Miri Multi-room Incubator for IVF. EU MDD Class IIa Medical Device. VIP treatment for high success rate embryos in IVF. tested and certified

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1 VIP treatment for high success rate embryos in IVF Miri Multi-room Incubator for IVF Designed in Denmark Made in the E.U. EU MDD Class IIa Medical Device tested and certified

2 3 Miri Multi-room Incubator for IVF A ground-breaking design for IVF Designed for the fertility laboratory, the new Esco Miri delivers features that not only make sense, but deliver top performance making it the perfect choice for routine incubation of embryos during IVF. 6 chambers Advanced temperature regulation Embryo-Safe HEPA+VOC filtered air UV sterilization MEA-tested CO 2 +N 2 mixing Pre-mixed gas is not needed Certified Medical Device IEC/EN (3rd Edition EU MDD Class IIa Medical Device Maximize embryo growth potential by providing VIP treatment Elevated O 2 concentration isn t always a good thing While oxygen (O 2 is necessary for normal aerobic metabolism, it is a double-edged sword as it can harm the developing embryo through oxidative damage. Recent studies highlight the benefit of having suppressed oxygen levels when incubating human embryos reflecting the natural low oxygen conditions in the womb. Oxygen range: 20-5% Carbon dioxide range: % Temperature: 25 Ambient to 40 C Gas recovery: less than 3 minutes Temperature recovery: less than 1 minute Shhh... Do not disturb The Miri s overall design provides cultured embryos a minimum-stress environment. The 6-chamber format prevents cross-contamination while HEPA+VOC filtration cleans the airstream. The small chamber volumes and direct heat regulation further translate to faster temperature and gas recovery. Common Stressors: - Temperature fluctuations - Gas concentration fluctuations - Non-optimal ph - Volatile Organic Compounds (VOCs The Silent Embryo Hypothesis The Miri works on the principle of the Silent Embryo Hypothesis. This states that the hallmark of an embryo with maximum developmental potential is low metabolism. That is, a compromised embryo acquires an elevated metabolism to respond to effects of stress or other developmental issues, for example: DNA damage repair, and so on. Hand in hand to provide only the best in embryo incubation

3 4 An advanced temperature regulation system for routine/long-term embryo incubation at your fingertips At the heart of any incubator is its temperature regulation and the Miri boasts one of the most advanced systems available for IVF. The Miri s 6 chambers are completely independent from each other. This is ideal because any disruption (e.g., temperature drop after opening the lid has zero impact on the rest of the system. Furthermore, calibration is so much simpler because there is no crossover of heat from adjacent chambers. Temperature regulation is thus completely independent per chamber. The Miri features a total of 12 temperature controlled points. That is 2 points for every chamber: one on the bottom and another on the heated lid. The heated lid is another great feature of the Miri as it prevents condensation and enhances temperature uniformity across cultured dishes. Heated Lid - Prevents condensation - Enhances temperature regulation/recovery - Excellent uniformity between chamber top and bottom Heated Bottom - Provides direct heat to the cultures through the heating optimization plates Control Panel Buttons - The simple 4-button control panel allows for easy and intuitive operation Mute Button - Temporarily mutes alarm messages and sound for 5 minutes Fast Recovery There are many advantages to using benchtop multi-room incubators. One important benefit is the speed of recovering temperature and gas parameters after opening a chamber. Miri gas composition recovery: Less than 3 minutes Miri temperature recovery: Less than 1 minute Heating optimization plates Each chamber contains a heating optimization plate to facilitate heat transfer directly to the culture dishes. Has inserts to fit various dish sizes Removable for easy cleaning The little details count 37 o C IVF practitioners deal with precious and fragile little things (embryos and often, the little details make a big difference. The Miri has a large LED display that can be easily seen from a distance. Also, the glass lid tops, while acting as chamber insulators, can be written on--- a very useful feature for organization. Oil Media The dishes fit into the inserts so that the heat is directly transferred to the media

4 The Miri s reliable gas mixing system allows for gas phase flexibility Do you prefer pure, pre-mixed, or just plain CO 2 control? The Miri s gas mixer gives total control over CO 2 and O 2 concentration levels while also giving flexibility over what gas input is desired.* Moreover, the HEPA+VOC filter and UV sterilization ensure only the highest quality of air is circulated to the cultures. *Input of pure gases is recommended A suite of IVF-essential features BNC connection for ph monitoring, USB communication port, and port for external alarm monitoring The Miri can be connected to a PC to avail of data logging via the supplied software included. Connections to external alarm monitoring systems and ph measurments are also possible. Stress-free validation of chamber parameters Top row: 6 x PT1000 validation sensors Bottom row: 6 gas sample ports Pre-mixed gas is NOT required Miri can accept pure gas (and even pre-mixed gas if desired. High quality airstream via HEPA+VOC filter + UV The filter module can easily be replaced once used up. PT1000 temperature sensors are built-in, which are completely independent from the main circuitry. Gas sampling ports are likewise available for all 6 chambers. The use of 100% CO 2 and 100% N 2 as input gases is much cheaper and easier to source than using pre-mixed gas. The gas in the Miri is continuously recirculated through a HEPA/VOC filter. 185-nm filtered UV-C light sterilizes the airstream before passing through the filter. Full-featured and User-friendly Control panel, display, and data logging software The Miri can be connected to an easy-to-use, feature-packed data logging software installed on any ordinary PC and connected via USB. Complete parameters are displayed. Histories of any alarm events are logged. The data-logger stores continuous performance data of the machine throughout its use. These can be viewed in graphs. Multiple machines can be connected and managed from a single computer. All real-time parameters of the machine can be conveniently viewed. These include the temperature of all monitored temperature and gas concentration points, gas input pressures, gas flow rates, current gas readings, and all set points. All performance data of the machine are continuously logged and can be viewed in convenient graphs. Details of any alarm events, such as out-of-range parameters, are also stored for retrieval. ph measurement can also be monitored and stored in the data logging software. Conditions that put the Miri into alarm state are recorded. It is possible for the software to send alerts as well.

