SAFETY DATA SHEET SECTION 1: Identification of the substance/mixture and of the company/undertaking Identification of the substance or mixture Product code 4488971 Product name MEMBRANE PROTEIN PTS DYE Company/undertaking identification Life Technologies Corporation 5781 Van Allen Way PO Box 6482 Carlsbad, CA 92008 +1 760 603 7200 Life Technologies Japan Co. Ltd. 2-4-3 Showajima Ota-ku, Tokyo Japan, 143-0004 TEL +81-3-6832-9300 24 hour Emergency Response: 866-536-0631 301-431-8585 Outside of the U.S. ++1-301-431-8585 Country specific Emergency Number (if available): CHEMTREC Japan (Tokyo) +(81)-345209637 (Greeting language: Japanese) For Research Use Only.Not for use in diagnostic procedures GHS - Classification Signal word Danger SECTION 2: Hazards identification Health hazards Acute oral toxicity Category 4 Skin corrosion/irritation Category 1 Serious eye damage/eye irritation Category 1 Physical hazards Not Hazardous Revision date 08-Mar-2016 Page 1 / 6
hazard statements H302 - Harmful if swallowed H314 - Causes severe skin burns and eye damage H318 - Causes serious eye damage Precautionary Statements P303 + P361 + P353 - IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower P301 + P312 - IF SWALLOWED: Call a POISON CENTRE or doctor/physician if you feel unwell P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing P310 - Immediately call a POISON CENTRE or doctor/physician P264 - Wash hands thoroughly after handling P280 - Wear protective gloves/protective clothing/eye protection/face protection Principle Routes of Exposure/ Potential Health effects eyes Skin Inhalation INGESTION Specific effects Carcinogenic effects Mutagenic effects Reproductive toxicity Sensitisation Target Organ Effects Risk of serious damage to eyes. Causes burns. May cause irritation of respiratory tract. Harmful if swallowed. Not applicable. None under normal use conditions. SECTION 3: Composition/information on ingredients Component CAS-No. Weight percent 4,4-difluoro-1,3,5,7-tetramethyl-8-(4-maleimidylphenyl)- - 60-100 4-bora-3a,4a-diaza-s-indacene ( 60-100 ) We recommend handling all chemicals with caution. SECTION 4: First aid measures Skin contact Wash off immediately with plenty of water for at least 15 minutes. Take off all contaminated clothing and wash it before re-use. Immediate medical attention is required. Eye contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Immediate medical attention is required. INGESTION Call a doctor or poison control centre immediately. Never give anything by mouth to an unconscious person. Do not induce vomiting without medical advice. Inhalation Remove to fresh air. If not breathing, give artificial respiration. Call a doctor or poison control centre immediately. Most important symptoms and effects, both acute and delayed H302 - Harmful if swallowed, H314 - Causes severe skin burns and eye damage, H318 - Causes serious eye damage Revision date 08-Mar-2016 Page 2 / 6
Notes to Physician Treat symptomatically. SECTION 5: Firefighting measures Suitable extinguishing media Special protective equipment for firefighters Specific hazards arising from the chemical Water spray. Carbon dioxide (CO2). Foam. Dry chemical. Wear self-contained breathing apparatus and protective suit. Not known SECTION 6: Accidental release measures Personal precautions Methods for cleaning up Ensure adequate ventilation. Avoid contact with skin, eyes or clothing. Use personal protection equipment. Take up mechanically, placing in appropriate containers for disposal. Environmental precautions Prevent further leakage or spillage if safe to do so. Prevent product from entering drains. See Section 12 for more information. SECTION 7: Handling and storage Handling Storage Always wear recommended Personal Protective Equipment. Wear personal protective equipment. Keep in a dry, cool and well-ventilated place. Keep in properly labelled containers. SECTION 8: Exposure controls/personal protection Exposure Limits Chemical Name Japan REL - Ceiling Limits Japan OEL (TWA) 4,4-difluoro-1,3,5,7-tetramethyl-8-(4-maleimidy None None lphenyl)-4-bora-3a,4a-diaza-s-indacene Engineering measures Ensure adequate ventilation, especially in confined areas. Personal protective equipment Personal Protective