Maximize precision and functionality of medical technology, clinical diagnostics and industrial analytics

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1 Maximize precision and functionality of medical technology, clinical diagnostics and industrial analytics Analytical and Medical Device Industry Proven solutions and local expertise to help overcome your toughest challenges.

2 A rapidly developing and highly innovative industry requires precision and consistency to achieve top-level results There is no room for error when working with human health. When working in medical or analytical applications, the highest levels of accuracy, reliability and purity are demanded. Every action influences human health and therefore must be supported by the industry s highest standards and leading innovations. This is not only valid for healthcare professionals, but also for industries supporting their daily work. Emerson has been setting the standards in analytical and medical technology for over 20 years and can help you to achieve optimal results in medical, diagnostics and industrial analysis. Worldwide research and development spending in medical technology reached 26.9 billion US Dollar in With about $120/hour engineering cost, experienced development partners and reliable suppliers are a cost-saving potential An estimated 70% of all decisions related to health care affecting diagnosis or treatment of diseases involve an analytical investigation. Precision and purity of the media are therefore the first and foremost requirement for all technological parts related to analysis. ph 2 12,400 patent applications in 2016 in Europe have been related to medical technology industry representing more than any other sector in Europe and showing the innovative and high-tech spirit.

3 Proven accuracy and reliability for challenging applications Emerson s experienced engineers and extensive and industry-proven valve portfolio for analytical and medical applications provide perfect fluid handling solutions to ensure optimal performance and results. Get optimal results and maximum reliability in analytical applications Prevent contamination of samples, even with aggressive media Reduce unnecessary waste media using low internal volume valves Minimize heat transfer into the fluid using low power consumption valves Focus on patient safety in medical technology Maximize sterile handling of media Manage highest complexity in surgical procedures Prevent any contamination using media-isolated valves Keep track of the environment through water analysis or emission analysis Achieve supreme accuracy with proportional or general service valves Solve challenges related to pressurized or aggressive gases Fast response time allows valve actuation without significant delay 3

4 Problem-solving valve technologies for your challenging applications General Service Valves General service valves are used mainly as pilot valves or for the handling of inert gases. These valves are suitable for applications in almost all areas of analytical and medical technology. Their compact size and easy installation allows several valves to be mounted on a subbase or custom valve manifold. Isolation Valves Isolation valves use a sealing mechanism to separate the valve body and the handled fluid. Different technologies such as a flapper, bellow, lever, pinch or rocker meet the demands of different media, making them suitable for any kind of application. Flapper Mechanism Bellow Seal System Proportional Valves Proportional valves quickly and accurately adjust output pressure in relation to an electrical control signal. They are designed for applications with quickly changing flow demands and are highly customizable. Pressure Control: Sentronic D Sentronic Plus Lever Mechanism Flow Control: Piezotronic Pinch Mechanism Rocker Mechanism Preciflow Posiflow 4

5 Clinical Diagnostics and Bioinstrumentation For the handling and dosing of samples and analytical liquids, you require maximum accuracy and a minimal external influence on the specimen. Learn more. u p6 Hemodialysis Our solutions meet the maximum requirements in terms of heat transfer and other influences on human blood. Learn how this can be linked to increased patient comfort. u p8 Ventilation and Oxygen Therapy Reliable and accurate gas handling during ventilation of patients or lightweight solutions required for homecare and hospital therapy. Learn more. u p10 Dental Supplies Small footprint manifolds supporting a variety of functions such as air, water supply and suction, enable you to save space and time during assembly. Learn more. u p12 Industrial Analyzers and Chromatography Management of aggressive media is a central part of industrial analysis and chromatography. Tailored solutions will allow you to minimize external influences and implement robust components. Learn more. u p14 Therapy Equipment and Surgical Instruments Hospital and outpatient procedures cover a wide range of applications. Emerson s customized fluid handling solutions help meet every requirement. Learn more. u p16 5

