I-1 General Situation of NSAIDs in China NSAID, non-steroidal anti-inflammatory drugs, is a series of medicines with the curative effects such as defervesce, acesodyne, anti-inflammation, anti-rheumatism, etc.. Table I-2.5-1 Output of major NSAID bulk pharmaceuticals in China, 2000-2007 Item Year Analgin Aspirin Ibuprofen Naproxen/Na proxen sodium Others Total of NSAID 2000 29,545 12,412 10,506 747 148 5,408 58,766 2001 28,620 13,175 10,120 848 230 7,544 60,537 2002 40,625 13999 10591 1309 209 8000 74,733 Output, tonne 2003 43,026 10,540 9,573 829 199 8,500 72,667 2004 48,211 9,500 12,715 N/A 370 N/A N/A 2005 59,400 N/A N/A N/A N/A N/A N/A 2007 78,746 13,580 11,370 4,089 1,100 11,900 120,785 2000 50.28% 21.12% 17.88% 1.27% 0.25% 9.20% 100.00% 2001 47.28% 21.76% 16.72% 1.40% 0.38% 12.46% 100.00% Output share, % 2002 54.36% 18.73% 14.17% 1.75% 0.28% 10.70% 100.00% 2003 59.21% 14.50% 13.17% 1.14% 0.27% 11.70% 100.00% 2007 65.20% 11.24% 9.41% 3.39% 0.91% 9.85% 100.00% 2000 19,834 7,200 6,300 0 50 4000 37,384 2001 21,552 7,595 6781 325 15 5000 41,268 2002 27,848 8,114 6284 135 165 42,546 Export, tonne 2003 28,163 8,100 5,077 455 195 5,500 47,490 2004 32,810 7,394 7,572 1,370 339 9,158 58,644 2005 39,821 N/A N/A N/A N/A N/A N/A 2007 46,412 4,7581 N/A2 4,019 N/A N/A N/A 2000 2 0 0 0 0 500 502 2001 2 0 0 0 0 500 502 Import, tonne 2002 0 0 0 0 0 500 500 2003 1 1 0 0 0 500 502 2007 6 N/A N/A N/A N/A N/A N/A 2000 9,713 5,212 4,206 747 98 1,908 21,884 2001 7,070 5,580 3,339 523 215 3,044 19,771 Apparent consumption tonne 2002 12,777 5,885 4,307 1,174 44 8,500 32,687 2003 14,864 2,441 4,496 374 4 3,500 25,679 2004 15,406 2,106 5,143 N/A N/A N/A N/A 2005 19,581 N/A N/A N/A N/A N/A N/A 2007 32,340 N/A N/A N/A N/A N/A N/A Apparent consumption share, % 2000 44.38% 23.82% 19.22% 3.41% 0.45% 8.72% 100.00% 2001 35.76% 28.22% 16.89% 2.65% 1.09% 15.40% 100.00% 2002 39.09% 18.00% 13.18% 3.59% 0.13% 26.00% 100.00% 2003 57.88% 9.51% 17.51% 1.46% 0.02% 13.63% 100.00%
I-3 Brief Review of Industry in China Table I-3.1 Overview of paracetamol industry development in China Time Event Influence 1959-1960 end 1970s to 1980s in the 1990s 2001-2006 2007-2008 Started to produce paracetamol in 1959 The output was only 24 tonnes in 1960. Commercial production of paracetamol started The output in 1980 was 1,362 tonnes. By 1985 it was 5,549 tonnes, and by 1990, it was 8,893. Began to export paracetamol to the overseas market, from trail quantity to large quantity. Chinese paracetamol enjoyed two golden times: in 1993-1996 and in late 1990s. It had been accepted gradually by the overseas customers 1991-1996 The golden time for expansion 1996-2000. By 2000, China s paracetamol output was nearly 30,000 tonnes, three times that of 1991. China s supply capability and the export kept growing. Chinese manufacturers began to diversify. has become the dominant variety among traditional bulk medicines in China in 2006. Export tax rebate on paracetamol has reduced since July 1, 2007 The price of crude oil increased sharply to USD147.25/barrel on July 11th. Financial crisis of US was further worse in 2008, which affected the price of raw material and export volume China began to have its own paracetamol started industrialization, and products began to enter international market. developed fast promoted by demand from domestic and overseas markets. went into a quick expansion and slim profit age. faced domestic and international press.
