i) Research Papers in peer-reviewed journals
|
|
- Marjorie Lamb
- 5 years ago
- Views:
Transcription
1 Dr Kicman Publications List: Currently 46 Research Papers Published in Journals, with another 3 Papers in Submission/Press, 14 Reviews published in Journals/Books and 5 Extended Proceedings. i) Research Papers in peer-reviewed journals 2011 Turfus SC, Braithwaite RA Parkin MC, Cowan DA, Smith NW, Kicman AT. Metabolites of Lorazepam; Relevance of Past Findings to Present Day Use of LC-MS/MS in Analytical Toxicology. Drug Test Anal (current submission) Bell C, George C, Kicman AT, Traynor AD. Development of a rapid LC- MS/MS method for direct urinalysis of designer drugs. Drug Test Anal (current submission) Gavrilovic I, Mitchell K, Brailsford AD, Cowan DA, Kicman AT, Ansell RJ. A molecularly imprinted receptor for separation of testosterone and epitestosterone, based on a steroidal cross-linker. Steroids (in press) Brailsford AD, Cowan DA, Kicman AT. Urinary gamma-hydroxybutyrate concentrations in 1126 female subjects. J Anal Toxicol 2010; 34: Goucher E, Kicman A, Wolff K, Smith N, Jickells S. Hydrophilic stationary phases: A practical approach for the co-analysis of compounds with varying polarity in biological matrices. Journal of Separation Science 2010; 33: Turfus SC, Parkin MC, Cowan DA, Halket JM, Smith NW, Braithwaite RA, Elliot SP, Steventon GB, Kicman AT. Use of human microsomes and deuterated substrates; An alternative approach for the identification of novel metabolites of ketamine by mass spectrometry. Drug Metabolism and Disposition 2009;37: Goucher E, Kicman AT, Smith NW, Jickells S. The detection and quantification of lorazepam and its 3-O-glucuronide in fingerprint deposits by LC-MS/MS. Journal of Separation Science 2009, 32, Graham M, Ryan P, Baker JS, Davies B,Thomas NE, Cooper SM, Evans P, Easmon S,.Walker CJ, Cowan DA, Kicman AT. Counterfeiting in performance- and image-enhancing drugs. Drug Testing and Analysis 2009, 1, Walker CJ, Cowan DA, James VH, Lau JC, Kicman AT). Doping in sport-1. Excretion of 19-norandrosterone by healthy women, including those using contraceptives containing norethisterone. Steroids, 2009;74: Walker CJ, Cowan DA, James VH, Lau JC, Kicman AT Doping in sport-2. Quantification of the impurity 19-norandrostenedione in pharmaceutical preparations of norethisterone. Steroids, 2009;74:
2 Walker CJ, Cowan DA, James VH, Lau JC, Kicman AT. Doping in sport: 3. Metabolic conversion of oral norethisterone to urinary 19-norandrosterone. Steroids, 2009;74: Parkin MC, Turfus SC, Smith NW, Halket JH, Braithwaite RA, Elliott SP, Cowan DA, Kicman AT. (2008) Detection of ketamine and its metabolites in urine by ultra high pressure liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci, 2008;876: Cowan DA, Kicman AT, Kubli-Garfias C, Welchman HJ. Ion trap MS/MS of intact testosterone and epitestosterone conjugates--adducts, fragile ions and the advantages of derivatisation. Steroids 2008;73: Graham MR, Baker JS, Evans P, Kicman A, Cowan D, Hullin D, et al. Physical effects of short-term recombinant human growth hormone administration in abstinent steroid dependency. Hormone Research 2008;69: Graham MR, Davies B, Kicman A, Cowan D, Hullin D, Baker JS. Recombinant human growth hormone in abstinent androgenic-anabolic steroid use: psychological, endocrine and trophic factor effects. Current Neurovascular Research 2007;4:9-18. Graham MR, Baker JS, Evans P, Kicman A, Cowan D, Hullin D, Davies B. Evidence for a decrease in cardiovascular risk factors following recombinant growth hormone administration in abstinent anabolic-androgenic steroid users. Growth Horm IGF Res 2007;17: Graham MR, Baker JS, Evans P, Kicman A, Cowan D, Hullin D, Davies B. Short-term recombinant human growth hormone administration improves respiratory function in abstinent anabolic-androgenic steroid users. Growth Horm IGF Res 2007;17: Walton MJ, Anderson RA, Kicman AT, Elton RA, Ossowska K, Baird DT. A diurnal variation in testicular hormone production is maintained following gonadotrophin suppression in normal men. Clin Endocrinol 2007;66: Graham MR, Grace FM, Boobier W, Hullin D, Kicman A, Cowan D, et al. Homocysteine induced cardiovascular events: a consequence of long term anabolic-androgenic steroid (AAS) abuse. British Journal of Sports Medicine 2006;40: Cawood ML, Field HP, Ford CG, Gillingwater S, Kicman AT, Cowan D, Barth JH. Testosterone measurements by isotope-dilution liquid chromatography-tandem mass spectrometry: validation of a method for routine clinical practise. Clin Chem 2005;51:
3 Malatos S, Neubert H, Kicman AT, Iles RK. Identification of placental transforming growth factor beta and bikunin metabolites as contaminants of pharmaceutical human chrorionic gondadotrophin preparations by proteomic techniques. Mol Cell Proteomics 2005;4: Bassindale T, Cowan DA, Dale S, Leeds AR, Hutt AJ, Wheeler MJ, Kicman AT. Effects of oral administration of androstenedione on plasma androgens in young women using hormonal contraception. J Clin Endo Metab 2004;89: Brady BM. Walton M, Hollow N, Kicman AT, Baird DT, Anderson RA. Depot testosterone with etonogestrel implants result in induction of azoospermia in all men for long-term contraception. Hum Reprod 2004;19: Jacoby ES, Kicman AT, Iles RK. Identification of post-translational modifications resulting from LHbeta polymorphisms by matrix-assisted laser desorption time-of-flight mass spectrometric analysis of pituitary LHbeta core fragment. J Mol Endocrinol 2003;30: Kicman AT, Bassindale T, Cowan DA, Dale S, Hutt AJ, Leeds AR. Effect of androstenedione ingestion on plasma testosterone in young women; a dietary supplement with