SAFETY DATA SHEET Revision Number 3 Product Name Cat No. : 1. Identification all-trans-retinoic acid AC207340000; AC207340010; AC207340050; AC207341000 CAS-No 302-79-4 Synonyms Vitamin A acid Recommended Use Uses advised against Laboratory chemicals. Not for food, drug, pesticide or biocidal product use Details of the supplier of the safety data sheet Company Fisher Scientific One Reagent Lane Fair Lawn, NJ 07410 Tel: (201) 796-7100 Acros Organics One Reagent Lane Fair Lawn, NJ 07410 Emergency Telephone Number For information US call: 001-800-ACROS-01 / Europe call: +32 14 57 52 11 Emergency Number US:001-201-796-7100 / Europe: +32 14 57 52 99 CHEMTREC Tel. No.US:001-800-424-9300 / Europe:001-703-527-3887 2. Hazard(s) identification Classification This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200) Acute oral toxicity Category 4 Acute dermal toxicity Category 4 Skin Corrosion/irritation Category 2 Serious Eye Damage/Eye Irritation Category 2 Reproductive Toxicity Category 2 Specific target organ toxicity (single exposure) Category 3 Target Organs - Respiratory system. Label Elements Signal Word Warning Hazard Statements Harmful if swallowed Harmful in contact with skin Causes skin irritation Causes serious eye irritation May cause respiratory irritation Suspected of damaging fertility or the unborn child Page 1 / 7
Precautionary Statements Prevention Obtain special instructions before use Do not handle until all safety precautions have been read and understood Use personal protective equipment as required Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product Avoid breathing dust/fume/gas/mist/vapors/spray Use only outdoors or in a well-ventilated area Wear protective gloves/protective clothing/eye protection/face protection Response IF exposed or concerned: Get medical attention/advice Inhalation IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing Skin IF ON SKIN: Wash with plenty of soap and water Call a POISON CENTER or doctor/physician if you feel unwell If skin irritation occurs: Get medical advice/attention Take off contaminated clothing and wash before reuse Eyes IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing If eye irritation persists: Get medical advice/attention Ingestion IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell Rinse mouth Storage Store locked up Store in a well-ventilated place. Keep container tightly closed Disposal Dispose of contents/container to an approved waste disposal plant Hazards not otherwise classified (HNOC) WARNING. Reproductive Harm - https://www.p65warnings.ca.gov/. 3. Composition/Information on Ingredients Component CAS-No Weight % all-trans Retinoic acid 302-79-4 97 4. First-aid measures Eye Contact Skin Contact Inhalation Ingestion Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get medical attention. Obtain medical attention. Wash off immediately with plenty of water for at least 15 minutes. Move to fresh air. If breathing is difficult, give oxygen. Obtain medical attention. Do not induce vomiting. Obtain medical attention. Page 2 / 7
Most important symptoms and effects Notes to Physician Suitable Extinguishing Media Unsuitable Extinguishing Media Flash Point Method -. Treat symptomatically 5. Fire-fighting measures Water spray. Carbon dioxide (CO 2). Dry chemical. Chemical foam. Autoignition Temperature Explosion Limits Upper Lower Sensitivity to Mechanical Impact Sensitivity to Static Discharge Specific Hazards Arising from the Chemical Thermal decomposition can lead to release of irritating gases and vapors. Hazardous Combustion Products Carbon monoxide (CO) Carbon dioxide (CO2) Protective Equipment and Precautions for Firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. NFPA Health 2 Flammability 1 Instability 1 Physical hazards N/A Personal Precautions Environmental Precautions 6. Accidental release measures Use personal protective equipment. Ensure adequate ventilation. Avoid dust formation. Do not get in eyes, on skin, or on clothing. Do not breathe dust/fume/gas/mist/vapors/spray. Should not be released into the environment. Methods for Containment and Clean Sweep up or vacuum up spillage and collect in suitable container for disposal. Do not let Up this chemical enter the environment. Handling Storage Exposure Guidelines 7. Handling and storage Avoid contact with skin and eyes. Avoid dust formation. Do not breathe dust. Do not ingest. Use only in area provided with appropriate exhaust ventilation. Wear personal protective equipment. Keep in a dry place. Keep container tightly closed. Keep away from direct sunlight. Store in freezer. Store under an inert atmosphere. 8. Exposure controls / personal protection This product does not contain any hazardous materials with occupational exposure limitsestablished by the region specific regulatory bodies. Engineering Measures Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close to the workstation location. Page 3 / 7
