FORENSIC SCIENCE PAPER No. 9 : Drugs of Abuse MODULE No. 28 : Drug Abuse in Sports
|
|
- Buck Jennings
- 5 years ago
- Views:
Transcription
1 SUBJECT Paper No. and Title Module No. and Title Module Tag FORENSIC SCIENCE PAPER No. 9: Drugs of Abuse MODULE No. 28: Drug Abuse in Sports FSC_P9_M28
2 TABLE OF CONTENTS 1. Learning Outcomes 2. Introduction 3. Forensic Issues 4. Classification of Prohibited Substances in Sports 5. Some Notable Drugs used in Sports 6. Analytical Approach to detect Dope Drugs 7. Summary
3 1. Learning Outcomes After studying this module, you shall be able to know about The commonly use Drugs in sports. Classification and nature of the Drugs used in Sports. The techniques for detection of these drugs. 2. Introduction Drug abuse in sport is habitually called as doping. The universal word dope is being used both as a noun and as a verb. The word does not appear in this context before the twentieth century regardless of the practice of horse nobbling, which was known well before this time. For example, the story of the famous trial of Daniel Dawson, publicly executed at Cambridge in 1812 for poisoning racehorses with arsenic. The abuse of drugs in an attempt to enhance performance in human sporting competitions is not new. For example, the Greek authors Phylostratos and Galen stated on the ethics of participants in the Olympics who would take any preparation to improve their performance. Roman gladiators were often intoxicated to make their fights more vigorous and gruesome as demanded by the spectators. The effect of drugs on performance is often exceptionally difficult to determine, and there is little conclusive available work for any species. The results that have been published are often contradictory as some of the workers advocate an increase in the competitor s performance and others suggest no improvement. The assessment systems used to evaluate the effect of drugs may not sufficiently relate to the appropriate sporting performance, such as increase in muscle strength and sprint running. Moreover, athletes may take far larger amounts of drugs than would be ethically acceptable in most human experiments. The toxic side-effects of drugs are less difficult to ascertain, but the conclusions drawn from the available data are often contingent. However, there is sufficient evidence of the harmful effects when certain drugs are misused to validate their prohibition from sports competitions. In human sports, the main monitoring body is International Olympic Committee (IOC). Nevertheless, since 1999, doping concerns have been taken over by the World Anti-Doping Agency (WADA).
4 3. Forensic Issues For most substances, the mere presence of the substance or an analytic metabolite in the biological fluid sampled constitutes an offence, but for some substances there is a reporting threshold. If the drug is detected, but it is less than the reporting threshold, no offence is reasoned to have occurred. Multifaceted rules apply to some of the substances, not least because some have therapeutic uses. The obligation is on the athlete to obtain a Therapeutic Use Exemption for certain categories of substances, with the substances covered under this possible exemption made clear in the WADA list. The WADA list also recognizes that some anabolic agents and hormones are produced endogenously. The fundamental rationale is that, an offence is considered to have occurred if one or more of these prohibited substances are detected in an athlete s specimen at a level outside of that which is considered to be the normal range in humans for the substance. For some substances, offences apply both in-competition or out of- competition, whereas for others an offence applies only if the substance is detected in-competition. For some sports, specific classes of substances are prohibited. For example, beta-blockers are prohibited in-competition in sports such as shooting, billiards and gymnastics. Alcohol is prohibited in-competition for sports such as motorcycling, power boating and archery. The emphasis when prohibiting use of a substance is on whether or not the use of a substance or method is proposed to enhance sport performance. The position regarding excessive quantities of normal nutrients is much argued. Although they are not currently included in a prohibited list, there is no hesitation that certain vitamins, notably B1, C and E and also Creatine have been used in large doses with the purpose of affecting performance. 4. Classification of Prohibited Substances in Sports 4.1 Stimulants This group of drugs includes psychomotor stimulants, sympathomimetic amines and other diverse CNS stimulants. They may produce alertness, wakefulness and an increase in the ability to concentrate. In addition they may improve the competence to exercise strenuously or produce a decreased sensitivity to pain. These effects are potentially of benefit to a wide variety of sports involving sustained physical and mental activity.
5 4.1.1 Amphetamines: Amphetamines are stimulants that include several structurally related drugs dextroamphetamine, methamphetamine, Phenmetrazine, and methyl phenidate. Physicians prescribe these drugs on a short term basis for treatment of obesity and also to treat narcolepsy and minimal brain dysfunction in children Cocaine: Cocaine, also a Central Nervous System Stimulant, when snorted, affects the brain within few minutes, the peak effect come within minutes. When injected cocaine takes about 15 seconds to affect the brain. The euphoria following cocaine use is in some ways similar to the intense euphoria following an outstanding athletic performance. Both are in part facilitated through the pleasure brain. The individual feels energetic and hyper alert Sympathomimetic Amines: Sympathomimetic Amines are group of stimulants of which ephedrine is an example. However, Pseudoephedrine and phenylpropanolamine, which used to be in banned list of WADA is no more in the same category. The ephedrine is also found in low doses in cough, cold and sinus medications. Because these medicines are broadly used by the people as over the counter drugs, they are effortlessly abused by competing athletes for their stimulant effects. Prohibited stimulants: Adrafinil, Adrenaline, Amfepramone, Amphetamine, Amfetaminil, Amiphenazole, Benzfetamine, Benzylpiperazine, Bromantane, Cathine, Clobenzorex, Cocaine, Cropropamide, Crotetamide, Cyclazodone, Dimethylamphetamine, Ephedrine, Etamivan, Etilamphetamine, Etilefrine, Famprofazone, Fenbutrazate, Fencamfamin, Fencamine, Fenetylline, Fenfluramine, Fenproporex, Furfenorex, Heptaminol, P-Hydroxyamphetamine, Isometheptene, Levmethamphetamine, Meclofenoxate, Mefenorex, Mephentermine, Mesocarb, Methylenedioxyamphetamine, Methamphetamine, Methylephedrine, Methylphenidate, Modafinil, Nikethamide, Norfenefrine, Norfenfluramine, Octopamine, Ortetamine, Oxilofrine, Pemoline, Pentetrazol, Phendimetrazine, Phenmetrazine, Phenpromethamine, Phentermine, 4- Phenylpiracetam, Prolintane, Propylhexedrine, Selegiline, Sibutramine, Strychnine, Tuaminoheptane and other substances with a similar chemical structure or similar biological effect(s).