6 Clinical Diagnostics and Bioinstrumentation Applications within clinical diagnostics and bioinstrumentation include immunoassay, hematology, sample preparation, DNA sequencing, polymerase chain reaction (PCR) and genotyping. As samples are precious and results are fundamental for diagnosis, precise dosage and minimal exogenous influence are central requirements. The specific design of miniature valves reduces the heating of the media and unnecessary waste. What s your opportunity? Make the best out of the given samples by exact dosage and save cost and time Minimize external factors influencing the biological material with media-isolated valves Challenge A customer in India developing a new hematology analyzer required isolation valves to control the flow of reagent and waste. High purity is demanded and there is a need for low power consumption to reduce potential heat transfer into the fluid. A very tight project deadline created the need for fast delivery of suitable solutions. Results Assisting the customer with its development, Emerson s Rapid Engineered Solution program met the request for isolation valve samples within two days. Fifteen ASCO Series 110 isolation valves, which met the customer s requirements, are used to control the flow of reagent in the analyzer. In addition, the very compact ASCO Series 055 isolation valve manages waste from the washing section. Benefits Fast response helped to maintain the project schedule Valves met customer s challenging specifications 6

7 Featured clinical diagnostics and bioinstrumentation solutions Flapper valves (Series 068 & 068 Proportional) Pinch valves (e.g. Series 045) Rocker valves (e.g. Series 067) Low heat transfer Fast response time Low power No pumping or sticking effects due to flapper technology Related products Lever valves (e.g. Series 283) Silent operation Isolates fluid from coil to reduce heating Excellent candidate for applications in which valve may not be in contact with medium because of isolation Zero dead volume to prevent sample cross contamination Space saving design Ability to handle different tubing hardness and sizes Hermetic separation of control mechanism and the fluid within the tubing assuring maximum purity of liquids Can be used with highly aggressive liquids Removable and rotatable solenoids for easy installation General service valves (e.g. Series RB) Rocker mechanism, combined with a separating diaphragm, prevents heat transfer to the fluid and eliminates the sticking effect of the valve seat Excellent self-draining capability and easy-to-flush low-volume internal cavity Diaphragm valves (e.g. Series 055) Designed for use with aggressive and corrosive liquids and gases Large orifice sizes for high flow-rate and high pressure applications Ideal for quickly flushing systems and routing aggressive reagents to chemical reaction vessels and waste containers Small footprint and compact design Great for manifold setup Lightweight for portable medical devices Excellent flushability if required Compact design for easy installation Low power consumption Long life even for aggressive liquids PTFE Isolation design for aggressive fluids Excellent self draining capability Compact architecture For more information, visit Emerson.com/ASCO 7

8 Hemodialysis Hemodialysis is an extracorporeal process of filtering waste products such as creatinine and urea, as well as free water, out of a patient s blood within the context of renal replacement therapies in an outpatient or inpatient setting. This also includes hemodialysis for paediatric patients or peritoneal hemodialysis. In acute cases of kidney injuries, hemofiltration may take place in an intensive care setting. Besides heat influence on the blood and the strict isolation of fluids, patient comfort through reduced noise at home or at a centre is crucial. What s your opportunity? Minimize external factors influencing the blood circulation with media-isolated valves Increase patient comfort with noise reduction Challenge A US contract manufacturing and design company developing a charcoal hemoperfusion filter required a custom valve to be constructed for a demonstration unit. Blood passes through the filter driven by the dialysis machine, with the high flow rate controlled using a pinch valve. The filter featured harder tubing than normal, which required greater force to be exerted by the valve to ensure precise operation. The customer required a solution very quickly to support a forthcoming presentation of the unit to the customer. Results Working closely with the contract manufacturing company Emerson developed a customized version of the ASCO Series 284 pinch valve that provided greater coil and spring force to pinch down on the tubing. The aseptic device, which also provides silent operation, exceeded the customer s requirements and provided a suitable flow control solution. The ability to design and construct a custom device in a short time frame was critical. Benefits Ensured project deadline was met Customized valve met customer s specific requirements 8

9 Featured hemodialysis solutions/related products Pinch valves (e.g. Series 284) Isolation valves (e.g. Series 068) General service valves (e.g. Series 188) Silent operation Isolates fluid from coil to reduce heating Space saving design Ability to handle different tubing hardness and sizes Hermetic separation of control mechanism and the fluid within the tubing assuring maximum purity of liquids Low heat transfer Fast response time Low power No pumping or sticking effects due to flapper technology Small footprint and compact design Great for manifold setup Lightweight for portable medical devices For more information, visit Emerson.com/ASCO 9

