Revision Date 13-Jul IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING. Pyridostigmine bromide (Mestinon)

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1 Issuing date no data available Safety Data Sheet Version Product identifier 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Product Code(s) Product name AB Pyridostigmine bromide (Mestinon) 1.2 Relevant identified uses of the substance or mixture and uses advised against Recommended use Uses advised against For research use only 1.3 Details of the supplier of the safety data sheet Supplier Abcam plc 330 Cambridge Science Park Cambridge CB4 0FL UK Tel: +44 (0) Fax: +44 (0) For further information, please contact: technical@abcam.com 1.4 Emergency telephone number Emergency telephone - Tel: +44 (0) ( ) 2.1 Classification of the substance or mixture 2. HAZARDS IDENTIFICATION GHS / CLP - REGULATION (EC) No 1272/2008 Acute oral toxicity Category 2 Skin sensitization Category 1 Reproductive toxicity Category Label elements Page 1 / 8

2 Signal Word Danger Hazard statements H300 - Fatal if swallowed H317 - May cause an allergic skin reaction H361 - Suspected of damaging fertility or the unborn child Precautionary Statements - EU ( 28, 1272/2008) P301 + P310 - IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician P302 + P352 - IF ON SKIN: Wash with plenty of soap and water P333 + P313 - If skin irritation or rash occurs: Get medical advice/ attention P308 + P313 - IF exposed or concerned: Get medical advice/ attention P261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray P280 - Wear protective gloves/ eye protection/ face protection P264 - Wash face, hands and any exposed skin thoroughly after handling P270 - Do not eat, drink or smoke when using this product P201 - Obtain special instructions before use P202 - Do not handle until all safety precautions have been read and understood P330 - Rinse mouth P501 - Dispose of contents/ container to an approved waste disposal plant P405 - Store locked up P272 - Contaminated work clothing should not be allowed out of the workplace P363 - Wash contaminated clothing before reuse 2.3 Other information Caution - substance not yet tested completely 3.1 Substances 3. COMPOSITION/INFORMATION ON INGREDIENTS Chemical Name EC-No CAS-No Weight % Classification (Reg. 1272/2008) Pyridostigmine bromide Acute Tox. 2 (H300) Skin Sens. 1 (H317) Repr. 2 (H361fd) For the full text of the H-Statements mentioned in this Section, see Section 16 REACH Registration Number no data available 4. FIRST AID MEASURES 4.1 Description of first aid measures General advice Immediate medical attention is required. Page 2 / 8

3 Eye contact Immediately flush with plenty of water. After initial flushing, remove any contact lenses and continue flushing for at least 15 minutes. Skin contact Ingestion Inhalation Protection of first-aiders Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. May cause an allergic skin reaction. If symptoms persist, call a physician. Rinse mouth. Do not induce vomiting without medical advice. Never give anything by mouth to an unconscious person. Call a physician or poison control center immediately. Move to fresh air. Use personal protective equipment. Ensure that medical personnel are aware of the material(s) involved, and take precautions to protect themselves. 4.2 Most important symptoms and effects, both acute and delayed Main symptoms. 4.3 Indication of any immediate medical attention and special treatment needed Notes to physician 5.1 Extinguishing media May cause sensitization of susceptible persons. Treat symptomatically. 5. FIRE-FIGHTING MEASURES Suitable extinguishing media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Extinguishing media which shall not be used for safety reasons. 5.2 Special hazards arising from the substance or mixture Special hazard Thermal decomposition can lead to release of toxic and corrosive gases/vapors. 5.3 Advice for fire-fighters Special protective equipment for fire-fighters Wear self-contained breathing apparatus and protective suit. 6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid contact with the skin and the eyes. Avoid dust formation. Ensure adequate ventilation. Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak. Refer to protective measures listed in sections 7 and Environmental precautions Prevent further leakage or spillage if safe to do so. 6.3 Methods and materials for containment and cleaning up 6. ACCIDENTAL RELEASE MEASURES Contain and collect spillage with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite) and place in container for disposal according to local/national regulations (see Section 13). Page 3 / 8