6 4.2 Narcotics Analgesics Narcotics are derivatives of Opium and consist of powerful painkiller drugs. Narcotics are not perceived as ergogenic drug. However, their use, misuse and abuse potential in sports may be high because of pressures on the athlete to perform competitively despite varied musculo-skeletal injuries. The pressure on the athletes to perform well is so intense that they sometimes turn to narcotics as an emotional escape. These drugs are banned so as to decrease the risk of tragic conditions. Prohibited Narcotics analgesics: Buprenorphine, Dextromoramide, Diamorphine (Heroin), Fentanyl and its derivatives, Hydromorphone, Methadone, Morphine, Oxycodone, Oxymorphone, Pentazocine, Pethidine 4.3 Anabolic Steroids Anabolic steroids are synthetic derivatives of the natural male hormones Testosterone, which is produced principally by testes in males and is responsible for androgenic (masculinizing) and anabolic (tissue- building) effects. The abuse of anabolic steroids has historic foundations in man s aspiration to create a body building wonder drug. This group of drugs is responsible for the most pervasive abuse of drugs in sports. In human sport, anabolic steroids are used as bodybuilding drugs, occasionally in very large quantities, in events such as weightlifting and shot-putting. There are generally two chemical types based upon the androstane and estrane ring systems: those with a 17α-alkyl group, which are active orally but possess hepatotoxicity, and 19-nor derivatives administered by injection. Although steroidal estrogens and some stilbenes reputedly possess anabolic activity and are engaged in beef production, they do not appear to be used as doping agents. Anabolic Steroids reverse the negative or catabolic effects of exercise have on muscle. During exercise the adrenal glands naturally secrete glucocorticoids that induce muscle breakdown. Anabolic Steroids minimize this catabolism and thus build muscles.
7 4.3.1 Exogenous Anabolic Agents: Androstenediol, Androstenedione, Bolandiol, Bolasterone, Boldenone, Boldione, Calusterone, Clostebol, Danazol, Dehydrochlormethyltestosterone, Desoxymethyltestosterone, Drostanolone, Ethylestrenol, Fluoxymesterone, Formebolone, Furazabol, Gestrinone, 4- Hydroxytestosterone, Mestanolone, Mesterolone, Metenolone, Metandienone, Methandriol, Methasterone, Methyldienolone, Methyl-1-Testosterone, Methylnortestosterone, Methyltrienolone, Methyltestosterone, Mibolerone, Nandrolone, 19-Norandrostenedione, Norboletone, Norclostebol, Norethandrolone, Oxabolone, Oxandrolone, Oxymesterone, Oxymetholone, Prostanozol, Quinbolone, Stanozolol, Stenbolone, 1-Testosterone, Tetrahydrogestrinone, Trenbolone and other substances with a similar chemical structure or similar biological effect(s) Endogenous anabolic agents: Androstenediol, androstenedione, Dihydrotestosterone, Prasterone, Testosterone and metabolites and isomers Other anabolic agents: Clenbuterol, Selective Androgen Receptor Modulators (SARMs), Tibolone, Zeranol, Zilpaterol 4.4 Masking agents & Diuretics Masking agents are the products that have a potential to impair the excretion of prohibited substances, to conceal their presence in urine or other samples used in doping control, or to change hematological parameters and Diuretics are one of them. Diuretics are the drugs that increase the rate of urine formation. In general, the diuretics act directly on the kidney tubules to yield the desired clinical effects. Clinically, diuretics are used to control hypertension, to reduce oedema and as an adjunct in treating congestive heart failure. Athletes use diuretics for acute reduction of weight to meet weight limits in weight categories to gain advantage in sports like boxing, judo or weightlifting, etc. Prohibited Diuretics: Acetazolamide, Amiloride, Bumetanide, Canrenone, Chlortalidone, Etacrynic Acid, Furosemide, Indapamide, Metolazone, Spironolactone, Thiazides, Triamterene and other substances with a similar chemical structure or similar biological effect(s), Epitestosterone, Probenecid, Alpha-Reductase inhibitors, plasma expanders and other substances with similar biological effect.
8 4.5 Hormones and related substances There has been significant apprehension in recent years over the use of peptide hormones such as Erythropoietin (EPO) and darbepoietin. Athletes recognized the potential for Erythropoietin to increase erythrocyte production and hence oxygen uptake. Human Chorionic Gonadotropin (hcg) is a glycoprotein hormone produced in the body, particularly during pregnancy. Administration of hcg stimulates testosterone production but does not raise the testosterone/ epitestosterone ratio. Peptide hormones act as messengers from one organ to another to stimulate growth, influence sex drive and behaviour. Prohibited Hormones and related Substances: Corticotrophins (ACTH), Erythropoietin (EPO), Human Chorionic Gonadotropin (hcg), Human Growth Hormone (hgh), Insulins, Insulin-Like Growth Factors (e.g. IGF-1), Mechano Growth Factors (MGFs), Luteinising Hormone (LH), Anti-Estrogenic Substances, aromatase inhibitors, Selective Estrogen Receptor Modulators (SERMs), agents modifying myostatin function(s). 4.6 Beta- Blockers Beta Blockers or Beta- 2 Antagonists as well as their dextro and levo isomers are prohibited. Their use entails a therapeutic use exemption. As an exception, Formoterol, Salbutamol, Salmetarol and Terbutaline when administered by inhalation to prevent or treat asthma and exercise induced asthma describes an abbreviated Therapeutic use exemption. A beta antagonist increases skeletal muscle mass, lipolysis, decreases fat deposition and thereby increasing lean body mass. They also increase non shivering thermogenesis via Beta receptors in brown adipose tissue. Prohibited Beta Blockers: Acebutolol, Alprenolol, Atenolol, Betaxolol, Bisoprolol, Bunolol, Carteolol, Carvedilol, Celiprolol, Esmolol, Labetalol, Levobunolol, Metipranolol, Metoprolol, Nadolol, Oxprenolol, Pindolol, Propranolol, Sotalol, Timolol and related compounds.
