SAFETY DATA SHEET Page 1 of 6 IVOMEC Pour-On for Cattle & Deer Reviewed on: 10 September 2007

Transcription

1 SAFETY DATA SHEET Page 1 of 6 SECTION 1: IDENTIFICATION OF THE SUBSTANCE AND SUPPLIER Product name: Product code: IVOMEC Pour-On for Cattle & Deer A5303 Recommended use: For the treatment and control of major internal and external parasites of cattle. Company details: Merial Ancare Address: Level 3, Merial Building Osterley Way Manukau City New Zealand Telephone number: Phone: Fax: Emergency telephone number: Date of preparation: 10 September 2007 Merial Ancare Freephone: National Poisons Centre: (0800 POISON) Fire Service, Ambulance: Dial 111 SECTION 2: COMPOSITION/INFORMATION ON INGREDIENTS Chemical characterization: Multicomponent Liquid / Avermectin Product components: Name CAS Proportion Ivermectin % Isopropyl Alcohol % SECTION 3: HAZARDS IDENTIFICATION Hazard classifications: 3.1B, 6.1D, 6.3B, 6.4A, 6.8C, 9.1A, 9.2C, 9.3C, 9.4A Priority and secondary identifiers: Risk and safety phrases: Danger Highly Flammable Liquid & Vapour Keep Out of Reach of Children Ecotoxic Highly flammable liquid and vapour Do not use or store near heat or open flame. Harmful may be harmful if swallowed, inhaled or absorbed through the skin. Do not eat, drink or smoke while using. Wear protective clothing such as impervious gloves, waterproof hat, coat and trousers when using. Remove protective clothing and wash hands and face thoroughly before meals and after work. Warning may cause mild skin irritation. Avoid skin contact. Harmful may cause eye irritation. Avoid contact with eyes. May cause reproductive/development damage from repeated oral exposure. Ecotoxic Very toxic to aquatic organisms. Avoid contamination of any water supply with product or empty container. Harmful to the soil environment. Apply only as directed. Harmful to terrestrial vertebrates. Apply only as directed. Avoid contact with skin Very toxic to terrestrial invertebrates. Apply only as directed SECTION 4: FIRST AID MEASURES

2 Page 2 of 6 Necessary first aid measures: Workplace facilities: Required instructions: Notes for medical personnel: Contact the National Poisons Information Centre for further information: phone 0800 POISON ( ) Eye Contact: Immediately flush with plenty of water for at least 15 minutes. Get medical attention if irritation occurs or persists. Skin Contact: Wash thoroughly with plenty of soap and water after handling. Get medical attention if irritation occurs. Inhalation: Remove to fresh air. If breathing is difficult, give oxygen. If not breathing, artificial respiration. If symptoms appear, get medical attention. Ingestion: Get immediate medical attention. No antidotes are available. DO NOT induce vomiting. In case of symptomatic effect provide treatment to maintain life functions. SECTION 5: FIRE FIGHTING MEASURES Type of hazard: Fire hazard properties: Regulatory requirements: Extinguishing media and methods: Hazchem code: Recommended protective clothing: Isopropyl alcohol will not burn or ignite under normal usage but is a dangerous fire hazard and a moderate explosion hazard when exposed to heat, flames, or oxidizers. Vapours are heavier than air and may travel a considerable distance to an ignition source and flashback. Flash Point: 14 C (58 F). Flash Point Test Method: Penske closed cup Flammable Limits: LEL% 2.5 (IPA) UEL% - not available If involved in a fire, carbon monoxide may be generated. Carbon dioxide, dry chemical, alcohol resistant foam. Use water spray to cool fire-exposed containers. A fine water mist may be used to smother fire or to disperse vapours. DO NOT use a solid stream of water since the stream will scatter and spread the fire. 2Y[E] Firefighters should wear self-contained breathing apparatus and full protective equipment. SECTION 6: ACCIDENTAL RELEASE MEASURES Emergency procedures: Environmental Data: Eliminate all ignition sources. Absorb small spills on spill pillows or other suitable absorbing material and place in a sealed container for disposal. Dike large spills and transfer to an appropriate container for disposal. Use suitable protective equipment. Follow all fire prevention procedures. Contact emergency response personnel for large spills. Keep unnecessary persons away. Ivermectin is very toxic to certain aquatic species. Avoid contact of spilled materials and runoff with soil and surface waterways. Residual surface material should be removed with towels moistened with methanol. Incinerate all spilled materials and residues at temperatures greater than 500 C. Ivermectin: LC50 (Daphnia Magna) = 36 ppt (parts per trillion) SECTION 7: HANDLING AND STORAGE

