School of Postgraduate Medicine

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1 RISK ASSESSMENT NUMBER: School of Postgraduate Medicine CONTROL OF SUBSTANCE HAZARDOUS TO HEALTH RISK ASSESSMENT FORM FOR ACTIVITIES INVOLVING HAZARDOUS SUBSTANCES This form must be completed prior to the commencement of work involving a hazardous substance, other than a biological agent*, in order that a suitable and sufficient assessment of health risks is made. (*work involving a biological agent requires separate assessment) HELP! Where a # appears, clicking on a data entry box, or on the arrow of a pull-down menu, and pressing F1 will reveal help available. PART 1 Date of assessment: 12/7/02 Process/Activity: Agarose gel electrophoresis PART 2 INFORMATION GATHERING FOR SUBSTANCES HAZARDOUS TO HEALTH I. Hazard Identification SUBSTANCES IN PROCESS/ACTIVITY HAZARD RATING CHIP-PHRASE CODES (see appendix 1 & 2) MSDS CAS no. RISK CODES SAFETY CODES 1 Ethylenediaminetetra MEDIUM R22, R36 S26, S28, S acetic acid (EDTA) 2 Boric acid R36, R37, R38 S22, S26, S R62, R63 S37, S39, S45 3 Trizma base MEDIUM R 36, R37, R38 S26, S Agarose LOW NONE NONE 5 Ethidium bromide R23, R40 S4, S9, S20 S36, S37, S39, S45 6 Bromophenol blue MEDIUM R22, R36, R37 R38 S3, S7, S8 S23, S24, S25 S ylene cyanol MEDIUM R36, R37, R38 S26, S Sucrose MEDIUM R20, R22, R36, R38 S3, S7, S8 S23, S24, S25 S36

2 te: Consideration must be given to any mixing of substances and the products of any reaction. Substances of unknown toxicity should be assigned a High or Very High rating. CHIP-RISK CODES may identify other properties of the substance (eg. flammable) that may entail additional precautions (see control measures). II. Exposure Potential For exposures by inhalation: Consult EH40 Occupational Exposure Limits (OEL) listings (published annually by HSE), available from the safety officer φ. Occupational Exposure Standard (OES) inhalation should be reduced to this level or lower. Maximum Exposure Limit (MEL) must never be exceeded. Substances may have short-term (15min) or long term (8h) limits in ppm or mgm -3 (ppm=gm -3 ). Route(s) by which exposure to the substance(s) is hazardous to health: 1=skin, broken; 2=skin, unbroken; 3=Eye contact; 4=Inhalation; 5=Injection; 6=Ingestion Complete the table and determine estimated risks for each substance: SUBSTANCE (see table above) Complete when applies: Exposure Route(s)# (see above) Calculated SVP/OES# EPOSURE POTENTIAL# ESTIMATED RISK#* MEL OES MEDIUM MEDIUM 2 MEDIUM 3 MEDIUM MEDIUM 4 LOW LOW 5 MEDIUM 6 MEDIUM MEDIUM 7 MEDIUM MEDIUM 8 MEDIUM MEDIUM *The risk inherent in the activity is a function of the highest hazardous properties of the substances and the exposure potential of the process in which the substances are used. Thus: RISK=HAZARD RATING*EPOSURE POTENTIAL φ Where Occupational Hygiene Monitoring (OHM) is considered necessary (to ensure compliance with OEL) the Occupational Health Unit (OHU) must be informed. Records of any monitoring must be kept. If OHM has not been performed and is considered necessary, who will undertake this? (eg., supervisor, HSU) PART 3 HAZARD REDUCTION Reducing an initial hazard could reduce the estimated risk. Answer the questions below (check boxes), if you respond YES to any of them complete the sections Justify Continued Use and Remedial Action. QUESTION YES NO JUSTIFY CONTINUED USE# REMEDIAL ACTION# Can the use of ANY of the substances be avoided? Can smaller amounts of ANY substance be used practically? Can safer physical forms be used in ANY case?