9 5. Some Notable Drugs used in Sports 5.1 Nandrolone Nandrolone is an anabolic steroid. Anabolic steroids are natural or synthetic versions of testosterone, a hormone that is produced naturally in males and, to a lesser extent, in females. Anabolic steroids are used in combination with appropriate diet and moderate exercise to promote a gain of protein in the body and to increase lean body mass (including muscle tissue). Nandrolone Nandrolone increases production and urinary excretion of erythropoietin. It may also have a direct action on bone marrow. Nandrolone binds to the androgen receptor to a greater degree than testosterone, but due to its inability to act on the muscle in ways unmediated by the receptor, has less overall effect on muscle growth.
10 5.2 Dehydroepiandrsterone (DHEA) Dehydroepiandrsterone (DHEA) is a steroid hormone secreted in greater quantity by the adrenal glands. It is released when adrenal cortex gets a message from Adrenocorticotropic hormone (ACTH). ACTH is released by the pituitary gland of the brain. Dehydroepiandrsterone (DHEA) DHEA is a week androgen that circulates in two inter convertible forms unconjugated Dehydroepiandrsterone (DHEA) and Dehydroepiandrsterone Sulphate (DHEAS). Athlete use DHEA for several reasons, like as an anti- catabolic agent to increase levels of androgens such as androstenediol and testosterone. It is challenging to detect because DHEA is a precursor in testosterone formation. It would increase the concentration of both testosterone and epitestosterone 5.3 Human Growth Hormone (hgh) Human Growth Hormone (hgh) is a hormone that is synthesized and secreted by cells in the pituitary gland located at the base of the brain. hgh is known to act on many aspects of cellular metabolism and is also essential for skeletal growth in humans.
11 The reason for hgh abuse appears to be based in deceitful promises that it is as effective as anabolic steroids, with fewer side effects, is less possible to be detected and may protect the athlete who has abused anabolic steroid and wishes to stop muscle meltdown. Commonly, hgh is abused in sports to increase muscle mass and strength, to increase slender body mass, to improve the appearance of musculature and to increase final adult height. 5.4 Erythropoietin Erythropoietin (EPO) is a glycoprotein produces by the kidney that functions to regulate Red Blood Corpuscles (RBC) production. This glycoprotein has a half- life of 6-8 hours. Approximately, 90% of Erythropoietin is synthesized in the renal cortical cells, whereas, the rest is synthesized in extrarenal sites, mainly liver. Erythropoietin is now potentially available in mass quantities through the process of genetic engineering. Experts speculate that the potential use and abuse of erythropoietin may be vast. Erythropoietin and Recombinant Erythropoietin (r-epo) is used precisely by endurance athletes to increase aerobic endurance with effects similar to that of blood doping. Erythropoietin is a major factor in the stimulation, proliferation and maturation of the bone marrow stem cell, which in turn increases rate of RBC production. 5.5 Gonadotrophins Human chorionic gonadotropin (hcg) is a glycoprotein hormone produced in the body by placental trophoblast cells, chiefly during pregnancy. Administration of hcg stimulates testosterone production but does not increase the testosterone/ epitestosterone ratio. Initially, this made hcg administration challenging to detect, but methods of detection have now been developed for use in human sports drug testing. Its major physiological role is stimulation of corpus luteum, to maintain synthesis and secretion of hormone progesterone during pregnancy. Abuse of hcg has become popular because it stimulates secretion of both testosterone and epitestosterone resulting in urinary excretion ratio set by WADA.
12 5.6 Androstenedione More recently, scientists involved in doping in sports have noted the use of so-called prohormones. An example is the use of Androstenedione, which has been promoted to body builders in dietary supplements and claimed to have an anabolic effect. Androstenedione or Andro is a hormone produced by the adrenal glands, ovaries and testes. It is a hormone that is normally converted to testosterone and estradiol in both men and women. Androstenedione is accessible legally only in prescription form, and is a controlled substance. Manufacturers and bodybuilding magazines peddle its ability to allow athletes to train harder and recuperate more rapidly. However, its use as a performance-enhancing drug is illegal. Serum concentrations of estrogen in men can increase with androstenedione administration, giving rise to an increased risk of gynaecomastia. 6. Analytical Approach to detect Dope Drugs Dope is generally administered at or proximate the therapeutic dose, which results in relatively low concentrations in biological fluids. Consequently, screening procedures must be both sensitive and comprehensive. Generally, the screening procedures depend upon the detection of either the unchanged drug or its metabolites. The identification of the corresponding metabolites is often advantageous supplementary evidence to support the identification of the parent drug. Instrumental methods Gas Chromatography using Nitrogen Phosphorus Detection (GC- NPD), High Performance Liquid Chromatography using Ultraviolet Detection (HPLC- UV), Gas Chromatography- Mass Spectroscopy (GC- MS) and Liquid Chromatography- Mass Spectroscopy (LC-MS) are the predominant analytical methods in most human sports drug-testing laboratories. Even if not routinely used for screening, some kind of TLC technology is sporadically used by many laboratories to isolate or purify a compound of interest followed by the analysis of the scrape from the TLC plate by GC- MS, LC-MS, etc.
13 7. Summary The usage of performance enhancing drugs is banned in sports. However, physical exercise and exertion impose upon the body an increased demand of nutrients and oxygen. The body can meet the demand only upto a certain level beyond which exhaustion sets in. A sports person needs to keep himself vigorous, energetic, full of vitality and endurance. To achieve all this, some sports persons resort to pills and injections as shortcuts to success. According to International Olympic Committee (IOC), Doping is the administration of or use by a contending athlete of any substance foreign to the body or any physiological substance taken in abnormal quantity or taken by an abnormal route of entry into a body with a sole purpose for increasing in an artificial and unfair manner his performance in competition. Dope testing in Olympics began in 1968, but till 1983, drug testing and detection in international competitions were very ineffective, due to non- availability of standard technology. The World Anti-Doping Code International Standard for Testing pronounces the procedure for sample collection. The two matrices specified for testing are Urine and Blood. Urine is the preferred body fluid in all species. Its collection is non-invasive; it is generally available in sufficient quantity; and the drugs or their metabolites tend to be present in relatively high concentrations. The disadvantages are that a drug may be present as its metabolites or in a conjugated form, and the parent drug may be present only in a relatively low concentration. Drug concentrations in blood are interpreted more effortlessly than those in urine, and certain drugs that are not excreted in urine in detectable quantities (e.g. reserpine, or Human Growth Hormone) can be detected in blood.