potential health risks. Clin Chem 2003;49:167-9 (technical brief) Kicman AT, Fallon JK, Cowan DA, Walker C, Easmon S, Mackintosh D. Candida albicans in urine can produce testosterone: impact on the testosterone/epitestosterone sports drug test. Clin Chem 2002;48: (technical brief). Kinniburgh D, Zhu H, Cheng L, Kicman AT, Baird DT, Anderson RA. Oral desogestrel with testosterone pellets induces consistent suppression of spermatogenesis to azoospermia in both Caucasian and Chinese men. Hum Reprod 2002;17: Forsling ML, Fallon JK, Shah D, Tilbrook GS, Cowan DA, Kicman AT, et al. The effect of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') and its metabolites on neurohypophysial hormone release from the isolated rat hypothalamus. Br J Pharmacol 2002;135: Fallon JK, Shah D, Kicman AT, Hutt AJ, Henry JA, Cowan DA, et al. Action of MDMA (ecstasy) and its metabolites on arginine vasopressin release. Ann N Y Acad Sci 2002;965: Neubert H, Kicman AT, Cowan DA, Bansal SS. Synthesis of a dendron and dendrimer consisting of MALDI matrix like branching units. Tetrahedron Letters 2002;43:
4 Neubert H, Jacoby ES, Bansal SS, Iles RK, Cowan DA, Kicman AT. Enhanced affinity capture MALDI-TOF MS: Orientation of an immunoglobulin G using recombinant protein G. Anal Chem 2002;74: Forsling M, Fallon JK, Kicman AT, Hutt AJ, Cowan DA, Henry JA. Arginine vasopressin release in response to the administration of 3,4- methylenedioxymethamphetamine ("ecstasy"): is metabolism a contributory factor? J Pharm Pharmacol 2001;53: Jacoby ES, Kicman AT, Laidler P, Iles RK. Determination of the glycoforms of human chorionic gonadotropin beta-core fragment by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Clin Chem 2000;46: Kicman AT, Coutts SB, Cowan DA, Handelsman DJ, Howe CJ, Burring S, et al. Adrenal and gonadal contributions to urinary excretion and plasma concentration of epitestosterone in men--effect of adrenal stimulation and implications for detection of testosterone abuse. Clin Endocrinol (Oxf) 1999;50: Fallon JK, Kicman AT, Henry JA, Milligan PJ, Cowan DA, Hutt AJ. Stereospecific analysis and enantiomeric disposition of 3,4- methylenedioxymethamphetamine (Ecstasy) in humans. Clin Chem 1999;45: Butler SA, Laidler P, Porter JR, Kicman AT, Chard T, Cowan DA, et al. The beta-subunit of human chorionic gonadotrophin exists as a homodimer. J Mol Endocrinol 1999;22: Henry JA, Fallon JK, Kicman AT, Hutt AJ, Cowan DA, Forsling M. Lowdose MDMA ("ecstasy") induces vasopressin secretion [research letter]. Lancet 1998;351:1784. Laidler P, Cowan DA, Houghton E, Kicman AT, Marshall DE. Discrimination of mammalian growth hormones by peptide-mass mapping. Rapid Commun Mass Spectrom 1998;12: Kicman AT, Miell JP, Teale JD, Powrie J, Wood PJ, Laidler P, et al. Serum IGF-I and IGF binding proteins 2 and 3 as potential markers of doping with human GH. Clin Endocrinol (Oxf) 1997;47: Wheeler MJ, Zhong YB, Kicman AT, Coutts SB. The measurement of testosterone in hair. J Endocrinol 1998;159:R5-8. 4
5 1997 Laidler P, Cowan DA, Hider RC, Kicman AT. Characterization of human chorionic gonadotropin microheterogeneity by capillary electrophoresis: potential application for quality control in the pharmaceutical industry. Pharmaceutical Sciences. 1997;3: Coutts, S. B., Kicman, A. T., Hurst, D. T. & Cowan, D. A. 1997, 'Intramuscular administration of 5 alpha-dihydrotestosterone heptanoate: changes in urinary hormone profile', Clin Chem, vol. 43, no. 11, pp Kicman AT, Coutts SB, Walker CJ, Cowan DA. Proposed confirmatory procedure for detecting 5 alpha- dihydrotestosterone doping in male athletes. Clin Chem 1995;41: Laidler P, Cowan DA, Hider RC, Keane A, Kicman AT. Tryptic mapping of human chorionic gonadotropin by matrix-assisted laser desorption/ionization mass spectrometry. Rapid Commun Mass Spectrom 1995;9: Kicman AT, Cowan DA, Myhre L, Nilsson S, Tomten S, Oftebro H. Effect on sports drug tests of ingesting meat from steroid (methenolone)-treated livestock. Clin Chem 1994;40: Laidler P, Cowan DA, Hider RC, Kicman AT. New decision limits and quality-control material for detecting human chorionic gonadotropin misuse in sports. Clin Chem 1994;40: Kicman AT, Oftebro H, Walker C, Norman N, Cowan DA. Potential use of ketoconazole in a dynamic endocrine test to differentiate between biological outliers and testosterone use by athletes. Clin Chem 1993;39: Southan GJ, Brooks RV, Cowan DA, Kicman AT, Unnadkat N, Walker CJ. Possible indices for the detection of the administration of dihydrotestosterone to athletes. J Steroid Biochem Mol Biol 1992;42: Kicman AT, Brooks RV, Collyer SC, Cowan DA, Nanjee MN, Southan GJ, et al. Criteria to indicate testosterone administration. Br J Sports Med 1990;24:
6 ii) Reviews: Cole C, Jones L, McVeigh J, Kicman A, Syed Q, Bellis M. Adulterants in illicit drugs: a review of empirical evidence. Drug Test Anal 2011;3: All of the below were invited reviews Kicman AT. Biochemical and Physiological Aspects of Endogenous Androgens. Handbook of Experimental Pharmacology. 2010; 195:25-64 Kicman AT, Houghton E, Gower DB. Anabolic steroids: Metabolism, doping and detection in human and equestrian sports.. Steroid Analysis (2 nd Edition). Springer, 2010 Analysis of Corticosteroids. Steroid Analysis (2 nd Edition). Fraser R, Gower DB, Honour JW, Ingram MC, Kicman AT, Makin HLJ, Stewart, PM. Springer 2010 Kicman AT, Cowan DA. Subject-based Profiling for the Detection of Testosterone Administration in Sport. Drug Testing and Analysis. 