10 Ventilation and Oxygen Therapy Patients with respiratory diseases often require oxygen therapy or oxygen conservers for daily life. In more severe cases, continuous positive airway pressure (CPAP) therapy, incubation or ventilation might be necessary. Proportional valves or general service valves deliver consistent cycles of operation without contamination of the gas. For long-lasting and delicate applications, such as infant incubation or anaesthesia delivery for long-lasting surgical procedures, reliability of all components involved is vital. What s your opportunity? Maximize reliability and consistency for airway applications Minimize external factors influencing the gas concentration with media-separating valves Integrate lightweight solutions ensuring portability of the devices Challenge Results Benefits 10 A startup company was developing a low-cost ventilator for continuous respiratory support with a user-friendly design targeted at developing countries. The ventilator incorporated valves that controlled the containment, mixing and distribution of air to the patient. The company needed technical support and education on the functionality of the fluidics, a turnkey product solution, plus manufacturing support on a global basis. Emerson supported the customer s project team with technical assistance and responded to changing requirements as the ventilator was designed. The final design used an Emerson fluid automation solution consisting of standard Series 411 miniature solenoid valves and four custom solenoid valves modified to deliver the required performance. Emerson s global footprint enabled local support at the customer s design center in California and at its manufacturing centers in India and Singapore. The customer chose Emerson because it was the only supplier that could provide a high level of global application expertise, plus a comprehensive fluid automation package. Provided technical support and fluidics education Designed comprehensive fluid automation solution Modified valves to perform to customer s specifications Supported customer s global manufacturing centers

11 Featured ventilation and oxygen therapy solutions Proportional valves (e.g. Series 202 Preciflow including 12.7mm or IPC version) Used to proportionally control the flow of air and inert gases by varying the electrical input signal to the coil Low hysteresis (<3%), excellent repeatability (<1%), and high sensitivity (<0.1%) Valves do not require a minimum operating pressure and are well suited for vacuum operation Preciflow IPC version Low hysteresis (<5%), excellent repeatability (<1%), and high sensitivity (<1%) IPC (Inlet Pressure Compensated) reduces spring wear and tear and creates more precise control cartridge design for small footprint Preciflow 12.7mm version Low hysteresis (<5%), excellent repeatability (<1%) and high sensitivity (<0.1%) Power consumption as low as 1W to meet the most stringent instrument power requirements Related products Pressure regulator (e.g. Series 624) General service valves (e.g. Series RB) Flat spring valves (Series 065) Lightweight, compact design Tamper-resistant design (manifold) Excellent for oxygen therapy and ventilation applications 342 Special version for water in dental applications Small footprint and compact design Great for manifold setup Lightweight for portable medical devices Long life time and high reliability Compact design and small footprint Easy to install and manifold Material allows usage with a broad range of gases Flat spring enables short response times, precise adjustment and very low switching noise For more information, visit Emerson.com/ASCO 11

12 Dental supplies A dental chair is not just a piece of furniture, it incorporates a range of features and meets a variety of different requirements. It must be comfortable for the patient, easily adjusted precisely by the dentist and deliver air, water and suction for the dental equipment to be used during an odontotherapy. The delivery of these supplies through the chair provides optimal access and vision within the examination area. Customized solutions allow manifolds to be installed which, control all these functions, saving time and space during the assembly process. What s your opportunity? Combine the required features for dental supplies in one manifold Minimize required space and save time for assembly Challenge The valve supplies water to cool the dentist s drill and to wash away any blood and dental matter. The water and waste can build up in the mouth, which requires suction to extract it. There is a legal and industry requirement to totally separate the water inlet from the waste material. This normally requires two valves, one to supply the water and one to control the suction. The dental chair manufacturer was looking for a means of combining the two functions into one to save space. Results Our designers worked with the customer to develop an engineered solution that combined the water supply and back suction control valves onto one manifold. The special manifold unit incorporates both functions, while ensuring total separation to prevent the returning water from mixing with the clean water. The back-suction part of the valve was designed to cope with the drilling waste, which could block any small orifices and collect in any cavities. Benefits Because the supplied manifold combines two valve functions into one, it is compact in size and makes installation and assembly easier. 12

