Pay-as-You-Go Information Integration

Transcription

1 Pay-as-You-Go Information Integration David Maier & Nicholas B. Rayner Department of Computer Science Portland State University II Workshop

2 Dataspace Management* Dealing with all information in an enterprise, regardless of form Universal services: cataloging, keyword search Source identification and relationships Information enhancement Dataspace profiling *Michael J. Franklin, Alon Y. Halevy, David Maier: From databases to dataspaces: a new abstraction for information management. SIGMOD Record 34(4): (2005) II Workshop

3 Pay-as-You-Go Interested in dataspace approaches that have incremental return on investment (ROI) Information Integration: Benefit by the end of the day Me: Incremental characterization and customization Enhance single source Enhance a combination of sources II Workshop

4 RxSafe Project* Combined medication record for elders in rural Oregon Goals Consolidated medication list for crossprovider awareness and reconciliation Detection and prevention of errors in medication therapy * AHRQ 1 UC1 HS , also NSF IIS II Workshop

5 RxSafe Dataspace Medication records Assisted living facilities, Primary care clinics, Hospital, Pharmacies Standards for medication information National Drug Code Directory (NDCD), FDA, packaged drugs RxNorm, NLM, describing clinical drugs National Drug File Reference Terminology (NDF-RT), VA, drug classes II Workshop

6 NDCD: National Drug Code Directory listings l_seq_no lblcode prodcode tradename f_seq_no formulation l_seq_no strength unit ingredient_name firms f_seq_no lblcode firm_name packages l_seq_no pkgcode pkgsize Codes for drug packages II Workshop

7 Sample NDC: l_seq_no lblcode prodcode tradename f_seq_no Vicodin tab l_seq_no strength unit ingredient_name MG Hydrocodone MG Acetaminophen l_seq_no pkgcode pkgsize f_seq_no lblcode firmname Amerisource II Workshop

8 RxNorm Published Structure [RxNorm: A Guide for the Perplexed, 8

9 RxNorm Supplied Structure [based on RxNorm Documentation, 9

10 RxNorm: Comparing Representations 10

11 NDF-RT National Drug File Reference Terminology From Veterans Affairs Drug class Chemical class Effects and actions II Workshop

12 NDF-RT (Blue) II Workshop

13 Issues Internal properties of sources What is a key, foreign key in NDCD Generic structure Comparability Tradename (NDCD) vs. Brand Name (RxNorm) Convention changes across releases II Workshop

14 Connectivity: RxNorm and NDF-RT Classes for 54% of brand names (RxNorm of 11/16/05) 14

15 Dataspace Workbench Interactive tool suite for dataspace characterization and customization Similar properties have similar verification or discovery procedures Properties of same type suggest same customizations II Workshop

16 Architectural Framework Modularized components for different property types, with 3 components Probe: property verification or inference <c1,hasform,c2> c1=clinical drug, c2=dose form Switch: customization that exploits property hasform(clinical_drug, Dose_Form) Check: ensure updates don t invalidate Might be easier than probe II Workshop

17 Module 1: Proposed Functional Dependencies 17

18 Applying Module 1 to NDCD Firms and Listings share two columns lblcode contains FDA-assigned labeler codes for firms firm_seq_no contains an arbitrary primary key for Firms lblcode firm_seq_no? true FD in both tables key in Firms firm_seq_no lblcode? key in Firms violated in Listings 18

19 Applying Module 1: Described Violations firm_seq_no lblcode count LETE 1 19

20 Module 2: Linking Through Equivalency 20

21 Applying Module 2: RxNorm and NDF-RT ingredient class? Almost of 1,068 singleingredient drugs have >1 class Partition! 21

22 What s the Benefit? SELECT DISTINCT i.scd, c.class FROM scd_ing AS i INNER JOIN scd_class AS c ON i.scd = c.scd WHERE i.scd IN ('Penicillin G UNT Oral Tablet', 'Ibuprofen 200 MG Oral Capsule', 'Acebutolol 400 MG Oral Capsule'); scd class Acebutolol 400 MG Oral Capsule BETA-BLOCKERS/RELATED SELECT DISTINCT i.scd, c.class FROM scd_ing_lim AS i INNER JOIN scd_ing_lim_scd_class_equivlink AS c ON i.ing = c.ing WHERE i.scd IN ('Penicillin G UNT Oral Tablet', 'Ibuprofen 200 MG Oral Capsule', 'Acebutolol 400 MG Oral Capsule'); scd class Acebutolol 400 MG Oral Capsule BETA-BLOCKERS/RELATED Ibuprofen 200 MG Oral Capsule NONSALICYLATE NSAIS, ANTIRHEUMATIC Penicillin G UNT Oral Tablet PENICILLIN G-RELATED PENICILLINS II Workshop

23 Next Module: Path Analysis Clinical Drug (SCD) N = 20,249 has_tradename 11,912 Branded Drug (SBD) N = 11,912 isa 16,626 Clinical Drug Form (SCDF) N = 5,727 has_tradename 8,326 isa 11,753 Branded Drug Form (SBDF) N = 8,326 II Workshop

24 Different Paths, Different Results: Finding the Branded Drug Forms of Single-Ingredient Clinical Drugs Clinical Drug (SCD) N = 20,249 isa 16,626 Clinical Drug Form (SCDF) N = 5,727 has_tradename 11,912 11,753 47,187 has_tradename 8,326 Branded Drug (SBD) N = 11,912 isa 11,753 Branded Drug Form (SBDF) N = 8,326 II Workshop

25 What Next? Module interactions Hiding or enabling customizations Redoing sequences of customizations on update Expand beyond relational model Sample data inspection More declarative implementation of modules II Workshop

26 Extras II Workshop

27 Example: Ivermectin SBD SCD Ivermectin 3 MG Oral Tablet Ivermectin 3 MG Oral Tablet has_tradename [Stromectol] Ivermectin 6 MG Oral Tablet Ivermectin 6 MG Oral Tablet 1 1 [Mectizan] 2 1 isa isa 1 1 SCDF Ivermectin Oral Tablet has_tradename 1 2 SBDF Ivermectin Oral Tablet [Stromectol] Ivermectin Oral Tablet [Mectizan] II Workshop

28 Intermediaries Filter Information SCD-SBDF Path Result from Ivermectin 3 MG Oral Tablet via SBD SCD SBD SBDF Ivermectin 3 MG Oral Tablet Ivermectin 3 MG Oral Tablet [Stromectol] Ivermectin Oral Tablet [Stromectol] SCD-SBDF Path Result from Ivermectin 3 MG Oral Tablet via SCDF SCD SCDF SBDF Ivermectin 3 MG Oral Tablet Ivermectin 3 MG Oral Tablet Ivermectin Oral Tablet Ivermectin Oral Tablet Ivermectin Oral Tablet [Stromectol] Ivermectin Oral Tablet [Mectizan] II Workshop