Material Safety Data Sheet

Transcription

1 1. Identification Material Safety Data Sheet Product Name: Original Name: Substance: Hydroxypropyl Methylcellulose E464 Hydroxypropyl Methylcellulose Manufacturer s Name: Section: Address: Phone Number: Fax Number: Emergency Contact: Emergency Phone Number: Samsung Fine Chemicals Co. Ltd. Pharmaceuticals Division 129B 4L. Namdong Industrial Complex, Gozan-dong Namdong-gu, Incheon, Korea Recommended Use: Food additive for Food applications 2. Hazard Identification (1) GHS Classification Hazard Classification Explosives Flammable Gases Flammable Aerosols Oxidizing Gases Gases Under Pressure Flammable Liquids Flammable Solids Self-Reactive Substances Pyrophoric Liquids Pyrophoric Solids Self-Heating Substances Substance which in contact with water emit flammable gases Oxidizing Liquids Oxidizing Solids Organic Peroxides Corrosive to Metals Acute Toxicity (Oral) Acute Toxicity (Skin) Acute Toxicity (Inhalation Gases) Acute Toxicity (Inhalation Vapor) Acute Toxicity (Inhalation Mist) Skin Corrosion/Irritation Serious Eye Damage/Eye Irritation Respiratory Sensitization Skin Sensitization Germ Cell Mutagenicity Carcinogenicity Reproductive Toxicity Specific Target Organ and Systemic Toxicity (Single Exposure) (self-classification)

2 Specific Target Organ and Systemic Toxicity (Repeated Exposure) Aspiration Hazard Acute Hazards to the Aquatic Environment* Chronic Hazards to the Aquatic Environment* *Environmental Hazards (2) GHS Label GHS Classification GHS Label Elements (Systemic Toxicity) Not Required (3) Other Hazards which do not results in Classification Take precautionary measures against generation and accumulation of dust when handling in large quantities or in bulk. May cause dust explosion with heat, sparks or static electricity when dust accumulates in large quantities. (Minimum explosive dust concentration: 55g/m 3 ) Avoid contact with open flame, heat, static electricity and sparks when the dust is generated. Avoid contact with oxidizing agents to avoid explosion and combustion. Use normal extinguishers when there is ignition. May cause irritation in contact with eyes, throat, skin and abrasive irritation. Use safety goggles, masks and gloves when handling. This is expected to have low hazard toxicity for usual industrial handling. Dust ingestion and inhalation may cause irritation to eyes and nose. May cause coughing or unpleasant feeling. Spilled powder becomes slippery when wet. 3. Composition/Information on Ingredients (1) Substance or Mixture: Substance (2) Information on Ingredients: Common Name Hydroxypropyl Methylcellulose Chemical Name Cellulose, 2-hydroxypropyl methyl ether Chemical Structure CAS Number Proportion Range More than 95% 4. First Aid Measures Inhalation: Skin Contact: Eye Contact: Ingestion: Remove person to fresh air and get medical attention Wash the contaminated area with soap and water sufficiently If irritation develops get medical attention Flush eyes with plenty of fresh water while holding eyelids open Get immediate medical attention Remove contact lenses if they don t adhere Wash mouth with water and get medical attention Expected immediate and delayed symptoms: Nothing has been reported Recommended personal protective equipment for first aid responders: Use rubber gloves and masks if needed

3 5. Fire Fighting Measures Suitable extinguishing media: Unsuitable extinguishing media: Specific hazards in case of fire: Specific extinguishing measure: Special protective equipment for fire fighters: Water, water spray or dry chemical powder High pressure water jet May cause toxic and irritating gases with fire May cause dust explosion if dust is generated near flame Use suitable extinguishing media except for water if the combustion expands with water spray Use suitable breathing apparatus and chemical protective cloths Take special care if dry chemical powder or carbon dioxide is used for firefighting in closed spaces 6. Accidental Release Measures Personal precautions: Emergency procedures: Environmental precautions: Methods for containment and cleaning up: Precautions for secondary disaster: Take precautions to avoid eye contact and inhalation Spilled powder becomes slippery when wet Wear suitable protective equipment (see section 8 of MSDS) Remove sources of ignition near the spillage area In case of small spills, flush the remaining material with plenty of water In case of large spills, vacuum or scrap up as much as possible then flush the remaining Do not wash into drain Vacuum or scrap up as much as possible in covered containers using non-sparking tools then flush the remainder with water. Remove sources of ignition Prevent spillage to drains 7. Handling and Storage Handling Engineering Controls: Cautions: Local and Whole Exhaust Ventilation: The substance is flammable and has the hazards of dust explosion Keep away from heat, sparks and flames All equipment and operators should be sufficiently grounded Oxygen concentration should be decreased by nitrogen or inert gas in case of large storage tank (1.5m in diameter or larger). Oxygen level monitoring is recommended General precautions outlined in the National Fire Protection Associations NFPA 654 Standard for the Prevention of Fire and Dust Explosions from the Manufacturing, Processing and Handling of Combustible Particulate Solids and NFPA 77 Recommended Practice on Static Electricity are recommended Handle material so as to minimize dust generation Where generating dust, use local exhaust ventilation with explosion proofing