5 6 Airflow Diagram O 2 from atmosphere Gas mixing HEPA+VOC filtration Provide total control of the gas phase environment The built-in gas mixer and the high-performance CO 2 (nondispersive infrared and O 2 (medical-grade MOX-1 sensors allow accurate control of gas phase composition in the chambers. Recirculation CO 2 N 2 UV sterilization Incubation chambers Product features Number of compartments 6 completely separate heating chambers Heating method Direct heat transfer via heated bottom, also with heated lid and heating optimization plate Total capacity Heating plates customized for several types of dishes, for example Falcon or Nunc 24 x IVF 4-well dishes 24 x Petri dishes Ø 60 mm 48 x Petri dishes Ø 35 mm Input gas 100% CO2, 100% N 2 (pre-mixed gas NOT required Simulated humidification (Optional HEPA/VOC filtered airstream YES UV sterilized airstream YES, 185nm filtered UV-C light, can be switched OFF Data logging YES, optional via supplied software Alarms YES, audible+visible, for out-of-range parameters temperature, gas concentration, gas pressure and power cut off (can be connected to external monitoring systems Stackable YES Ordering Information Item COde MRI-6A10-9N Description Esco Miri Multi-Room Incubator, 115V, for Nunc dishes MRI-6A10-8N Esco Miri Multi-Room Incubator, 230V, for Nunc dishes MRI-6A10-9F Esco Miri Multi-Room Incubator, 115V, for Falcon dishes MRI-6A10-8F Esco Miri Multi-Room Incubator, 230V, for Falcon dishes MRA-1007 HEPA+VOC filter (recommended to be replaced every 3 months MRA-1014 Stacking frame for 2 units MRA Stacking frame for 2 units

6 7 General Specification Miri Multi-room incubator Product code: XQ-1(MRI-6A Overall dimensions (WxDxH 700 x 580 x 150 mm ( 27.6 x 22.9 x 6 Power supply 115/230V, 50/60Hz Power consumption 280 W Temperature control range C *Gas consumption (CO 2 < 2 L/h **Gas consumption (N 2 < 12 L/h CO 2 control range % O 2 control range 20-5% Input gas pressure (CO bar (8.7 psi Input gas pressure (N bar (8.7 psi Net Weight 35 kg (77.2 lbs Shipping Weight 40 kg (88.2 lbs Shipping Dimension 840 x 735 x 300mm (33.1 X 29 x 11.9 * Under normal condition (CO 2 set point reached at 5.0%, all lids closed * * Under normal condition (O 2 set point reached at 5.0%, all lids closed Certification IEC/EN (3 rd Edition EU MDD Class IIa Medical Device MDD Class IIa IEC/EN rd Edition Medical Devices 1609

7 PT Esco Bintan Indonesia Global Network Global Offices Distributors Esco Medical Product: ART Workstations Upright CO 2 Incubators Bench Top Incubators Time Lapse Incubators Infertility is viewed as a problem that has social, psychological, and economic impacts to the afflicted individuals and couples. It is a global concern that knows no race nor creed. It has been estimated that 1 in 6 couples would struggle with infertility at least once in their lifetime. The vision of Esco Medical is to support Assisted Reproductive Technologies (ART, such as IVF, by developing practical and state-of-the-art technological solutions for improving clinical success rates and patient satisfaction. All Esco Medical products are designed with the IVF clinic in mind and developed with the Silent Embryo Hypothesis as a guiding principle. The Silent Embryo Hypothesis states that the less disturbed an embryo can remain, the better its developmental potential will be. It is on these foundations that Esco Medical remains committed to providing world class ART, worldwide. At Esco Medical, life has begun. 21 Changi South Street 1 Singapore Tel Fax csis-medical@escoglobal.com Esco Global Offices Manama, Bahrain Beijing, China Chengdu, China Guangzhou, China Shanghai, China Bangalore, India Delhi, India Mumbai, India Banten, Indonesia Osaka, Japan Kuala Lumpur, Malaysia Melaka, Malaysia Manila, Philippines Singapore Seoul, South Korea Salisbury, UK Philadelphia, PA, USA Hanoi, Vietnam _ART Equipment_MRI_Brochure_A4_vA_27-June-2013 Esco can accept no responsibility for possible errors in catalogues, brochures and other printed materials. Esco reserves the right to alter its products and specifications without notice. All trademarks and logotypes in this material are the property of Esco and the respective companies. escoglobal.com LIVE SUPPORT Esco Micro Pte Ltd Cert. No: Cert. No: /E