3 Are there less hazardous substitutes for ANY substance? Any proposed actions may either be checked at review or will be required to be in place before approval of the assessment is given. te: For estimated risks that are LOW and considered not significant, finish the assessment now. precautions are necessary for the purposes of COSHH. If this does not apply continue with the assessment. PART 4 CONTROL MEASURES I. Special SAFETY Precautions (identified from CHIP-CODES) Specify: NONE II. Engineering Control Measures The entire procedure can be carried out safely on the open bench # Good general ventilation (eg. window open) is required and sufficient Full containment is required during part or all of the procedure*# *Specify the type of enclosure and when it must be used: Partial containment (Local Exhaust Ventilation) is required during part or all of the procedure** **Specify the type of LEV to be used and when it must be used: Where engineering controls are used eg. fume hoods, etc. are these subject to a formal performance test, at least every 14 months, and records kept? If no, this must be arranged. Is air monitoring required to validate control of exposure to ANY of the substances? If YES, then specify the arrangements for this to be carried out: II. Personal Protective Equipment (PPE) Where adequate control of exposure to the hazardous substance(s) cannot be achieved by substitution or engineering controls the following type(s) of PPE will be required for part or all of the activity. Eye protection Face protection Gloves (disposable) Respirator / mask Other (eg. clothing) Specify when during the activity the item(s) of PPE must be worn: Wear gloves and laboratory coat throughout, wear eye protection when handling hazardous chemicals by route 3, wear mask when handling chemicals by route 4 n-disposable items of PPE must be inspected regularly and records retained for inspection III. Emergency Procedures Written emergency instructions are available at the work site(s) # Emergency contact details are provided at the work site(s) Materials for neutralising spills of chemicals are available Proper and sufficient spill kits are available If necessary, are specific procedures available for the safe transport of the substance(s) between laboratories or buildings?

4 If applicable, will a person with the appropriate expertise be available to deal with spillages of particularly hazardous substances* *Specify whom and how they are to be contacted: Dr John Grey, Microbiology department The locations of the following are known to the user: Eye irrigation point Fire-fighting equipment First aid box The user knows how to summon the following personnel: First aider External emergency services IV. Waste Disposal Routes Disposal/Decontamination of hazardous substances and contaminated items will be done by: Route Substance(s) (by number): 1.Flushing to drain (no pre-treatment required) 2.Flushing to drain (after decontamination) 3.Clinical (yellow) waste bins (no pre-treatment required) for incineration 1,2,3,4,5,6,7,8 4.Clinical (yellow) waste bins (after decontamination) for incineration 5.Sharps bin (no pre-treatment required) 6.Sharps bin (after decontamination) 7.Decontamination only (re-usable items/surfaces) 8.Waste solvent bottles (specialist contractor disposal when full) 1, V. Training te: Formal training will be given regarding Local Rules that apply to work with hazardous substances. A written record of attendance for all users must be kept. Users must arrange (via SPGM) to attend formal training Have all users received formal training for work with hazardous substances? Have all users received training from supervisor (or delegated staff)? VI. Supervision Workers must be aware of who their direct supervisor is for the work (in the laboratory) Are all users aware of who will directly supervise the activity? VII. Implications for Persons t Involved in the Work Activity Identify any persons in the following groups, not directly involved with the work activity, who may be at risk from the hazards of the activity. Academic staff Technical staff Postgraduates Undergraduates Maintenance staff Secretaries Cleaning staff Emergency personnel Contractors Visitors Others Persons identified above may need to be informed, in part or in full, of the information contained in this risk assessment. VIII. Health Monitoring Is monitoring required to ensure that the control of exposure to the hazardous substance(s) is adequate? Are there sensitizers or carcinogens in use? If yes, the Occupational Health Unit must be notified and a surveillance record be completedφ.

5 I. Instructions for the Work Activity All laboratory activities require precise written procedures (Standard Operating Procedure-SOP). A SOP form should be completed using information from this (and any other) risk assessment. A SOP has been completed and is attached (reference n o ). Accreditation and Verification of Assessment The completed assessment must be signed and dated by the person making the assessment and then checked and signed by the senior person with responsibility for the area in which the activity is to be undertaken. Assessor: Name Julia Magnay Signed Date Verifier : Name Prof AJ EL HAJ Signed Date An electronic copy of the assessment should be returned to the departmental Safety Officer and it will be made available centrally at \\PGM1\safety The hard copy (with signatures) must be kept readily available where the activity is to be undertaken. The assessment must be reviewed at regular intervals and immediately when there is any change that may affect its validity. APPENDI 1 CHIP-RISK PHRASES

6 HAZARD RATING VERY (TOICITY) VERY (CARCINOGENICITY) VERY (MUTAGENICITY) VERY (REPROTOICITY) VERY (SENSITISATION) CHIP-HAZARD RATING TABLE WARNING RISK PHRASES SYMBOL T+ R28 T+ R27 Very toxic if swallowed Very toxic in contact with skin T+ R26 Very toxic by inhalation T+ R32 Contact with acids liberates very toxic gas T+ R39 Danger of very serious irreversible effects T R45 May cause cancer (Category 1, 2 carcinogens) T R49 May cause cancer by inhalation T R46 May cause heritable genetic damage (Category 1, 2 mutagens) T R60 May impair fertility T R61 May cause harm to the unborn child (Category 1, 2 reprotoxins) n or i R42 May cause sensitisation by inhalation n or i R43 May cause sensitisation by skin contact T R25 Toxic if swallowed (TOICITY) (CARCINOGENICITY) (MUTAGENICITY) (REPROTOICITY) (SKIN/EYE DAMAGE) MEDIUM (TOICITY) MEDIUM (REPROTOICITY) MEDIUM (SKIN/EYE DAMAGE) T R24 Toxic in contact with skin T R23 Toxic by inhalation T R29 Contact with water liberates toxic gas T R31 Contact with acids liberates toxic gas n R48 Danger of serious damage to health by prolonged exposure n R40 Possible risk of irreversible effects (Category 3 carcinogen) n R40 Possible risk of irreversible effects (Category 3 mutagen) n R62 Possible risk of impaired fertility n R63 Possible risk of harm to the unborn child (Category 3 reprotoxin) C R35 Causes severe burns i R41 Risk of serious damage to the eyes n R22 Harmful if swallowed n R20 Harmful by inhalation n R33 Danger of cumulative effects n R64 May cause harm to breast-fed babies n R21 Harmful in contact with the skin C R34 Causes burns i R38 Irritating to the skin