2009; 1: Kicman AT. Pharmacology of anabolic steroids. British Journal of Pharmacology 2008;154: Graham MR, Davies B, Grace FM, Kicman A, Baker JS. Anabolic steroid use: patterns of use and detection of doping. Sports medicine (Auckland, NZ 2008;38: Kicman AT, Parkin MC, Iles RK. An introduction to mass spectrometry based proteomics - Detection and characterization of gonadotropins and related molecules. Molecular and Cellular Endocrinology 2007;260: James VHT, Kicman AT (first draft authors). Medical aspects of drug use in the gym. Drug Therap Bull. 2004;42:1-5. Kicman AT, Gower DB. Anabolic steroids in sport: biochemical, clinical and analytical perspectives. Ann Clin Biochem 2003;40: Gower DB, Houghton E, Kicman AT. Anabolic steroids:metabolism, doping and detection. In: Makin HLJ, Gower DB, Kirk DN, eds. Steroid analysis. First edition. ed. Glasgow: Blackie Academic and Professional (imprint of Chapman & Hall), 1995: Cowan DA, Kicman AT. Doping with Peptide Hormones. In: Hemmersbach P, Birkeland KI. Blood samples in doping control. Pensumtjeneste (On Demand Publishing). 1994: Kicman AT, Brooks RV, Cowan DA. Human chorionic gonadotrophin and sport. Br J Sports Med 1991;25: Kicman AT, Cowan DA. Peptide hormones and sport: misuse and detection. Br Med Bull 1992;48:
7 iii) Examples of Extended Proceedings: Gavrilovic I, Ansell RJ, Brailsford AD, Cowan DA, Kicman AT, Molecularly imprinted polymers selective for testosterone; potential application for GC/C/IRMS sample clean-up. Proceedings of the Manfred Donike Workshop. Koln: Sport und Buch Strauss, Walker CJ, Cowan DA, Taylor NF, Kicman AT. Determination of xenobiotic glucocorticoids by gas chromatography-mass spectrometry. In: Schanzer W, Geyer H, Gotzmann A, Mareck U, eds. Recent Advances in Doping Analysis (14) - Proceedings of the Manfred Donike Workshop. Koln: Sport und Buch Strauss, 2006; Bassindale T, Cowan DA, Dale S, Hutt AJ, Leeds AR, Kicman AT. Disposition of androstenedione and testosterone following oral administration of androstenedione to healthy female volunteers; influence on the urinary T/E profile. In: Schanzer W, Geyer H, Gotzmann A, Mareck U, eds. Recent Advances in Doping Analysis (10) - Proceedings of the Manfred Donike Workshop. Koln: Sport und Buch Strauss, 2002; Approaches to the analysis of protein hormones. Discrimination of mammalian growth hormones by peptide-mass mapping. Proceedings of the 12th International Conference of Racing Analysts and Veterinarians. 2000; pp Laidler P, Cowan DA, Hider RC, Kicman AT. Qualitative analysis of hcg for confirmatory purposes. In: Schanzer W, Geyer H, Gotzmann A, Mareck-Engelke U, eds. Recent Advances in Doping Analysis (4) - Proceedings of the Manfred Donike Workshop. Koln: Sport und Buch Strauss, 1997:
RECENT ADVANCES IN DOPING ANALYSIS (4)
W. SCHANZER H. GEYER A. GOTZMANN U. MARECK-ENGELKE (Editors) RECENT ADVANCES IN DOPING ANALYSIS (4) Proceedings of the Manfred Donike Workshop 14th Cologne Workshop on Dope Analysis 17th to 22nd March
More informationWADA Technical Document TD2017NA
HARMONIZATION OF ANALYSIS AND REPORTING OF 19-NORSTEROIDS RELATED TO NANDROLONE 1.0 Introduction This document has been established to harmonize the Confirmation Procedure for the analysis and reporting
More informationRECENT ADVANCES IN DOPING ANALYSIS (2)
M. DONIKE H. GEYER A. GOTZMANN U. MARECK-ENGELKE (EDITORS) RECENT ADVANCES IN DOPING ANALYSIS (2) Proceedings of the 12th Cologne Workshop on Dope Analysis 10th to 15th April 1994 SPORT und BUCH StrauB
More informationWADA Technical Document TD2018MRPL
MINIMUM REQUIRED PERFORMANCE LEVELS FOR DETECTION AND IDENTIFICATION OF NON-THRESHOLD SUBSTANCES In order to ensure that all WADA-accredited Laboratories can report the presence of Prohibited Substances,
More informationDISCUSSION:PERSPECTIVES OF STEROID PROFILING
10 DISCUSSION:PERSPECTIVES OF STEROID PROFILING REVIEWED STEROID PROFILING AND TESTOSTERONE Initially, the abuse of steroids in sports was focussed on chemically modified derivatives of testosterone. These
More informationViapath Innovation Academy 5 December 2014
Viapath Innovation Academy 5 December 2014 Interview with Dr Andrew Kicman of King s College London conducted by Robert Dunn of the Future Leaders in Innovation Group, Viapath. How did you choose your
More informationWADA Technical Document TD2016EAAS. Endogenous Anabolic Androgenic Steroids Measurement and Reporting
Endogenous Anabolic Androgenic Steroids Measurement and Reporting Introduction The purpose of this Technical Document (TD) is to harmonize the approaches to the measurement and reporting of Endogenous
More informationWADA Technical Document TD2014EAAS. Endogenous Anabolic Androgenic Steroids Measurement and Reporting
Endogenous Anabolic Androgenic Steroids Measurement and Reporting 1.0 Introduction The purpose of this Technical is to harmonize the approaches to the measurement and reporting of endogenous anabolic androgenic
More informationPaul J. Perry, 1,3 * John H. MacIndoe, 2 William R. Yates, 1 Shane D. Scott, 3 and Timothy L. Holman 1. Toxicology
Clinical Chemistry 43:5 731 735 (1997) Drug Monitoring and Toxicology Detection of anabolic steroid administration: ratio of urinary testosterone to epitestosterone vs the ratio of urinary testosterone
More informationRECENT ADVANCES IN DOPING ANALYSIS (5)
W. SCHANZER H. GEYER A. GOTZMANN U. MARECK-ENGELKE (EDITORS) RECENT ADVANCES IN DOPING ANALYSIS (5) Proceedings of the Manfred Donike Workshop 15th Cologne Workshop on Dope Analysis 23rd to 28th February
More informationWADA Technical Document TD2018EAAS. Endogenous Anabolic Androgenic Steroids Measurement and Reporting
Endogenous Anabolic Androgenic Steroids Measurement and Reporting 1.0 Introduction The purpose of this Technical Document (TD) is to harmonize the approaches to the measurement and reporting of Endogenous