SUBSTITUTES APPENDIX A OF THE OMAC 1999 OLYMPIC MOVEMENT ANTI-DOPING CODE APPENDIX A PROHIBITED CLASSES OF SUBSTANCES AND PROHIBITED METHODS 2003
SUBSTITUTES APPENDIX A OF THE OMAC 1999 OLYMPIC MOVEMENT ANTI-DOPING CODE APPENDIX A PROHIBITED CLASSES OF SUBSTANCES AND PROHIBITED METHODS 2003 1 January 2003 I. PROHIBITED CLASSES OF SUBSTANCES A. STIMULANTS
More informationMODULE No. 34: Doping in Sports
Subject Paper No and Title Module No and Title Module Tag Paper No. 10; Forensic Toxicology Module No 35; Doping in sports FSC_P10_M34 TABLE OF CONTENTS 1. Learning Outcomes 2. Introduction - Doping in
More informationGAA ANTI-DOPING CODE
GAA ANTI-DOPING CODE Preamble The GAA is dedicated to the ideals that in its Games the spirit of fair play prevails, the health of players is paramount, and that doping can have no place in Gaelic Games.
More informationTEST REPORT. Plant: Please do not hesitate to contact us if you have any immediate questions pertaining to your product.
January 10, 2008 TEST REPORT Send To: 4C690 Customer: 4C690 Plant: 4C690 Sample Description: Nano Pro PRP Test Type: SS - Special Testing Thank you for having your product tested by NSF. The enclosed report
More informationTEST REPORT. An NSF International Company. 4C690 BIOPHARMA SCIENTIFIC, INC NANCY RIDGE ROAD SUITE 103 SAN DIEGO CA Attn: DR. JOHN H.
March 16, 2007 An NSF International Company TEST REPORT Send To: 4C690 Customer: 4C690 Plant: 4C690 Sample Description: Nano Greens 10 Test Type: SS - Special Testing Thank you for having your product
More informationTHE 2007 PROHIBITED LIST INTERNATIONAL STANDARD
The World Anti-Doping Code THE 2007 PROHIBITED LIST INTERNATIONAL STANDARD The official text of the Prohibited List shall be maintained by WADA and shall be published in English and French. In the event
More informationTHE 2008 PROHIBITED LIST INTERNATIONAL STANDARD
The World Anti-Doping Code THE 2008 PROHIBITED LIST INTERNATIONAL STANDARD The official text of the Prohibited List shall be maintained by WADA and shall be published in English and French. In the event
More informationTHE 2004 PROHIBITED LIST INTERNATIONAL STANDARD
The World Anti-Doping Code THE 2004 PROHIBITED LIST INTERNATIONAL STANDARD This List shall come into effect on January 1 st 2004. THE PROCESS It is mandatory under the World Anti-Doping Code for the Prohibited
More informationVoluntary Anti-Doping Association Official Prohibited List
Voluntary Anti-Doping Association Official Prohibited List This document contains the Official Prohibited List (Substances and Methods) of the Voluntary Anti-Doping Association (VADA). VADA guidelines
More informationNational Association of Staredown Professionals Official Rules and Regulations
National Association of Staredown Professionals Official Rules and Regulations The following code of rules is written to govern the sport of Staredown by the National Association of Staredown Professionals
More informationForm 08-3d Academic Year Drug-Testing Consent Division I
Academic Year 2010-11 Drug-Testing Consent Division I For: Action: Due date: Student-athletes. Sign and return to your director of athletics. At the time your intercollegiate squad first reports for practice
More informationInternational Standard. Prohibited List 2008
International Standard Prohibited List 2008 The 2008 Prohibited List This list shall come into effect on 1 January 2008 Published by: The World Anti-Doping Agency e-mail: info@wada-ama.org www.wada-ama.org
More informationSubstances and Methods Prohibited at all times (In- and Out-of-Competition)
The World Anti-Doping Code 2013 Prohibited List This List shall come into effect on 1 January 2013. In accordance with Article 4.2.2 of the World Anti-Doping Code, all Prohibited Substances shall be considered
More informationDrugs and Sports. Coaches watch Video on Two Olympic Athletes who used Performance Enhancing Drugs:
1 Drugs and Sports Objectives: Coaches will understand the concept of performance enhancement drug. Coaches will have access to a list of performance enhancement drugs, and the effects they have on health.
