Click http://www.guidechem.com/cas-676/676570-37-9.html for suppliers of this product TETANUS TOXIN (cas 676570-37-9) MSDS 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name CAS-No. : : Tetanus toxin, from Clostridium tetani 676570-37-9 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances 2. 2.1 HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Acute toxicity, Oral (Category 2) Acute toxicity, Inhalation (Category 2) Acute toxicity, Dermal (Category 3) Classification according to EU Directives 67/548/EEC or 1999/45/EC Very toxic by inhalation, in contact with skin and if swallowed. 2.2 Label elements Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram Signal word Hazard statement(s) H300 H311 H330 Precautionary statement(s) P260 P264 P280 P284 P301 + P310 P310 Supplemental Hazard Statements Danger Fatal if swallowed. Toxic in contact with skin. Fatal if inhaled. Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. Wash hands thoroughly after handling. Wear protective gloves/ protective clothing. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. Immediately call a POISON CENTER or doctor/ physician. none According to European Directive 67/548/EEC as amended. Hazard symbol(s) R-phrase(s) R26/27/28 S-phrase(s) S28 S36/37 S45 Very toxic by inhalation, in contact with skin and if swallowed. After contact with skin, wash immediately with plenty of water. Wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). 2.3 Other hazards - none 3. COMPOSITION/INFORMATION ON INGREDIENTS
3.2 Mixtures Component Classification Concentration Clostridium tetani CAS-No. 676570-37-9 Acute Tox. 2; H300, H310, 17,12 % H330 T+, R26/27/28 lactose CAS-No. EC-No. 63-42-3 200-559-2-1,25 % 4-(2-Hydroxyethyl)piperazin-1-ylethanesulphonic acid CAS-No. 7365-45-9 EC-No. 230-907-9-81,63 % For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16 4. 4.1 FIRST AID MEASURES Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. 4.2 Most important symptoms and effects, both acute and delayed This material is a powerful neurotoxin. Exposure may cause musclespasms, muscle rigidity, paralysis, and death. 4.3 Indication of immediate medical attention and special treatment needed 5. 5.1 FIRE-FIGHTING MEASURES Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. 5.2 5.3 5.4 Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx), Sulphur oxides Precautions for fire-fighters Wear self contained breathing apparatus for fire fighting if necessary. Further information 6. 6.1 6.2 6.3 ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. 6.4 Reference to other sections For disposal see section 13. 7. 7.1 7.2 HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed.normal measures for preventive fire protection. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2-8 C 7.3 Specific end uses 8. 8.1 EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters 8.2 Exposure controls Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). 9. 9.1 PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties a) b) c) d) e) f) Appearance Odour Odour Threshold ph Melting/freezing point Initial boiling point and boiling range Form: solid
g) h) Flash point Evaporation rate not applicable i) Flammability (solid, gas) j) k) l) Upper/lower flammability or explosive limits Vapour pressure Vapour density m) Relative density n) o) p) q) r) s) t) Water solubility Partition coefficient: n- octanol/water Autoignition temperature Decomposition temperature Viscosity Explosive properties Oxidizing properties 9.2 Other safety information 10. 10.1 10.2 10.3 10.4 10.5 10.6 STABILITY AND REACTIVITY Reactivity Chemical stability Possibility of hazardous reactions Conditions to avoid Incompatible materials Strong acids Hazardous decomposition products Other decomposition products - 11. 11.1 TOXICOLOGICAL INFORMATION Information on toxicological effects Acute toxicity Skin corrosion/irritation Serious eye damage/eye irritation Respiratory or skin sensitization Germ cell mutagenicity Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity Specific target organ toxicity - single exposure Specific target organ toxicity - repeated exposure Aspiration hazard Potential health effects Inhalation Ingestion Skin Eyes May be fatal if inhaled. May cause respiratory tract irritation. May be fatal if swallowed. Toxic if absorbed through skin. May cause skin irritation. May cause eye irritation. Signs and Symptoms of Exposure This material is a powerful neurotoxin. Exposure may cause musclespasms, muscle rigidity, paralysis, and death. Additional Information RTECS: Not available 12. 12.1 12.2 12.3 12.4 12.5 12.6 ECOLOGICAL INFORMATION Toxicity Persistence and degradability Bioaccumulative potential Mobility in soil Results of PBT and vpvb assessment Other adverse effects 13. 13.1 DISPOSAL CONSIDERATIONS Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging Dispose of as unused product. 14. 14.1 TRANSPORT INFORMATION UN-Number ADR/RID: 3462 IMDG: 3462 IATA: 3462 14.2 UN proper shipping name ADR/RID: TOXINS EXTRAC TED FROM LIVING SOURCES, SOLID, N.O.S. (Clostridium tetani) IMDG: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S. (Clostridium tetani) IATA: Toxins, extracted from living sources, solid, n.o.s. (Clostridium tetani) Passenger Aircraft: Not permitted for transport 14.3 Transport hazard class(es) ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1 14.4 Packaging group ADR/RID: I IMDG: I IATA: I
14.5 14.6 Environmental hazards ADR/RID: no Special precautions for users IMDG Marine pollutant: no IATA: no 15. REGULATORY INFORMATION This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. 15.1 15.2 Safety, health and environmental regulations/legislation specific for the substance or mixture Chemical Safety Assessment 16. OTHER INFORMATION Text of H-code(s) and R-phrase(s) mentioned in Section 3 Acute Tox. H300 H310 H330 T+ R26/27/28 Acute toxicity Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Very toxic Very toxic by inhalation, in contact with skin and if swallowed. Further information The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information this document is based on the resent state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. guidechem shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.