MATERIAL SAFETY DATA SHEET
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1 Page 1 of 5 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Pfizer Animal Health Pfizer Inc 235 East 42nd Street New York, NY Emergency telephone number: (24 hrs.) Telephone: Pfizer Ltd, Kent CT13 9NJ United Kingdom (0) Emergency telephone number: ChemSafe (24 hours): +44 (0) Trade Name: Chemical Family: Intended Use: VANGUARD Veterinary Vaccine 2. COMPOSITION/INFORMATION ON INGREDIENTS Hazardous Ingredient CAS Number EU EINECS List % < ## Ingredient CAS Number EU EINECS List % Canine Parainfluenza NOT ASSIGNED Not listed * Canine Parvovirus NOT ASSIGNED Not listed * Aluminum hydroxide gel * Canine Adenovirus Type 2 NOT ASSIGNED Not listed * Canine Distemper NOT ASSIGNED Not listed * Leptospira canicola NOT ASSIGNED Not listed * Leptospira grippotyphosa NOT ASSIGNED Not listed * Leptospira icterohaemorrhagiae NOT ASSIGNED Not listed * Leptospira pomona NOT ASSIGNED Not listed * Additional Information: * Proprietary ## Trace Ingredient(s) indicated as hazardous have been assessed under standards for workplace safety. 3. HAZARDS IDENTIFICATION Appearance: Statement of Hazard: Additional Hazard Information: Short Term: EU Indication of danger: Freeze-dried preparation plus liquid vaccine Non-hazardous in accordance with international standards for workplace safety. In the event of accidental injection, an allergic reaction may occur. If an allergic reaction occurs, the worker should be removed to the nearest emergency room and the appropriate therapy instituted. Not classified
2 Page 2 of 5 Note: This document has been prepared in accordance with standards for workplace safety, which require the inclusion of all known hazards of the active substance or its intermediates regardless of the potential risk. The precautionary statements and warnings included may not apply in all cases. Your needs may vary depending upon the potential for exposure in your workplace. 4. FIRST AID MEASURES Eye Contact: Skin Contact: Ingestion: Inhalation: Flush with water while holding eyelids open for at least 15 minutes. Seek medical attention immediately. Remove contaminated clothing. Flush area with large amounts of water. Use soap. Seek medical attention. Never give anything by mouth to an unconscious person. Wash out mouth with water. Do not induce vomiting unless directed by medical personnel. Seek medical attention immediately. Remove to fresh air and keep patient at rest. Seek medical attention immediately. 5. FIRE FIGHTING MEASURES Extinguishing Media: Hazardous Combustion Products: Fire Fighting Procedures: Fire / Explosion Hazards: Use carbon dioxide, dry chemical, or water spray. Formation of toxic gases is possible during heating or fire. During all fire fighting activities, wear appropriate protective equipment, including selfcontained breathing apparatus. Not applicable 6. ACCIDENTAL RELEASE MEASURES Health and Safety Precautions: Measures for Cleaning / Collecting: Measures for Environmental Protections: Additional Consideration for Large Spills: Personnel involved in clean-up should wear appropriate personal protective equipment (see Section 8). Minimize exposure. Contain the source of spill if it is safe to do so. Collect spilled material by a method that controls dust generation. A damp cloth or a filtered vacuum should be used to clean spills of dry solids. Clean spill area thoroughly. Place waste in an appropriately labeled, sealed container for disposal. Care should be taken to avoid environmental release. Non-essential personnel should be evacuated from affected area. Report emergency situations immediately. Clean up operations should only be undertaken by trained personnel. 7. HANDLING AND STORAGE General Handling: Storage Conditions: Storage Temperature: Use adequate ventilation. Avoid contact with eyes, skin and clothing. Avoid breathing dust, vapor or mist. Use appropriate personal protective equipment. Do not freeze. Store away from light. 2-8 C (36-46 F)
