Conforms to Code of Practice for the Preparation of Safety Data Sheets for Hazardous Chemicals. RNA Isolation Kit, Part Number

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Conforms to Code of Practice for the Preparation of Safety Data Sheets for Hazardous Chemicals Product identifier SAFETY DATA SHEET Section 1. Identification Part No. (Chemical Kit) 200345 Part No. RNA Isolation Kit, Part Number 200345 RNA Isolation Kit, Part Number 200345 200345-21 200345-17 200345-14 200345-16 Equilibrated 200345-64 with Succinic Isoamyl 200345-18 Alcohol Relevant identified uses of the substance or mixture and uses advised against Analytical reagent. 0.75 ml (750 µl 14.33 M) 100 ml 100 ml ph 4.0 7.5 ml 75 ml 15 ml Supplier/Manufacturer Agilent Technologies Australia Pty Ltd 679 Springvale Road Mulgrave Victoria 3170, Australia 1800 802 402 Emergency telephone number (with hours of operation) CHEMTREC (61)-290372994 Section 2. Hazard(s) identification Classification of the substance or mixture H227 FLAMMABLE LIQUIDS - Category 4 H301 ACUTE TOXICITY (oral) - Category 3 H310 ACUTE TOXICITY (dermal) - Category 2 H330 ACUTE TOXICITY (inhalation) - Category 2 H315 SKIN CORROSION/IRRITATION - Category 2 H318 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 1 H317 SKIN SENSITISATION - Category 1 H335 SPECIFIC TARGET ORGAN TOXICITY - SINGLE EXPOSURE (Respiratory tract irritation) - Category 3 H411 LONG-TERM AQUATIC HAZARD - Category 2 H225 FLAMMABLE LIQUIDS - Category 2 H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2A H336 SPECIFIC TARGET ORGAN TOXICITY - SINGLE EXPOSURE (Narcotic effects) - Category 3 H302 ACUTE TOXICITY (oral) - Category 4 H332 ACUTE TOXICITY (inhalation) - Category 4 H412 LONG-TERM AQUATIC HAZARD - Category 3 Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 1/38

Section 2. Hazard(s) identification H315 SKIN CORROSION/IRRITATION - Category 2 H319 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 2A H227 FLAMMABLE LIQUIDS - Category 4 H301 ACUTE TOXICITY (oral) - Category 3 H311 ACUTE TOXICITY (dermal) - Category 3 H331 ACUTE TOXICITY (inhalation) - Category 3 H314 SKIN CORROSION/IRRITATION - Category 1B H318 SERIOUS EYE DAMAGE/EYE IRRITATION - Category 1 H341 GERM CELL MUTAGENICITY - Category 2 H373 SPECIFIC TARGET ORGAN TOXICITY - REPEATED EXPOSURE - Category 2 H302 ACUTE TOXICITY (oral) - Category 4 H315 SKIN CORROSION/IRRITATION - Category 2 H351 CARCINOGENICITY - Category 2 H373 SPECIFIC TARGET ORGAN TOXICITY - REPEATED EXPOSURE - Category 2 Percentage of the mixture consisting of ingredient(s) of unknown hazards to the aquatic environment 2% GHS label elements Hazard pictograms Signal word DANGER DANGER WARNING WARNING DANGER WARNING Hazard statements H227 - Combustible liquid. H310 + H330 - Fatal in contact with skin or if inhaled. H301 - Toxic if swallowed. H318 - Causes serious eye damage. H315 - Causes skin irritation. H317 - May cause an allergic skin reaction. H335 - May cause respiratory irritation. H411 - Toxic to aquatic life with long lasting effects. H225 - Highly flammable liquid and vapour. H319 - Causes serious eye irritation. H336 - May cause drowsiness or dizziness. H302 + H332 - Harmful if swallowed or if inhaled. H412 - Harmful to aquatic life with long lasting effects. H319 - Causes serious eye irritation. H315 - Causes skin irritation. H227 - Combustible liquid. H301 + H311 + H331 - Toxic if swallowed, in contact with skin or if inhaled. H314 - Causes severe skin burns and eye damage. Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 2/38