13 Featured dental supplies solutions Modular dental manifold (Series 252) Flexible solution Isolation valves for control water The product is in compliance with the new alimentary/sanitary norms Related products Series 202 Posiflow Filter Regulator Used to proportionally control the flow of air and inert gases by varying the electrical input signal to the coil Low hysteresis (<3%), excellent repeatability (<1%), and high sensitivity (<0.1%) Possibility to control the speed of a connected instrument Excellent candidate for applications requiring high flow No minimum operating pressure differential Well suited for vacuum applications High flow with a wide range of adjustable output pressure ranges Optional low profile integrated gauge, round gauge, digital gauge or digital pressure switch Threaded ports allow for individual or modular mounting Innovative two position plastic drain with manual and semiautomatic functions. Additional drains include an automatic style (brass) and manual (stainless steel) Wide pressure regulation ranges: 0,3-0,5 to 3-6 bar Reliability and durability, low hysteresis, rolling diaphragm, no friction Non-self-relieving regulator For more information, visit Emerson.com/ASCO 13

14 Industrial Analyzers and Chromatography Industrial analysis and chromatography covers a broad range of different applications. This includes mass flow controllers, high power liquid chromatography (HPLC) for chemical analysis and identification of each component within a mixture, as well as water or air emission analyzers for environmental examinations, such as leakage detection. What s your opportunity? Proven consistent components made for pressurized and/or aggressive media Minimize external factors influencing the sample with media-isolated valves Leverage our extensive portfolio and know-how for industry-proven customized solutions Challenge Results Benefits 14 An analytical instrument manufacturer was designing a continuous chromatography machine for process development and single-use manufacturing. The machine incorporated a pneumatic valve to apply pressure to a proprietary diaphragm valve. The customer required a pneumatic valve that could operate with high pressure (300 psig) and low flow (<.025 Cv), plus offer Ethernet connectivity to a control system. The customer turned to Emerson s Analytical and Medical Group to design a turnkey fluid automation solution. Emerson was the only supplier that could meet the application s high-pressure, low-flow, and Ethernet connectivity requirements in one package. The custom manifold assembly combined the Series 411 miniature valves with a G3 Ethernet manifold. Emerson s capability to meet the application s demanding requirements meant the customer did not have to redesign the instrument to operate at lower pressure and higher flow. The analytical instrument manufacturer was pleased with the solution s performance and is working with Emerson on the next generation of products. Created single-source custom valve assembly Achieved customer s high-pressure, low-flow and Ethernet connectivity requirements Optimized instrument s performance

15 Featured industrial analyzers and chromatography solutions General service valves (e.g. Series 411) Proportional valves (e.g. Series 202 Preciflow 12.7mm version) Lever valves (e.g. Series 283) Small footprint and compact design Great for manifold setup Related products Used to proportionally control the flow of air and inert gases by varying the electrical input signal to the coil Low hysteresis (<3%), excellent repeatability (<1%), and high sensitivity (<0.1%) Possibility to control the speed of a connected instrument Excellent candidate for applications requiring high flow No minimum operating pressure differential Well suited for vacuum applications Designed for use with aggressive and corrosive liquids and gases Large orifice sizes for high flow-rate and high pressure applications Ideal for quickly flushing systems and routing aggressive reagents to chemical reaction vessels and waste containers Sentronic Proportional valves Diaphragm valves (e.g. Series 055) High precision and accuracy making it an ideal candidate for analytical applications Can be used as pilot for other valves Software for calibration of parameters included Excellent flushability if required Compact design for easy installation Low power consumption Long life-time even for aggressive liquids PTFE isolation design for aggressive fluids Excellent self draining capability Compact architecture For more information, visit Emerson.com/ASCO 15

16 Therapy Equipment and Surgical Instruments Therapy equipment and surgical instruments serve a broad range of applications in a hospital or outpatient settings. The adjustment of a hospital bed, insufflation during an endoscopic procedure or argon-enhanced surgical procedures require gas handling for adequate treatment of patients. For surgical procedures, fluid management determines visibility during operations, whereas organ preservation helps transplant vital organs from donor to receiver. All these applications have one thing in common patients lives depend on the reliability and accuracy of the medical device and all of its components. What s your opportunity? Implement reliable and accurate components in your medical devices Benefit from a broad range of products and features Leverage our extensive portfolio and know-how for industry-proven customized solutions Challenge A global medical device maker produces surgical suction equipment for laparoscopic arthroscopic procedures. A pinch valve in the device provides suction to clean its lens for clearer viewing by the surgeon. The inexpensive pinch valve initially specified for the equipment did not meet the required delivery schedule. It also had issues leaking in the pinch energised state. Results The medical device maker was familiar with Emerson s reputation for quality and turned to the company to help solve its pinch valve problem. The Emerson Series 284 pinch valve was selected for its reliability and repeatable response. It also had a better appearance than the competing valve being considered, plus it met the customer s delivery requirements. With the Emerson pinch valve installed, nurses and technicians could easily remove the surgical suction device s tubing from the patient. The customer also benefited from Emerson s application knowledge and technical support. Benefits Achieved highly repeatable and reliable instrument response Fulfilled customer s rapid delivery schedule Improved medical operating procedures 16