More informationWADA Technical Document TD2010EAAS. Endogenous Anabolic Androgenic Steroids Testing, Reporting and Interpretive Guidance
Endogenous Anabolic Androgenic Steroids Testing, Reporting and Interpretive Guidance 1.0 Introduction The purpose of this Technical Document is to further harmonize the approaches to the detection and
More informationImport, seizure and analysis of prohibited doping products imported into Switzerland
Import, seizure and analysis of prohibited doping products imported into Switzerland Play the Game, 26-30 November, Eindhoven Christina Weber, PhD Introduction Since October 2012 new Sports Law in Switzerland
More informationExtend the time window for the detection of low level anabolic androgenic steroids and their metabolites
Application Note Doping Control Extend the time window for the detection of low level anabolic androgenic steroids and their metabolites Steroid profiling, screening, and confirmatory analysis using the
More informationThe ICL Insider. Lab Testing: Testosterone. In This Issue. The Debate
The ICL Insider February 2017 Volume 2, Issue 2 Lab Testing: Testosterone In This Issue Testosterone shashtilak@iclabs.ca Next Issue: Expected Release April 2017 The Debate Aging is accompanied by various
More informationIntroduction to the Doping Problem
Introduction to the Doping Problem Jordi Segura Director, WADA Accredited Antidoping Laboratory, IMIM-Hospital del Mar, Barcelona, Spain Doping and Society: towards the perfect human machine? ESOF, Barcelona
More informationRECENT ADVANCES IN DOPING ANALYSIS (8)
w. SCHANZER H. GEYER A. GOTZMANN U. MARECK-ENGELKE (EDITORS) RECENT ADVANCES IN DOPING ANALYSIS (8) Proceedings of the Manfred Donike Workshop 18th Cologne Workshop on Dope Analysis 20th to 25th February
More informationMay 1, By John Heim,Doug Staples
1 of 7 7/11/2014 3:39 PM May 1, 2010 By John Heim,Doug Staples Anabolic steroid screening analysis in urine is complex and labor intensive requiring sensitive instrumentation and optimized chromatographic
More informationSimultaneous Determination of a Panel of 22 Steroids in Urine and Serum by SPE and LC-MS/MS
Simultaneous Determination of a Panel of 22 Steroids in Urine and Serum by SPE and LC-MS/MS UCT Part Numbers: CUQAX22Z Clean-Up C8+QAX, 2mg/1mL BETA-GLUC- ml Beta-Glucuronidase Enzyme, liquid form SLAQID21-3UM
More informationLongterm Detection of Anabolic Steroid Metabolites in Urine
Longterm Detection of Anabolic Steroid Metabolites in Urine Application Note Forensics/Doping Control Author Stephan Baumann Agilent Technologies, Inc. 5301 Stevens Creek Blvd Santa Clara, CA 95051 USA
More informationAntiduretic Hormone, Growth. Hormone & Anabolic Steroids
Goudarz Sadeghi, DVM, PhD, DSc Associate Professor of Pharmacology University of Tehran Faculty of Veterinary Medicine Veterinary Pharmacology Endocrine System Antiduretic Hormone, Growth Hormone & Anabolic
More informationPsychology. Psychology & Performance Enhancing Substances. The Ideal Performance State. Relationship Between Confidence and Athletic Performance
Psychology & Performance Enhancing Substances Psychology The Ideal Performance State Absence of fear no fear of failure No thinking about or analysis of performance Narrow focus of attention concentrated
More informationReproductive DHT Analyte Information
Reproductive DHT Analyte Information - 1 - DHT Introduction Dihydrotestosterone (DHT) together with other important steroid hormones such as testosterone, androstenedione (ASD) and dehydroepiandrosterone
More informationRECENT ADVANCES IN DOPING ANALYSIS (6)
W. SCHANZER H. GEYER A. GOTZMANN U. MARECK-ENGELKE (EDITORS) RECENT ADVANCES IN DOPING ANALYSIS (6) Proceedings of the Manfred Donike Workshop 16th Cologne Workshop on Dope Analysis 15th to 20th March
More informationUpdates on Anti-doping and TUE Management in Paralympic Sport
International Paralympic Committee Updates on Anti-doping and TUE Management in Paralympic Sport Matthew Fedoruk, Ph.D. March 15, 2018 PyeongChang 2018 IPC Medical / Sports Science Committee Workshops
More informationRECENT ADVANCES IN DOPING ANALYSIS
w. SCHANZER H. GEYER A. GOTZMANN U. MARECK-ENGELKE (EDITORS) RECENT ADVANCES IN DOPING ANALYSIS (7) Proceedings of the Manfred Donike Workshop 17th Cologne Workshop on Dope Analysis 14th to 19th March
More informationOral Testosterone Administration Detected by Testosterone Glucuronidation Measured in Blood Spots Dried on Filter Paper
Clinical Chemistry 46:4 515 522 (2000) Drug Monitoring and Toxicology Oral Testosterone Administration Detected by Testosterone Glucuronidation Measured in Blood Spots Dried on Filter Paper Shi-Hua Peng,
More informationQUANTITATIVE DETERMINATION OF METABOLIC PRODUCTS OF 19- NORANDROSTENEDIOL IN HUMAN PLASMA USING GAS CHROMATOGRAPHY/MASS SPECTROMETRY
0090-9556/06/3408-1328 1335$20.00 DRUG METABOLISM AND DISPOSITION Vol. 34, No. 8 Copyright 2006 by The American Society for Pharmacology and Experimental Therapeutics 10165/3129438 DMD 34:1328 1335, 2006
More informationQK;L~ " ~\~01. June 26, 2006
June 26, 2006 Office of Special Nutritionals (HFS-450) Center for Food Safety and Applied Nutrition Food and Drug Administration 200 C Street, S.W. (HFS-450) Washington, DC 20204 Dear Dr. Walker : Pursuant
More informationDevelopment of a Clinical Research Method for the Measurement of Testosterone. Dihydrotestosterone
Development of a Clinical Research Method for the Measurement of Testosterone and Dihydrotestosterone Martijn van Faassen, Maarten van den Noort and Ido Kima University Medical Center, Groningen, Netherlands
More informationPerformance Profiling: A Role for Sport Science in the Fight Against Doping?
