Chronic Wasting Disease: Please shoot all the deer so we can eat Cheerios in peace! Nathan Moore, not a farmer, local crank,

Transcription

1 Chronic Wasting Disease: Please shoot all the deer so we can eat Cheerios in peace! Nathan Moore, not a farmer, local crank, also Physics Professor, WSU Guide Hunting Deer Storey/dp/

2 Review: things that make you sick Category Example Mass (mass in Da) How you die (guessing) Parasite Tapeworm, Malaria 5 long!!! 1 gram is (7e24) Mutations 3e9 base pairs per DNA chain Bacteria E. Coli, Salmonella, Botulism 2 T Da (2e12) Cancer Starvation, organ failure Reproduction 600 B Da (6e11) Poisoning by toxins? Division Eggs/cyst >adult Virus HIV, Cold, Chicken Pox 600 M Da (6e8) Secondary effects Hijacking cell production machinery Prion CWD, vcjd 35 k Da (4e4) Spongy mass in your brain Chemical Ethanol, Cocaine 46 Da (5e1), 303 Da (3e2) 1 Dalton ~= 1 proton mass ~=10^ 27kg. Parasite mass of 1 gram estimates as 1 gram of Carbon, 6e23*12~=7e24. Poisoning (depressant or stimulant) Hijacking membrane proteins (?)

3 Review: Biology traverses incredible scale! Category Example Mass (mass in Da) Prion equivalent Think of it as Parasite Tapeworm, Malaria 5 long!!! 1.7e20 1% of the Moon 1 gram is (7e24) Mutations (DNA) Bacteria Virus 3e9 base pairs per DNA (Cell) E. Coli, Salmonella, Botulism HIV, Cold, Chicken Pox 2 T Da (2e12) Half a cruise ship 600 B Da (6e11) All of the people in Minneapolis 600 M Da (6e8) Garbage Truck Prion CWD, vcjd 35 k Da (4e4) 1 Can of Family sized tomato soup Chemical Ethanol, Cocaine 46 Da (5e1), 303 Da (3e2) 1 Dalton ~= 1 proton mass ~=10^ 27kg. Parasite mass of 1 gram estimates as 1 gram of Carbon, 6e23*12~=7e24. A single DNA base pair is 15x bigger than an ethanol Paperclip

4 What is Chronic Wasting Disease (CWD)? Not a Bacteria (like ear infection, or food poisoning) Not a Virus (HIV or a cold) Probably: a badly behaved protein, a broken cellular machine, a prion disease/

5 CWD Prion disease/ scientist.com/?articles.view/articleno/38721/title/the Bright Side of Prions/

6 Is my deer infected? Typical Google result Generation # of prions E E E E E E E E E E E E E E E E E E E E E E E E E+07 Exponential Growth! cwd map spells trouble future deer hunting/

7 CWD in Wisconsin 45% of the Bucks in Richland Co.

8 rmation/chronic_wasting_disease/ c wasting disease research

9 Fall 2017: 7 CWD positive deer in Cedar Valley Discovered by deer death (BAH inspection leg. audit) How did the CWD get there? Taxidermy? How long has the CWD been there? (2+ years?) Fence has been damaged for years Passed BAH inspection (for years)!!! Prediction: Fall 18 unlimited shooting in the red circle 2018 Legislature accomplished: NOTHING!!!

10 CWD kills cervids. Can CWD kill you? In humans, the prion disease is called Variant Creutzfeldt Jakob Disease (vcjd). Deer (CWD) prion are not human (vcjd) prion. Local nurse (and hunter) told me the late stage vcjd symptoms are basically the same as brain cancer (hospice). It is believed that cow prion disease (Mad Cow) can lead to vcjd in humans. But, no observed transmission from deer (CWD) to humans (vcjd) But, Macaque monkeys, genetically very close to humans, develop CWD/vCJD when fed equivalent of one 7oz steak per month We ll know in 30 years. cow disease basics _article

11 How do you clean prion off your knife? The WHO suggests: 1hr in bleach and then 1 hr in 121C autoclave 15psi in a pressure cooker yields ~121C Note! Instant pot is ~12psi, not good enough.