3 Page 3 of 6 Precautions for safe handling: Store in closed containers in a cool, dry, well-ventilated area away from oxidizers, heat, sparks, and open flame. Follow local regulations for the storage of flammable liquids. Portect containers from physical damage. Protect from light. Avoid contact with eyes and skin. Do not breathe vapours or mist. Do not ingest. Do not smoke or eat while handling the product. Wash thoroughly after handling. The containers should be stored in their original boxes when not in use. If stored at temperatures below 0 C IVOMEC Pour-On for Cattle may appear cloudy. Allowing to warm at room temperature will restore the normal appearance without affecting efficacy. Keep container closed when not in use. Before opening large containers, release any pressure build-up by loosening closure slowly. Do not transfer contents to unlabelled containers. Do not store in aluminium containers. Use only with adequate ventilation. This product is for application to skin surface only. Do not give orally or parenterally. Regulatory requirements: Handling practices: Approved handlers: Approved handler not required unless >500L Conditions for safe storage: Keep receptacle tightly sealed. Store in a cool, dry, well ventilated place. Store site requirements: Store in a cool location. Packaging: Packing group II SECTION 8: EXPOSURE CONTROL/PERSONAL PROTECTION Workplace exposure standards: Application in the workplace: Exposure standards outside the workplace: Engineering controls: Personal protection: References: The product does not contain any relevant quantities of materials with critical values that have to be monitored at the workplace. Respiratory protection is recommended if the potential for exposure to aerosols exists. Respiratory: If use results in vapour/mist concentrations above the ECL, an approved respirator for vapours/mists is recommended. Hands/Arms: Avoid accidental splashes. If necessary rubber gloves and boots with a waterproof coat should be worn when applying product. Eye/Face: To protect against accidental eye contact, goggles should be worn. Additional Protective Equipment: Protective clothing such as overalls and/or apron. Wash protective clothing after use. Ventilation: Proper ventilation should be maintained at all times to prevent high vapour/mist conditions. Use only in well ventilated areas or outdoors. SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES Specify product data: Appearance: Clean, clear, violet liquid. Odour/Threshold Level (ppm): Characteristic smell of isopropyl alcohol. Do not test for odour. Boiling Point: Isopropyl alcohol: 82.5 C / 180 F Flash Point: 14 C (58 F). Volatile Components (%w/w): 80%