Section 2. Hazard(s) identification Precautionary statements H341 - Suspected of causing genetic defects. H373 - May cause damage to organs through prolonged or repeated exposure. H302 - Harmful if swallowed. H315 - Causes skin irritation. H351 - Suspected of causing cancer. H373 - May cause damage to organs through prolonged or repeated exposure. Prevention P280 - Wear protective gloves. Wear eye or face protection. P284 - Wear respiratory protection. P210 - Keep away from flames and hot surfaces. - No smoking. P271 - Use only outdoors or in a well-ventilated area. P273 - Avoid release to the environment. P262 - Do not get in eyes, on skin, or on clothing. P260 - Do not breathe vapour. P270 - Do not eat, drink or smoke when using this product. P264 - Wash hands thoroughly after handling. P272 - Contaminated work clothing should not be allowed out of the workplace. P280 - Wear protective gloves. Wear eye or face protection. P210 - Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P241 - Use explosion-proof electrical, ventilating, lighting and all material-handling equipment. P242 - Use only non-sparking tools. P243 - Take precautionary measures against static discharge. P233 - Keep container tightly closed. P271 - Use only outdoors or in a well-ventilated area. P261 - Avoid breathing vapour. P264 - Wash hands thoroughly after handling. P271 - Use only outdoors or in a well-ventilated area. P273 - Avoid release to the environment. P261 - Avoid breathing vapour. P270 - Do not eat, drink or smoke when using this product. P264 - Wash hands thoroughly after handling. P280 - Wear protective gloves. Wear eye or face protection. P264 - Wash hands thoroughly after handling. P201 - Obtain special instructions before use. P202 - Do not handle until all safety precautions have been read and understood. P281 - Use personal protective equipment as required. P280 - Wear protective gloves. Wear eye or face protection. Wear protective clothing. P210 - Keep away from flames and hot surfaces. - No smoking. P271 - Use only outdoors or in a well-ventilated area. P260 - Do not breathe vapour. P270 - Do not eat, drink or smoke when using this product. P264 - Wash hands thoroughly after handling. P201 - Obtain special instructions before use. Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 3/38

Section 2. Hazard(s) identification P202 - Do not handle until all safety precautions have been read and understood. P281 - Use personal protective equipment as required. P280 - Wear protective gloves. P260 - Do not breathe vapour. P270 - Do not eat, drink or smoke when using this product. P264 - Wash hands thoroughly after handling. Response P391 - Collect spillage. P304 + P340 + P310 - IF INHALED Remove victim to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or physician. P301 + P310 + P330 - IF SWALLOWED Immediately call a POISON CENTER or physician. Rinse mouth. P302 + P361 + P350 + P310 + P362 + P363 - IF ON SKIN Take off immediately all contaminated clothing. Gently wash with plenty of soap and water. Immediately call a POISON CENTER or physician. Take off contaminated clothing. Wash contaminated clothing before reuse. P333 + P313 - If skin irritation or rash occurs Get medical attention. P305 + P351 + P338 + P310 - IF IN EYES Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or physician. P304 + P340 + P312 - IF INHALED Remove victim to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or physician if you feel unwell. P303 + P361 + P353 - IF ON SKIN (or hair) Take off immediately all contaminated clothing. Rinse skin with water or shower. P305 + P351 + P338 - IF IN EYES Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337 + P313 - If eye irritation persists Get medical attention. P304 + P340 + P312 - IF INHALED Remove victim to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or physician if you feel unwell. P301 + P312 + P330 - IF SWALLOWED Call a POISON CENTER or physician if you feel unwell. Rinse mouth. P302 + P352 + P362 + P363 - IF ON SKIN Wash with plenty of soap and water. Take off contaminated clothing. Wash contaminated clothing before reuse. P332 + P313 - If skin irritation occurs Get medical attention. P305 + P351 + P338 - IF IN EYES Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337 + P313 - If eye irritation persists Get medical attention. P314 - Get medical attention if you feel unwell. Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 4/38

