Kit Summary. AB EpiSeeker DNA-Protein Binding Assay Kit (Fluorometric)

Transcription

1 Page 1 Kit Summary Product Code(s) Product name AB EpiSeeker DNA-Protein Binding Assay Kit (Fluorometric) Fluoro developer Chemical Name EC-No CAS-No Weight % Classification (67/548) Classification (Reg. 1272/2008) REACH Registration Number SYBR-Green Not hazardous No data available DTT (500X) Chemical Name EC-No CAS-No Weight % Classification (67/548) DTT Xn; R36/37/38 Xn;R22 Classification (Reg. 1272/2008) STOT SE 3 (H335) Skin Irrit. 2 (H315) Eye Irrit. 2 (H319) Acute Tox. 4 (H302) REACH Registration Number GHS / CLP - REGULATION (EC) No 1272/2008

2 Page 2 Signal Word WARNING Hazard statements H315 - Causes skin irritation H319 - Causes serious eye irritation H335 - May cause respiratory irritation Precautionary Statements - EU ( 28, 1272/2008) P261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing DSD / DPD - Classification according to EU Directives 67/548/EEC or 1999/45/EC Classification Xn - Harmful R-phrase(s) R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin S-phrase(s) contains DTT Transport information IMDG/IMO RID ADR ICAO IATA

3 MATERIAL SAFETY DATA SHEET Issuing Date: No data available Version Product identifier 1. Identification of the substance/mixture and of the company/undertaking Product name Fluoro developer 1.2 Relevant identified uses of the substance or mixture and uses advised against Recommended use Uses advised against 1.3 Details of the supplier of the safety data sheet Supplier Abcam plc 330 Cambridge Science Park Cambridge CB4 0FL UK Tel: +44 (0) Fax: +44 (0) For further information, please contact: technical@abcam.com 1.4 Emergency telephone number Emergency telephone - Tel: +44 (0) ( BST) 2.1 Classification of the substance or mixture 2. Hazards identification GHS / CLP - REGULATION (EC) No 1272/2008 Ozone not applicable DSD / DPD - Classification according to EU Directives 67/548/EEC or 1999/45/EC For the full text of the R-phrases mentioned in this Section, see Section 16 Symbol(s) Not dangerous 2.2 Label elements Not dangerous

4 Fluoro developer 2.3 OTHER INFORMATION 3.1 Substances 3. Composition/information on ingredients For the full text of the R-phrases mentioned in this Section, see Section 16 For the full text of the H-Statements mentioned in this Section, see Section Description of first aid measures 4. First aid measures Eye contact Skin contact Ingestion Inhalation Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. Clean mouth with water and afterwards drink plenty of water. Move to fresh air. 4.2 Most important symptoms and effects, both acute and delayed Main symptoms. 4.3 Indication of any immediate medical attention and special treatment needed Notes to physician 5.1 Extinguishing media Treat symptomatically. 5. Fire-fighting measures Suitable extinguishing media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Extinguishing media which shall not be used for safety reasons. 5.2 Special hazards arising from the substance or mixture Special hazard None in particular. 5.3 Advice for fire-fighters Special protective equipment for fire-fighters As in any fire, wear self-contained breathing apparatus and full protective gear. 6. Accidental release measures Page 4 / 17

5 Fluoro developer 6.1 Personal precautions, protective equipment and emergency procedures Ensure adequate ventilation. See Section 12 for additional information. 6.2 Environmental precautions Prevent further leakage or spillage if safe to do so. 6.3 Methods and materials for containment and cleaning up Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust). 7.1 Precautions for safe handling Ensure adequate ventilation. 7.2 Conditions for safe storage, including any incompatibilities Keep container tightly closed in a dry and well-ventilated place. 7.3 Specific end uses 7. Handling and storage Specific use(s) Exposure scenario.. 8. Exposure controls/personal protection 8.1 Control parameters Exposure limits This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies. Derived No Effect Level (DNEL) Predicted No Effect Concentration (PNEC) 8.2 Exposure controls Engineering measures Personal protective equipment Eye protection Hand protection Skin and body protection Respiratory protection Thermal hazards Ensure adequate ventilation, especially in confined areas. Tightly fitting safety goggles. Protective gloves. Long sleeved clothing. No special protective equipment required. Page 5 / 17

6 Fluoro developer Hygiene measures Handle in accordance with good industrial hygiene and safety practice. Environmental exposure controls. 9.1 Information on basic physical and chemical properties 9. Physical and chemical properties Physical C Odor Appearance Property ph Melting/freezing point Boiling point/boiling range Flash Point Evaporation rate Flammability (solid, gas) Flammability Limits in Air upper flammability limit lower flammability limit Values Note Vapor pressure Vapor density Relative density Water solubility Solubility in other solvents Partition coefficient: n-octanol/water Autoignition temperature Decomposition temperature Viscosity, kinematic Explosive properties 9.2 OTHER INFORMATION VOC Content 10. Stability and reactivity 10.1 Reactivity Chemical stability Stable under normal conditions Possibility of hazardous reactions None under normal processing Conditions to avoid Heat, flames and sparks 10.5 Incompatible materials Page 6 / 17