Equipment requirements are dependent on the user institution's risk assessment and are specific to the risk assessment for each laboratory where this material may be used. Respiratory protection Hand Protection Eye protection Skin and body protection Hygiene measures Environmental exposure controls In case of insufficient ventilation, wear suitable respiratory equipment. Impervious gloves. Safety glasses with side-shields. Lightweight protective clothing. Handle in accordance with good industrial hygiene and safety practice. No special environmental precautions required. SECTION 9: Physical and chemical properties General information Revision date 08-Mar-2016 Page 3 / 6
Form powder Appearance No information available Odour Odour Threshold Boiling point / boiling range C F Melting point / melting range C F flash point C F Autoignition temperature C F Evaporation rate Flammability (solid, gas) Oxidising properties Water solubility Upper explosion limit Lower explosion limit Partition coefficient: n-octanol/water Vapour Pressure vapour density Viscosity ph value SECTION 10: Stability and reactivity Stability Materials to avoid Possibility of hazardous reactions Hazardous decomposition products polymerisation Conditions to avoid Stable under normal conditions. Hazardous reaction has not been reported None under normal processing. None under normal processing. SECTION 11: Toxicological information Acute toxicity Chemical Name LD50 (oral,rat/mouse) LD50 (dermal,rat/rabbit) LC50 (inhalation,rat/mouse) 4,4-difluoro-1,3,5,7-tetramethyl-8-( 4-maleimidylphenyl)-4-bora-3a,4adiaza-s-indacene Principle Routes of Exposure/ Potential Health effects eyes Skin Inhalation INGESTION Risk of serious damage to eyes. Causes burns. May cause irritation of respiratory tract. Harmful if swallowed. Revision date 08-Mar-2016 Page 4 / 6
Carcinogenic effects Mutagenic effects Reproductive toxicity Sensitisation Target Organ Effects None under normal use conditions SECTION 12: Ecological information Ecotoxicity Mobility Biodegradation Bioaccumulation Contains no substances known to be hazardous to the environment or not degradable in waste water treatment plants. SECTION 13: Disposal considerations Dispose of contents/containers in accordance with local regulations. SECTION 14: Transport information This product is subject to the de minimis exceptions for dangerous goods / hazardous materials in accordance with the following regulations: IATA 2.6.10, ADR 3.5.1.4, and U.S. DOT 49 CFR 173.4b. IATA Proper Shipping Name Corrosive solid, n.o.s. (Maleimide) Hazard Class 8 Subsidiary class None Packing group II UN-No 1759 Environmental hazards None Japan Chemical Inventories Not applicable. SECTION 15: Regulatory information Revision date 08-Mar-2016 Page 5 / 6
SECTION 16: Other information Unless specifically referenced in section 15 of this SDS, we have determined that this product does not require further notification or listing under the following Japanese regulations or laws: Fire Service Law, Poisonous and Deleterious Substance Control Law, Pollutant Release and Transfer Register, Industrial Safety and Health Law, Chemical Substance Control Law, Prohibition of Chemical Weapons and Regulation Specific Chemicals, Water Pollution Control Law, Air Pollution Control Law, Narcotics and Psychotropic Control Act, Stimulants Control Act, and Cannabis Control Act. Reason for revision SDS sections updated. For Research Use Only.Not for use in diagnostic procedures. "The above information was acquired by diligent search and/or investigation and the recommendations are based on prudent application of professional judgment. The information shall not be taken as being all inclusive and is to be used only as a guide. All materials and mixtures may present unknown hazards and should be used with caution. Since the Company cannot control the actual methods, volumes, or conditions of use, the Company shall not be held liable for any damages or losses resulting from the handling or from contact with the product as described herein. THE INFORMATION IN THIS SDS DOES NOT CONSTITUTE A WARRENTY, EXPRESSED OR IMPLIED, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PUPOSE" End of Safety Data Sheet Revision date 08-Mar-2016 Page 6 / 6