INTEGRATED FLUID SYSTEM, SENSORS, SCALES, PLC
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1 INTEGRATED FLUID SYSTEM, SENSORS, SCALES, PLC
2 QUATTROFLOW QUATERNARY DIAPHRAGM PUMP FEATURING HPNE DRIVE INTRODUCING Quattroflow Diaphragm Pumps tap into nature itself in order to convey extremely delicate biologically active molecules. The displacement pump mimics the human heart. The four-piston quaternary diaphragm technology generates a gentle pumping through soft heartbeats. Each beat of the four diaphragms is generated by an eccentric shaft which is connected to the servo motor. The evolutionary design gently, safely and securely conveys aqueous solutions and biologics that are sensitive to shear force with minimal impact. It makes for the perfect model to ensure the safe, reliable and efficient transfer of biologic materials. Couple this with minimal corresponding temperature increase and you have the ideal solution for critical applications within biopharmaceutical manufacturing. These Include: Tangential Flow Filtration (TFF) Chromatography Centrifuge feed Virus filtration Purification Inline dilution DRIVING FORWARD YOUR BIOPROCESS Combined with the HPNE drive, you can calibrate the pump to specific fluids and accurately measure pressure as well as flow and other parameters. PUMP+ DRIVE= RESULTS 2
3 QF150 FLOW RATE VERSUS RPM 4.0 TECHNICAL DATA SPECIFICATION QUATTROFLOW QF150SS QUATTROFLOW QF150SU-EZ Eccentric Shaft LPM 2.15 LPM Flow Rate Maximum: Eccentric Shaft LPM 3.8 LPM Eccentric Shaft LPM 0.01 LPM Flow Rate Minimum: Eccentric Shaft LPM 0.02 LPM 3.0 No Back Pressure (Pulsating Flow) 1 Bar Back Pressure (Pulsating Flow) 2 Bar Back Pressure (Pulsating Flow) No Back Pressure (No pulsation) 1 Bar Back Pressure (No pulsation) Pressure: Maximum Temperature: Pump Speed Range: Suction Lift 3000 RPM: Temperature of Fluid < 40 C (104 F) 6 Bar (87 PSI) 4 Bar (58 PSI) Temperature of Fluid > 40 C (104 F) 4 Bar (58 PSI) 4 Bar (58 PSI) Fluid 80 C (176 F) 60 C (140 F) CIP 90 C (194 F) N/A SIP 130 C (260 F) N/A Autoclave 130 C (260 F) 130 C (260 F) RPM Turndown 300:1 300:1 Eccentric Shaft m ( ft) m ( ft) Eccentric Shaft m ( ft) 2-3 m ( ft) Flow Rates (LPM) Bar Back Pressure (No pulsation) Priming Minimum Pump Speed RPM 2000 RPM Minimum Flow Free Flow LPM 1.25 LPM Minimum Pump Speed RPM 1000 RPM Minimum Flow Free Flow LPM 1.25 LPM 1.0 Approximated Volume per Revolution at Free Output 1.2 ml 1.2 ml Volume Specifications: Filling Volume Without Connectors 15 ml 15 ml Residual volume 1-3 ml (depends on installation position) 1-3 ml (depends on installation position) Product Wetted Surface cm 2 (inch 2 ) 112 (17) 112 (17) Connectors 1/4" TC ¼ TC, ¼ HB, 3/8 HB RPM Connection Specification: Position of Connectors Inline Inline Number of Flow Directions 4 4 Drive Shaft Diameter 7mm 7mm Pump Housing SS316L PP HPNE FLOWMAXX RANGE Product Wetted Materials: Non-product Materials Certificates: Valve Plate SS316L PP Diaphragms TPE TPE Valves EPDM EPDM O-Rings EPDM EPDM Membrane Cover SS316L PP Bearing Housing SS316L SS316L Base Plate SS316L SS316L Shroud SS316L SS316L Elastomers (product wetted) USP<88> Cl. VI; FDA21CFR177; USP<88> Cl. VI; FDA21CFR177; Stainless Steel Parts (product wetted) 3.1; Surface Roughness; Ferrite Content N/A 4
4 QF1200 FLOW RATE VERSUS RPM TECHNICAL DATA SPECIFICATION QUATTROFLOW QF1200SS QUATTROFLOW QF1200SU-M QUATTROFLOW QF1200SU-EZ Eccentric Shaft LPM LPM LPM Flow Rate Maximum: Eccentric Shaft LPM 27.4 LPM 27.4 LPM 30.0 No Back Pressure 1 Bar Back Pressure 2 Bar Back Pressure Flow Rate Minimum: Eccentric Shaft LPM 0.32 LPM 0.32 LPM Eccentric Shaft LPM 0.5 LPM 0.5 LPM 22.5 Pressure: Maximum Temperature: Pump Speed Range: Temperature of Fluid < 40 C (104 F) 6 Bar (87 PSI) 4 Bar (58 PSI) 4 Bar (58 PSI) Temperature of Fluid > 40 C (104 F) 4 Bar (58 PSI) 4 Bar (58 PSI) 4 Bar (58 PSI) Fluid 80 C (176 F) 50 C (122 F) 60 C (140 F) CIP 90 C (194 F) N/A N/A SIP 130 C (260 F) N/A N/A Autoclave 130 C (260 F) N/A 130 C (260 F) RPM Turndown 240:1 240:1 240:1 Flow Rates (LPM) 5.0 Suction Lift 1800 RPM: Eccentric Shaft 3 