TECHNICAL REPORT International Journal of Sports Physiology and Performance, 2009, 4, 129-133 2009 Human Kinetics, Inc. Performance Profiling: A Role for Sport Science in the Fight Against Doping? Yorck
More informationInfluence on the alternative steroid profile, part I
Van Renterghem P, Deventer K, Van Eenoo P Influence on the alternative steroid profile, part I DoCoLab, Ghent University, Ghent, Belgium Abstract To date, knowledge of steroid profiling has gone beyond
More informationDrugs in Sport. Fifth Edition. Edited by David R. Mottram. Routledge. Taylor & Francis Group LONDON AND NEW YORK
Drugs in Sport Fifth Edition Edited by David R. Mottram Routledge Taylor & Francis Group LONDON AND NEW YORK Contents Contributors xv SECTION I The basis for and regulation of drug use in sport I 1 An
More informationT he anabolic androgenic steroid 19-
325 REVIEW Urine nandrolone metabolites: false positive doping test? R M N Kohler, M I Lambert... The aim of this review is to analyse the studies on nandrolone metabolism to determine if it is possible
More informationFair Competition and Drug Control
Fair Competition and Drug Control Speaker: Dr. Yves Bonnaire General Manager, Laboratoire des Course Hippiques Dr Yves BONNAIRE Advisory Council LOGO PROHIBITED SUBSTANCES an update. PROHIBITED SUBSTANCES
More informationGC-MS(/MS) investigations on long-term metabolites of 17-methyl steroids
M.K. Parr 1), G. Fußhöller 1), M. Gütschow 2), C. Hess 1,2), W. Schänzer 1) GC-MS(/MS) investigations on long-term metabolites of 17-methyl steroids 1) Institute of Biochemistry, German Sport University,
More informationSPECIFIC DETECTION OF ANDROST-4-ENE-3,17-DIONE
7 SPECIFIC DETECTION OF ANDROST-4-ENE-3,17-DIONE ADMINISTRATION BY PROFILING OXYGENATED METABOLITES Abstract For the selective detection of androst-4-ene-3,17-dione ( 4-AEDIONE) administration, the analysis
More informationDecember 12, 2012 House Hearing. HGH Testing in the NFL: Is the Science Ready? Conducted by the House Committee on Oversight and Government Reform
December 12, 2012 House Hearing HGH Testing in the NFL: Is the Science Ready? Conducted by the House Committee on Oversight and Government Reform Testimony of Dr. Larry Bowers Chief Science Officer United
More information2011 PROHIBITED DRUG CLASSES AND METHODS. Dr Nicolas Theron Loch Logan Waterfront Sport and Travel Medicine Centre Tel :
2011 PROHIBITED DRUG CLASSES AND METHODS Dr Nicolas Theron Loch Logan Waterfront Sport and Travel Medicine Centre Tel : 051-4481389 Doping is defined as the administration of substances belonging to prohibited
More informationSIMPLE, EFFICIENT AND SIMULTANEOUS DETERMINATION OF ANABOLIC STEROIDS IN HUMAN URINE
SIMPLE, EFFICIENT AND SIMULTANEOUS DETERMINATION OF ANABOLIC STEROIDS IN HUMAN URINE Pages with reference to book, From 216 To 218 S.J. Khurshid, M. Riaz, S. Ahmed ( Nuclear Chemistry Division, Pakistan
More informationSPECIFIC DETECTION OF FOOD SUPPLEMENT STEROIDS
3 SPECIFIC DETECTIN F FD SUPPLEMENT STERIDS ABSTRACT Since the nineties steroid containing food supplement products have become widely available. After the introduction of these products, a frequently
More informationPerformance Enhancing Drugs in Sports
Performance Enhancing Drugs in Sports Mark D. Price, M.D., Ph.D Assistant Professor, Department of Orthopedic Surgery University of Massachusetts Medical School Historical Perspective 1889 Brown-Sequard
More informationMonitoring Hormone Therapy Mark Newman, M.S. President of Precision Analytical Inc.
Mr Mark Newman Monitoring Hormone Therapy Mark Newman, M.S. President of Precision Analytical Inc. 2 Avoiding Pitfalls in (B)HRT Monitoring and Picking the Right Lab Test Objectives: Outline how expected
More informationDrugs and Ethics in Sport
Drugs and Ethics in Sport Ethics the practice of making principled choices between right and wrong explicitly reflecting on moral beliefs and practices Principles for an Ethical Framework Respect Basic
More informationSkin metabolism of steroid hormones as endogenous compounds?