17 Featured ventilation and oxygen therapy solutions General service valves (e.g. Series RB) Proportional valves (e.g. Series 202 Preciflow 12.7mm version) Pinch valves (e.g. Series 045) Small footprint and compact design Great for manifold setup Lightweight for portable medical devices Related products Used to proportionally control the flow of air and inert gases by varying the electrical input signal to the coil Low hysteresis (<3%), excellent repeatability (<1%), and high sensitivity (<0.1%) Possibility to control the speed of a connected instrument Excellent candidate for applications requiring high flow No minimum operating pressure differential Well suited for vacuum applications Silent operation Isolates fluid from coil to reduce heating Excellent candidate for applications in which valve may not be in contact with medium because of isolation Zero dead volume to prevent sample cross contamination Space saving design Ability to handle different tubing hardness and sizes Hermetic separation of control mechanism and the fluid within the tubing assuring maximum purity of liquids Can be used with highly aggressive liquids Removable and rotatable solenoids for easy installation Flat spring valves (Series 065) Piezotronic (Series 630) Long life-time and high reliability Compact design and small footprint Easy to install and manifold Material allows usage with a broad range of gases Flat spring enables short response times and their precise adjustment, in combination with very low switching noise Miniature, ultra-low power consumption almost no heat dissipation Variable flow, proportional to the control signal No wearing parts: practically unlimited service life No inductive peaks when switching: no circuit protection necessary Valves do not require a minimum operating pressure For more information, visit Emerson.com/ASCO 17

18 Proven tailored solutions and global expertise meets your requirements Emerson s Rapid Engineered Solutions program focuses on the unique need of analytical and medical instrument makers and the highly compressed timelines for new product development. The program creates microfluidic valves and fluidic assemblies customized to your exact needs, and delivers them at unprecedented speeds. This unique program leverages the expertise and resources of Emerson s global Analytical & Medical team and its dedicated prototype labs. The team s customized fluidic solutions are designed for quick and efficient manufacturing. Local technical support is provided by expert product specialists, trained in analytical and medical applications. We can help you to build simplified fluidic paths into your product, optimizing the design and reducing costs. This enables better products to get to market faster. Our technical expertise and product customization capabilities enable fast turnaround on complex, high-performing fluidic systems. Our unique Rapid Engineered Solutions program simplifies your fluidic path designs, which in turn maximizes performance efficiencies and reduces your manufacturing and operating costs. From concept to production, we deliver your complete manifold assembly, including valves, electrical terminations, pins and housings. 18

19 With locations all over the world, we are always nearby to help you solve your problems no matter where you are. Contact us today! 19

20 Get started Emerson delivers time-tested and innovative automation solutions designed to help you improve your device s overall accuracy and reliability. Contact us now for world-class technologies and services that can maximize your medical or analytical application. Getting started is easy. Visit Emerson.com/ASCO Emerson Automation Solutions ASCO L.P. United States Dylan Drive Novi, MI USA T E. info-valve@asco.com Emerson Automation Solutions ASCO Numatics GmbH Germany Otto-Hahn Straße Ölbronn-Dürrn T E. asconumatics-de@emerson.com Emerson Automation Solutions ASCO Valve (Shanghai) Co., Ltd. China 4th Floor, Emerson Building 1582 Gu Mei Road, Xu Hui District Shanghai , P.R. China T E. shanghai.asco@emerson.com The Emerson logo is a trademark and service mark of Emerson Electric Co. ASCO is a registered trademark of one of the Emerson family of companies. All other marks are the property of their respective owners Emerson Electric Co. All rights reserved.

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