More informationForm 14-3d Academic Year
Form 14-3d Academic Year 2014-15 Drug-Testing Consent NCAA Division I For: Student-athletes. Action: Sign and return to your director of athletics. Due date: At the time your intercollegiate squad first
More informationPROHIBITED CLASSES OF SUBSTANCES AND PROHIBITED METHODS
International Olympic Committee Medical Code PROHIBITED CLASSES OF SUBSTANCES AND PROHIBITED METHODS 31 st January 1998 Antagen av RF:s Dopingkommission med svenska tillämpningar och med giltighet inom
More informationForm 17-1b Academic Year:
Form 17-1b Academic Year: 2017-18 Drug-Testing Consent NCAA Division I For: Student-athletes. Action: Sign and return to your director of athletics. Due date: At the time your intercollegiate squad first
More informationClient: Ultimate Fitness Events - USA 600 Golden Gate St Lake Orion, MI Phone: (248) Identification: 104 DOB: Sex:
Laboratory Directors: Mark J. DeMeo, M.D.; Richard R. Wilber, M.D. Identification: 104 DOB: Sex: Account #: Requisition #: 131535 900007 Collected by: DR. SHAWN JENNINGS Accession #: 160622-01174 Collected:
More informationSports Sciences. Sports Medicines: Prohibited Drugs and Substances. (References WADA 1 January 2013)
Sports Sciences Sports Medicines: Prohibited Drugs and Substances (References WADA 1 January 2013) THE 2013 PROHIBITED LIST WORLD ANTI-DOPING CODE Valid w.e.f 1 January 2013 In accordance with Article
More informationTHE 2013 PROHIBITED LIST WORLD ANTI-DOPING CODE
BGBl. III - Ausgegeben am 20. Dezember 2012 - Nr. 189 1 von 6 ANTI-DOPING CONVENTION (ETS No. 135) AMENDMENTS TO THE APPENDIX approved by the Monitoring Group under Article 11.1.b of the Convention at
More informationLIST OF DRUGS. Anabolic Steroids
LIST OF DRUGS NOTE: A natural athlete DOES NOT consume any of these substances in any form at any point of his/her life. Anabolic Steroids Anadrol Anavar Anderone Andropen 1-Androstendiol 1-Androstendione
More informationThe United States Cycling Federation
The United States Cycling Federation Welcome! On behalf of the USCF, we hope that you are looking forward to a new year of bike racing. We are glad that you are a member and hope that you will find many
More information2008 Adverse Analytical Findings and Atypical Findings Reported by Accredited Laboratories. Overview of Results
2008 Findings and Atypical Findings Overview of Results Table A All Sports Differentiation between Olympic and Non-Olympic Sports A A A A Atypical Total (%) Findings 2 (%) (%) Olympic Sports Non-Olympic
More informationTHE 2013 PROHIBITED LIST
The World Anti-Doping Code THE 2013 PROHIBITED LIST INTERNATIONAL STANDARD The official text of the Prohibited List shall be maintained by WADA and shall be published in English and French. In the event
More informationSubstances and Methods Prohibited at all times (In- and Out-of-Competition)
The World Anti-Doping Code 2014 Prohibited List This List shall come into effect on 1 January 2014. In accordance with Article 4.2.2 of the World Anti-Doping Code, all Prohibited Substances shall be considered
More informationWADA Technical Document TD2018MRPL
MINIMUM REQUIRED PERFORMANCE LEVELS FOR DETECTION AND IDENTIFICATION OF NON-THRESHOLD SUBSTANCES In order to ensure that all WADA-accredited Laboratories can report the presence of Prohibited Substances,
More information2011 PROHIBITED DRUG CLASSES AND METHODS. Dr Nicolas Theron Loch Logan Waterfront Sport and Travel Medicine Centre Tel :
2011 PROHIBITED DRUG CLASSES AND METHODS Dr Nicolas Theron Loch Logan Waterfront Sport and Travel Medicine Centre Tel : 051-4481389 Doping is defined as the administration of substances belonging to prohibited
More informationTHE 2014 PROHIBITED LIST WORLD ANTI-DOPING CODE
BGBl. III - Ausgegeben am 20. Jänner 2014 - Nr. 18 1 von 6 ANTI-DOPING CONVENTION (ETS No. 135) AMENDMENTS TO THE APPENDIX (approved by the Monitoring Group under Article 11.1.b of the Convention following
More informationTEAM TRYOUTS
2013-2014 TEAM TRYOUTS SPRINTS, JUMPS, HURDLES & LONG SPRINTS (400, 800) The tryout will take place over a span of 3 practices. Those dates are Wednesday September 4 th, Thursday September 5 th and Friday
More informationTO BE COMPLETED BY THE STUDENT: Name: Banner ID: Date(s) of Tryout:
MIAMI UNIVERSITY Athletic Compliance Office TRYOUT POLICY CHECKLIST FOR TRYOUT STUDENTS TO BE COMPLETED BY THE STUDENT: Name: Banner ID: Sport: DOB: Date(s) of Tryout: I have completed and attached the
More informationUNIVERSITY OF UTAH ATHLETICS
Athletics Compliance Office STUDENT-ATHLETE MEDICAL RELEASES UNIVERSITY OF UTAH ATHLETICS Student-Athlete Name Sport ID # Student-Athlete Local Address Student-Athlete Phone # of Birth PART I: Assumption
More informationAmateur Athletic Union Powerlifting Adult Substance Abuse Program 2003
Amateur Athletic Union Powerlifting Adult Substance Abuse Program 2003 AAU Adult Powerlifting Substance Abuse Program A. Introduction B. Overview of the program C. Organization D. Responsibilities of the
More informationDrugs and Ethics in Sport
Drugs and Ethics in Sport Ethics the practice of making principled choices between right and wrong explicitly reflecting on moral beliefs and practices Principles for an Ethical Framework Respect Basic
More informationPROHIBITED LIST JANUARY 2016
WORLD ANTI-DOPING CODE INTERNATIONAL STANDARD PROHIBITED LIST JANUARY 2016 This List shall come into effect on 1 January 2016. The official text of the Prohibited List shall be maintained by WADA and shall
More information2. PROHIBITED SUBSTANCES
2. PROHIBITED SUBSTANCES All Players shall be prohibited from using, possessing, selling, facilitating the sale of, distributing, or facilitating the distribution of any Drug of Abuse, Performance Enhancing
More informationDrugs in Sport. Fifth Edition. Edited by David R. Mottram. Routledge. Taylor & Francis Group LONDON AND NEW YORK
Drugs in Sport Fifth Edition Edited by David R. Mottram Routledge Taylor & Francis Group LONDON AND NEW YORK Contents Contributors xv SECTION I The basis for and regulation of drug use in sport I 1 An
More informationSt. Peter s Prep Athletics Parental Permission for Participation
St. Peter s Prep Athletics Parental Permission for Participation I do hereby grant permission for my son to participate in the program with no restrictions. I understand this sport is fully sponsored by
More informationDiana Heiman, MD Associate Professor, Family Medicine Residency Director East Tennessee State University
Diana Heiman, MD Associate Professor, Family Medicine Residency Director East Tennessee State University Objectives Introduce governing bodies in sport Review banned and restricted substances Discuss therapeutic
More informationInternational Convention Against Doping in Sport FINAL DRAFT
ED/2005/CONV-DOP rev.2 International Convention Against Doping in Sport FINAL DRAFT ED/2005/CONV-DOP rev.2 Preamble The General Conference of the United Nations Educational, Scientific and Cultural Organisation