Section 2. Hazard(s) identification P308 + P313 - IF exposed or concerned Get medical attention. P304 + P340 + P310 - IF INHALED Remove victim to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or physician. P301 + P310 + P330 + P331 - IF SWALLOWED Immediately call a POISON CENTER or physician. Rinse mouth. Do NOT induce vomiting. P303 + P361 + P353 + P363 + P310 - IF ON SKIN (or hair) Take off immediately all contaminated clothing. Rinse skin with water or shower. Wash contaminated clothing before reuse. Immediately call a POISON CENTER or physician. P302 + P352 + P312 - IF ON SKIN Wash with plenty of soap and water. Call a POISON CENTER or physician if you feel unwell. P305 + P351 + P338 + P310 - IF IN EYES Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or physician. P314 - Get medical attention if you feel unwell. P308 + P313 - IF exposed or concerned Get medical attention. P301 + P312 + P330 - IF SWALLOWED Call a POISON CENTER or physician if you feel unwell. Rinse mouth. P302 + P352 + P362 + P363 - IF ON SKIN Wash with plenty of soap and water. Take off contaminated clothing. Wash contaminated clothing before reuse. P332 + P313 - If skin irritation occurs Get medical attention. Storage P405 - Store locked up. P403 - Store in a well-ventilated place. P235 - Keep cool. P405 - Store locked up. P403 - Store in a well-ventilated place. P235 - Keep cool. Not applicable. Not applicable. P405 - Store locked up. P403 - Store in a well-ventilated place. P235 - Keep cool. P405 - Store locked up. Disposal P501 - Dispose of contents and container in accordance with all local, regional, national and international regulations. P501 - Dispose of contents and container in accordance with all local, regional, national and international regulations. P501 - Dispose of contents and container in accordance with all local, regional, national and international regulations. Not applicable. P501 - Dispose of contents and container in accordance with all local, regional, national and international regulations. P501 - Dispose of contents and container in Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 5/38

Section 2. Hazard(s) identification Supplemental label elements Other hazards which do not result in classification accordance with all local, regional, national and international regulations. Not applicable. Not applicable. Not applicable. Not applicable. Not applicable. Not applicable. None known. None known. None known. None known. Causes digestive tract burns. None known. Section 3. Composition and ingredient information Substance/mixture Substance Substance Mixture Mixture Mixture Mixture CAS number/other identifiers Ingredient name % (w/w) CAS number 2-Mercaptoethanol 100 60-24-2 Propan-2-ol 100 67-63-0 Guanidinium thiocyanate 30-55 593-84-0 acetic acid 10-30 64-19-7 Phenol 90 108-95-2 Trichloromethane 90 67-66-3 3-Methylbutan-1-ol 3 123-51-3 There are no additional ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section. Occupational exposure limits, if available, are listed in Section 8. Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 6/38

Section 4. First aid measures Description of necessary first aid measures Eye contact Inhalation Get medical attention immediately. Call a poison center or physician. Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes. Chemical burns must be treated promptly by a physician. Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes. Get medical attention. Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes. Get medical attention if irritation occurs. Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes. Get medical attention. Get medical attention immediately. Call a poison center or physician. Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes. Chemical burns must be treated promptly by a physician. Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes. Get medical attention. Get medical attention immediately. Call a poison center or physician. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If it is suspected that fumes are still present, the rescuer should wear an appropriate mask or selfcontained breathing apparatus. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If it is suspected that fumes are still present, the rescuer should wear an appropriate mask or self-contained breathing apparatus. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouthto-mouth resuscitation. Get medical attention. If necessary, call a poison center or physician. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If it is suspected Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 7/38

Section 4. First aid measures Skin contact that fumes are still present, the rescuer should wear an appropriate mask or self-contained breathing apparatus. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouthto-mouth resuscitation. Get medical attention if adverse health effects persist or are severe. If necessary, call a poison center or physician. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. In case of inhalation of decomposition products in a fire, symptoms may be delayed. The exposed person may need to be kept under medical surveillance for 48 hours. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. Get medical attention if adverse health effects persist or are severe. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately. Call a poison center or physician. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If it is suspected that fumes are still present, the rescuer should wear an appropriate mask or selfcontained breathing apparatus. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. Get medical attention. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. In case of inhalation of decomposition products in a fire, symptoms may be delayed. The exposed person may need to be kept under medical surveillance for 48 hours. Get medical attention immediately. Call a poison center or physician. Gently wash with plenty of soap and water. Remove contaminated clothing and shoes. Wash contaminated clothing thoroughly with water before removing it, or wear gloves. Continue to rinse for at least 10 minutes. Chemical burns must be treated promptly by a physician. In the event of any complaints or symptoms, avoid further exposure. Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 8/38

