and sources of ignition. Protective Equipment and Precautions for Firefighters As in any fire, wear self-contained breathing apparatus and full protective gear. Do not move cargo or vehicle if cargo has been exposed to heat. Move containers from fire area if you can do it without risk. For massive fire, use unmanned hose holders or monitor nozzles. NFPA Health Hazard 1 Flammability 2 Stability 4 Physical and Chemical Hazards - HMIS Health Hazard 1 Flammability 2 Stability 4 Personal Precautions - 6. ACCIDENTAL RELEASE MEASURES Personal Precautions Evacuate personnel to safe areas. Ensure adequate ventilation. Avoid dust formation. ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Take precautionary measures against static discharges. All equipment used when handling the product must be grounded. Page 2 / 7
Methods for Containment Methods for Cleaning Up Other Information Prevent further leakage or spillage if safe to do so Use personal protective equipment. Cover powder spill with plastic sheet or tarp to minimize spreading and keep powder dry. Take up mechanically and collect in suitable container for disposal. Avoid dust formation. Clean contaminated surface thoroughly. Knock down dust cloud with water spray. Refer to protective measures listed in Sections 7 and 8. 7. HANDLING AND STORAGE Handling Storage Ensure adequate ventilation. Keep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharges. Use only in an area containing flame proof equipment. Avoid dust formation in confined areas. Remove and wash contaminated clothing before re-use. Keep in properly labeled containers. Keep containers tightly closed in a cool, well-ventilated place. Keep away from open flames, hot surfaces and sources of ignition. Keep at temperatures between 2 and 8 C. 8. EXPOSURE CONTROLS / PERSONAL PROTECTION Exposure Guidelines Engineering Measures Personal Protective Equipment Eye/Face Protection Skin and Body Protection Respiratory Protection Hygiene Measures This product does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies. Showers, eyewash stations, and ventilation systems. Tightly fitting safety goggles. Antistatic boots. Wear fire/flame resistant/retardant clothing. Long sleeved clothing. In case of insufficient ventilation wear suitable respiratory equipment. When using, do not eat, drink or smoke. Regular cleaning of equipment, work area and clothing. Remove and wash contaminated clothing before re-use. Keep away from food, drink and animal feeding stuffs. Wash hands before breaks and immediately after handling the product. Page 3 / 7
9. PHYSICAL AND CHEMICAL PROPERTIES Appearance White to off-white. Odor No information available Odor Threshold No information available. Physical State Powder. ph 7.0 Flash Point No information available. Autoignition Temperature Not applicable Decomposition Temperature No information available. Boiling Point/Range No information available. Melting Point/Range 205 C / 401 F Flammability Limits in Air No information available. Explosion Limits No information available. Specific Gravity No information available. Water Solubility 0.95g/100ml. Solubility No information available. Evaporation Rate No information available Vapor Pressure No information available. Vapor Density No information available. VOC Content Not applicable. Partition Coefficient (noctanol/water) No information available. 10. STABILITY AND REACTIVITY Stability Incompatible Products Conditions to Avoid Stable under recommended storage conditions. Risk of explosion by shock, friction, fire or other sources of ignition. Oxidizing agents. Heat, flames and sparks. Shock. Temperatures above 75 C / 167 F. Hazardous Decomposition Products Thermal decomposition can lead to release of irritating gases and vapors. Nitrogen oxides (NOx). Carbon monoxide (CO). Carbon dioxide (CO2). Hazardous Polymerization Hazardous polymerization does not occur. 11. TOXICOLOGICAL INFORMATION Acute Toxicity Product Information Product does not present an acute toxicity hazard based on known or supplied information. Chronic Toxicity Chronic Toxicity Mutagenic Effects Target Organ Effects Possible risks of irreversible effects. In vitro tests have shown mutagenic effects. In vivo tests did not show mutagenic effects. None known. Page 4 / 7
Ecotoxicity Ecotoxicity effects. 12. ECOLOGICAL INFORMATION Chemical Name Log Pow 1-hydroxy-7-azabenzotriazole 0.11 13. DISPOSAL CONSIDERATIONS Waste Disposal Method This material, as supplied, is a hazardous waste according to federal regulations (40 CFR 261). Contaminated Packaging US EPA Waste Number Dispose of in accordance with local regulations. D001 14. TRANSPORT INFORMATION DOT TDG MEX ICAO IATA IMDG/IMO RID ADR ADN Page 5 / 7
International Inventories 15. REGULATORY INFORMATION TSCA DSL EINECS/ELINCS ENCS CHINA KECL PICCS AICS Not listed on inventory. For purposes of 40 CFR 720.36, this product is for Research and Development (R&D) Use Only. U.S. Federal Regulations SARA 313 Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372. SARA 311/312 Hazard Categories Acute Health Hazard Chronic Health Hazard Fire Hazard Sudden Release of Pressure Hazard Reactive Hazard Clean Water Act This product does not contain any substances regulated as pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40 CFR 122.42) CERCLA This material, as supplied, does not contain any substances regulated as hazardous substances under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments and Reauthorization Act (SARA) (40 CFR 355). There may be specific reporting requirements at the local, regional, or state level pertaining to releases of this material. U.S. State Regulations California Proposition 65 This product does not contain any Proposition 65 chemicals. U.S. State Right-to-Know Regulations This product does not contain any substances regulated by state right-to-know regulations. International Regulations Canada This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all the information required by the CPR. Page 6 / 7
WHMIS Hazard Class B4 Flammable solid D2B Toxic materials 16. OTHER INFORMATION Issuing Date 29-Jun-2007 Revision Note No information available Disclaimer The information provided on this MSDS is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered as a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other material or in any process, unless specified in the text. End of MSDS Page 7 / 7