More information2009 Adverse Analytical Findings and Atypical Findings Reported by Accredited Laboratories. Overview of Results. A Samples. Adverse Analytical
2009 Findings and Atypical Findings Reported by Accredited Laboratories Overview of Results Table A All Sports Differentiation between Olympic and Non-Olympic Sports A A A A Atypical,3 (%) Findings 2,3
More informationIntroduction to the Doping Problem
Introduction to the Doping Problem Jordi Segura Director, WADA Accredited Antidoping Laboratory, IMIM-Hospital del Mar, Barcelona, Spain Doping and Society: towards the perfect human machine? ESOF, Barcelona
More informationADAU RAW POWER PENNSYLVANIA STATE POWERLIFTING CHAMPIONSHIPS
ADAU RAW POWER PENNSYLVANIA STATE POWERLIFTING CHAMPIONSHIPS Saturday 8 May 0 Kumite Classic/FAST Expo (www.pghfitness.com) Monroeville Convention Center 0 Mall Boulevard Monroeville, PA 546 Schedule:
More informationNO ATHLETE WILL USE ANY ILLICIT OR SPORT ENHANCING SUBSTANCES, NOR WILL ANY ATHLETE ABUSE PRESCRIBED MEDICATIONS, ALCOHOL, OR USE TOBACCO SUBSTANCES
Indiana University South Bend Drug Testing Policy All student-athletes are advised that it is the policy of the IU South Bend Department of Athletics that NO ATHLETE WILL USE ANY ILLICIT OR SPORT ENHANCING
More informationTHE 2015 PROHIBITED LIST WORLD ANTI-DOPING CODE
BGBl. III - Ausgegeben am 2. Dezember 2014 - Nr. 229 1 von 8 ANTI-DOPING CONVENTION (ETS No. 135) AMENDMENT TO THE APPENDIX approved by the Monitoring Group under Article 11.1.b of the Convention at its
More informationPsychology. Psychology & Performance Enhancing Substances. The Ideal Performance State. Relationship Between Confidence and Athletic Performance
Psychology & Performance Enhancing Substances Psychology The Ideal Performance State Absence of fear no fear of failure No thinking about or analysis of performance Narrow focus of attention concentrated
More informationAnti-Doping Regulations
Anti-Doping Regulations 1 Application The Regulations apply to all Cricketers playing, or a member of a squad selected to play, in any match at any level, controlled by, or held under the auspices of,
More informationUpdates on Anti-doping and TUE Management in Paralympic Sport
International Paralympic Committee Updates on Anti-doping and TUE Management in Paralympic Sport Matthew Fedoruk, Ph.D. March 15, 2018 PyeongChang 2018 IPC Medical / Sports Science Committee Workshops
More information2016 Prohibited List
The World Anti-Doping Code 2016 Prohibited List This List shall come into effect on 1 January 2016. In accordance with Article 4.2.2 of the World Anti-Doping Code, all Prohibited Substances shall be considered
More informationICADS/Annex I/2016 INTERNATIONAL CONVENTION AGAINST DOPING IN SPORT. Annex I Prohibited List International Standard
ICADS/Annex I/2016 INTERNATIONAL CONVENTION AGAINST DOPING IN SPORT Annex I Prohibited List International Standard Paris, 1 January 2016 THE 2016 PROHIBITED LIST WORLD ANTI-DOPING CODE Valid 1 January
More informationSMART 4 Sports Panel. Drug Free Sport 1 7/13/07
Ball State University SMART S Drug-Testing Price List Effective: July 1, 2007 June 30, 2008 SMART (Sports Monitoring Addressing Real Threats) drug-testing panels are designed to target substances specific
More informationDRUG-TESTING PROGRAM
DRUG-TESTING PROGRAM Copyright 2017 CrossFit Inc. All Rights Reserved. CrossFit is a registered trademark of CrossFit Inc 2017 DRUG-TESTING PROGRAM 1. DRUG-FREE COMPETITION As the world s definitive test
More information2006 Guide to Prohibited Substances and Prohibited Methods of Doping
2006 Guide to Prohibited Substances and Prohibited Methods of Doping DRUG REFERENCE ONLINE TM (DRO TM ) Drug Reference Online TM is a searchable, web-accessible database containing accurate and up-to-date
More informationSecretaries/Chief Executive Officers of Unions and Regional Associations in Membership of the IRB
To: Secretaries/Chief Executive Officers of Unions and Regional Associations in Membership of the IRB From: David Carrigy, Head of External & Member Relations Date: December 18, 2012 Re: 2013 WADA Prohibited
More information2016 Prohibited List
16 September 2015 2016 Prohibited List Summary of Major Modifications and Explanatory Notes SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OF- COMPETITION) PROHIBITED SUBSTANCES S2: Peptide
More informationWhat every physician should know about doping and doping control
COMMUNICATION What every physician should know about doping and doping control What every physician should know about doping and doping control O que todo médico deveria conhecer sobre doping e controle
More informationAndrogenes and Antiandrogenes
Androgenes and Antiandrogenes Androgens The androgens are a group of steroids that have anabolic and/or masculinizing effects in both males and females. Testosterone [tess-toss-terone], the most important
More informationDoping in Sports: Catching and Preventing It An Expert Interview With Gary I. Wadler, MD
Doping in Sports: Catching and Preventing It An Expert Interview With Gary I. Wadler, MD Carol Peckham; Gary I. Wadler, MD As part of our coverage of the 2012 Olympics, Medscape interviewed Gary I. Wadler,
More informationWADA Technical Document TD2014EAAS. Endogenous Anabolic Androgenic Steroids Measurement and Reporting
Endogenous Anabolic Androgenic Steroids Measurement and Reporting 1.0 Introduction The purpose of this Technical is to harmonize the approaches to the measurement and reporting of endogenous anabolic androgenic
More informationTexas Health & Safety Code Penalty Group 3. Effective: September 1, 2009
Texas Health & Safety Code 481.104 Penalty Group 3 Effective: September 1, 2009 (a) Penalty Group 3 consists of: (1) a material, compound, mixture, or preparation that contains any quantity of the following
More informationPROHIBITED LIST JANUARY 2016
WORLD ANTI-DOPING CODE INTERNATIONAL STANDARD 00 00 0 ~~~~ " " " " " ' ' ',,,,,",,",,,,,,",,",,,,,,, ",,",,," " " " ~~~~ " ~~~~,"","," ~~~~ "," " " ' " ","',"',",","","' " " ", " " " " I 0 00 000 00 0
More informationTHE 2017 PROHIBITED LIST. WORLD ANTI-DOPING CODE
REGULATION 21 SCHEDULE 2 SCHEDULE 2. THE 2017 PROHIBITED LIST. WORLD ANTI-DOPING CODE Valid 1 January 2017 In accordance with Article 4.2.2 of the World Anti-Doping Code, all Prohibited Substances shall
More informationFollowing an Olympics shadowed by the Russian
CEUQuiz Performance Enhancing Drugs Scandals, Oversite and Advancement Following an Olympics shadowed by the Russian performance enhancing drug (PED) scandal, banned substances once again reach the forefront
More informationHeading: Critical Question 3: What Ethical issues are related to improving performance
Syllabus Critical Question 3 Heading: Critical Question 3: What Ethical issues are related to improving performance Heading: Use of Drugs Doping is the practice of using artificial substances or methods
More informationEssential Standards. 8.ATOD.2 Understand the health risks associated with alcohol, tobacco, and other drug use.