Section 4. First aid measures Ingestion Wash clothing before reuse. Clean shoes thoroughly before reuse. Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur. Wash clothing before reuse. Clean shoes thoroughly before reuse. Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Get medical attention if symptoms occur. Wash clothing before reuse. Clean shoes thoroughly before reuse. Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Continue to rinse for at least 10 minutes. Get medical attention. Wash clothing before reuse. Clean shoes thoroughly before reuse. Get medical attention immediately. Call a poison center or physician. Wash with plenty of soap and water. Remove contaminated clothing and shoes. Wash contaminated clothing thoroughly with water before removing it, or wear gloves. Continue to rinse for at least 10 minutes. Chemical burns must be treated promptly by a physician. Wash clothing before reuse. Clean shoes thoroughly before reuse. Flush contaminated skin with plenty of water. Remove contaminated clothing and shoes. Continue to rinse for at least 10 minutes. Get medical attention. Wash clothing before reuse. Clean shoes thoroughly before reuse. Get medical attention immediately. Call a poison center or physician. Wash out mouth with water. Remove dentures if any. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Chemical burns must be treated promptly by a physician. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. Wash out mouth with water. Remove dentures if any. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Get medical attention. If necessary, call a poison center or physician. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. Wash out mouth with water. Remove dentures if any. Remove victim to fresh air and keep at rest in a Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 9/38

Section 4. First aid measures position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Get medical attention. If necessary, call a poison center or physician. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. Wash out mouth with water. Remove dentures if any. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Get medical attention if adverse health effects persist or are severe. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately. Call a poison center or physician. Wash out mouth with water. Remove dentures if any. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Chemical burns must be treated promptly by a physician. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. Wash out mouth with water. Remove dentures if any. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Get medical attention. If necessary, call a poison center or physician. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 10/38

Section 4. First aid measures Most important symptoms/effects, acute and delayed Potential acute health effects Eye contact Causes serious eye damage. Causes serious eye irritation. Causes serious eye irritation. Causes serious eye damage. Inhalation Fatal if inhaled. May cause respiratory irritation. Can cause central nervous system (CNS) depression. May cause drowsiness or dizziness. Harmful if inhaled. Toxic if inhaled. Skin contact Fatal in contact with skin. Causes skin irritation. May cause an allergic skin reaction. Causes skin irritation. Causes severe burns. Toxic in contact with skin. Causes skin irritation. Ingestion Over-exposure signs/symptoms Toxic if swallowed. Can cause central nervous system (CNS) depression. Harmful if swallowed. Toxic if swallowed. Corrosive to the digestive tract. Causes burns. Harmful if swallowed. Eye contact Adverse symptoms may include the following pain watering redness Adverse symptoms may include the following pain or irritation watering redness No specific data. Adverse symptoms may include the following pain or irritation watering redness Adverse symptoms may include the following pain watering redness Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 11/38

Section 4. First aid measures Inhalation Adverse symptoms may include the following respiratory tract irritation coughing Adverse symptoms may include the following nausea or vomiting headache drowsiness/fatigue dizziness/vertigo unconsciousness No specific data. No specific data. No specific data. No specific data. Skin contact Adverse symptoms may include the following pain or irritation redness blistering may occur No specific data. No specific data. Adverse symptoms may include the following irritation redness Adverse symptoms may include the following pain or irritation redness Ingestion Adverse symptoms may include the following pain or irritation watering redness blistering may occur Adverse symptoms may include the following irritation redness Adverse symptoms may include the following stomach pains No specific data. No specific data. No specific data. Adverse symptoms may include the following stomach pains No specific data. Indication of immediate medical attention and special treatment needed, if necessary Notes to physician Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled. Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled. In case of inhalation of decomposition products in a fire, symptoms may be delayed. The exposed person may need to be kept under medical Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 12/38

Section 4. First aid measures surveillance for 48 hours. Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled. Treat symptomatically. Contact poison treatment specialist immediately if large quantities have been ingested or inhaled. In case of inhalation of decomposition products in a fire, symptoms may be delayed. The exposed person may need to be kept under medical surveillance for 48 hours. Specific treatments No specific treatment. No specific treatment. No specific treatment. No specific treatment. No specific treatment. No specific treatment. Protection of first-aiders No action shall be taken involving any personal risk or without suitable training. If it is suspected that fumes are still present, the rescuer should wear an appropriate mask or self-contained breathing apparatus. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. Wash contaminated clothing thoroughly with water before removing it, or wear gloves. No action shall be taken involving any personal risk or without suitable training. If it is suspected that fumes are still present, the rescuer should wear an appropriate mask or self-contained breathing apparatus. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. No action shall be taken involving any personal risk or without suitable training. If it is suspected that fumes are still present, the rescuer should wear an appropriate mask or self-contained breathing apparatus. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. No action shall be taken involving any personal risk or without suitable training. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. No action shall be taken involving any personal risk or without suitable training. If it is suspected that fumes are still present, the rescuer should wear an appropriate mask or self-contained breathing apparatus. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. Wash contaminated clothing thoroughly with water before removing it, or wear gloves. No action shall be taken involving any personal risk or without suitable training. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. See toxicological information (Section 11) Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 13/38