12 So, if your deer is positive, throw away your knife, and your table, and your sink, and your hands Do the nice people at Ledebuhr bleach and autoclave their knives between each deer? xoooo 5 oooxo 2 So, on average oxooo 4 oooox 1 ooxoo 3 ( )/5 = 3 contaminated deer Conclusion: If any of the deer at a processor are CWD positive, on average, half of the deer at that processor are CWD contaminated.

13 Transmission: Prions are indestructible, don t move them! Prions are present in: Carcass, saliva, manure, urine So, DON T FEED DEER (slobber on the corn/salt lick transmits prion)

14 CWD prevalence near Madison, Wisconsin data shows the same trend. 9 of 11 mineral (salt) licks showed CWD prion in the soil around the lick! 05 cwd prions soilwisconsin mineral.html

15 Transmission: Prions are indestructible, don t move them! Prions are present in: Carcass, saliva, manure, urine So, DON T MOVE CARCASSES MN DNR: bone out meat

16 Transmission: Prions are indestructible, don t move them! Prions are present in: Carcass, saliva, manure, urine So, DON T FEED DEER (slobber on the salt/corn lick) DON T MOVE CARCASSES DON T LET DEER PEE IN YOUR GARDEN DON T LET DEER PEE ON THE OATS YOUR CHEERIOS ARE MADE FROM

17 Plants can transmit prion. CWD Liquid on plant leaves CWD Liquid on soil, plants pull CWD from soil Hamsters eat prion containing plants

18 So, another reason to be mad at the deer. They re transmitting an incurable brain disease! If there are fewer deer, transmission might be stopped controlled! Note, this is how your body controls infections

19 Data from the MN DNR: TEST YOUR DEER! Zone 346: 2909 deer registered, 291 tested. Is the CWD free label really valid?

20 CWD Exposure odds: 1 out of 11,909 (MN DNR numbers) 7 out of 2909 (Zone 346 numbers) this is 1 in 415! injuries/preventable death overview/odds of dying/ Lifetime odds of death for selected causes, United States, 2016 Cause of Death Odds of Dying Heart Disease 1 in 6 Cancer 1 in 7 Motor Vehicle Crash 1 in 102 Fall 1 in 119 Gun Assault 1 in 285 Fire or Smoke 1 in 1,506 Choking on Food 1 in 3,138 Bicyclist 1 in 4,050 Accidental Gun Discharge 1 in 8,305 Sunstroke 1 in 8,976 Electrocution, Radiation, 1 in 14,630 Extreme Temperatures and Pressure

21 2017 Chatfield outbreak: Albatross like movement patterns, Initiated by carcass dumping? start

22 How do deer migrate? Half stick around, half disperse. Note the long tail.

23 How do deer migrate? Half stick around, half disperse. Note the long tail.

24 Defensive Summary: Shoot all the deer you can. Test them for CWD (only 10% of people do this!) Butcher deer yourself, isolate or autoclave knives. Build an 8 fence around your garden. Call General Mills and ask how they re testing incoming grain for CWD prion. Call your legislature rep and ask why they didn t do anything about CWD this spring. Or: Policy idea, $5000 bounty per CWD positive deer. Target field, $350M public money.

25 Offensive Public Policy (via Mike Foy, WI DNR staff) $5000 bounty per CWD positive deer. Normal deer license procedure. There are about 18 deer/mi^2 in WI, 10 deer/mi^2 in MN MN: 86,943 mi^2 *10deer/mi^2 *0.1% infection rate = ~= 870 CWD+ deer ~= $4.3 million WI: 65,498 mi^2 * 18deer/mi^2 * 5% infection rate = ~= 58,000 CWD+ deer ~= $290 million The Milwaukee Bucks stadium subsidy was $250 million. Is pro basketball or deer hunting a bigger economic and cultural event in WI? county sportsmen backproposal to pay hunters landowners for/article_fd a 5c92 85a3 892ff06f5204.html