Essential Standards 8.ATOD.2 Understand the health risks associated with alcohol, tobacco, and other drug use. Clarifying Objective 8.ATOD.2.2 Evaluate the magnitude and likelihood of the risks associated
More informationAnnex I Prohibited List International Standard
ICDS/Annex I/2017 Annex I Prohibited List International Standard According to letter DG/3/16/7036-2, the amendments to Annex I to the International Convention against Doping in Sport will enter into force
More informationHair Testing to provide additional evidence in doping cases of potential (clenbuterol) contaminations
Hair Testing to provide additional evidence in doping cases of potential (clenbuterol) contaminations Detlef Thieme Institute of Doping Analysis, Dresden, Germany Beijing, Oct 2017 [M. Jahn (www.kreischa.net)]
More informationCHAPTER XVI PDL 101 HUMAN ANATOMY & PHYSIOLOGY. Ms. K. GOWRI. M.Pharm., Lecturer.
CHAPTER XVI PDL 101 HUMAN ANATOMY & PHYSIOLOGY Ms. K. GOWRI. M.Pharm., Lecturer. Muscle Cell Metabolism Muscle Cells Provide ATP to Drive the Crossbridge Cycle The sources of ATP: Available ATP in the
More informationADOPTED REGULATION OF THE STATE BOARD OF PHARMACY. LCB File No. R Effective October 24, 2014
ADOPTED REGULATION OF THE STATE BOARD OF PHARMACY LCB File No. R016-14 Effective October 24, 2014 EXPLANATION Matter in italics is new; matter in brackets [omitted material] is material to be omitted.
More informationFair Competition and Drug Control
Fair Competition and Drug Control Speaker: Dr. Yves Bonnaire General Manager, Laboratoire des Course Hippiques Dr Yves BONNAIRE Advisory Council LOGO PROHIBITED SUBSTANCES an update. PROHIBITED SUBSTANCES
More informationTHE WORLD ANTI-DOPING CODE INTERNATIONAL STANDARD PROHIBITED LIST JANUARY 2017
THE WORLD ANTI-DOPING CODE INTERNATIONAL STANDARD PROHIBITED LIST JANUARY 2017 The official text of the Prohibited List shall be maintained by WADA and shall be published in English and French. In the
More informationBANNED & RESTRICTED SUBTANCES IN SPORTS
BANNED & RESTRICTED SUBTANCES IN SPORTS TEAM PHYSICIAN COURSE Feb 2015: San Antonio SUZANNE HECHT, MD OBJECTIVES Introduce governing bodies in sports Review ban and restricted substances Discuss therapeutic
More informationAnti-Doping Convention
European Treaty Series - No. 135 Anti-Doping Convention Strasbourg, 16.XI.1989 Appendix AMENDMENTS TO THE APPENDIX (approved by the Monitoring Group under Article 11.1.b of the Convention at its 45th meeting)
More informationNational Anti Doping Agency India PROHIBITED LIST
National Anti Doping Agency India PROHIBITED LIST - 2017 This List is effective from 1 January 2017 In accordance with Article 4.2.2 of the World Anti-Doping Code, all Prohibited Substances shall be considered
More informationVoluntary Anti-Doping Association Official Prohibited List
Voluntary Anti-Doping Association Official Prohibited List This document contains the Official Prohibited List (Substances and Methods) of the Voluntary Anti-Doping Association (VADA). VADA guidelines
More informationSession of HOUSE BILL No By Committee on Corrections and Juvenile Justice 1-26
Session of 0 HOUSE BILL No. 0 By Committee on Corrections and Juvenile Justice - 0 0 0 AN ACT concerning controlled substances; relating to methamphetamine precursors; amending K.S.A. -0 and - and K.S.A.
More informationLearning Goals. What are steroids? Who uses steroids? Why do people use steroids? What are the health risks associated with using steroids?
Learning Goals What are steroids? Who uses steroids? Why do people use steroids? What are the health risks associated with using steroids? Performance Enhancing Drugs Nutritional Aids Pharmacological Aids
More informationPERFORMANCE ENHANCING DRUGS
PERFORMANCE ENHANCING DRUGS L I S A C O H E N, P H A R M. D., C D E, C D O E, C V D O E A S S O C I A T E P R O F E S S O R O F P H A R M A C Y P R A C T I C E DISCLOSURES I have no financial relationship
More informationWe Are For Clean Basketball
We Are For Clean Basketball What is doping? DOPING is the use of substances and methods intended to improve the performance of a player. It poses a risk to health. It is contrary to sporting ethics. Doping
More informationWe Are For Clean Basketball
We Are For Clean Basketball What is doping? DOPING is the use of substances and methods intended to improve the performance of a player. It poses a risk to health. It is contrary to sporting ethics. Doping
More informationLIFETIME FITNESS HEALTHY NUTRITION. UNIT 2 Lesson 14 FLEXIBILITY LEAN BODY COMPOSITION
LIFETIME FITNESS HEALTHY NUTRITION MUSCULAR STRENGTH AEROBIC ENDURANCE UNIT 2 Lesson 14 FLEXIBILITY LEAN BODY COMPOSITION MUSCULAR ENDURANCE Created by Derek G. Becher B.P.E., B. Ed., AFLCA Resistance
More informationBiology Advanced Unit 5: Energy, Exercise and Coordination
Pearson Edexcel International Advanced Level Biology Advanced Unit 5: Energy, Exercise and Coordination June 2015 Scientific Article for use with Question 7 Paper Reference WBI05/01 Do not return the insert
More informationADOPTED REGULATION OF THE STATE BOARD OF PHARMACY. LCB File No. R Effective November 14, 1997
ADOPTED REGULATION OF THE STATE BOARD OF PHARMACY LCB File No. R132-97 Effective November 14, 1997 EXPLANATION Matter in italics is new; matter in brackets [ ] is material to be omitted. AUTHORITY: 1,
More informationAUGUST, Sport is. What is doping? Page 2. Can sport be free? Page 3. How disabillities impact the access to sports? Page 4. + the Test!