Eccentric Shaft m ( ft.) m ( ft.) m ( ft.) 7.5 Minimum Pump Speed RPM 1200 RPM 1200 RPM Priming Minimum Flow Free Flow LPM 7.2 LPM 7.2 LPM Minimum Pump Speed RPM 500 RPM 500 RPM Volume Specifications: Minimum Flow Free Flow 5 Approximated Volume per Revolution at Free Output 3 Approximated Volume per Revolution at Free Output 5 Filling Volume Without Connectors 5 LPM 5 LPM 5 LPM 5.8 ml 5.8 ml 5.8 ml 9.6 ml 9.6 ml 9.6 ml 75 ml 75 ml 75 ml RPM Residual volume 8-26 ml (depends on installation position) 8-26 ml (depends on installation position) 8-26 ml (depends on installation position) HPNE FLOWMAXX RANGE Product Wetted Surface cm 2 (inch 2 ) 367 (57) 367 (57) 367 (57) Connectors 1/2" TC, 3/4" TC 3/8" HB, 1/2" HB, 3/4" TC, 90 3/4" TC 3/8" HB, 1/2" HB, 3/4" HB, 3/4" TC Connection Specification: Position of Connectors Inline Front Inline Number of Flow Directions Drive Shaft Diameter 14 mm 14 mm 14 mm Pump Housing SS316L PE (injection molded) PP Valve Plate SS316L PE (injection molded) PP Product Wetted Materials: Diaphragms TPE TPE TPE Valves EPDM EPDM EPDM O-Rings EPDM EPDM EPDM Membrane Cover SS316L PP PP Bearing Housing SS316L SS316L SS316L Non-product Materials Base Plate SS316L SS316L SS316L Shroud SS316L SS316L SS316L Elastomers (product wetted) USP<88> Cl. VI; FDA21CFR177; USP <88> Cl. VI; FDA21CFR177; USP <88> Cl. VI; FDA21CFR177; Certificates: Stainless Steel Parts (product 3.1; Surface Roughness; Ferrite wetted) Content N/A N/A 6
5 QF4400 FLOW RATE VERSUS RPM TECHNICAL DATA Flow Rate Maximum: Flow Rate Minimum: SPECIFICATION QUATTROFLOW QF4400SS (SS QUATTROFLOW QF4400SS (PP VALVE PLATE) VALVE PLATE) QUATTROFLOW QF4400SU Eccentric Shaft LPM 57.9 LPM 57.9 LPM Eccentric Shaft LPM 128 LPM 128 LPM Eccentric Shaft LPM 2.4 LPM 2.4 LPM Eccentric Shaft LPM 3.8 LPM 3.8 LPM No Back Pressure 1 Bar Back Pressure 2 Bar Back Pressure Pressure: Maximum Temperature: Pump Speed Range: Suction Lift 1200 RPM: Temperature of Fluid < 40 C (104 F) 6 Bar (87 PSI) 6 Bar (87 PSI) 4 Bar (58 PSI) Temperature of Fluid > 40 C (104 F) 4 Bar (58 PSI) 4 Bar (58 PSI) 4 Bar (58 PSI) Fluid 80 C (176 F) 80 C (176 F) 60 C (140 F) CIP 90 C (194 F) 90 C (194 F) N/A SIP 130 C (260 F) N/A N/A Autoclave 130 C (260 F) N/A 130 C (260 F) RPM RPM RPM RPM Turndown 60:1 60:1 60:1 Eccentric Shaft m ( ft) m ( ft) m ( ft) Eccentric Shaft m ( ft) m ( ft) m ( ft) Flow Rates (LPM) Minimum Pump Speed RPM 700 RPM 700 RPM Priming Minimum Flow Free Flow LPM 37.5 LPM 37.5 LPM Minimum Pump Speed RPM 500 RPM 500 RPM Minimum Flow Free Flow LPM 53.3 LPM 53.3 LPM Approximated Volume per Revolution at Free Output 3 52 ml 52 ml 52 ml RPM Volume Specifications: Approximated Volume per Revolution at Free Output 6 Filling Volume Without Connectors 95 ml 95 ml 95 ml 820 ml 820 ml 820 ml Residual volume 80 ml 80 ml 80 ml HPNE FLOWMAXX RANGE Product Wetted Surface cm 2 (inch 2 ) 1669 (259) 1669 (259) 1669 (259) Connectors 1" TC, 1.5" TC 1" TC, 1.5" TC 3/4" HB, 1" TC, 1.5" TC Connection Specification: Position of Connectors Front Front Front Number of Flow Directions Drive Shaft Diameter 28 mm 28 mm 28 mm Pump Housing SS316L SS316L PP Valve Plate SS316L PP PP Product Wetted Materials: Diaphragms TPE TPE TPE Valves EPDM EPDM EPDM O-Rings EPDM EPDM EPDM Membrane Cover SS316L PP PP Bearing Housing SS316L SS316L SS316L Non-product Materials Base Plate SS316L SS316L SS316L Shroud SS316L SS316L SS316L Elastomers (product wetted) USP<88> Cl. VI; FDA21CFR177; USP <88> Cl. VI; FDA21CFR177; USP <88> Cl. VI; FDA21CFR177; Certificates: Stainless Steel Parts (product 3.1; Surface Roughness; Ferrite 3.1; Surface Roughness; Ferrite wetted) Content Content N/A 8