Section 5. Firefighting measures Extinguishing media Suitable extinguishing media Unsuitable extinguishing media Use dry chemical, CO₂, water spray (fog) or foam. Use dry chemical, CO₂, water spray (fog) or foam. Use an extinguishing agent suitable for the surrounding fire. Use an extinguishing agent suitable for the surrounding fire. Use dry chemical, CO₂, water spray (fog) or foam. Use an extinguishing agent suitable for the surrounding fire. Do not use water jet. Do not use water jet. None known. None known. Do not use water jet. None known. Specific hazards arising from the chemical Combustible liquid. In a fire or if heated, a pressure increase will occur and the container may burst, with the risk of a subsequent explosion. The vapour/gas is heavier than air and will spread along the ground. Vapours may accumulate in low or confined areas or travel a considerable distance to a source of ignition and flash back. Runoff to sewer may create fire or explosion hazard. This material is toxic to aquatic life with long lasting effects. Fire water contaminated with this material must be contained and prevented from being discharged to any waterway, sewer or drain. Highly flammable liquid and vapour. In a fire or if heated, a pressure increase will occur and the container may burst, with the risk of a subsequent explosion. The vapour/gas is heavier than air and will spread along the ground. Vapours may accumulate in low or confined areas or travel a considerable distance to a source of ignition and flash back. Runoff to sewer may create fire or explosion hazard. In a fire or if heated, a pressure increase will occur and the container may burst. This material is harmful to aquatic life with long lasting effects. Fire water contaminated with this material must be contained and prevented from being discharged to any waterway, sewer or drain. In a fire or if heated, a pressure increase will occur and the container may burst. Combustible liquid. In a fire or if heated, a pressure increase will occur and the container may burst, with the risk of a subsequent explosion. Runoff to sewer may create fire or explosion hazard. In a fire or if heated, a pressure increase will occur and the container may burst. Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 14/38

Section 5. Firefighting measures Hazardous thermal decomposition products Decomposition products may include the following materials carbon dioxide carbon monoxide sulfur oxides Decomposition products may include the following materials carbon dioxide carbon monoxide Decomposition products may include the following materials carbon dioxide carbon monoxide nitrogen oxides sulfur oxides Decomposition products may include the following materials carbon dioxide carbon monoxide metal oxide/oxides Decomposition products may include the following materials carbon dioxide carbon monoxide Decomposition products may include the following materials carbon dioxide carbon monoxide halogenated compounds carbonyl halides Special protective actions for fire-fighters Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Move containers from fire area if this can be done without risk. Use water spray to keep fire-exposed containers cool. Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Move containers from fire area if this can be done without risk. Use water spray to keep fire-exposed containers cool. Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Move containers from fire area if this can be done without risk. Use water spray to keep fire-exposed containers cool. Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 15/38

Section 5. Firefighting measures Special protective equipment for fire-fighters Hazchem code 2X 2YE 2X 2Z Section 6. Accidental release measures Personal precautions, protective equipment and emergency procedures For non-emergency personnel Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. Fire-fighters should wear appropriate protective equipment and self-contained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode. No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilt material. Shut off all ignition sources. No flares, smoking or flames in hazard area. Do not breathe vapour or mist. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment. No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilt material. Shut off all ignition sources. No flares, smoking or flames in hazard area. Avoid breathing vapour or mist. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment. No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilt material. Avoid breathing vapour or mist. Provide adequate ventilation. Wear appropriate Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 16/38

Section 6. Accidental release measures respirator when ventilation is inadequate. Put on appropriate personal protective equipment. No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilt material. Avoid breathing vapour or mist. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment. No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilt material. Shut off all ignition sources. No flares, smoking or flames in hazard area. Do not breathe vapour or mist. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment. No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilt material. Avoid breathing vapour or mist. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Put on appropriate personal protective equipment. For emergency responders If specialised clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel". If specialised clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel". If specialised clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel". If specialised clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel". If specialised clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel". If specialised clothing is required to deal with the spillage, take note of any information in Section 8 on suitable and unsuitable materials. See also the information in "For non-emergency personnel". Environmental precautions Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Water polluting material. May be harmful to the environment if released in large quantities. Collect spillage. Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 17/38