3 Page 3 of 5 8. EXPOSURE CONTROLS / PERSONAL PROTECTION OSHA - Final PELS - TWAs: ACGIH Threshold Limit Value (TWA) ACGIH Threshold Limit Value (STEL) ACGIH - Skin Absorption Designation Australia STEL Australia TWA = 0.03 mg/m 3 STEL Skin - potential significant contribution to overall exposure by the cutaneous route = 0.03 mg/m 3 STEL Engineering Controls: Engineering controls should be used as the primary means to control exposures. Personal Protective Equipment: Hands: Eyes: Skin: Respiratory protection: Wear impervious gloves if skin contact is possible. Safety glasses or goggles Use protective clothing (uniforms, lab coats, disposable coveralls, etc.) in both production and laboratory areas. If the applicable Occupational Exposure Limit (OEL) is exceeded, wear an appropriate respirator with a protection factor sufficient to control exposures to below the OEL. 9. PHYSICAL AND CHEMICAL PROPERTIES: Physical State: Molecular Formula: Freeze-dried preparation plus liquid vaccine Color: Molecular Weight: No data available. 10. STABILITY AND REACTIVITY Stability: Conditions to Avoid: Incompatible Materials: Stable under normal conditions of use. Store at 2-8 C. Prolonged exposure to higher temperatures may adversely affect potency. Do not freeze. This material can be denatured or inactivated by a variety of organic solvents, salts or heavy metals. 11. TOXICOLOGICAL INFORMATION General Information: The antigens included in this product are non-infectious. All have been prepared from modified or inactivated preparations of microorganisms. Acute Toxicity: (Species, Route, End Point, Dose) Rat Oral LD50 75 mg/kg Rat Subcutaneous LD50 98 mg/kg Aluminum hydroxide gel Rat Intraperitoneal LD mg/kg
4 Page 4 of 5 Rat Oral LD mg/kg Rat Subcutaneous LD mg/kg Mouse IM LD mg/kg Rat IM LD mg/kg Irritation / Sensitization: (Study Type, Species, Severity) Eye Irritation Rabbit Mild Eye Irritation Rabbit Non-irritating Reproduction & Development Toxicity: (Duration, Species, Route, Dose, End Point, Effect(s)) Embryo / Fetal Development Rat Intramuscular 75 mg/kg/day LOAEL Developmental toxicity Carcinogen Status: None of the components of this formulation are listed as a carcinogen by IARC, NTP or OSHA. 12. ECOLOGICAL INFORMATION Environmental Overview: The environmental characteristics of this material have not been fully evaluated. Releases to the environment should be avoided. 13. DISPOSAL CONSIDERATIONS Disposal Procedures: Observe all local and national regulations when disposing of this material. This product contains trace quantities of mercury and may qualify as a RCRA Hazardous Waste. Status should be confirmed using the EPA Toxicity Characteristic Leaching Procedure (TCLP). 14. TRANSPORT INFORMATION Not regulated for transport under USDOT, EUADR, IATA, or IMDG regulations. 15. REGULATORY INFORMATION EU Indication of danger: Not classified OSHA Label:
5 Page 5 of 5 Non-hazardous in accordance with international standards for workplace safety. Canada - WHMIS: Classifications WHMIS hazard class: None required This product has been classified in accordance with the hazard criteria of the CPR and the MSDS contains all of the information required by the CPR. CERCLA/SARA 313 Emission reporting = 1.0 % Supplier notification limit California Proposition 65 Developmental Inventory - United States TSCA - Sect. 8(b) Present EU EINECS List California Proposition 65 Aminoglycosides- developmental EU EINECS List Standard for the Uniform Scheduling present for Drugs and Poisons - Schedule 4: Aluminum hydroxide gel Inventory - United States TSCA - Sect. 8(b) Present EU EINECS List OTHER INFORMATION Reasons for Revision: Updated Section 2 - Composition / Information on Ingredients. Prepared by: Toxicology and Hazard Communication Pfizer Global Environment, Health, and Safety Pfizer Inc believes that the information contained in this Material Safety Data Sheet is accurate, and while it is provided in good faith, it is without warranty of any kind, expressed or implied. End of Safety Data Sheet
MATERIAL SAFETY DATA SHEET
Page 1 of 5 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Pfizer Animal Health Pfizer Inc 235 East 42nd Street New York, NY 10017 Poison Control Center Phone: 1-866-531-8896
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