Skin metabolism of steroid hormones as endogenous compounds? Van Luu-The Department of Molecular Medicine Laval University Québec, Canada This work has been supported by L Oréal Research Steroid hormones
More informationDiana Heiman, MD Associate Professor, Family Medicine Residency Director East Tennessee State University
Diana Heiman, MD Associate Professor, Family Medicine Residency Director East Tennessee State University Objectives Introduce governing bodies in sport Review banned and restricted substances Discuss therapeutic
More informationNational Institute for Public Health and the Environment Annual CRL workshop 22 October Update on natural Hormone studies
2008 Annual CRL workshop 22 October 2008 Update on natural Hormone studies Natural hormone studies: update Possible approaches - C12/C13 ratio: can result in proof of abuse - Determination of intact esters
More informationAndrogenes and Antiandrogenes
Androgenes and Antiandrogenes Androgens The androgens are a group of steroids that have anabolic and/or masculinizing effects in both males and females. Testosterone [tess-toss-terone], the most important
More informationThe Effect of Oral Dehydroepiandrosterone (DHEA) on the Urine Testosterone/Epitestosterone (T/E) Ratio in Human Male Volunteers*
The Effect of Oral Dehydroepiandrosterone (DHEA) on the Urine Testosterone/Epitestosterone (T/E) Ratio in Human Male Volunteers* Thomas Z. Bosy 1, Karla A. Moore 1,t, and Alphonse Poklis 2 I Armed Forces
More informationTestosterone Topical/Buccal/Nasal
BENEFIT APPLICATION Testosterone Topical/Buccal/Nasal DRUG POLICY Benefit determinations are based on the applicable contract language in effect at the time the services were rendered. Exclusions, limitations
More informationIcd-10 low levels of testosterone
Icd-10 low levels of testosterone The Borg System is 100 % Icd-10 low levels of testosterone 1-10-2017 if your hormone levels are too high or too low, you may have a hormone disorder. Hormone diseases
More informationStatistical discrimination of steroid profiles introduction of steroidomics in doping analysis
P. Van Renterghem a, Pierre-Edouard Sottas b, Martial Saugy b, F.T. Delbeke a, P. Van Eenoo a Statistical discrimination of steroid profiles introduction of steroidomics in doping analysis a DoCoLab -
More informationWe will begin momentarily at 2pm ET. Slides available now! Recordings available as an exclusive ACS member benefit.
We will begin momentarily at 2pm ET Slides available now! Recordings available as an exclusive ACS member benefit. www.acs.org/acswebinars Contact ACS Webinars at acswebinars@acs.org 1 Have Questions?
More informationMALE HORMONE THERAPY OPTIONS
MALE HORMONE THERAPY OPTIONS The following tables have been compiled by Women s staff pharmacists to represent some of the more frequently prescribed regimens for men. The Women s logo is placed throughout
More informationAnabolic agents: recent strategies for their detection and protection from inadvertent doping
Anabolic agents: recent strategies for their detection and protection from inadvertent doping Hans Geyer, 1,2 Wilhelm Schänzer, 1 Mario Thevis 1,2 Review 1 Institute of Biochemistry, Center for Preventive
More informationGrowth Hormone & Somatotropin are an Ergogenic Aid
Growth Hormone & Somatotropin are an Ergogenic Aid BPK 312 MARCH 28 2017 MICHAEL MORKOS PAUL SOURIAL DEL INGVALDSON Table of Contents 1. Hypothesis 2. Clinical Use 3. Mechanism of Action 4. Growth hormone
More informationIssues. What is a low testosterone? Who needs testosterone therapy? Benefits/adverse effects of testosterone replacement Treatment options
Male Hypogonadism Jauch Symposium Waterloo, IA May 17, 2013 Janet A. Schlechte, M.D. Disclosure of Financial Relationships Janet A. Schlechte, M.D. has no relationships with any proprietary entity producing
More informationAdverse effects of anabolic androgenic steroids abuse on gonadal function, glucose homeostasis and cardiovascular function
Adverse effects of anabolic androgenic steroids abuse on gonadal function, glucose homeostasis and cardiovascular function Associate Professor Caroline Kistorp, Ph.D Department of Internal Medicine, Herlev
More informationProviron. Proviron Functions & Traits: (Mesterolone)
Proviron (Mesterolone) Proviron represents one of the oldest anabolic androgenic steroids on the market. A product of the giant pharmaceutical company Schering, it would first appear in 1934. Officially
More informationURINARY STEROID PROFILES IN DOPING TESTING. - In relation to natural variation and drug administration
From THE DEPARTMENT OF LABORATORY MEDICINE Division of Clinical Pharmacology Karolinska Institutet, Stockholm, Sweden URINARY STEROID PROFILES IN DOPING TESTING - In relation to natural variation and drug
More informationAndrogen Measurements
Chapter 5 / Androgen Measurements 63 Androgen Measurements Methods, Interpretation, and Limitations 5 Frank Z. Stanczyk SUMMARY Androgens are measured primarily in serum by direct and indirect (with one
More informationLevels of the natural hormones 17β-oestradiol and testosterone in serum of cattle: results from population studies in Poland
DE G DE GRUYTER OPEN J Vet Res 60, 461-466, 2016 DOI: 10.1515/jvetres-2016-0055 Levels of the natural hormones 17β-oestradiol and testosterone in serum of cattle: results from population studies in Poland
More informationTESTOFEN. Anabolic & Androgenic Activity GENCOR PACIFIC, INC. Fenugreek Extract standardized for FENUSIDE TM. Copyright 2005 by Gencor Pacific, Inc.