4 7.1 Precautions for safe handling Wear personal protective equipment. Avoid contact with skin, eyes and clothing. Avoid dust formation. Use only in area provided with appropriate exhaust ventilation. Do not eat, drink or smoke when using this product. Remove and wash contaminated clothing before re-use. 7.2 Conditions for safe storage, including any incompatibilities 7.3 Specific end uses 7. HANDLING AND STORAGE Keep containers tightly closed in a dry, cool and well-ventilated place. Keep out of the reach of children. Keep in properly labeled containers. Specific use(s) Exposure scenario.. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION 8.1 Control parameters Exposure limits National occupational exposure limits Derived No Effect Level Predicted No Effect Concentration 8.2 Exposure controls Engineering measures Personal protective equipment Eye protection Hand protection Skin and body protection Respiratory protection Thermal hazards Hygiene measures Environmental exposure controls Ensure adequate ventilation, especially in confined areas. Safety glasses with side-shields. Impervious gloves. Impervious clothing. No special protective equipment required. When using, do not eat, drink or smoke. Remove and wash contaminated clothing before re-use. Provide regular cleaning of equipment, work area and clothing. Wash hands before breaks and immediately after handling the product. Keep away from food, drink and animal feeding stuffs. Do not allow material to contaminate ground water system. 9.1 Information on basic physical and chemical properties 9. PHYSICAL AND CHEMICAL PROPERTIES Physical C Odor Appearance Property ph Melting/freezing point Values Note Page 4 / 8

5 Boiling point/boiling range Flash Point Evaporation rate Flammability (solid, gas) Flammability Limits in Air upper flammability limit lower flammability limit Vapor pressure Vapor density Relative density Water solubility Soluble in water Solubility in other solvents Ethanol, Dimethylsulfoxide Partition coefficient: n-octanol/water Autoignition temperature Decomposition temperature Viscosity, kinematic Explosive properties 9.2 Other information VOC Content(%) 10. STABILITY AND REACTIVITY 10.1 Reactivity Chemical stability Stable under normal conditions Precautionary Statements None under normal processing Conditions to avoid Heat, flames and sparks 10.5 Incompatible materials None in particular 10.6 Hazardous decomposition products Carbon monoxide (CO). Carbon dioxide (CO2). Nitrogen oxides (NOx). Hydrogen bromide Information on toxicological effects 11. TOXICOLOGICAL INFORMATION Acute toxicity Product Information Inhalation Eye contact Very toxic if swallowed. May cause sensitization of susceptible persons. There is no data available for this product. There is no data available for this product. Page 5 / 8

6 Skin contact May cause sensitization by skin contact. Ingestion Very toxic if swallowed. Chemical Name Pyridostigmine bromide LD50 Oral 37.5 mg/kg (Rat) LD50 Dermal LC50 Inhalation Chronic toxicity Corrosivity. Sensitization Neurological effects Reproductive toxicity Mutagenic effects Developmental Toxicity Target Organ Effects As a precaution the product should be treated as a sensitizer.. Product is or contains a chemical which is a known or suspected reproductive hazard.. Contains ingredients that have suspected developmental hazards. Possible risk of harm to the unborn child. May cause birth defects ECOLOGICAL INFORMATION 12.1 Toxicity Ecotoxicity effects As supplied, the preparation is not expected to present significant adverse environmental effects Persistence and degradability Bioaccumulative potential Mobility in soil Results of PBT and vpvb assessment Other adverse effects. 13. DISPOSAL CONSIDERATIONS 13.1 Waste treatment methods Page 6 / 8

7 Waste from residues / unused products Contaminated packaging Other information Dispose of in accordance with local regulations. Empty containers should be taken to an approved waste handling site for recycling or disposal. According to the European Waste Catalogue, Waste Codes are not product specific, but application specific. Waste codes should be assigned by the user based on the application for which the product was used. 14. TRANSPORT INFORMATION ADR Excepted Quantity Proper shipping name Toxic solid, organic, n.o.s. (Pyridostigmine bromide) Hazard class 6.1 UN/ID No 2811 Packing group II IATA Excepted Quantity UN/ID No 2811 Proper shipping name Toxic solid, organic, n.o.s. (Pyridostigmine bromide) Hazard class 6.1 Packing group II DOT Excepted Quantity Proper shipping name Toxic solid, organic, n.o.s. (Pyridostigmine bromide) Hazard class 6.1 UN/ID No 2811 Packing group II 15. REGULATORY INFORMATION 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture Chemical Safety Assessment. 16. OTHER INFORMATION Full text of H-Statements referred to under sections 2 and 3 H300 - Fatal if swallowed H317 - May cause an allergic skin reaction H361fd - Suspected of damaging fertility. Suspected of damaging the unborn child Hazard statements H300 - Fatal if swallowed H317 - May cause an allergic skin reaction H361 - Suspected of damaging fertility or the unborn child Revision Date 13-Jul-2015 Page 7 / 8

8 Revision Note not applicable. This safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006 Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text. End of SDS Page 8 / 8