7 LOW HAZARD i R36 Irritating to the eyes i R37 Irritating to the respiratory system Low hazard compounds are any compound whose label bears none of the above risks APPENDI 2 CHIP-SAFETY PHRASES S1 S2 S3 S4 S5 S6 S7 S8 S9 S12 S13 S14 S15 S16 S17 S18 S20 S21 S22 S23 S24 S25 S26 S27 S28 S29 S30 S33 S35 S36 S37 S38 S39 S40 S41 Keep locked up Keep out of reach of children Keep in a cool place Keep away from living quarters Keep contents under (appropriate liquid specified by supplier) Keep under (inert gas to be specified by supplier) Keep container tightly closed Keep container dry Keep container in a well ventilated place Do not keep the container sealed Keep away from food, drink, and animal feeding stuffs Keep away from (incompatible materials specified by supplier Keep away from heat Keep away from sources of ignition Keep away from combustible material Handle and open container with care When using do not eat or drink When using do not smoke Do not breathe dust Do not breathe gas/fumes/vapour/spray (specified by supplier) Avoid contact with skin Avoid contact with the eyes In case of contact with the eyes, rinse immediately with plenty of water and seek medical advice Take off immediately all contaminated clothing After contact with the skin, wash immediately with plenty of (specified by supplier) Do not empty into drains Never add water to this product Take precautionary measures against static discharges This material and its container must be disposed of in a safe way Wear suitable protective clothing Wear suitable gloves In case of insufficient ventilation, wear suitable respiratory equipment Wear eye/face protection To clean the floor and all objects contaminated by this material use (specified by supplier) In case of fire and/or explosion do not breathe fumes

8 S42 S43 S45 S46 S47 S48 S49 S50 S51 S52 S53 S56 S57 S59 S60 S61 S62 During fumigation/spraying wear suitable respiratory equipment (appropriate wording to be specified) In case of fire, use (indicate in the space the precise type of fire fighting equipment. If water increases the risk add-never use water) In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) If swallowed seek medical advice immediately and show this container or label Keep at temperature not exceeding ºC (specified by supplier) Keep wetted with (specified by supplier) Keep only in the original container Do not mix with (specified by supplier) Use only in well ventilated areas t recommended for interior use Avoid exposure-obtain special instructions before use Dispose of this material and its container to hazardous or special waste collection point Use appropriate containment to avoid environmental contamination Refer to manufacturer/supplier for information on recovery/recycling This material and/or its container must be disposed of as hazardous waste Avoid release to the environment. Refer to special instructions/safety data sheet If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label APPENDI 3 EPOSURE POTENTIAL SCORE > (A) Quantity of substance (B) Physical characteristics of substance (C) Characteristics of operation (including primary containment-see notes below) < 1g or ml 1-100g or ml >100g or ml Dense solids, n-volatile liquid, skin absorption OEL >500ppm (0.5mgm -3 ) Predominantly enclosed system, low chance of mishap Dusty solids, Freeze-dried solids, Volatile liquids, Low skin absorption OEL ppm ( mgm -3 ), SVP/OES <100 Partially open system, low chance of mishap Gases, Highly volatile liquids, Aerosols, Easily absorbed through skin OEL <10ppm (0.01mgm -3 ), SVP/OES >100 physical barrier, any operation where chance of mishap is medium or high (includes dispensing of chemicals) tes: 1) Time factors, such as frequency and duration of the activity, should also be considered. Continuous operations on a daily basis should raise the exposure estimate to the next category.

9 2) It is important that the evaluation is based only on estimates of potential exposure arising from the activity itself without additional control measures. The effect of secondary containment, such as fume hoods, should not be included as this would pre-judge descisions on the level of containment required. 3) In deciding on the volatility of a liquid, the volatility at the temperature of use must be taken into account. 4) Primary containment is that containment provided by the apparatus or equipment in which the substance is handled. Secondary containment is the additional containment needed to ensure appropriate control of exposure.