GENCOR PACIFIC, INC. 920E. Orangethorpe Avenue, Suite B, Anaheim, CA. 92801 Ph: 714.870.8723 714.870.8724 efax: 732.875.0306 drjit@gencorpacific.com manu@gencorpacific.com www.gencorpacific.com TESTOFEN
More informationELIGIBILITY REGULATIONS FOR THE FEMALE CLASSIFICATION (ATHLETES WITH DIFFERENCES OF SEX DEVELOPMENT) EXPLANATORY NOTES/Q&A
What is the change? In April 2018, the IAAF issued new Eligibility Regulations for the Female Classification (Athlete with Differences of Sexual Development). These new Regulations, which come into effect
More informationHARVARD PILGRIM HEALTH CARE RECOMMENDED MEDICATION REQUEST GUIDELINES
Generic Brand HICL GCN Exception/Other METHYL ANDROID METHITEST METHYL TESTRED 01404 ROUTE MISCELL. CYPIONATE ENANTHATE GUIDELINES FOR USE ANDRODERM ANDROGEL AXIRON FORTESTA NATESTO STRIANT TESTIM VOGELXO
More informationSports drug testing an analyst s perspective
Sports drug testing an analyst s perspective Graham J. Trout and Rymantas Kazlauskas Australian Sports Drug Testing Laboratory, Australian Government Analytical Laboratories, Sydney, Australia. E-mail:
More informationCOMMUNITY REFERENCE LABORATORIES IN THE FIELD OF VETERINARY PUBLIC HEALTH WITHIN THE EUROPEAN UNION
COMMUNITY REFERENCE LABORATORIES IN THE FIELD OF VETERINARY PUBLIC HEALTH WITHIN THE EUROPEAN UNION CRL for residues RIVM-ARO at Bilthoven, NL --------------------------------- Annual Report January 2003
More informationChapter 5. General discussion
Chapter 5. General discussion 127 Chapter 5 In 2003, two review papers concluded that endogenous androgens do not show any consistent association with cardiovascular disease (CVD) risk 1,2. Apparently,
More informationStructure Characterization and Analysis of Drugs Relevant to Sports Drug Testing by GC-Q/TOF
Structure Characterization and Analysis of Drugs Relevant to Sports Drug Testing by GC-Q/TOF Mario Thevis Agilent eseminar, September 11, 2013 1771: Testicular implantation to capons Castrated roosters
More informationEvaluation of Testosterone/Epitestosterone Ratio Influential Factors as Determined in Doping Analysis
Iournal of Analytical Toxicology, Vol. 24, March 2000 Evaluation of Testosterone/Epitestosterone Ratio Influential Factors as Determined in Doping Analysis D.H. van de Kerkhofl,*, D. de Boer 1,2, J.H.H.
More informationDr Tarza Jamal Pharmacology Lecture 2
Contraceptives and androgen hormone Contraceptives: Currently, interference with ovulation is the most common pharmacologic intervention for preventing pregnancy. Major classes of contraceptives 1. Combination
More informationCreatine. Travis Harvey, PhD, CSCS
Creatine Travis Harvey, PhD, CSCS Overview This is not exhaustive it s applicable Disclaimer BLUF Myths Legends Protective effects Move, Shoot, Communicate Bottom Line Collectively, results from these
More informationEVALUATION OF INFLUENTIAL FACTORS ON THE T/E RATIO AS DETERMINED IN DOPING ANALYSIS ABSTRACT
1 EVALUATION OF INFLUENTIAL FACTORS ON THE T/E RATIO AS DETERMINED IN DOPING ANALYSIS ABSTRACT The ratio of the concentration of testosterone glucuronide to the concentration of epitestosterone glucuronide
More informationThe Science of. NUTRICULA Longevity Journal
32 December, 2011 The Science of 33 NUTRICULA Longevity Journal As men age, there is often a decline in libido and sexual function. This decline frequently interferes in intimacy within romantic relationships,
More informationThe Application of QuEChERS in the Extraction of Anabolic Steroids in Whole Blood
The Application of QuEChERS in the Extraction of Anabolic Steroids in Whole Blood UCT Part Numbers: ECQUUS1015CT- Enviro-Clean 15 ml centrifuge tube with 400 mg MgSO 4 and 100 mg NaCl CUMPS2CT - Enviro-Clean
More informationAnabolic Androgenic Steroids
Anabolic Androgenic Steroids 1 / 6 2 / 6 3 / 6 Anabolic Androgenic Steroids What are anabolic steroids? Anabolic steroids are synthetic, or human-made, variations of the male sex hormone testosterone.
More informationForm 08-3d Academic Year Drug-Testing Consent Division I
Academic Year 2010-11 Drug-Testing Consent Division I For: Action: Due date: Student-athletes. Sign and return to your director of athletics. At the time your intercollegiate squad first reports for practice
More informationEFFECTS OF REVIVOGEN SCALP THERAPY ON TESTOSTERONE METABOLISM IN RECONSTRUCTED HUMAN EPIDERMIS
IN VITRO BIOLOGICAL TESTING BIOalternatives The state-of-the-art laboratory Proposal n : AD070315C-2 Study n : AD070315B EFFECTS OF REVIVOGEN SCALP THERAPY ON TESTOSTERONE METABOLISM IN RECONSTRUCTED HUMAN
More informationHair Testing to provide additional evidence in doping cases of potential (clenbuterol) contaminations
Hair Testing to provide additional evidence in doping cases of potential (clenbuterol) contaminations Detlef Thieme Institute of Doping Analysis, Dresden, Germany Beijing, Oct 2017 [M. Jahn (www.kreischa.net)]
More informationMODULE No. 34: Doping in Sports
Subject Paper No and Title Module No and Title Module Tag Paper No. 10; Forensic Toxicology Module No 35; Doping in sports FSC_P10_M34 TABLE OF CONTENTS 1. Learning Outcomes 2. Introduction - Doping in
More informationSample purification procedure for confirmation of 3 -hydroxy stanozolol by gas chromatography/high resolution mass spectrometry
Author proof done Research Article Sample purification procedure for confirmation of 3 -hydroxy stanozolol by gas chromatography/high resolution mass spectrometry S. Ahi, I. M. Reddy, A. Beotra, R. Lal,
More informationTestosterone Hormone Replacement Drug Class Prior Authorization Protocol
Testosterone Hormone Replacement Drug Class Prior Authorization Protocol Line of Business: Medicaid P&T Approval Date: February 21, 2018 Effective date: April 1, 2018 This policy has been developed through
More informationThe Body and the Law: How Physiological and Legal Obstacles Combine to Create Barriers to Accurate Drug Testing
Marquette Sports Law Review Volume 19 Issue 1 Fall Article 10 The Body and the Law: How Physiological and Legal Obstacles Combine to Create Barriers to Accurate Drug Testing Genevieve F.E. Birren Jeremy
More informationHigh speed UHPLC-MS/MS determination of multiple steroids in human serum using the Nexera MX system for multiplex analysis
PO-CON695E High speed UHPLC-MS/MS determination of multiple steroids in human serum using the Nexera MX system for multiplex analysis MSACL 6 EU Neil Loftus, Stephane Moreau, Mikaël Levi 3, Anja Grüning
More informationTESTOFEN HUMAN CLINICAL TRIAL GENCOR PACIFIC, INC. Copyright 2006 by Gencor Pacific, Inc.