7 Fluoro developer None in particular 10.6 Hazardous decomposition products None under normal use Information on toxicological effects 11. Toxicological information Acute toxicity Product Information Inhalation Eye contact Skin contact Ingestion Product does not present an acute toxicity hazard based on known or supplied information. There is no data available for this product. There is no data available for this product. There is no data available for this product. There is no data available for this product. Chronic toxicity Corrosivity Sensitization Neurological effects Reproductive toxicity Mutagenic effects Target Organ Effects Ecological information 12.1 Toxicity Ecotoxicity effects Contains no substances known to be hazardous to the environment or that are not degradable in waste water treatment plants Persistence and degradability Bioaccumulative potential Page 7 / 17

8 Fluoro developer Mobility in soil Results of PBT and vpvb assessment Other adverse effects Waste treatment methods 13. Disposal considerations Waste from residues / unused products Contaminated packaging Dispose of in accordance with local regulations. Empty containers should be taken to an approved waste handling site for recycling or disposal. 14. Transport information IMDG/IMO RID ADR ICAO IATA 15. Regulatory information 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture Chemical Safety Assessment. 16. Other information Revision Date: Revision Note 24-Oct-2011 not applicable. Page 8 / 17

9 Fluoro developer This safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006 Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text. End of SDS Page 9 / 17

10 MATERIAL SAFETY DATA SHEET Issuing Date: No data available Version Product identifier 1. Identification of the substance/mixture and of the company/undertaking Product name DTT (500X) 1.2 Relevant identified uses of the substance or mixture and uses advised against Recommended use Uses advised against 1.3 Details of the supplier of the safety data sheet Supplier Abcam plc 330 Cambridge Science Park Cambridge CB4 0FL UK Tel: +44 (0) Fax: +44 (0) For further information, please contact: technical@abcam.com 1.4 Emergency telephone number Emergency telephone - Tel: +44 (0) ( BST) 2. Hazards identification 2.1 Classification of the substance or mixture GHS / CLP - REGULATION (EC) No 1272/2008 Acute oral toxicity Category 4 Skin corrosion/irritation Category 2 Serious eye damage/eye irritation Category 2 Specific target organ systemic toxicity (single exposure) Category 3 Ozone not applicable Page 10 / 17

11 DTT (500X) DSD / DPD - Classification according to EU Directives 67/548/EEC or 1999/45/EC For the full text of the R-phrases mentioned in this Section, see Section 16 Symbol(s) Xn - Harmful R-code(s) Xn;R22 - Xi;R36/37/ Label elements Signal Word WARNING Hazard statements H302 - Harmful if swallowed H315 - Causes skin irritation H319 - Causes serious eye irritation H335 - May cause respiratory irritation Precautionary Statements - EU ( 28, 1272/2008) P261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing 2.3 OTHER INFORMATION 3.1 Substances 3. Composition/information on ingredients Chemical Name EC-No CAS-No Weight % Classification (67/548) DTT Xn; R36/37/38 Xn;R22 Classification (Reg. 1272/2008) STOT SE 3 (H335) Skin Irrit. 2 (H315) Eye Irrit. 2 (H319) Acute Tox. 4 (H302) REACH Registration Number No data available For the full text of the R-phrases mentioned in this Section, see Section 16 For the full text of the H-Statements mentioned in this Section, see Section Description of first aid measures 4. First aid measures General advice If symptoms persist, call a physician. Do not breathe dust/fume/gas/mist/vapors/spray. Do not get in eyes, on skin, or on clothing. Page 11 / 17

12 DTT (500X) Eye contact Immediately flush with plenty of water. After initial flushing, remove any contact lenses and continue flushing for at least 15 minutes. Keep eye wide open while rinsing. If symptoms persist, call a physician. Skin contact Ingestion Inhalation Protection of first-aiders Consult a physician if necessary. Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. Remove and wash contaminated clothing before re-use. Wash off immediately with plenty of water. If skin irritation persists, call a physician. Immediate medical attention is not required. Rinse mouth. Drink plenty of water. If symptoms persist, call a physician. Do NOT induce vomiting. Clean mouth with water and afterwards drink plenty of water. Never give anything by mouth to an unconscious person. Consult a physician. Move to fresh air. Consult a physician. If breathing is irregular or stopped, administer artificial respiration. Avoid direct contact with skin. Use barrier to give mouth-to-mouth resuscitation. Artificial respiration and/or oxygen may be necessary. Immediate medical attention is not required. Move to fresh air in case of accidental inhalation of vapors. If symptoms persist, call a physician. Use personal protective equipment. 4.2 Most important symptoms and effects, both acute and delayed Main symptoms. 4.3 Indication of any immediate medical attention and special treatment needed Notes to physician 5.1 Extinguishing media Treat symptomatically. 5. Fire-fighting measures Suitable extinguishing media Use extinguishing measures that are appropriate to local circumstances and the surrounding environment. Extinguishing media which shall not be used for safety reasons. 5.2 Special hazards arising from the substance or mixture Special hazard None in particular. 5.3 Advice for fire-fighters Special protective equipment for fire-fighters As in any fire, wear self-contained breathing apparatus and full protective gear. 6. Accidental release measures 6.1 Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak. See Section 12 for additional information. 6.2 Environmental precautions Page 12 / 17