6 HOW TO USE The technology is used in conjunction with aqueous-based fluids that are typically handled in research, pilot plant, and/or production facilities of the pharmaceutical and biotech industries. EXAMPLES OF PRODUCT USE: Solutions containing proteins (albumin, IgG, clotting factors, monoclonal antibodies, enzymes, vaccines) Solutions of polymers or suspensions (silicon, latex, chromatographic media) Cell suspensions (bacteria, yeast, algae, fungi, mammalian cells) Colloidal solutions Suspensions of viruses or phage FEATURES BENEFITS Minimal maintenance Minimal downtime Low pulsation Superior containment Variable wide flow Capable of dry run Self-priming Cleanable outer surface Linear turndown Compact design Pressure shut-off Low heat generation High purity Minimum particle shedding Quiet operation Lower life cycle cost Ease of use Quick start-up Scaleable No cell damage Low shear Walk away operation 10
7 P UMP A PPLICAT I O NS Feed pump for centrifuges or separ ators? Feed pump for homogenizers? Feed pump for filling machines? Quattroflow pumps can be found in all areas of biologic manufacturing. The tech ensures safety, ef ficiency and reliability when handling biologics such as plasma products, therapeutic proteins, monoclonal antibodies, vaccines, and other high value products. FILTRATION TECHNOLOGY : To recirculate feed/retentate (e.g. membrane cassettes, hollow fiber, spiral D ID YO U KN O W? wound, ceramic elements) Feed pump for filter cartridges or depth filters CHRO MATOGRAPHY : Packing of chromatography columns Chromatography purification Feed pump to mix gradients Fill finish In-line dilution mixing 12 HPN E Q uat t rofl ow p um p s c an al s o b e out fi t t e d w i t h a s i ngl e us e he ad w hi c h e nab l e s t he m to meet strict s p e e d-t o-m ar k e t m anufac t ur i ng de m ands.
8 TO R Q U E SPECS TORQUE SPECS (NM) QF150 QF1200 QF4400 QF20K Pressure Plate SU Pump Chamber SU Cover Membrane Housing Clamp Ring PP 5 PP 20 1-piece 2 SST 6 SST 18 SST 15 2-piece Stainless Steel Pumps Stainless Steel Pump Cover Membrane Housing
9 MEET HIGH PURITY NEW ENGLAND WHO WE ARE Single Use Fluid Path Assemblies... High Purity Design Assembly Supply Under the auspices of ISO , High Purity New England designs, tests, validates, manufactures and distributes: Single-use products Connectors Tubing Components and systems Designs Systems to the biopharma and pharmaceutical industries SINGLE-USE, MANY BENEFITS Single-use assemblies have fast-become an economic and logical necessity. Meet HPNE - your trusted and approved vendor. HPConnexx is our own ISO-Certified, custom, singleuse assembly service. We work with you to design and optimize an assembly with any commercial components that you specify and that you are comfortable with. Our technical background enables us to provide valuable feedback for process improvements and avoid costly mistakes. 16
10 5 REASONS TO CHOOSE HPNE: ADDED IN THE BIOPROCESS From buffer solutions to cell cultures, your needs are unique. HPNE secures a return on your investment by way of a 5 step process. ONE TWO THREE ASSESS DESIGN IMPROVE Monitor & provide Reduce cost of Reduce costs and If we don t get you, With insights generated, HPNE is hands-on. detailed guidance to building, maintaining downtime for cleaning, how can we get results? the team fuses its Reactivity makes way inform extractable inventory and labor by cleaning validation, That s why the team expertise with best of for proactivity. We ll and leachable outsourcing assembly sterilization and process gets things underway by breed process solutions monitor your activity, testing production engineering assessing your current in designing systems to assessing existing and operation. your needs. new needs. FOUR Integrate stainless steel FIVE ISO 9001: IMPLEMENT You ll judge us on the OVERSEE The team will seek with single-use for hybrid 2015 Certified products results. And rightly out, recommend & operation and services so. Custom parts are implement continuous therefore assembled improvements. This and implemented with ensures you maximize pinpoint precision. efficiency & productivity. 18
11 GETTING CONNECTED WITH BETTER PROCESSES High Purity New England Inc, 25 Thurber Boulevard, Unit #4, Smithfield, RI GOT A QUESTION?GET AN ANSWER! Ready to get connected with a holistic start-to-finish service which optimizes your in-process supply chain? Great. HPNE is standing by to discuss your needs. Call: info@hp-ne.com Visit:
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