Personal Protective Equipment Eye/face Protection Skin and body protection Respiratory Protection Hygiene Measures Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Wear appropriate protective gloves and clothing to prevent skin exposure. Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Handle in accordance with good industrial hygiene and safety practice. 9. Physical and chemical properties Physical State Powder Solid Appearance Yellow Odor Odor Threshold ph Melting Point/Range 179-184 C / 354.2-363.2 F Boiling Point/Range Flash Point Evaporation Rate Flammability (solid,gas) Flammability or explosive limits Upper Lower Vapor Pressure Vapor Density Specific Gravity Solubility Partition coefficient; n-octanol/water Autoignition Temperature Decomposition Temperature Viscosity Molecular Formula C20 H28 O2 Molecular Weight 300.44 10. Stability and reactivity Reactive Hazard Stability Conditions to Avoid Incompatible Materials None known, based on information available Stable under normal conditions. Air sensitive. Light sensitive. Exposure to air. Exposure to light. Incompatible products. Strong oxidizing agents, Strong reducing agents Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2) Hazardous Polymerization Hazardous Reactions Acute Toxicity Hazardous polymerization does not occur. None under normal processing. 11. Toxicological information Product Information Page 4 / 7
Component Information Component LD50 Oral LD50 Dermal LC50 Inhalation all-trans Retinoic acid LD50 = 2 g/kg ( Rat ) Not listed Not listed Toxicologically Synergistic Products Delayed and immediate effects as well as chronic effects from short and long-term exposure Irritation Sensitization Carcinogenicity Irritating to eyes, respiratory system and skin The table below indicates whether each agency has listed any ingredient as a carcinogen. Component CAS-No IARC NTP ACGIH OSHA Mexico all-trans Retinoic acid 302-79-4 Not listed Not listed Not listed Not listed Not listed Mutagenic Effects Reproductive Effects Developmental Effects Teratogenicity STOT - single exposure STOT - repeated exposure Aspiration hazard Symptoms / effects,both acute and delayed Endocrine Disruptor Information Other Adverse Effects Ecotoxicity Do not empty into drains. Persistence and Degradability Bioaccumulation/ Accumulation Mobility Waste Disposal Methods DOT TDG IATA IMDG/IMO.. Teratogenic effects have occurred in experimental animals. Respiratory system None known The toxicological properties have not been fully investigated. See actual entry in RTECS for complete information. 12. Ecological information Insoluble in water. Is not likely mobile in the environment due its low water solubility. 13. Disposal considerations Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Chemical waste generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification. 14. Transport information 15. Regulatory information Page 5 / 7
International Inventories Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECL all-trans Retinoic acid X X - 206-129-0 - X - X X X Legend: X - Listed E - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA. F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA. N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designated polymer made with any free-radical initiator regardless of the amount used. P - Indicates a commenced PMN substance R - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA. S - Indicates a substance that is identified in a proposed or final Significant New Use Rule T - Indicates a substance that is the subject of a Section 4 test rule under TSCA. XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data Base Production and Site Reports (40 CFR 710(B). Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater. Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactants that comprises one of the eligibility criteria for the exemption rule. U.S. Federal Regulations TSCA 12(b) SARA 313 SARA 311/312 Hazard Categories CWA (Clean Water Act) Clean Air Act See section 2 for more information OSHA Occupational Safety and Health Administration CERCLA California Proposition 65 This product contains the following proposition 65 chemicals Component CAS-No California Prop. 65 Prop 65 NSRL Category all-trans Retinoic acid 302-79-4 Developmental - Developmental U.S. State Right-to-Know Regulations U.S. Department of Transportation Reportable Quantity (RQ): DOT Marine Pollutant DOT Severe Marine Pollutant N N N U.S. Department of Homeland Security This product does not contain any DHS chemicals. Other International Regulations Mexico - Grade Prepared By 16. Other information Regulatory Affairs Thermo Fisher Scientific Page 6 / 7
Email: EMSDS.RA@thermofisher.com Revision Date Print Date Revision Summary 19-Jan-2018 19-Jan-2018 This document has been updated to comply with the US OSHA HazCom 2012 Standard replacing the current legislation under 29 CFR 1910.1200 to align with the Globally Harmonized System of Classification and Labeling of Chemicals (GHS). Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text End of SDS Page 7 / 7