4 Precautions for safe handling: Storage Engineering Controls: Store packaging material: Avoid open flame, heat and sparks Avoid contact with strong acid, strong base or strong oxidizing agents Read and understand MSDS and other safety issues before use Avoid fall, put down and shock packages Avoid contact with flame, heat and sparks during storage Use explosion proof designs to electrical facilities where acceptable In storing, follow all regulations in regards to this substance in your country or region Store in rooms out of direct sunlight Material which can protect from absorbing moisture is recommended 8. Exposure Controls/Personal Protection Exposure Limits Controlled Limits: OSHA Vacated PELs: Engineering Controls: Not mentioned No OSHA Vacated PELs are listed for this chemical. Ventilation may be necessary to control air contaminates of the working area under their exposure limits (Guideline: Respirable Dust 2 mg/m 3 or Total Dust 8 mg/m 3 ) Safety shower and eye bath are required near the handling area Explosion proofing is needed for electrical equipment and ventilation All equipment and operators should be sufficiently grounded All systems need to be closed for inerting and preventing powder leakage or ventilation system should be used Monitoring of the oxygen level is recommended when inert gas is used in the process Recommended Personal Protective Equipment Respiratory protection: Use dust and mist respirator if needed Hand protection: Chemical resistant gloves are recommended Eye protection: Safety goggles are needed Skin protection: Use suitable safety clothing with anti-static effect Caution on general hygiene: Wash hands after handling

5 9. Physical and Chemical Properties Appearance White to off white powder Odour Odourless or slight odour ph 5 8 (2% aqueous solution) Melting point/freezing point Initial boiling point and boiling range Flammability Explosive limits Minimum explosive dust concentration 55 g/m 3 Vapour pressure Vapour density Relative density Bulk density (Loose) More than 0.20 g/cm 3 Solubility This solubility dissolves in cold water, to become a clear and viscous solution Partition coefficient; n-octanol/water Auto ignition temperature Decomposition temperature C Odour threshold Evaporation rate Flammability (solid, gas) Flammable 10. Stability and Reactivity Reactivity: Possibility of hazardous reactions: Conditions to avoid: Incompatible material: Hygroscopic Stable under normal temperature and pressure Dust explosion Reacts with strong acids, strong bases, peroxides and strong oxidizing agents Do not generate dust cloud when handling Avoid contact with heat, sparks or open flames Avoid contact from oxidizing agents Hazardous decomposition products: May form carbon monoxide, carbon dioxide and other toxic gases when burning 11. Toxicological Information Acute Toxicity Oral LD50 Vapour LC50 Mist LC50 Skin LD50 Skin corrosion/irritation May cause irritation Serious exe damage/irritation Dust may cause eye irritation Respiratory sensitization May cause chest discomfort and damage of respiratory system Skin sensitization Negative response Germ cell mutagenicity Negative Carcinogenicity Negative response Reproductive toxicity No adverse effects STOST single exposure STOST repeated exposure No significant symptoms were observed Aspiration hazard

6 12. Ecological Information Acute eco-toxicity Chronic eco-toxicity Other adverse effects The biochemical oxygen demand (BOD) for the hydroxypropyl methylcellulose solution (0.1 10ppm) is less than 5mg O 2 /L 13. Disposal Considerations Disposal of this material: Disposal of contaminated packages: Contact a licensed professional waste disposal service Observe all federal, state and local environmental regulations Remove whole remaining material from the container prior to disposal 14. Transport Information UN number UN proper shipping name Transport hazard class Packing group Environmental hazards Special precautions for the user: in accordance with the UN Model Regulations Secure package containers to prevent slippage and damage If the substance is released in large quantities on transporting, take emergency procedures to prevent disasters and call the nearest fire station and related organization 15. Regulatory Information This material is not hazardous as defined by 49CFR by the U.S. department of transportation 16. Other Information The information in this MSDS is written in good faith, but no warranty is given, to what is expressed or implied. This information is to the best of our knowledge is considered accurate and reliable and is presented in good faith. As ( i ) use conditions of this information and applicable regulations may differ from one location or country to another and may change with time and ( ii ) the application of this product may differ from one user to another recipient of this information is responsible for determining whether the information in this document is appropriate for recipient s use. Since Samsung Fine Chemicals cannot control how this information is used, all liability is disclaimed and Samsung Fine Chemicals assumes no obligation or liability therefore. No warranty, express or implied, is given nor is freedom from any patent owned by Samsung Fine Chemicals or others to be inferred. All materials may present unknown hazards and should be used in caution. Although certain hazards are described, we cannot guarantee that these are the only hazards that exist. Therefore, we request users to take responsibility for investigating the necessary information.