13 DTT (500X) Prevent entry into waterways, sewers, basements or confined areas. Do not flush into surface water or sanitary sewer system. Prevent further leakage or spillage if safe to do so. Prevent product from entering drains. 6.3 Methods and materials for containment and cleaning up Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust). 7.2 Conditions for safe storage, including any incompatibilities 7.3 Specific end uses 7. Handling and storage 7.1 Precautions for safe handling Avoid contact with skin, eyes and clothing. Wear personal protective equipment. Remove and wash contaminated clothing before re-use. Do not breathe vapors or spray mist. Do not eat, drink or smoke when using this product. Use only in area provided with appropriate exhaust ventilation. Keep container tightly closed in a dry and well-ventilated place. Keep out of the reach of children. Keep containers tightly closed in a cool, well-ventilated place. Keep in properly labeled containers. Specific use(s) Exposure scenario.. 8. Exposure controls/personal protection 8.1 Control parameters Exposure limits This product, as supplied, does not contain any hazardous materials with occupational exposure limits established by the region specific regulatory bodies. Derived No Effect Level (DNEL) Predicted No Effect Concentration (PNEC) 8.2 Exposure controls Engineering measures Personal protective equipment Eye protection Hand protection Skin and body protection Respiratory protection Thermal hazards Hygiene measures Environmental exposure controls Ensure adequate ventilation, especially in confined areas. Tightly fitting safety goggles. Protective gloves. Long sleeved clothing. Apron. Impervious gloves. No special protective equipment required. When using, do not eat, drink or smoke. Provide regular cleaning of equipment, work area and clothing. Do not allow material to contaminate ground water system. Page 13 / 17

14 DTT (500X) 9.1 Information on basic physical and chemical properties 9. Physical and chemical properties Physical C Odor Appearance Property ph Melting/freezing point Boiling point/boiling range Flash Point Evaporation rate Flammability (solid, gas) Flammability Limits in Air upper flammability limit lower flammability limit Values Note Vapor pressure Vapor density Relative density Water solubility Solubility in other solvents Partition coefficient: n-octanol/waterno information available Autoignition temperature Decomposition temperature Viscosity, kinematic Explosive properties 9.2 OTHER INFORMATION VOC Content 10. Stability and reactivity 10.1 Reactivity Chemical stability Stable under normal conditions Possibility of hazardous reactions None under normal processing Conditions to avoid Heat, flames and sparks 10.5 Incompatible materials None in particular 10.6 Hazardous decomposition products Page 14 / 17

15 DTT (500X) None under normal use Information on toxicological effects 11. Toxicological information Acute toxicity Product Information Inhalation Eye contact Skin contact Ingestion Product does not present an acute toxicity hazard based on known or supplied information. There is no data available for this product. There is no data available for this product. There is no data available for this product. There is no data available for this product. Chronic toxicity Corrosivity Sensitization Neurological effects Reproductive toxicity Mutagenic effects Target Organ Effects Ecological information 12.1 Toxicity Ecotoxicity effects Contains no substances known to be hazardous to the environment or that are not degradable in waste water treatment plants Persistence and degradability Bioaccumulative potential. Page 15 / 17

16 DTT (500X) 12.4 Mobility in soil Results of PBT and vpvb assessment Other adverse effects Waste treatment methods 13. Disposal considerations Waste from residues / unused products Contaminated packaging OTHER INFORMATION Dispose of in accordance with local regulations. Empty containers should be taken to an approved waste handling site for recycling or disposal. According to the European Waste Catalogue, Waste Codes are not product specific, but application specific. Waste codes should be assigned by the user based on the application for which the product was used. 14. Transport information IMDG/IMO RID ADR ICAO IATA 15. Regulatory information 15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture Chemical Safety Assessment. 16. Other information Risk Combination Phrases R36/37/38 - Irritating to eyes, respiratory system and skin Page 16 / 17

17 DTT (500X) Full text of H-Statements referred to under section 2 and 3 H335 - May cause respiratory irritation H315 - Causes skin irritation H319 - Causes serious eye irritation H302 - Harmful if swallowed Hazard statements H302 - Harmful if swallowed H315 - Causes skin irritation H319 - Causes serious eye irritation H335 - May cause respiratory irritation Revision Date: Revision Note 24-Oct-2011 not applicable. This safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006 Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text. End of SDS Page 17 / 17