Sport is What is doping? Page 2 Can sport be free? Page 3 How disabillities impact the access to sports? Page 4 + the Test! Page 5 1 What is Doping? In competitive sports, doping refers to the use of forbidden
More informationWhat do these athletes have in common?
What do these athletes have in common? Drugs in Sport Why do athletes cheat? 1988 Olympics 100m Final Why is this photo so iconic? 1988 Olympics 100m Final First time ever 4 of the 8 finalists run under
More informationAgenda
Agenda Why are you participating in sport? Caring for sport The True Sport Movement The pressures on athletes What is doping? The fight against doping Sanctions for anti-doping violations The WADA Prohibited
More informationViapath Innovation Academy 5 December 2014
Viapath Innovation Academy 5 December 2014 Interview with Dr Andrew Kicman of King s College London conducted by Robert Dunn of the Future Leaders in Innovation Group, Viapath. How did you choose your
More informationHGH for Sale Natural Anti-Aging Human Growth Hormone
HGH for Sale Natural Anti-Aging Human Growth Hormone Human growth hormone is one of the hottest supplement trends on the market, and now you can purchase top-quality HGH to be delivered right to your home!
More informationAlcohol & Supplements and U16
Alcohol & Supplements and U16 Alcohol linked to sport in the post-event or post training binge drinking 20% is absorbed into the bloodstream through the stomach and the remainder through the small intestine
More informationSimultaneous Determination of a Panel of 22 Steroids in Urine and Serum by SPE and LC-MS/MS
Simultaneous Determination of a Panel of 22 Steroids in Urine and Serum by SPE and LC-MS/MS UCT Part Numbers: CUQAX22Z Clean-Up C8+QAX, 2mg/1mL BETA-GLUC- ml Beta-Glucuronidase Enzyme, liquid form SLAQID21-3UM
More informationThe all-embracing word DRUGS covers a wide range of substances.
DRUGS IN SPORT We have looked at a variety of Assets which sportspeople may be gifted with, develop and train for. But there is something else that some athletes use to train to win and that is DRUGS.
More informationUse of Performance Enhancing Substances Good Chemistry Gone Bad. Evan M. Klass, M.D., F.A.C.P.
Use of Performance Enhancing Substances 2017 Good Chemistry Gone Bad Evan M. Klass, M.D., F.A.C.P. Doping the use of banned athletic performance-enhancing drugs by competitors Performance enhancing substances
More informationDOPING POSITIVE CASES IN THE SEIBERSDORF LABORATORY THREE YEARS STATISTICS. Folie S E I B E R S D O R F. Folie
Günter Gmeiner DOPING POSITIVE CASES IN THE SEIBERSDORF LABORATORY THREE YEARS STATISTICS Folie 1 20.03.2007 Overview What are we doing in Seibersdorf? Where is Seibersdorf? Folie 2 20.03.2007 Where is
More informationAnti-doping rules and procedures
Anti-doping rules and procedures www.antidopings.lv www.facebook.com/antidopings.lv Vieda Lūsa Anti-Doping department of State Sports Medicine Centre in Latvia 1. What is it - Doping? 2. Why is Doping
More informationTHE WORLD ANTI-DOPING CODE INTERNATIONAL STANDARD PROHIBITED LIST JANUARY 2018
THE WORLD ANTI-DOPING CODE INTERNATIONAL STANDARD PROHIBITED LIST JANUARY 2018 The official text of the Prohibited List shall be maintained by WADA and shall be published in English and French. In the
More informationAnavar For Sale Oxandrolone
Anavar For Sale Oxandrolone Anavar (oxandrolone C 19 H 30 O 3 ) is an anabolic steroid that provides outstanding results. The Anavar steroid is a synthesized version of testosterone that boosts lean muscle
More informationList of Prohibited Substances
APPENDIX A List of Prohibited Substances The following substances and methods are prohibited by the National Football League: I. ANABOLIC AGENTS A. ANABOLIC/ANDROGENIC STEROIDS: Androstenediol Androstederm
More informationPROPOSED REGULATION OF THE STATE BOARD OF PHARMACY. LCB File No. R June 26, NAC is hereby amended to read as follows:
PROPOSED REGULATION OF THE STATE BOARD OF PHARMACY LCB File No. R003-01 June 26, 2001 EXPLANATION Matter in italics is new; matter in brackets [omitted material] is material to be omitted. AUTHORITY: 1,
More informationAustralian Supplement Survey Summary
Australian Supplement Survey Summary Introduction LGC, an established international life sciences measurement and testing company, has been analysing nutritional supplements for substances prohibited
More informationCh 17 Endocrinology, Part 2
Ch 17 Endocrinology, Part 2 Adrenal Gland (p 525) Steroid hormones and their glands Other endocrine glands Compare Endocrine and Nervous systems Developed by John Gallagher, MS, DVM Adrenal (or Suprarenal)
More informationPROPOSED REGULATION OF THE STATE BOARD OF PHARMACY
LCB FILE NO. R163-01 PROPOSED REGULATION OF THE STATE BOARD OF PHARMACY REGULATIONS REGARDING PRODUCTS CONTAINING EPHEDRINE, PSEUDOEPHEDRINE, OR PHENLYPROPANOLAMINE NAC 453.010 shall be amended to add
More information