Section 6. Accidental release measures caused environmental pollution (sewers, waterways, soil or air). Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Water polluting material. May be harmful to the environment if released in large quantities. Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Methods and material for containment and cleaning up Methods for cleaning up Stop leak if without risk. Move containers from spill area. Use spark-proof tools and explosion-proof equipment. Dilute with water and mop up if watersoluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor. Stop leak if without risk. Move containers from spill area. Use spark-proof tools and explosion-proof equipment. Dilute with water and mop up if watersoluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor. Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor. Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor. Stop leak if without risk. Move containers from spill area. Use spark-proof tools and explosion-proof equipment. Dilute with water and mop up if watersoluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste disposal contractor. Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble. Alternatively, or if water-insoluble, absorb with an inert dry material and place in an appropriate waste disposal container. Dispose of via a licensed waste Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 18/38

Section 6. Accidental release measures Section 7. Handling and storage Precautions for safe handling disposal contractor. Protective measures Put on appropriate personal protective equipment (see Section 8). Persons with a history of skin sensitization problems should not be employed in any process in which this product is used. Do not get in eyes or on skin or clothing. Do not breathe vapour or mist. Do not ingest. Avoid release to the environment. Use only with adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Do not enter storage areas and confined spaces unless adequately ventilated. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Store and use away from heat, sparks, open flame or any other ignition source. Use explosion-proof electrical (ventilating, lighting and material handling) equipment. Use only non-sparking tools. Empty containers retain product residue and can be hazardous. Do not reuse container. Put on appropriate personal protective equipment (see Section 8). Do not ingest. Avoid contact with eyes, skin and clothing. Avoid breathing vapour or mist. Use only with adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Do not enter storage areas and confined spaces unless adequately ventilated. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Store and use away from heat, sparks, open flame or any other ignition source. Use explosionproof electrical (ventilating, lighting and material handling) equipment. Use only non-sparking tools. Take precautionary measures against electrostatic discharges. Empty containers retain product residue and can be hazardous. Do not reuse container. Put on appropriate personal protective equipment (see Section 8). Do not ingest. Avoid contact with eyes, skin and clothing. Avoid breathing vapour or mist. Avoid release to the environment. Use only with adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Empty containers retain product residue and can be hazardous. Do not reuse container. Put on appropriate personal protective equipment (see Section 8). Do not ingest. Avoid contact with eyes, skin and clothing. Avoid breathing vapour or mist. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Empty containers retain product residue and can be hazardous. Do not reuse container. Put on appropriate personal protective equipment (see Section 8). Avoid exposure - obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Do not get in eyes or on skin or clothing. Do not breathe vapour or mist. Do not ingest. Use only with Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 19/38

Section 7. Handling and storage Advice on general occupational hygiene adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Do not enter storage areas and confined spaces unless adequately ventilated. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Store and use away from heat, sparks, open flame or any other ignition source. Use explosion-proof electrical (ventilating, lighting and material handling) equipment. Use only non-sparking tools. Empty containers retain product residue and can be hazardous. Do not reuse container. Put on appropriate personal protective equipment (see Section 8). Avoid exposure - obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Do not get in eyes or on skin or clothing. Do not breathe vapour or mist. Do not ingest. If during normal use the material presents a respiratory hazard, use only with adequate ventilation or wear appropriate respirator. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Empty containers retain product residue and can be hazardous. Do not reuse container. Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures. Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures. Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures. Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures. Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures. Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 20/38

Section 7. Handling and storage before eating, drinking and smoking. Remove contaminated clothing and protective equipment before entering eating areas. See also Section 8 for additional information on hygiene measures. Conditions for safe storage, including any incompatibilities Store in accordance with local regulations. Store in a segregated and approved area. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Store locked up. Eliminate all ignition sources. Separate from oxidizing materials. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. Store in accordance with local regulations. Store in a segregated and approved area. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Store locked up. Eliminate all ignition sources. Separate from oxidizing materials. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. Store in accordance with local regulations. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. Store in accordance with local regulations. Store in a segregated and approved area. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials (see Section 10) and food and drink. Store locked up. Eliminate all ignition sources. Separate from oxidizing materials. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination. Store in accordance with local regulations. Store in original container protected from direct sunlight in a Date of issue/date of revision 31/08/2016 Date of previous issue 21/08/2014. Version 5 21/38