GENCOR PACIFIC, INC. 920 E. Orangethorpe Avenue, Suite B, Anaheim, CA 92801 Ph: 714.870.8723 714.870.8724 efax: 732.875.0306 drjit@gencorpacific.com gita@gencorpacific.com www.gencorpacific.com TESTOFEN
More informationUnitedHealthcare Pharmacy Clinical Pharmacy Programs
UnitedHealthcare Pharmacy Clinical Pharmacy Programs Program Number 2017 P 2018-9 Program Prior Authorization/Medical Necessity Topical Androgens Medication Axiron*, Androderm, Androgel*, Fortesta*, Natesto*,
More informationLEUCINE. - A major driving force for Muscle Protein Synthesis
LEUCINE - A major driving force for Muscle Protein Synthesis An article by Professor Don MacLaren, 2016. Leucine is one of the 9 essential amino acids that are required to be ingested by the body since
More informationLearning Goals. What are steroids? Who uses steroids? Why do people use steroids? What are the health risks associated with using steroids?
Learning Goals What are steroids? Who uses steroids? Why do people use steroids? What are the health risks associated with using steroids? Performance Enhancing Drugs Nutritional Aids Pharmacological Aids
More informationDrug Class Monograph
Drug Class Monograph Class: Testosterone Hormone Replacement Drug: Androderm (testosterone transdermal system), Androgel (testosterone topical gel), Axiron (testosterone topical solution), Aveed (testosterone
More informationA review of analytical strategies for the detection of endogenous steroid abuse in food production
Review Published online in Wiley Online Library (www.drugtestinganalysis.com) DOI 10.1002/dta.1354 A review of analytical strategies for the detection of endogenous steroid abuse in food production J.
More informationSue Marty, Ph.D., D.A.B.T. The Dow Chemical Company TERA Endocrine Workshop April 23, 2013
Sue Marty, Ph.D., D.A.B.T. The Dow Chemical Company TERA Endocrine Workshop April 23, 2013 Agenda Value of WoE/MoA determinations in EDSP Information used to examine potential endocrine activity and/or
More informationLIFETIME FITNESS HEALTHY NUTRITION. UNIT 2 Lesson 14 FLEXIBILITY LEAN BODY COMPOSITION
LIFETIME FITNESS HEALTHY NUTRITION MUSCULAR STRENGTH AEROBIC ENDURANCE UNIT 2 Lesson 14 FLEXIBILITY LEAN BODY COMPOSITION MUSCULAR ENDURANCE Created by Derek G. Becher B.P.E., B. Ed., AFLCA Resistance
More informationTestosterone Hormone Replacement Drug Class Prior Authorization Protocol
Line of business: Medi-Cal Effective Date: August 16, 2017 Revision Date: August 16, 2017 Testosterone Hormone Replacement Drug Class Prior Authorization Protocol This policy has been developed through
More informationNow it is. easy to switch. CHS TM Steroid Profiling kit and software. Brochure not for distribution in the USA and Canada
Now it is easy to switch to Clinical MSMS CHS TM Steroid Profiling kit and software Brochure not for distribution in the USA and Canada 2 Meeting your needs for steroid assays PerkinElmer s new CHS MSMS
More informationTrenbolone. Trenbolone Acetate Functions & Traits: Trenbolone Acetate
Trenbolone Trenbolone Acetate Trenbolone Acetate is an extremely powerful anabolic steroid and is considered the single greatest anabolic steroid by many performance enhancing athletes. This is one of
More informationGrowth Hormone s Impact as a Safe Ergogenic Aid to Increase Body Size
Growth Hormone s Impact as a Safe Ergogenic Aid to Increase Body Size Point Argument: Growth Hormone is a Safe Ergogenic Aid to Increase Body Size Monica Chauhan Carissa Eastwood Emily Lefler Mar. 28,
More informationUse of Performance Enhancing Substances Good Chemistry Gone Bad. Evan M. Klass, M.D., F.A.C.P.
Use of Performance Enhancing Substances 2017 Good Chemistry Gone Bad Evan M. Klass, M.D., F.A.C.P. Doping the use of banned athletic performance-enhancing drugs by competitors Performance enhancing substances
More informationLJMU Research Online
LJMU Research Online Kimergård, A, Breindahl, T, Hindersson, P and McVeigh, J The composition of anabolic steroids from the illicit market is largely unknown: implications for clinical case reports (Commentary)
More informationGas Chromatography-Mass Spectrometry Analysis Of Organics In Drinking Water: Concentrates And Advanced Waste Treatment Concentrates, Vol.
Gas Chromatography-Mass Spectrometry Analysis Of Organics In Drinking Water: Concentrates And Advanced Waste Treatment Concentrates, Vol. 1 Microbiological & Chemical Exposure Assessment - last day were
More informationWhat is the optimal design of a rocker shoe
What is the optimal design of a rocker shoe University of Salford School of Health, Sport and Rehabilitation Sciences Deutsche Sporthochschule Köln J Chapman, S Preece, C Nester, B Braunstein, P Bruggerman
More information