4 Page 4 of 6 Required specifications: Further specifications: Specific advice: SECTION 10: STABILITY AND REACTIVITY Stability of the substance: Conditions to avoid: Material to avoid: Hazardous decomposition products: Hazardous polymerization: Specific data: Stable under normal conditions of storage and use. None known. Isopropyl alcohol is incompatible with acetaldehyde, chlorine, ethylene oxide, hypochlorous acid, isocyanates, phosgene, oleum, perchloric acid, and strong oxidizing agents. If involved in a fire, carbon monoxide may be generated. None known. Data and interpretation: SECTION 11: TOXICOLOGICAL INFORMATION LD/LC50 values that are relevant for classification: Isopropanol Oral LD mg/kg (rat) Dermal LD mg/kg (rabbit) Inhalative LC50/4 h 30 mg/l (rat) Ivermectin Comp. B1a (C48H74O14) Comp. B1b (C47H72O14) Oral LD Oral >15 mg/kg (adult human) LD50 ~80 mg/kg (dog) 25 mg/kg (mouse) 50 mg/kg (rat) >24 mg/kg (Rhesus monkey) Dermal LD mg/kg (rabbit) >660 mg/kg (rat) Inhalative LC50/4h >0.4 mg/kg (rat) LD Subcutaneous >1.6 mg/kg (adult human) LD50 Intraperitoneal 55 mg/kg (rat) LD50 Subcutaneous ~10 mg/kg (juvenile dog) Summaries data: Effects of Acute Exposure: Eye Contact : Direct contact of the solution with eyes can cause irritation. Skin Contact: Ivermectin is non-irritating in animal studies. Although skin absorption of this formulation of ivermectin is not established, it has been shown that less than 1% of the closely related compound abamectin is absorbed through the skin of rhesus monkeys when it is applied as emulsifiable concentrate or suspended in alcohol. Prolonged or repeated contact may cause irritation and/or drying and cracking of the skin. Inhalation: Vapours of isopropyl alcohol may cause mild irritation of the nose and throat. Prolonged exposures to isopropyl alcohol above the TLV may cause nausea, headache and mild narcosis. Ingestion: Oral toxicity of the solution is low. Pure ivermectin is considered highly toxic in acute animal studies. The acute oral toxicity studies of ivermectin have shown clear differences among species in sensitivity to ivermectin toxicity. Rodents are uniquely sensitive compared to the other species in which the compound has been tested. It is therefore inappropriate to base human risk assessment on the response in mice. Ivermectin is used at a therapeutic dose of 200mcg/kg in a variety of species, including human. Ivermectin can be excreted in milk.

5 Page 5 of 6 If overexposed to ivermectin, symptoms may include decreased activity, slow rate of breathing, dilation of the pupils, muscle tremors, and incoordination. Ingesting a large amount of isopropyl alcohol will cause burning of the gastrointestinal tract, nausea, vomiting, bleeding, CNS depression, haemolysis, and pulmonary damage. Effects of Chronic Exposure: Carcinogen Designation: Unknown for product mixture. When this product is used according to the directions, prolonged exposure of man is not expected. Ivermectin has tested negative in several mutagenicity studies. Ivermectin was administered to dogs daily for 3 months and to monkeys daily for 2 weeks. In dogs there was no effect up to 500mcg/kg/day and in adult rhesus monkeys there was no effect at the maximum dosage used 1.2mg/kg/day. At higher doses in dogs there was dilation of the pupils, and at still higher doses tremor and anorexia were noted. Ivermectin can be given during gestation in horses, cattle, pigs and sheep. The results of the developmental toxicity studies with ivermectin demonstrate that a low incidence of abnormalities was produced only at dosage levels at or near those producing severe signs of maternotixicity including death in some dams. Therefore, ivermectin is not considered to be selectively embryotoxic. Years of widespread clinical use of ivermectin in pregnant animals of a variety of species have failed to produce any evidence of development toxicity, further supporting the above conclusion Dr William C Campbell, Ivermectin and Abamectin, (New York; Springer-Verlag, 1989) 100. Not listed with the International Agency for Research on Cancer SECTION 12: ENVIRONMENTAL INFORMATION Potential environmental interactions: Data organisation : Environmental risk and safety phrases: Ivermectin: LC50 (Daphnia Magna) = 36 ppt (parts per trillion) Hazardous to certain aquatic and marine organisms. Marine pollutant SECTION 13: DISPOSAL CONSIDERATIONS Disposal information : Refer to Section 6. Do not flush into drains or natural waterways or areas draining into potable water supplies. SECTION 14: TRANSPORT INFORMATION Relevant information: Other requirements: Maximum Transport Quantity: 250 L DG Class 3 for road transport UN 1219 Tracking not required. SECTION 15: REGULATORY INFORMATION Registered pursuant to the ACVM Act 1997, No. A5303. See Regulatory status: for registration conditions. Approved pursuant to the HSNO Act 1996, Approval Code HSR See for approval conditions. HSNO and ACVM controls: Refer to Section 3

6 Page 6 of 6 List exposure limits: SECTION 16: OTHER INFORMATION Additional information: For product information visit the Merial website While the information set forth is believed to be accurate as of the date hereof, MERIAL NZ LTD. makes no warranty with respect hereto and disclaims all liability from reliance thereon.