I-5 Production Situation of in 2008 List and Geographical Distribution of Active Manufacturers in 2008 Table I-5.1-1 Production summary of paracetamol in the past years No. Abbreviation Location GMP 08 Cap. '08 Cap. '07 Cap. '06 Cap. '05 (t/a) Prod. Oct '08 Prod. Apr '05 Output 07 (t) Output 05 (t) Est. exp. 07 Est. exp. 05 (Y/N) (t/a) (t/a) (t/a) (t/m)* (t/m)* (t) (t) II-1.01 Lu an Pharm Shandong Yes 24,000 24,000 24,000 24,000 1,500 2,000 18,736 14,000 16,167 9,871 II-1.02 Zhejiang Conler Zhejiang Yes 12,000 12,000 12,000 14,000 800 800 7,606 7,000 6,684 5,964 II-1.03 Hebei Jiheng Hebei Yes 15,000 15,000 13,000 12,000 1,100 1,000 10,000 6,000 6,334 4,101 II-1.04 Wuxi Rhodia Jiangsu Yes 7,000 7,000 6,000 5,000 800 500 5,600 5,700 5,560 5,579 II-1.05 Bengbu Bayi Anhui Yes 15,000 15,000 15,000 5,000 400 400 8,000 5,000 1,563 3,284 II-1.06 Zhejiang Conch Zhejiang Yes 5,000 5,000 5,000 5,000 120 300 1,000 3,500 67 1,738 II-1.07 Jilin Baikang Jilin Yes 5,000 5,000 5,000 4,000 400 400 3,338 3,000 1,312 1,537 II-1.08 Jiangsu Huagang Jiangsu Yes 8,000 8,000 5,000 5,000 450 450 5,000 3,000 11 2,769 II-1.09 Tianjin Bofa Tianjin Yes 10,000 5,500 0 0 700-5,339-3,870 - II-1.10 Jiangsu World Kindly Jiangsu Applying 5,000 5,000 0 0 450-3,000-2,299 - II-1.11 Anhui Jiameng Anhui Yes 5,000 4,500 4,500 4,500 400 255 3,500 2,000-391 II-1.12 Liaoning Tiancheng Liaoning Yes 5,000 5,000 4,500 3,000 200 100 2,000 1500 552 455 II-1.13 Anhui Yong an Anhui Yes 8,000 8,000 8,000 5,000 300 0 4,000 1,000-0 II-2.01 Guangdong Jinshi (idled) Guangdong Yes - - 300 300-30 66 200-14 II-2.02 Shaanxi Nuoke (idled) Shaanxi - - - 6,000 5,000-300 500 3,000-58 II-3.01 Henan Xin an (stopped) Henan Yes - - 4,000 4,000-200 360 1,500-11 II-3.02 Tianjin Xinxin (stopped) Tianjin - - - 5,500 3,000-480 701 2,000 155 2,303 II-3.03 Liaoning Jiutai (stopped) Liaoning - - - - 1,000-50 - - - 0 II-3.04 Anhui Topsun (stopped) Anhui - - - - 2,500-0 - 0-0 II-3.05 Jiangsu Guoheng (stopped) Jiangsu No - - 4,000 4,000-210 - 1000-282 Others/unidentifiable - - - - - - - - 0-1,466 Total 124,000 119,000 121,800 106,300 7,620 7,475 78,746 59,400 44,574 39,823 Source: CCM International Ltd.
I-8.1 Apparent Consumption of in China Table I-8.1-1 Production and consumption situation of paracetamol in China, 1993-2007, tonne Year Output Export Import Apparent consumption Annual increment 1993 10,905 7,411 N/A 3,494-1994 12,012 7,651 N/A 4,301 23.10% 1995 13,758 8,271 N/A 5,514 28.20% 1996 14,924 8,562 N/A 6,362 15.40% 1997 15,600 11,532 7 4,075-35.96% 1998 21,437 14,824 2 6,615 62.33% 1999 28,688 19,282 13 9,419 42.39% 2000 29,545 19,834 2 9,713 3.12% 2001 28,620 21,553 2 7,070-27.21% 2002 40,6251 27,849 2 12,778 80.76% 2003 43,0261 28,163 1 14,864 16.32% 2004 48,211 32,8112 6 15,406 3.65% 2005 59,400 39,8222 2 19,580 27.09% 2006 70,092 46,118 3 23,977 22.46% 2007 78,746 46,4122 7 32,341 34.88%
Table I-8.6-1 Major end users of bulk or DC grade paracetamol in China in 2008 Manufacturer Shanghai Johnson Johnson & Pharmaceutica ls Ltd. Tianjin SmithKline Preparation Active component Active content of Company Contact brand name paracetamol entity Tylenol Tablets tablet 500mg/tablet JV Tel: Tylenol Extended Relief tablet 650mg/tablet +86-21 Tylenol Cold 325mg/tablet -22058888 Tylenol Infant s Fever Drop 80mg/0.8ml Tylenol Children s Fever Liq uid Tylenol Junior Strength Cap let tablet 160mg/tablet Infant s Tylenol 80mg/0.8ml Acetaminophen Suspension Drops Children s Tylenol Acetaminophen Suspension Drops Tylenol Children s Cold Liquid Panadol tablet 500mg/tablet JV Tel: +86-22 - 24700888 Bristol-Myers Bufferin 500mg/tablet JV Tel: Squibb +86-21-23218100 Company Fax: +86-21 - 53862127 Jilin Wutai Gankang 250mg/tablet Tel: Group +86-431 -4655666....